SummaryTransform domain communication system is an adaptive anti‐interference system that can dynamically generate interference‐orthogonal waveforms. As a spread spectrum system, its low spectrum efficiency limits potential practical applications. In TDCS, cyclic code shift keying is an orthogonal modulation, whose symbols can be regarded as scalars in different dimensions. However, the constellation is restricted by signal time‐bandwidth product. In this study, extending constellation is proven to be a valid approach to improve spectrum efficiency. The combinatory of multidimensional vectors is designed mathematically to increase the variety of the scalars with the minimum orthogonality damage. On the basis of the design, an efficient modulation scheme, namely, multidimensional parallel combinatory transform domain communication system, is proposed, whose fundamental modulation symbols can be represented by the combinatory of a series of cyclic code shift keying symbols with phase shift keying modulation. Compared with the existing methods, multidimensional parallel combinatory transform domain communication system can achieve a considerably higher spectrum efficiency. The bit error rate performance is also improved to various extents. Theoretical spectrum efficiency and bit error rate of the proposed method are derived for additive white Gaussian noise and typical multipath fading channels. System with different spectral conditions and channel estimation methods is also simulated and analyzed to confirm the practical usability.