Paramagnetic Nanoparticles Research Articles

Electroosmotic effect on the flow of hybrid nanofluid containing para and ferri-magnetic nanoparticles through the micro-channel implementing Darcy law

This study investigates the flow of an incompressible electroosmotic hybrid nanofluid through a micro-channel. The hybrid nanofluid consists of paramagnetic (Ta) and ferrimagnetic (Fe3O4) nanoparticles suspended in ethylene glycol. The Darcy model is applied to the porous media in the momentum equation, and its effects are also considered in the temperature equation, accounting for frictional and Joule heating effects. The micro-channel is influenced by both pressure and magnetic flux. The study derives an exact solution for the proposed model and evaluates key engineering parameters, such as the heat transfer rate. The findings show that a higher particle volume fraction reduces the velocity distribution, while an increased Darcy parameter decreases the rate of heat transfer. Additionally, the heat transfer rate diminishes with increasing Darcy parameter and electric flux. Notably, the ferrimagnetic nanofluid exhibits better thermal conductivity than the paramagnetic nanofluid.

Geometric Structure of an Aqueous Solution of Paramagnetic Nanoparticles in the Presence of a Magnetic Field

Geometric Structure of an Aqueous Solution of Paramagnetic Nanoparticles in the Presence of a Magnetic Field

Applications of Nanotechnology in the Field of Cardiology.

Cardiovascular diseases (CVDs) are aleading cause of death globally, demanding innovative therapeutic strategies. Nanoformulations, including nanoparticles, address challenges in drug delivery, stem cell therapy, imaging, and gene delivery. Nanoparticles enhance drug solubility, bioavailability, and targeted delivery, with gas microbubbles, liposomal preparations, and paramagnetic nanoparticles showing potential in treating atherosclerosis and reducing systemic side effects. In stem cell therapy, nanoparticles improve cell culture, utilizing three-dimensional nanofiber scaffolds and enhancing cardiomyocyte growth. Gold nanoparticles and poly(lactic-co-glycolic acid) (PLGA)-derived microparticles promote stem cell survival. Stem cell imaging utilizes direct labeling with nanoparticles for magnetic resonance imaging (MRI), while optical tracking employs dye-conjugated nanoparticles. In gene delivery, polymeric nanoparticles like polyethylenimine (PEI) and dendrimers, graphene-based carriers, and chitosan nanoparticles offer alternatives to virus-mediated gene transfer. The potential of magnetic nanoparticles in gene therapy is explored, particularly in hepatocellular carcinoma. Overall, nanoparticles have transformative potential in cardiovascular disease management, with ongoing research poised to enhance clinical outcomes.

A Facile NMR Method for Pre-MRI Evaluation of Trigger-Responsive T1 Contrast Enhancement.

There is a growing interest in developing paramagnetic nanoparticles as responsive magnetic resonance imaging (MRI) contrast agents, which feature switchable T1 image contrast of water protons upon biochemical cues for better discerning diseases. However, performing an MRI is pragmatically limited by its cost and availability. Hence, a facile, routine method for measuring the T1 contrast is highly desired in early-stage development. This work presents a single-point inversion recovery (IR) nuclear magnetic resonance (NMR) method that can rapidly evaluate T1 contrast change by employing a single, optimized IR pulse sequence that minimizes water signal for "off-state" nanoparticles and allows for sensitively measuring the signal change with "switch-on" T1 contrast. Using peptide-induced liposomal gadopentetic acid (Gd3+-DTPA) release and redox-sensitive manganese oxide (MnO2) nanoparticles as a demonstration of generality, this method successfully evaluates the T1 shortening of water protons caused by liposomal Gd3+-DTPA release and Mn2+ formation from MnO2 reduction. Furthermore, the NMR measurement is highly correlated to T1-weighted MRI scans, suggesting its feasibility to predict the MRI results at the same field strength. This NMR method can be a low-cost, time-saving alternative for pre-MRI evaluation for a diversity of responsive T1 contrast systems.

Navigation of Magnetic Microrobotic Swarms With Maintained Structural Integrity in Fluidic Flow

Micro/nanorobots offer great promise in the next generation of biomedical applications. One of the significant challenges to apply micro/nanorobots in the circulatory system is that fluidic flow impacts their motion and swarm behaviors. Herein, we propose an actuation strategy to navigate paramagnetic nanoparticle swarms and maintain their integrity in fluidic flow. The generation, locomotion, and integrity of the swarms in fluidic flow were analyzed and validated in experiments. Our results show that the nanoparticles should be pregathered as a swarm before releasing them into fluidic flow to maintain an integrated shape. The swarm integrity is dependent on the flow rate, and the strength and pitch angle of the applied oscillating magnetic field. Based on the findings, the actuation strategy for swarm navigation in fluidic flow was established. The strength and pitch angle of the magnetic field were tuned to maintain swarm integrity while the field pitch angle was tuned to change swarm velocity. Using the proposed strategy, downstream and upstream navigation of the swarm were realized in a blood flow with a rate of 2 mm/s. It was also demonstrated that the swarm can be navigated into a tube for retraction. The downstream delivery rate and upstream retraction rate of the nanoparticles were 99.4% and 75.7%, respectively.

Eco friendly, green route method for the preparation of poly ethylene glycol (PEG) mediated surface modified iron oxide nanoparticles (PEG‐IONps) with potential biological activities

AbstractAmong the various nanoparticles, excessively paramagnetic iron oxide nanoparticles assume an outstanding job in biomedicine, mostly as Nano clinical imaging and treatment. These nanoparticles’ effective working relies on superficial alteration utilizing different specialists. Among them, polyethylene glycol (PEG)—biocompatible polymer is primarily used attributable to its unmistakable qualities. In this examination, the impact of PEG covering on the counter bacterial and against proliferative properties of iron oxide nanoparticles has been considered. PEG‐covered nanoparticles were incorporated by co‐precipitation technique portrayed by UV–visible spectroscopy, Fourier change infrared spectroscopy, electron microscopy, X‐ray diffraction, and vibrating test magnetometer thinks about which uncovers exceptionally stable crystalline, circular, nanoparticles with high polarization impact. Hostile to the bacterial movement was examined against Staphylococcus aureus, and Pseudomonas aeruginosa uncovers PEGlated IONps displayed upgraded action against both tried endure lower fixations. A higher zone of restraint was construed from PEGlated IONps treatment. Hostile to proliferative activity was contemplated against the PC3 cell line (Prostate cancer). PEGlated IONps prompted the most extreme decrease in cell suitability and changed the cell design by chronicle fracture and build‐up of atomic material. PEGlated IONps treatment uncovered a high rate of receptive oxygen species (ROS), which brought about apoptosis or necrotic cell demise. The present discoveries suggest that PEGlated IONps synthesized in this examination could be utilized as potential bioactive operators against medication‐safe pathogenic bacterial strains and malignant growth cells.

Chemical magnetism - surface force to move motors.

If redox reactions occur on the surface of a motor and a current loop arises, then in a non-uniform magnetic field, in addition to the usual magnetic force, such a motor will also be affected by a chemical magnetic force. The chemical magnetic force belongs to the class of surface forces. Here we analyze for the first time the properties of chemical magnets, which consist of three dissimilar metals, as well as the magnetic field generated by a chemical magnet using paramagnetic nanoparticles. The results of the study show that the chemical magnetic force depends on the concentration and type of electrolyte, the pH of the solution, the temperature, and the structure of the chemical magnet. The results obtained can contribute to the creation of devices where chemical energy is directly converted into kinetic energy of motion.

Morphology controlled synthesis of Fe3+-doped upconversion nanomaterials

This work details the synthesis of paramagnetic upconversion nanoparticles doped with Fe3+ in various morphologies via a thermal decomposition method, followed by comprehensive characterization using diverse analytical techniques.

Optimizing the functionalization of super-paramagnetic nanobeads for droplet-based protein secretion profiling of immune cells

The extremely dynamic functions of an active immune response are mainly determined by the presence of various soluble factors. The secreted factors organize the individual immune cells into functional tissues regulating the immune response. Dynamical single-cell studies are therefore fundamental to investigate the heterogeneity of immune cells’ behaviors over time. The available tools lack either of single cell resolution or time resolution; new tools are required to access both single cell and time resolution in order to better understand these dynamical single cell mechanisms. The powerful resolution and sensitivity improvement provided by droplet-based microfluidics deciphering the dynamic processes at the single-cell level could help to describe the fundamental mechanisms underlying immunity, develop new strategies for vaccination and cancer immunotherapy, or diagnose inflammatory diseases.The use of functionalized paramagnetic nanoparticles is a key feature of our droplet-based immunoassay. This work describes the optimization and comparison of various functionalization methods for the integration of ready-to-use super-paramagnetic nanobeads into our droplet-based assay. Among the three functionalization tested methods, the most promising one is based on boronic acid chemistry, in terms of both compatibility with the droplet microfluidic system and detection sensitivity. It was successfully applied to the characterization of TNFα secretion from human single monocytes.

Chitosan decorated cobalt zinc ferrite nanoferrofluid composites for potential cancer hyperthermia therapy: anti-cancer activity, genotoxicity, and immunotoxicity evaluation

Cancer, as the leading cause of death worldwide, has been constantly increasing in mortality every year. Among several therapeutics, nanoscale compounds showed promising results in overcoming cancer diseases. There are numerous types of research on the paramagnetic nanoparticles of iron oxide, which cause apoptosis and cancer cell death. In this study, cobalt/zinc/ferrite nanoferrofluid composites (~ 39 nm) were synthesized and decorated with chitosan to enhance the cell entry for potential applications in cancer therapy. The neat and chitosan-adorned cobalt zinc ferrite nanoferrofluid composites (~ 94 nm) displayed superparamagnetic properties. The nanocomposite exhibited anti-cancer activity against WEHI164 cancer cells in a dose- and time-dependent manner. The chitosan-coated nanocomposite was found to induce oxidative stress in WEHI164 cancer cells, as indicated by reactive oxygen species (ROS) production. Furthermore, DNA damage was indicated in WEHI164 cancer cells after exposure to chitosan-coated nanocomposites. Chitosan-coated nanocomposites promoted dendritic cell maturation by inducing the release of interleukin-6 proinflammatory cytokines. According to the results and ancillary studies, superparamagnetic nanoparticles coated with chitosan can be considered an effective and promising treatment for the destruction of cancer cells. Graphical Summary: Chitosan decorated cobalt zinc ferrite nanoferrofluid composites was fabricated for potential cancer hyperthermia therapy with high biocompatibility.

Nanospinbar-Assisted Convective Ionic Transfer Toward Dendrite-Free Li Metal Batteries

Building high-energy-density batteries with Li-metal anodes (LMAs) featuring ultrahigh specific capacity (3860 mAh g−1) and low working voltage (−3.04 V vs. SHE) have been revisited to surpass the energy density limit of current Li-ion batteries. For instance, a successful transition from conventional graphite (372 mAh g–1) to ultrathin LMAs can deliver higher cell energies (over 500 Wh kg–1). Nonetheless, Li electrodeposition is challenging due to the dendrite formation and random growth. Extensive Li dendrite growth can enlarge the active surface area where side reactions occur, thereby severely deteriorating the Li surface and depleting the electrolyte, leading to poor cycling stability. Eventually, the Li dendrite tips can pierce the separator, causing cell short-circuiting, thereby increasing the safety risk. This is a major hurdle that must be overcome prior to commercialization. Therefore, inhibiting uneven dendritic Li plating is essential for safe and stable cycling of rechargeable lithium metal batteries (LMBs).Inhibiting uneven, dendritic Li electroplating is crucial for the safe and stable cycling of LMBs. Homogeneous, fast Li+ transport toward the Li surface is required for uniform, dendrite-free deposition. Electrodeposition strongly depends on the mass transfer of the ionic species. In a diffusion-limited regime, such as higher currents and lack of convection, inherently limited Li+ diffusion causes a strong concentration gradient or even total Li+ depletion. Moreover, traditional ionic transport of static liquid electrolytes involving electromigration and molecular diffusion can trigger a greater disparity in Li concentration over the Li surface, leading to irregular dendrite growth.This study presents a microturbulence-assisted convective Li+ transfer for suppressing dendrite growth using a magnetic nanospinbar (NSB)-dispersed colloidal electrolyte. We synthesized an ultrahigh-aspect-ratio NSB consisting of a paramagnetic Fe3O4 nanoparticle array and a silica outer coating. Manipulating the external electromagnetic force can remotely control the rotation of individual NSBs without dispersion failure, thereby generating a microturbulence flow inside the cell. Regardless of the electrolyte composition, rotating the NSB can reduce the Li+ diffusion layer thickness from the bulk and evenly redistribute Li+ flux over the Li surface, thereby suppressing Li dendrite growth. The NSB-dispersed electrolyte with advanced salt/solvent compositions demonstrated stable cycling of LMBs over 600 cycles at 70% capacity retention, thereby outperforming the NSB-free cell.Figure. 1. Concept of convective Li+ transfer assisted by remote NSB stirring. Apart from stagnant electrolytes, magnetic-field-responsive NSB dispersed in the liquid electrolyte can redistribute Li+ flux near LMA through remote stirring, enabling facile, homogenous Li+ transfer and thereby leading to uniform, dendrite-free Li electroplating Figure 1

N-Hydroxysuccinamide functionalized iron oxide nanoparticles conjugated with 5-flurouracil for hyperthermic therapy of malignant liver cancer cells by DNA repair disruption

Magnetized iron oxide nanoparticles are ideal materials for biological and biomedical applications due to their biocompatibility, super paramagnetic behavior, surface capability, and chemical stability. This research article is narrating the overview of methodologies of preparation, functionalization, characterization and applications of Fe3O4 nanoparticles. Super paramagnetic nanoparticles are studied for their hyperthermia properties. The proposed mechanism behind the hyperthermia was damaging the proteins responsible for DNA repair thereby, directly accelerating the DNA damages on cancer cells by increasing the temperature in the vicinity of the cancer cells. In this study, super paramagnetic iron oxide (Fe3O4) nanoparticles (SPIONs) and anti-cancer drug, 5-fluorouracil, functionalized with N-Hydroxysuccinimide organic molecules. A specific absorption rate at 351 nm can be achieved using UV analysis. The magnetic Fe3O4 nanoparticles had a cubic crystalline structure. FE-SEM(field emission scanning Electron microscopy) with EDAX(energy dispersive X-ray analysis) analysis shows that the size of the SPION was about 30–100 nm range and the percentage of chemical compositions was higher in the order of Fe, O, C. for particle size analysis, the SPION were positively charged derived at +9.9 mV and its conductivity is measured at 0.826 mS/cm. In-vitro anti-cancerous activity analysis in Hep-G2 cells (liver cancer cells) shows that the 5-fluorouracil functionalized SPIONs have higher inhibition rate than the bare Fe3O4 nanoparticles. The Fe3O4 nanoparticles were studied for their hyperthermic abilities at two different frequencies such as 3.05 × 106 kAm−1s−1 and 4.58 × 106 kAm−1s−1.The bare Fe3O4 at low magnetic field, 10 mg was required to raise the temperature above 42°- 45 °C and at high magnetic field, 6 mg was enough to raise the same temperature. The 5-fluorouracil functionalized Fe3O4 shows that at low magnetic field, 6 mg is required to raise the hyperthermia temperature and at high magnetic field, 3 mg is required to raise the temperature above 42°- 45 °C. the rate of heating and the temperature achieved with time can be tuned with concentrations as well as magnetic component present in the Fe3O4 nanoparticles. Beyond this concentration, the rate of cell death was observed to increase. The saturation and low residual magnetization were revealed by the magnetization analysis, making them well suited for clinical applications

Leaching of Nano-Additives as a Method for Life-Cycle Suitability: A Study on 3D-Printed Nanocomposites for Wearables Applications

This study aims to develop a comprehensive process to evaluate the leaching behavior of 3D-printed nanocomposite samples as candidate materials for potential use in wearable devices. The study involves the immersion of the 3D-printed test coupons, produced via Fused Filament Fabrication (FFF), into artificial sweat and deionized water in a controlled environment provided by a dissolution apparatus. Three distinct nanocomposite filaments were used, each consisting of different polymer matrices: thermoplastic polyurethane (TPU), copolyester (TX1501), and polyamide (PA12). The additives incorporated within these filaments encompassed silver nanoparticles (AgNPs), chopped carbon fibers (CCFs), and super paramagnetic iron oxide nanoparticles (SPIONs), respectively. The current study aims to identify potential risks associated with the release of nanomaterials and additives, through SEM/EDX analysis and in vitro measurements of proinflammatory cytokines. Furthermore, this research contributes to the advancement of safe and reliable 3D-printed materials for wearable technologies, fostering their widespread adoption in various applications.

Super Para-Magnetic Iron Oxide Nanoparticles (SPIONs) in the Treatment of Cancer: Challenges, Approaches, and its Pivotal Role in Pancreatic, Colon, and Prostate Cancer.

Super Para-magnetic Iron Oxide Nanoparticles (SPIONs) have been manifested for their broad spectrum of applications ranging from biomedical imaging to the treatment of many diseases. Many experiments are being conducted across the globe to especially investigate their potential in the field of targeted treatment for malignant tissues. However, challenges pertaining to the desired delivery of anticancer drugs in the body remain unresolved or unattended. The bare iron oxide nanoparticles are liable to form agglomerates or get easily oxidized in the air which can lead to loss of their magnetism and viability. Moreover, in several reactions, these magnetic nanoparticles leach into the solution/ suspension, making it kinetically unstable. The nanoparticles, further readily metabolize in the stomach pH or are phagocytosed by macrophages. In this article, we address these issues by shedding light on the impact of controlling parameters like size, synthesis method, and surface engineering. After studying the existing literature, it is noted that currently, these magnetically guided delivery systems are being rigorously tested in areas like pancreatic cancer, colon cancer, and prostate cancer, which will be discussed in this review. The fact that the major issue in the conventional treatment of these cancers is intrinsic and acquired drug resistance is a key issue. In this context, the potential of SPIONs as efficient nanotherapeutics is presented. The article provides a deeper insight into the research conducted on these focused areas in cancer. This review also discusses, in brief, the consolidation of artificial intelligence in cancer nanomedicine assuring a better treatment outcome in near future.

A multifunctional iron catalyst-based colorimetric sensor for rapid bacterial detection in food

Herein, we report an on-site sensing system for detecting the presence of foodborne pathogen, Escherichia coli O157:H7, by using paramagnetic immuno-iron oxide nanoparticles (immuno-IONPs) that possess intrinsic peroxidase-like activity. The surface functionalization of IONPs with dextrin, followed by oxidation to form OxDex-IONPs, significantly improved their colloidal stability and peroxidase-like activity. The catalytic activity of OxDex-IONPs was employed to induce the oxidation of colorless 3,3′,5,5′-tetramethylbenzidine (TMB) to a blue product in the presence of hydrogen peroxide, which was successfully utilized in the development of a colorimetric sensor. The generation of specific signals in response to the target bacteria could be achieved through magnetophoresis, a technique that specifically fractionates the IONPs clustered with the target bacteria based on their faster mobility. The detection system was demonstrated to be compatible with real food samples, exhibiting a detection limit of around 80 CFU/mL. Due to its straightforward procedure and rapid analysis time of under 50 min, the proposed detection system would offer an effective way to monitor bacterial contamination and evaluate the safety of food.

Two-photon excited luminescence of structural light enhancement in subwavelength SiO2 coating europium ion-doped paramagnetic gadolinium oxide nanoparticle and application for magnetic resonance imaging

BackgroundOxides of lanthanide rare-earth elements show great potential in the fields of imaging and therapeutics due to their unique electrical, optical and magnetic properties. Oxides of lanthanide-based nanoparticles enable high-resolution imaging of biological tissues by magnetic resonance imaging (MRI), computed tomography (CT) imaging, and fluorescence imaging. In addition, they can be used to detect, treat, and regulate diseases by fine-tuning their structure and function. It remains challenging to achieve safer, efficient, and more sensitive nanoparticles for clinical applications through the structural design of functional and nanostructured rare-earth materials.ResultIn this study, we designed a mesoporous silica-coated core–shell structure of europium oxide ions to obtain near-infrared two-photon excitation fluorescence while maintaining high contrast and resolution in MRI. We designed enhanced 800 nm photoexcitation nanostructures, which were simulated by the finite-difference method (FDM) and finite-difference time-domain method (FDTD). The nanoparticle structure, two-photon absorption, up-conversion fluorescence, magnetic properties, cytotoxicity, and MRI were investigated in vivo and in vitro. The nanoparticle has an extremely strong optical fluorescence response and multiple excitation peaks in the visible light band under the 405 nm continuous-wave laser excitation. The nanoparticle was found to possess typical optical nonlinearity induced by two-photon absorption by ultrafast laser Z-scan technique. Two-photon excited fluorescence of visible red light at wavelengths of 615 nm and 701 nm, respectively, under excitation of the more biocompatible near-infrared (pulsed laser at 800 nm). In an in vitro MRI study, a T1 relaxation rate of 6.24 mM−1 s−1 was observed. MRI in vivo showed that the nanoparticles could significantly enhance the signal intensity in liver tissue.ConclusionsThese results suggest that this sample has applied potential in visible light fluorescence imaging and MRI.

The Effect of Internalized Paramagnetic Nanoparticles on Caenorhabditis elegans Locomotion in the Presence of Magnetic Field

Caenorhabditis elegans nematodes are broadly used to investigate the impact of environmental factors on animal physiology and behavior. Here, C. elegans with internalized paramagnetic nanoparticles were placed inside a magnetic field (MF) to explore its effects on locomotion. We hypothesized that internalized paramagnetic nanoparticles combined with external MF affect C. elegans’ locomotion machinery. To test our hypothesis, we used adult C. elegans fed on bacteria mixed with paramagnetic nanoparticles of 1 μm, 100, and 40 nm diameter. The presence of nanoparticles inside the worms’ body (alimentary canal, body muscle) was verified by fluorescent and electron microscopy. A custom-made software was used to track freely moving C. elegans in the absence or presence of MF, sequentially, for 200 + 200 s. We used established metrics to quantify locomotion-related parameters, including posture, motion, and path features. Key attributes of C. elegans locomotion (stay ratio, forward over backward motion, speed) were affected only in worms with internalized nanoparticles of 100 nm in the presence of MF (reduced speed, increased stay ratio, decreased forward/backward ratio), in contrast to untreated worms. Our work shows that internalized particles of specific properties affect C. elegans locomotion under MF. Hence, it contributes to clarifying the effects of MF and activated nanoparticles on C. elegans locomotion, thus fueling further research.

Novel Gadolinium-Free Ultrasmall Nanostructured Positive Contrast for Magnetic Resonance Angiography and Imaging.

Nanostructured contrast agents are promising alternatives to Gd3+-based chelates in magnetic resonance (MR) imaging techniques. A novel ultrasmall paramagnetic nanoparticle (UPN) was strategically designed to maximize the number of exposed paramagnetic sites and r1 while minimizing r2, by decorating 3 nm titanium dioxide nanoparticles with suitable amounts of iron oxide. Its relaxometric parameters are comparable to those of gadoteric acid (GA) in agar phantoms, and the r2/r1 ratio of 1.38 at 3 T is close to the ideal unitary value. The strong and prolonged contrast enhancement of UPN before renal excretion was confirmed by T1-weighted MR images of Wistar rats after intravenous bolus injection. Those results associated with good biocompatibility indicate its high potential as an alternative blood-pool contrast agent to the GA gold standard for MR angiography, especially for patients with severe renal impairment.

Magnetic actuation of otoliths allows behavioral and brain-wide neuronal exploration of vestibulo-motor processing in larval zebrafish

The vestibular system in the inner ear plays a central role in sensorimotor control by informing the brain about the orientation and acceleration of the head. However, most experiments in neurophysiology are performed using head-fixed configurations, depriving animals of vestibular inputs. To overcome this limitation, we decorated the utricular otolith of the vestibular system in larval zebrafish with paramagnetic nanoparticles. This procedure effectively endowed the animal with magneto-sensitive capacities: applied magnetic field gradients induced forces on the otoliths, resulting in robust behavioral responses comparable to those evoked byrotating the animal by up to 25°. We recorded the whole-brain neuronal response to this fictive motion stimulation using light-sheet functional imaging. Experiments performed in unilaterally injected fish revealed theactivation of a commissural inhibition between the brain hemispheres. This magnetic-based stimulation technique for larval zebrafish opens new perspectives to functionally dissect the neural circuits underlying vestibular processing and to develop multisensory virtual environments, including vestibular feedback.

Functionalized retinoic acid lipid nanocapsules promotes a two-front attack on inflammation and lack of demyelination on neurodegenerative disorders.

Demyelinating disorders, with a particular focus on multiple sclerosis (MS), have a multitude of detrimental cognitive and physical effects on the patients. Current treatment options that involve substances promoting remyelination fail in the clinics due to difficulties in reaching the central nervous system (CNS). Here, the dual encapsulation of retinoic acid (RA) into lipid nanocapsules with a nominal size of 70nm, and a low PdI of 0.1, coupled with super paramagnetic iron oxide nanoparticles (SPIONs) was accomplished, and joined by an external functionalization process with a transferrin-receptor binding peptide. This nanosystem showed a 3-fold improved internalization by endothelial cells compared to the free drug, ability to interact with oligodendrocyte progenitor cells and microglia, and improvements in the permeability through the blood-brain barrier by 5-fold. The lipid nanocapsules also induced the differentiation of oligodendrocyte progenitor cells into more mature, myelin producing oligodendrocytes, as evaluated by high-throughput image screening, by 3-5-fold. Furthermore, the ability to tame the inflammatory response was verified in lipopolysaccharide-stimulated microglia, suppressing the production of pro-inflammatory cytokines by 50-70%. Overall, the results show that this nanosystem can act in both the inflammatory microenvironment present at the CNS of affected patients, but also stimulate the differentiation of new oligodendrocytes, paving the way for a promising platform in the therapy of MS.