Parallel Detector Research Articles

Cone-beam consistency conditions for planar trajectories with parallel and perpendicular detectors

Cone-beam (CB) projections provide a first-order model for x-ray imaging with an area detector. CB consistency conditions (CBCCs), also known as range conditions for the 3D divergent x-ray transform, are equations that express the redundant information in a collection of CB projections. For applications purposes, CBCCs are most suitably expressed in terms of detector coordinates. CBCCs are only known for a few geometrical configurations, which depend on the source and detector trajectories. Here we only consider source trajectories that lie in a plane, and detector orientations that are parallel to the trajectory plane, or perpendicular to it. The parallel detector is stationary, but the vertical detector rotates around the center of the circular trajectory. We unify and generalize the existing known CBCCs for planar trajectories, by creating an intermediate geometry consisting of a parallel, rotating detector, and we develop new CBCCs for this geometry. Our main result is a theorem on CBCCs for a perpendicular detector, which must necessarily move in response to movement of the source. We also provide a theorem for the more difficult situation of a perpendicular detector but without the restriction that the target object be on one side or the other of the trajectory plane. We present a simple numerical simulations for a toy calibration problem to provide an example application of the new CBCCs.

A parallel line probe for spatially selective electrochemical NMR spectroscopy

In situ NMR is a valuable tool for studying electrochemical devices, including redox flow batteries and electrocatalytic reactors, capable of detecting reaction intermediates, metastable states, time evolution of processes or monitoring stability as a function of electrochemical conditions. Here we report a parallel line detector for spatially selective in situ electrochemical NMR spectroscopy. The detector consists of 17 copper wires and is doubly tuned to 1H/19F and X nuclei ranging from 63Cu (106.1 MHz) to 7Li (155.5 MHz). The flat geometry of the parallel line detector allows its insertion into a high electrode surface-to-volume electrochemical flow reactor, enabling a detector-in-a-reactor design. This integrated device is named “eReactor NMR probe”. Combined with B1-selective pulse sequences, selective detection of the nuclei at the electrode-electrolyte interface, that is within a distance of 800 μm from the electrode surface, has been achieved. The selective detection of 7Li and 19F nuclei is demonstrated using two electrolytes, LiCl and LiBF4 solutions, respectively. A good B1 homogeneity with an 810° to 90° pulse intensity ratio of 68–72 % was achieved. Using electrochemical plating of lithium metal as a model reaction, we further demonstrated the operando functionality of the probe. The new eReactor NMR probe offers a general method for studying flow electrochemistry, and we envision applications in a wide range of environmentally relevant energy systems, for example, Li metal batteries, electrochemical ammonia synthesis, carbon dioxide capture and reduction, redox flow batteries, fuel cells, water desalination, lignin oxidation etc.

Testing the reproducibility of in situ Lu[sbnd]Hf dating using Lu-rich garnet from the Tørdal pegmatites, southern Norway

In situ LuHf geochronology offers the potential for direct dating of garnet within petrographic context. However, the method requires matrix-matched standards to calibrate measured Lu/Hf ratios. In order to assess the accuracy of this calibration, as well as the reproducibility of the resulting LuHf dates, two Lu-rich (up to 1 wt% Lu) garnet samples from the Tørdal pegmatite field in southern Norway were analysed over six analytical sessions. Multi-session isochron LuHf dates of 930.3 ± 1.4 Ma (MSWD = 1.0, 164 analyses) and 930.3 ± 1.7 Ma (MSWD = 1.5; 125 analyses) were obtained, conform with previously published age constraints. The relative standard deviation of 0.1% between the analytical sessions indicates that the dates are highly reproducible. For each individual analytical session, age uncertainties of 0.3–0.6% were achieved by measuring high Lu count rates in analog detection mode. We further describe a calibration strategy that deals with LuHf datasets where Lu is measured in both pulse and analog detector mode. Given the high analytical precision and reproducibility, we suggest that the Tørdal garnets are suitable reference materials for future LA-ICP-MS/MS LuHf studies.

State and rate-of-change encoding in parallel mesoaccumbal dopamine pathways.

The nervous system uses fast- and slow-adapting sensory detectors in parallel to enable neuronal representations of external states and their temporal dynamics. It is unknown whether this dichotomy also applies to internal representations that have no direct correlation in the physical world. Here we find that two distinct dopamine (DA) neuron subtypes encode either a state or its rate-of-change. In mice performing a reward-seeking task, we found that the animal's behavioral state and rate-of-change were encoded by the sustained activity of DA neurons in medial ventral tegmental area (VTA) DA neurons and transient activity in lateral VTA DA neurons, respectively. The neural activity patterns of VTA DA cell bodies matched DA release patterns within anatomically defined mesoaccumbal pathways. Based on these results, we propose a model in which the DA system uses two parallel lines for proportional-differential encoding of a state variable and its temporal dynamics.

Effect of detector placement on joint estimation in X-ray fluorescence emission tomography.

Imaging the spatial distribution of low concentrations of metal is a growing problem of interest with applications in medical and material sciences. X-ray fluorescence emission tomography (XFET) is an emerging metal mapping imaging modality with potential sensitivity improvements and practical advantages over other methods. However, XFET detector placement must first be optimized to ensure accurate metal density quantification and adequate spatial resolution. In this work, we first use singular value decomposition of the imaging model and eigendecomposition of the object-specific Fisher information matrix to study how detector arrangement affects spatial resolution and feature preservation. We then perform joint image reconstructions of a numerical gold phantom. For this phantom, we show that two parallel detectors provide metal quantification with similar accuracy to four detectors, despite the resulting anisotropic spatial resolution in the attenuation map estimate. Two orthogonal detectors provide improved spatial resolution along one axis, but underestimate the metal concentration in distant regions. Therefore, this work demonstrates the minor effect of using fewer, but strategically placed, detectors in the case where detector placement is restricted. This work is a critical investigation into the limitations and capabilities of XFET prior to its translation to preclinical and benchtop uses.

Artificial intelligence-driven shimming for parallel high field nuclear magnetic resonance

Rapid drug development requires a high throughput screening technology. NMR could benefit from parallel detection but is hampered by technical obstacles. Detection sites must be magnetically shimmed to ppb uniformity, which for parallel detection is precluded by commercial shimming technology. Here we show that, by centering a separate shim system over each detector and employing deep learning to cope with overlapping non-orthogonal shimming fields, parallel detectors can be rapidly calibrated. Our implementation also reports the smallest NMR stripline detectors to date, based on an origami technique, facilitating further upscaling in the number of detection sites within the magnet bore.

MR-guided ion therapy: Detector response in magnetic fields during carbon ion irradiation.

Combining carbon ion therapy with on-bed MR imaging has the potential to bring particle therapy to a new level of precision. However, the introduction of magnetic fields brings challenges for dosimetry and quality assurance. For protons, a small, but significant change in detector response was shown in the presence of magnetic fields previously. For carbon ion beams, so far no such experiments have beenperformed. To investigate the influence of external magnetic fields on the response of air-filled ionizationchambers. Four commercially available ionization chambers, three thimble type (Farmer, Semiflex, and PinPoint), and a plane parallel (Bragg peak) detector were investigated. Detectors were aligned in water such that their effective point of measurement was located at 2 cm depth. Irradiations were performed using square fields for carbon ions of 186.1, 272.5, and 402.8MeV/u employing magnetic field strengths of 0, 0.25, 0.5, and 1 T. In addition, the detector response for protons and carbon ions was compared taking into account the secondary electron spectra and employing protons of 252.7 MeV forcomparison. For all four detectors, a statistically significant change in detector response, dependent on the magnetic field strength, was found. The effect was more pronounced for higher energies. The highest effects were found at 0.5 T for the PinPoint detector with a change in detector response of 1.1%. The response of different detector types appeared to be related to the cavity diameter. For proton and carbon ion irradiation with similar secondary electron spectra, the change in detector response was larger for carbon ions compared toprotons. A small, but significant dependence of the detector response was found for carbon ion irradiation in a magnetic field. The effect was found to be larger for smaller cavity diameters and at medium magnetic field strengths. Changes in detector response were more pronounced for carbon ions compared toprotons.

Improved Radio-Cesium Detection Using Quantitative Real-Time Autoradiography.

Cesium-134 and -137 are prevalent, long-lived, radio-toxic contaminants released into the environment during nuclear accidents. Large quantities of insoluble, respirable Cs-bearing microparticles (CsMPs) were released into the environment during the Fukushima Daiichi nuclear accident. Monitoring for CsMPs in environmental samples is essential to understand the impact of nuclear accidents. The current detection method used to screen for CsMPs (phosphor screen autoradiography) is slow and inefficient. We propose an improved method: real-time autoradiography that uses parallel ionization multiplier gaseous detectors. This technique permits spatially resolved measurement of radioactivity while providing spectrometric data from spatially heterogeneous samples-a potential step-change technique for use after nuclear accidents for forensic analysis. With our detector configuration, the minimum detectable activities are sufficiently low for detecting CsMPs. Further, for environmental samples, sample thickness does not detrimentally affect detector signal quality. The detector can measure and resolve individual radioactive particles ≥465 μm apart. Real-time autoradiography is a promising tool for radioactive particle detection.

Design and characterization of a pyroelectric detector based on three-dimensional structured hafnium oxide thin films

Pyroelectric detectors are used for gas analysis and flame detection because of their fast response and excellent performance. Most pyroelectric devices are based on monocrystalline lithium tantalate or pyroelectric lead zirconate titanate thin films deposited on a silicon (Si) substrate. In comparison, recently discovered pyroelectric-doped hafnium oxide (HfO2) offers the possibility of manufacturing completely complementary metal-oxide-semiconductor (CMOS)-compatible devices on large Si wafers. This is a promising approach to simplifying mass production of the sensor element and realizing new sensor structures with a high performance. Si substrates were structured with trenches and filled with thin-doped HfO2 layers by atomic layer deposition to multiply the pyroelectric current responsivity. An effective pyroelectric coefficient of up to 1300 μC / m2 / K was measured. Micromechanical structuring of the 6-in Si wafers was used to improve the thermal conversion of the sensor element. The applied plasmonic absorbers increase the infrared light absorption to >80 % for the spectral range of 3 to 5 μm, which was determined using Fourier transform infrared reflection measurements. In the first step, the performance of the sensor element was evaluated with an analog transimpedance amplifier with a feedback resistance of 5 GΩ. A specific detectivity D * > 1 · 107 cm√Hz / W was measured for the frequency range of 1 to 10 Hz. In addition, an application-specific integrated circuit was designed for the electrical signal conditioning to build a fully CMOS-compatible pyroelectric detector. It offers a simple to manufacture, flexible configuration, and digital communication interface with a signal-to-noise performance close to analog detectors. We present the measurement results of different sensor elements and detector types.

Fingerprinting and identification of isolated plastic polymers with pyrolysis comprehensive two-dimensional gas chromatography and flame ionization detection.

An approach using pyrolysis with comprehensive two-dimensional gas chromatography with flame ionization detection is introduced for identifying common isolated plastic polymers. A quadrupole mass spectrometer is employed as a parallel detector to aid method development and improve polymer identification in complex matrices. Common plastic polymers including polyethylene, polypropylene, polystyrene, polyvinyl chloride, polyamide, poly(methyl methacrylate), styrene-butadiene rubber, and polyethylene terephthalate are accurately identified within a total analysis time of 45min. A strategy to enhance compatibility of high-resolution capillary gas chromatography using a 150-µm internal diameter column technology and a larger internal volume microfurnace-based pyrolyzer is discussed. This strategy resulted in minimizing the band broadening effect caused by the pyrolyzer's internal volume and overcoming the slow pressure buildup when the sample is inserted into the furnace. Prolonged pressure buildup to reach a final pressure setting can cause a safety shutdown to the pneumatic control system. The developed approach is complementary to spectroscopic techniques by offering mass based, chemical composition analysis of plastics.

First demonstration of on-chip interpolation using a single photon counting microstrip detector

Despite being used in many X-ray applications, hybrid single photon counting detectors are limited in spatial resolution due to the diffusion of the charge produced by single photons between neighboring electronic channels, also called charge sharing. In this work, we demonstrate that on-chip interpolation can be used to improve the effective spatial resolution in a single photon counting detector without increasing the number and density of interconnects between the sensor and the readout electronics. We describe a digital communication scheme between neighboring channels exploiting charge sharing to obtain a spatial resolution better than the channel pitch, which has been implemented for the first time in the MYTHEN III microstrip detector. The interpolation is achieved directly on-chip at the time the photons are absorbed, limiting the data throughput and the computational effort and allowing a higher photon flux compared to interpolation using analog detectors. Here we show the first results obtained with this interpolation mechanism, characterizing the spatial resolution in terms of modulation transfer function. The spatial resolution of the 50 μm pitch MYTHEN III microstrip detector can be improved from the 20 lp/mm given by the physical strip pitch to an average resolution of approximately 30 lp/mm using the interpolation method.

Modified Klyshko method for an analog detector calibration.

We extend the absolute quantum efficiency (QE) calibration method, previously used only for photon counters, to analog detectors with a high dispersion of single-photon responses. Our approach is demonstrated on a reference-free measurement of a photomultiplier tube (PMT) cathode QE with 4% relative uncertainty. It involves not only measuring the biphoton field correlation function, but also a special approximation of the distribution of detector readings in order to determine the average number of photoelectrons and the average charge corresponding to a single photoelectron. Results of the calibration were verified in an independent experiment; the numbers of incident photons detected by the PMT and a single-photon counter are in good agreement.

Measurement of the Quantum Efficiency of Analog Detectors in the Parametric Down-Conversion Field

Approaches to the standard-free calibration of the quantum efficiency of a wide class of analog detectors based on the measurement of statistical characteristics of fields generated by parametric down-conversion are analyzed. General expressions are obtained for the noise reduction factor of the difference photocurrent and for the covariance of photocurrents in the signal and idler channels that take into account the possibility of strong fluctuations in the amplitudes of single-photon response functions of the detectors used. It is shown that the measurement of the noise reduction factor of the difference photocurrent using detectors that cannot operate in the photon counting mode is on its own insufficient to directly characterize the level of two-mode squeezing in the down-conversion field and to determine the quantum efficiency of photosensitive elements without additional calibration procedures. A method to determine the quantum efficiency of such detectors based on measuring the dependence of the normalized covariance of photocurrents on the parametric gain is proposed.

Sample-centred shimming enables independent parallel NMR detection

Two major technical challenges facing parallel nuclear magnetic resonance (NMR) spectroscopy, at the onset, include the need to achieve exceptional B_0 homogeneity, and good inter-detector radiofrequency signal decoupling, and have remained as technical obstacles that limit high throughput compound screening via NMR. In this contribution, we consider a compact detector system, consisting of two NMR ‘unit cell’ resonators that implement parallel B_0 shimming with parallel radiofrequency detection, as a prototype NMR environment, pointing the way towards achieving accelerated NMR analysis. The utility of our approach is established by achieving local field correction within the bore of a 1.05T permanent magnet MRI. Our forerunner platform suppresses signal cross-coupling in the range of -21 dB to -30 dB, under a geometrically decoupled scheme, leading to a halving of the necessary inter-coil separation. In this permanent magnet environment, two decoupled parallel NMR detector sites simultaneously achieve narrow spectral linewidth, overcoming the spatial inhomogeneity of the magnet from 400 to 28 Hz.

Entanglement harvesting between two inertial Unruh-DeWitt detectors from nonvacuum quantum fluctuations

Entanglement harvesting from the quantum field is a well-known fact that, in recent times, is being rigorously investigated further in flat and different curved backgrounds. The usually understood formulation studies the possibility of two uncorrelated Unruh-DeWitt detectors getting entangled over time due to the effects of quantum vacuum fluctuations. Our current work presents a thorough formulation to realize the entanglement harvesting from non-vacuum background fluctuations. In particular, we further consider single excitation field states and a pair of inertial detectors, respectively, in $(1+1)$ and $(1+3)$ dimensions for this investigation. Our main observation asserts that entanglement harvesting is suppressed compared to the vacuum fluctuations in this situation. Our other observations confirm a non-zero individual detector transition probability in this background and vanishing entanglement harvesting for parallel co-moving detectors. We look into the characteristics of the harvested entanglement and discuss its dependence on different system parameters.

Development of LTCC-packaged optocouplers as optical galvanic isolation for high-temperature applications

This paper reports high-temperature optocouplers for signal galvanic isolation. Low temperature co-fired ceramic (LTCC) technology was used in the design and fabrication of the high-temperature optocoupler package. The optimal coupling behaviors, driving capabilities and response speed of the optocouplers were concentrated and investigated in this paper. Emitters and detectors with different emission and spectral wavelengths were studied to achieve optimal coupling behaviors. Relatively high coupling efficiency is achieved with emitters and detectors of emission and spectral wavelength in the red spectrum (i.e., 620–750 nm), leading to higher current transfer ratios (CTR). To further enhance the electrical performance, optocouplers with multiple detectors in parallel were designed and fabricated. CTR, leakage current and response speed (i.e., propagation delay, rise time and fall time) of the optocouplers were characterized over a range of temperatures from 25 to 250 °C. The CTR degrades at high temperatures, while the leakage current and response speed show little degradation with varying temperatures. Furthermore, the behaviors of the optocouplers with varying temperatures are modeled and analyzed.

Study and characterisation of pad-based readout for RPC detector

The Resistive Plate Chamber (RPC) is a parallel plate avalanche type particle detector which uses a gas mixture as its active detection medium. While high resistivity materials like glass or bakelite plates are commonly used as the detector electrodes, plastic core-based and metal foil laminated pickup panels with segmented strips are used to readout the induced signals. Large area RPCs (of dimension 2 m× 2 m) of this design are chosen as the active detector elements for the India-based Neutrino Observatory's (INO) magnetised Iron Calorimeter (ICAL) detector. One of the main goals of the ICAL detector is a precision measurement of neutrino oscillation parameters. As part of the ongoing detector R&D, a pad-based — instead of strip-based readout — scheme is being developed to improve localization of particle hit positions, while retaining good charge profile and noise rate characteristics of the strip-based RPC based detectors.

ELSSI: parallel SNP-SNP interactions detection by ensemble multi-type detectors.

With the development of high-throughput genotyping technology, single nucleotide polymorphism (SNP)-SNP interactions (SSIs) detection has become an essential way for understanding disease susceptibility. Various methods have been proposed to detect SSIs. However, given the disease complexity and bias of individual SSI detectors, these single-detector-based methods are generally unscalable for real genome-wide data and with unfavorable results. We propose a novel ensemble learning-based approach (ELSSI) that can significantly reduce the bias of individual detectors and their computational load. ELSSI randomly divides SNPs into different subsets and evaluates them by multi-type detectors in parallel. Particularly, ELSSI introduces a four-stage pipeline (generate, score, switch and filter) to iteratively generate new SNP combination subsets from SNP subsets, score the combination subset by individual detectors, switch high-score combinations to other detectors for re-scoring, then filter out combinations with low scores. This pipeline makes ELSSI able to detect high-order SSIs from large genome-wide datasets. Experimental results on various simulated and real genome-wide datasets show the superior efficacy of ELSSI to state-of-the-art methods in detecting SSIs, especially for high-order ones. ELSSI is applicable with moderate PCs on the Internet and flexible to assemble new detectors. The code of ELSSI is available at https://www.sdu-idea.cn/codes.php?name=ELSSI.

Measurement-based validation of a commercial Monte Carlo dose calculation algorithm for electron beams.

This work presents the clinical validation of RayStation's electron Monte Carlo code by the use of diodes and plane parallel radiation detectors in homogenous and heterogeneous tissues. Results are evaluated against internationally accepted criteria. The Monte Carlo-based electron beam dose calculation code was validated using diodes, air- and liquid-filled parallel radiation detectors on an Elekta linac with beam energies of 4, 6, 8, 10, and 12MeV. Treatment setups with varying source-to-skin distances, different applicators, various cutouts, and oblique beam incidences were addressed, together with dose prediction behind lung-, air-, and bone-equivalent inserts. According to NCS (Netherlands Commission for Radiation Dosimetry) report 15 for nonstandard treatment setups, a dose agreement of 3% in the δ1 region (high-dose region around Zref ), a distance-to-agreement (DTA) of 3mm or a dose agreement of 10% in the δ2 region (regions with high-dose gradients), and 4% in the δ4 region (photon tail/low-dose region) were applied. During validation, clinical routine settings of 2×2×2-mm3 dose voxels and a statistically dose uncertainty of 0.6% (250000 histories/cm2 ) were used. RayStation's electron Monte Carlo code dose prediction was able to achieve the tolerances of NCS report 15. Output predictions as a function of the SSD improve with energy and applicator size. Cutout data revealed no field size or energy dependence on the accuracy of the dose prediction. Excellent agreement for the oblique incidence data was achieved and a maximum of one voxel difference was obtained for the DTA behind heterogeneous inserts. The accuracy of RayStation's Monte Carlo-based electron beam dose prediction for Elekta accelerators is confirmed for clinical treatment planning that is not only performed within an acceptable timeframe in terms of the number of histories but also addresses for homogenous and heterogeneous media.

Spectroscopic autoradiography of alpha particles using a parallel ionization multiplier gaseous detector

Geoscience is a field of study where nuclear instruments find their place for conducting specific measurements of radioactivity, usually to improve the monitoring of natural processes using naturally-occurring radioactive tracers, but also for the nuclear industry linked to the mining sector. In geological samples, the location and identification of the minerals bearing radioactivity at the thin-section scale remains a major challenge as the detection limit of the usual elementary microprobe techniques is far higher than the concentration of most of the natural radioactive decay products. The location of each decay product, as in the case of uranium-238 series in a geomaterial is interesting for relating radionuclide concentrations to mineralogy. The present study aims to provide spectroscopic autoradiography analysis method for measuring the initial energy of alpha particles with a parallel ionization multiplier gaseous detector. This spectroscopic autoradiography method was successfully used to reproduce the alpha spectra from a 238U decay chain on a geological sample at the thin-section scale. The characteristics of this measurement are an energy spectrum resolution of 17.2% (FWHM) at 4647 keV and a spatial resolution of at least 50 μm. Even if the efficiency of energy spectrum reconstruction is low (4.4%) compared to the efficiency of a simple autoradiograph (50%), this novel measurement approach offers the opportunity to select areas on an autoradiograph to perform an energy spectrum analysis within that area. This opens up possibilities for the detailed analysis of heterogeneous geological samples containing natural alpha emitters such as uranium-238 and radium-226.