This paper studies the asymptotic control problem of a class of large-scale high-order nonlinear systems (LSHONSs), and an asymptotic fuzzy adaptive dynamic surface controller is developed. Unknown nonlinear terms are learned online by fuzzy logic systems (FLSs) such that the accurate nonlinear model is released in the controller design procedure, where the parameters of FLSs are updated by developing adaptive laws. To compensate for the “boundary error” caused by the dynamic surface control method where a linear filter is added in the backstepping procedure to handle the “explosion of complexity” problem, a nonlinear filter is proposed to eliminate the boundary layer error. Some simulations are given to demonstrate the effectiveness of the proposed algorithm.