Parameters In Postmenopausal Women Research Articles

Metabolomic profiles of ovariectomized mice and their associations with body composition and frailty-related parameters in postmenopausal women.

Menopause, a dramatical estrogen-deficient condition, is considered the most significant milestone in women's health. To investigate the metabolite changes attributed to estrogen deficiency using random forest (RF)-based machine learning (ML) modeling strategy in ovariectomized (OVX) mice as well as determine the clinical relevance of selected metabolites in older women. Untargeted and targeted metabolomic analyses revealed that metabolites related to TCA cycle, sphingolipids, phospholipids, fatty acids, and amino acids, were significantly changed in the plasma and/or muscle of OVX mice. Subsequent ML classifiers based on RF algorithm selected alpha-ketoglutarate (AKG), arginine, carnosine, ceramide C24, phosphatidylcholine (PC) aa C36:6, and PC ae C42:3 in plasma as well as PC aa 34:1, PC aa C34:3, PC aa C36:5, PC aa C32:1, PC aa C36:2, and sphingosine in muscle as top featured metabolites that differentiate the OVX mice from the sham-operated group. When circulating levels of AKG, arginine, and carnosine, which showed the most significant changes in OVX mice blood, were measured in postmenopausal women, higher plasma AKG levels were associated with lower bone mass, weak grip strength, poor physical performance, and increased frailty risk. Metabolomics- and ML-based methods identified the key metabolites of blood and muscle that were significantly changed after ovariectomy in mice, and the clinical implication of several metabolites was investigated by looking at their correlation with body composition and frailty-related parameters in postmenopausal women. These findings provide crucial context for understanding the diverse physiological alterations caused by estrogen deficiency in women.

Relationship between dietary characteristics and heel quantitative ultrasound parameters in postmenopausal women from the OsteoLaus cohort

The role of dietary patterns in the development of osteoporosis is unclear. The heel quantitative ultrasound (QUS) is a potential alternative to Dual X-Ray Absorptiometry. Nutrients, foods, dietary patterns and compliance to dietary guidelines were compared between the lowest and the highest tertiles of QUS parameters [Broadband Ultrasound Attenuation (BUA), Speed of Sound (SOS), Stiffness Index (SI)], using data from the OsteoLaus cohort. Participants in the highest tertiles of QUS parameters (385 for BUA, 397 for SOS, 386 for SI) were younger, of higher body weight, and had less major osteoporotic fractures. Women in the highest tertiles of SI and BUA consumed more fat (35.1 ± 0.4 vs 33.9 ± 0.4 and 34.9 ± 0.4 vs 33.8 ± 0.4 gr/day for SI and BUA, respectively, p < 0.05), and complied less frequently with dairy intake guidelines [odds ratio (95% confidence interval): 0.70 (0.53–0.92) and 0.72 (0.55–0.95) for SI and BUA, respectively, p < 0.05] than women in the lowest tertile. No differences were found regarding dietary patterns, healthy dietary scores, or compliance to dietary guidelines. Postmenopausal women in the highest QUS tertiles were younger, of higher weight and BMI, consumed more monounsaturated fatty acids and less dairy and calcium than women in the lowest tertiles. No differences were found between QUS tertiles regarding dietary patterns.

Dual role of sclerostin and other parameters in postmenopausal women with osteoporosis

Background &amp; objective: Osteoporosis is a chronic progressive disease, characterized by decreased bone mass and damage to the microstructure of bone tissue, leading to decreased bone strength and increased risk of fractures. The main serious consequence of osteoporosis is fragility fracture. This case-control study was conducted to know the prevalence of osteoporosis in Iraqi postmenopausal women.&#x0D; Methodology: One hundred female patients visiting Al-Sader Teaching Hospital in Al-Najaf province of Iraq, were included in the study. To determine the percentage of their bone density we used a dual energy x-ray absorptiometry (DEXA). Blood samples were taken after diagnosing the disease. In addition, serum estrogen and vitamin D3 were measured by enzyme linked immune sorbent assay (ELISA), while alkaline phosphatase was measured by spectrophotometer. Data were gathered by direct interviews with the women. The study excluded those who had chronic diseases.&#x0D; Results: This study showed a significant increase (P &lt; 0.05) in the concentration of sclerostin and alkaline phosphatase and non-significant differences in vitamin D3 concentrations between patients and healthy group.&#x0D; Conclusion: Increased serum sclerostin and alkaline phosphatase levels in postmenopausal women with osteoporosis play an important role in the development of primary osteoporosis.&#x0D; Key word: Osteoporosis; Sclerostin; DEXA&#x0D; Citation: Ahmed NH, Jaffat HS, Alrufaie MM. Dual role of sclerostin and other parameters in postmenopausal women with osteoporosis. Anaesth. pain intensive care 2023;27(6):745−749; DOI: 10.35975/apic.v27i6.2349&#x0D; Received: August 22, 2023; Revised: August 29, 2023; Accepted: September 11, 2023

The Impact of Sustainable Exercise on Self-Efficacy and Life Satisfaction in Women before and after Menopause.

The study aims at elucidating the association between sustainable exercise and its influence on self-efficacy and life satisfaction in women during their premenopausal and postmenopausal stages. A relational screening model was employed on a sample of 422 women, with 215 premenopausal and 207 postmenopausal participants, utilizing convenience sampling. Participants' regularity of exercise and its duration was taken into consideration. Evaluation tools included the General Self-Efficacy Scale (GSES) and the Satisfaction with Life Scale (SWLS). Data were analyzed using a statistical software package with significance set at 0.05. Sustainable exercise demonstrated no significant difference in SWLS or GSES subdimensions among premenopausal women. However, postmenopausal women engaging in regular exercise reported significantly higher scores in SWLS and all GSES subdimensions. Moreover, positive correlations between age and SWLS scores, as well as between age and certain GSES subdimensions, were found in both pre- and postmenopausal periods. While sustainable exercise does not evidently impact the life satisfaction and self-efficacy of premenopausal women, it significantly enhances these parameters in postmenopausal women. Additionally, age appears to influence life satisfaction and specific self-efficacy subdimensions across both phases.

The Dual Role of Dickkopf-1 and Other Parameters in Postmenopausal Women with Osteoporosis

The Dual Role of Dickkopf-1 and Other Parameters in Postmenopausal Women with Osteoporosis

Effects of flaxseed (Linum usitatissimum) on climacteric symptoms and clinical parameters in post-menopausal women

Menopause is the irreversible and permanent cessation of menstruation after one year of amenorrhea. Common symptoms include vaginal dryness, hot flashes, night sweating, and bone pain. Traditionally Linum usitatissimum (Flaxseeds) has been used for the treatment of postmenopausal symptoms. However, the effect of this medicinal herb on the satiety hormone; leptin and body weight in menopausal women has not been elucidated well. This study was designed to evaluate the effect of flaxseeds on serum estrogen, progesterone, leptin, and malondialdehyde, body mass index, blood pressure in menopausal women. Moreover, the flaxseed effect on climacteric symptoms was also investigated.&#x0D; The study was carried out as an interventional pre-post design. The study was a six-week oral administration of 1000 mg flaxseed powder twice daily by menopausal women. The duration of the study was eight months. Serum levels of estrogen, progesterone, and leptin hormones as well as total plasma malondialdehyde were determined pre-and-post flaxseed intervention. Clinical symptoms and bothersome complaints of postmenopausal women such as hot flashes, vaginal dryness, bone pain, and night sweating were also evaluated. Furthermore, blood pressure elements and body mass index were also measured. The results showed that Linum usitatissimum seed powder significantly reduced vaginal dryness, hot flashes, bone pain, and night sweating in menopausal women. The same dose of flaxseed had no significant effects on serum estrogen and progesterone. However, it significantly decreased serum malondialdehyde and increased serum leptin. Flaxseed had a non-significant effect on body mass index and blood pressure. In conclusion Linum usitatissimum seed had significant efficacy in relieving vasomotor symptoms, decreasing oxidative stress, and increasing serum levels of leptin in menopausal women.&#x0D; Keywords: climacteric, estrogen, progesterone, leptin, malondialdehyde.

Effect of Ospemifene on Densitometric and Plasma Bone Metabolism Biomarkers in Postmenopausal Women Reporting Vulvar and Vaginal Atrophy (VVA).

Women reporting VVA symptoms were included. Bone health profile was investigated in 61 subjects treated with OSP (OSPG) (60 mg/day) and compared with a control group (CG) (n = 67) over 12 months. In the CG, BMD and T-score statistically decreased at the femoral neck (FN), total femur (TF), and lumbar spine (L1-L4). In the OSPG, BMD decreased significantly at FN but tended to remain stable at TF and L1-L4. No changes were observed in bone mineral markers after one year in either group, except BAP, which decreased in OSPG. Long-term OSP treatment improves bone mineral markers at TF and LS and slows bone loss at FN compared to the control group. Overall, OSP exerts a protective effect on bone loss in healthy menopausal women with VVA.

Changes in dual energy X-ray absorptiometry parameters in postmenopausal women with osteoporosis who received at least 12 months of denosumab treatment

Background/Aim: Denosumab is a human monoclonal antibody that binds to the receptor-activated nuclear factor kappa beta ligand (RANKL). Densosumab leads to a reduction in bone resorption by inhibiting RANKL and has been approved for treating postmenopausal osteoporosis (OP). The present study investigated real life data by evaluating the demographic data of postmenopausal patients with OP who received denosumab treatment and the changes in dual energy x-ray absorptiometry (DEXA) parameters before and after denosumab treatment.&#x0D; Methods: This retrospective cohort study included 49 postmenopausal female patients followed in our OP outpatient clinic who were treated with 60 mg subcutaneous denosumab every six months for at least 12 months. The study retrospectively analyzed and recorded patient age, body mass index, age of menopause, fracture history, antiresorptive and/or anabolic drug treatment history, and pre- and post-denosumab T-scores in addition to L1–4, femoral neck, and total hip bone mineral densities (BMDs) on DEXA scans. The changes that occurred before and after the treatment in addition to those that occurred after the treatment based on whether previous anabolic or antiresorptive agents had been used were statistically compared.&#x0D; Results: The L1–4 and total hip T-scores and L1–4 and total hip BMD values measured prior to denosumab treatment showed a statistically significant increase after denosumab treatment (P &lt; 0.001, P = 0.002, P = 0.028, and P = 0.002, respectively). No statistically significant changes in the femoral neck T-score and BMD after denosumab treatment compared to that before denosumab use (P = 0.056 and P = 0.138, respectively) were found. Furthermore, no statistically significant difference between the pre- and post-denosumab DEXA parameters in the patients who used antiresorptive agents and those who did not (P &gt; 0.05) was found. Additionally, pre- and post-denosumab parameters were not statistically significantly different between those who received and did not receive anabolic therapy before denosumab (P &gt; 0.05).&#x0D; Conclusion: Denosumab treatment for postmenopausal OP leads to a significant increase in lumbar and total hip T-scores and BMDs.

Effect of calcium supplement and physical exercises on selected parameters of postmenopausal osteoporosis in women

The aim of this study to identify the effect of the calcium supplement &amp; physical exercises selected parameters in postmenopausal women. Material and Methods: The study used a descriptive evaluative approach with a pre-experimental control before-after research design, in which investigators assessed the effects of calcium supplementation and physical exercise on selected parameters in postmenopausal women in the outpatient departments of selected Mumbai hospitals. The research comprised 30 postmenopausal women from Mumbai's orthopaedic outpatient clinics. A basic random sampling method was employed to select the sample. ECOS 16 Questionnaire and Mini Osteoporosis Scale were used to obtain data. Describing and inferential statistics were used to analyses the data. Result: According to the findings of this research, Posttest mean blood calcium level 8.64 with SD of ±0.302 was higher than the Pretest mean blood calcium level 8.22 with SD of ± 0.370. In the t-test study the gap in Pretest and Posttest average blood calcium level was found to be considerable at the level of 0.05 (t=3.45; p&lt;0.00001). This means that calcium supplements and exercise have a positive influence on postmenopausal women's calcium levels.

Does Serum Osteocalcin Level Affect Carotid Atherosclerosis in Post-Menopausal Diabetic Females? A Case-Control Study.

PurposeTo determine the association between serum osteocalcin and carotid intima media thickness (CIMT) in a group of post-menopausal females with type 2 diabetes (T2DM).Patients and MethodsThis cross-sectional study enrolled 75 postmenopausal women with T2DM and 40 age matched postmenopausal healthy females. Age, body mass index, blood pressure were recorded for all subjects. Laboratory tests including fasting blood glucose (FBG), glycated hemoglobin (HbA1c) and lipid profile were measured. Serum osteocalcin was measured using ELISA. Bone mineral density (BMD) was measured by DEXA scan. CIMT was assessed with B-mode ultrasonography.ResultsPatients with T2DM had significantly lower serum osteocalcin compared to control (63.73±27.20 vs 136.16±21.96 pg/mL, P<0.001). Patients with osteoporosis had significantly lower osteocalcin level compared to those with normal BMD. Patients with T2DM had a significant negative correlation between serum osteocalcin and CIMT (r= −0.332; P=0.003), FBG (r= −0.732; P< 0.001), HbA1c (r=−0.672; P< 0.001), and HOMA-IR (r= −0.672; P< 0.001). However, multiple linear regression analysis revealed that CIMT in patients with diabetes was only significantly associated with age (P= 0.001), duration of diabetes (P< 0.001), SBP (P< 0.001), HOMA-IR (P=0.033), LDL (P=0.005), and HDL (P< 0.001). Furthermore, serum insulin (β= −0.183, P=0.033), FBG (β= −0.604, P< 0.001) and LDL (β= −0.195, P= 0.02) were independently negatively correlated with serum osteocalcin.ConclusionIn this study, Postmenopausal women with diabetes had significantly lower osteocalcin compared to non-diabetic women. Although serum osteocalcin was negatively correlated with CIMT, multivariate regression analysis revealed that osteocalcin level was only independently related to worse glycemic parameters in postmenopausal women with T2DM.

The effect of micronized progesterone and medroxyprogesterone acetate in combination with transdermal estradiol on hemostatic biomarkers in postmenopausal women diagnosed with POI and early menopause: a randomized trial.

To compare the impact of micronized progesterone (MP) or medroxyprogesterone acetate (MPA) in combination with transdermal estradiol (t-E2) on traditional coagulation factors and thrombin generation parameters in postmenopausal women diagnosed with premature ovarian insufficiency or early menopause. Randomized prospective trial conducted in women diagnosed with premature ovarian insufficiency or early menopause and an intact uterus, recruited over 28 months. All participants were prescribed t-E2 and randomized to either cyclical MP or MPA using a web-based computer randomization software, Graph Pad. Thrombin generation parameters were measured at baseline and repeated after 3-months. Traditional hemostatic biomarkers were measured at baseline and repeated after 3, 6, and 12-months. Seventy-one participants were screened for the study, of whom 66 met the inclusion criteria. In total, 57 participants were randomized: 44 completed the thrombin generation assessment arm of the study, whilst 32 completed 12-months of the traditional coagulation factor screening component of the trial. Thrombin generation parameters did not significantly change from baseline after 3-months duration for either progestogen component when combined with t-E2, unlike the traditional coagulation factors. Protein C activity, free Protein S, and Antithrombin III levels decreased with time in both treatment arms. Fluctuations in traditional hemostatic biomarkers were not reproduced by parallel changes in thrombin generation parameters that remained neutral in both groups compared with baseline. The absence of statistically significant changes in thrombin generation for the first 3-months of hormone therapy use is reassuring and would suggest a neutral effect of both progestogens on the global coagulation assay.

Abstract 98: Effect of teriparatide, zolendronate or denosumab on HR-Pqct parameters in postmenopausal women with T2DM at high risk of fragility fractures: intrim analysis of an open label RCT

Abstract 98: Effect of teriparatide, zolendronate or denosumab on HR-Pqct parameters in postmenopausal women with T2DM at high risk of fragility fractures: intrim analysis of an open label RCT

Association among hsCRP Levels, Bone Mineral Density, and Periodontal Parameters in Postmenopausal Women

Association of Osteoporosis and periodontitis is well documented. Osteopenia being the initial state of bone loss prior to osteoporosis; finding its correlation with clinical attachment loss holds significance in the process of establishing early reduction in BMD as a risk factor for periodontitis. Objectives: The present cross sectional study aimed to explore the association of osteopenia with serum high sensitivity C-reactive protein (hsCRP) levels, and periodontal parameters in narrow age range postmenopausal (PM) women. Methods: 112 participants in this single centred cross sectional study were bifurcated into test group: osteopenic PM women [n=62], and control group: normal bone mineral density [BMD] PM women [n=50]. BMD, serum levels of hsCRP, and periodontal parameters were recorded. Results: Clinical attachment loss [CAL] and hsCRP were found to be significantly higher in the osteopenic PM group. Conclusion: An association of osteopenia with increased CAL in PM women was found, implicating postmenopausal osteopenia associated with increased risk of periodontitis. The present study hints towards the comprehensive management of Periodontitis and osteopenia in postmenopausal women by maintaining a good coordination between the physicians and dentists.

Premenopausal Bilateral Oophorectomy Effects on Clinical and Real-World Physical Function Measures

Women with premenopausal bilateral oophorectomy (PBO) are at increased risk for physical function (PF) declines. This study investigated the relationships of field-based physical activity measures with clinical PF and strength parameters in post-menopausal women with and without PBO. Women with (n=21; age=64±4 years; BMI=32±8 kg.m-2) and without (n=15; age=67±6 years; BMI=28±6 kg.m-2) PBO performed PF and strength tests (walking speed, distance walked, short physical performance battery (SPBB), leg and chest strength), and wore ankle accelerometers for 7 days (daily step count and loading index [the cumulative sum of each step’s skeletal loading]). Age, BMI, step count and loading index were entered into stepwise multiple regression to identify significant predictors of PF and strength parameters. Step count was a predictor of SPBB score in both groups. In women without PBO, step count was a predictor of walking speed; loading index was a predictor of leg strength; step count and loading index were predictors of distance; and step count and age were predictors of chest strength. For PBO women, loading index and BMI were predictors of walking speed and distance; BMI was a predictor of leg strength; and there were no predictors of chest strength. These data suggest while field-based physical activity was strongly and positively associated with clinical PF and strength measures for women without PBO, BMI was a dominant negative factor for PF in women with PBO. Future work will include a larger sample size and additional confounders to further elucidate underlying factors of reduced PF and mobility after PBO.

Changes in lipid profile and some biochemical parameters in postmenopausal women treated with honey

The study investigated the effect of natural honey on the lipid profile and some biochemical parameters among postmenopausal women, aged 45-65 years old. Sixty healthy postmenopausal women were given 20 g/day of natural honey and followed up for three months. The primary outcome was changes from baseline on the lipid profile and the chosen biochemical parameters (fasting blood sugar, serum calcium) and some anthropometric parameters. Paired t-test was performed to evaluate the difference between the baseline and the 3 month values of the parameters and lipid profiles. Sixty postmenopausal women successfully completed the study. The result showed that there were significant increases in HDL-C, calcium and significant decreases in LDL-C, TG, TC, and FBS concentrations in the blood of the research subjects after three months of treatment with honey compared with the values at baseline (p&amp;#60;0.05). Also there were significant decreases in the blood pressure, weight and waist circumference of the postmenopausal women after treatment when compared with baseline values (p&amp;#60;0.05). Natural honey helps in improving the lipid profile, FBS, Blood pressure, weights and waist circumference of postmenopausal women and can be included as part or alternative remedies in management of postmenopausal conditions.

Effectiveness of eight-week zinc supplementation on vitamin D3 status and leptin levels in a population of postmenopausal women: a double-blind randomized trial

BackgroundThe menopausal period is characterized by hormonal imbalance related to the alteration of parameters involved in lipid metabolism. In addition, menopause increases the risk of deficiencies of key vitamins and minerals such as vitamin D and zinc in such women. The present study investigates the influence of zinc supplementation on the status of vitamin D3 and other lipid parameters in postmenopausal women. MethodsFifty-one healthy postmenopausal women aged 44–76 years from the province of Granada (Spain) were divided into two groups (placebo and zinc) of 25 and 26 women, respectively. The zinc group was supplemented with 50 mg/day of zinc for 8 weeks. Nutrient intake assessment was performed by means of a 24 -h reminder. Zinc was determined by flame atomic absorption spectrophotometry. Vitamin D was analyzed by liquid chromatography - tandem mass spectrometry. Leptin was determined by enzyme immunoassay. ResultsZinc supplementation improved the initial vitamin D3 status of the postmenopausal population (p = 0.049). Plasma levels of 25−OH-D3 increased significantly after Zn supplementation in women with lower age at menopause (p = 0.045). Both intake and plasma zinc levels were inversely correlated to serum leptin levels (p = 0.044 and p = 0.033, respectively), being significantly lower in lower age at menopause (p < 0.001). ConclusionZinc supplementation improved vitamin D3 status and was associated to low leptin levels in the postmenopausal women of the study.

Sağlıklı Postmenopozal Kadınlarda Kalp Hızı Türbülansı Analizi

Objective: The aim of the present study was to investigate heart rate turbulence (HRT) parameters in postmenopausal women. Material and Methods: A total of 40 postmenopausal women and 43 healthy, regularly menstruating premenopausal women were taken as study and control groups, respectively. All patients had biochemical blood examination, 2-D echocardiography and 24-hour Holter monitorization. HRT parameters, namely turbulence onset (TO) and turbulence slope (TS) were calculated. Results: Age, body mass index (BMI), systolic and diastolic pressure, total cholesterol and LDL levels were higher in the postmenopausal group, whereas HDL levels were higher in the premenopausal group (p<0.05). TO was significantly higher, TS was significantly lower in postmenopausal women compared to premenopausal women (-2.76±1.34 vs 0.60±1.30 and 3.60±1.54 vs 1.60±1.48, p=0.000 for both, respectively). TO was positively correlated, TS negatively correlated with age, BMI, systolic and diastolic blood pressure and LDL cholesterol level. According to multivariate analysis only menopausal status and age had an independent effect on HRT parameters. Receiver operating characteristic analysis showed that the cut-off values of TO and TS for predicting menopausal status were 0.959 and 0.165, respectively (0.835 anti-image). These results showed that TO and TS had diagnostic value for predicting menopausal status. Conclusion: Postmenopausal women had blunted HRT response. It is a simple and easily obtainable test and should be implemented in cardiac evaluation in daily practice.

The efficacy of two-year yogic practice on selected pulmonary function test in postmenopausal women

Introduction and Aim: Menopausal transition has been well associated with a series of hormonal changes that has been linked to impairment of respiratory function. The present study was designed to evaluate the cumulative effect of practicing yoga on certain respiratory parameters in postmenopausal women.&#x0D; Materials and Methods: Sixty postmenopausal women were divided into two groups (n=30 each). Based on the duration of yoga, they were grouped into Group I – (Regularly doing yoga for one year) and Group II (Regularly doing yoga for the two years). The women not doing any yogic exercises were taken as the control group; Group Ia (for One year) and Group II a (for two years). The respiratory parameters were measured with the help of vitalograph.&#x0D; Results: All the observed respiratory parameters such as vital capacity (VC), Forced vital capacity (FVC), FEV1 (Forced expiratory volume during the 1st second.), FEV1 ratio, PEFR (Peak expiratory flow rate). FEF50 (Forced Expiratory Flow at 50%), showed a significant (P&lt;0.0001) improvement in Group II when compared to the Group I.&#x0D; Conclusion: Yoga practice can be advocated to improve pulmonary function tests in post-menopausal women which might help in preventing respiratory diseases during aging process. Optimum benefit of yoga was observed during the two years of yoga practice in the postmenopausal women. Continued practice of yoga might be also considered as a preventive exercise to impair age related morbidity and improve the quality of life.&#x0D;

Metabolic Syndrome: Prevalence of Its Components in Post Menopausal Females

Introduction: Metabolic syndrome is a cluster of metabolic abnormalities characterized by abdominal obesity, hyperglycemia, decreased high density lipoprotein (HDL), increased Triglycerides and high blood pressure, which predispose the individual at higher risk for both cardiovascular disease (CVD) and type 2 diabetes. Postmenopausal state is considered as a vulnerable period for developing MS. Aims and Objectives: To study the Prevalence of metabolic syndrome and its components in postmenopausal women. Material and Method: This study was conducted in the Department of biochemistry, MMIMSR, MMDU, Mullana, Ambala. A total of 100 postmenopausal women in the age group of above 45 years were recruited for this study after assessing their eligibility according to the selection criteria. Biochemical Investigations: Estimation of Fasting Serum glucose was done on Erba chem 7 analyzer and Total cholesterol, HDL and Serum Triglycerides was done on Dimension® clinical chemistry system manufactured by Siemens Healthcare Diagnostics (US). Results: The mean triglycerides and fasting serum glucose levels were significantly high (&lt;0.001) among postmenopausal women with metabolic syndrome. Overall prevalence of metabolic syndrome was 29%. Conclusions: Evaluating the biochemical parameters in postmenopausal women is useful for assessing the risk of developing metabolic syndrome in them. Monitoring the health status of these females can help to reduce the Prevalence of metabolic syndrome and thus the risk of developing cardiovascular disease.

The effect of camelina oil (α-linolenic acid) and canola oil (oleic acid) on lipid profile, blood pressure, and anthropometric parameters in postmenopausal women.

IntroductionCold-pressed camelina oil (Camelina sativa) is rich in polyunsaturated fatty acids and may have a beneficial effect on the reduction of cardiovascular risk.Material and methodsIn this study, we investigated the parameters contributing to the development of cardiovascular diseases, such as dietary intake, nutritional status, blood pressure, and lipid profile. Sixty postmenopausal women with dyslipidaemia were randomly assigned to two oil groups: camelina oil and canola oil. The subjects consumed daily 30 g of the test oils for 6 weeks. Before and after dietary intervention, the assessment of nutrition (4-day dietary recall), anthropometric parameters, lipid profile, and blood pressure were evaluated.ResultsDuring the dietary intervention, decreased low-density lipoprotein cholesterol concentration in both groups (15 mg/dl (0.4 mmol/l) reduction in the camelina oil group and 11 mg/dl (0.3 mmol/l) reduction in the canola oil group) was observed. In this study a decrease of waist circumference (approx. 1 cm) in the two groups was observed. In the group of women consuming camelina oil, a significant decrease of waist-to-hip ratio was seen. In the other anthropometric parameters no statistically significant changes were observed (body weight, body fat mass). After the intervention, no significant decreases in systolic and diastolic blood pressure were noticed.ConclusionsThe camelina and canola oil intake contributed to reduction of the consumption of saturated fatty acids in the diet, had a positive influence on the lipid profile parameters, and decreased the waist circumference, which may reduce the risk of cardiovascular disease.