Paradoxical Events Research Articles

Fluoroscopy-only guided transcatheter patent foramen ovale closure: the importance of pre-procedural echocardiography.

Percutaneous closure of a patent foramen ovale (PFO) to prevent recurrent paradoxical thromboembolic events has become the standard of care. However, it remains uncertain if transesophageal echocardiography (TOE) guidance improves procedural success with an existing comprehensive pre-procedural TOE. The aim of the study was to compare the effectiveness of percutaneous PFO closure guided by fluoroscopy (FS) only vs TOE plus FS. Consecutive patients undergoing percutaneous PFO closure between February 2017 and April 2023 were analyzed. Based on pre-procedural echocardiography, patients were scheduled either for an FS-only or TOE/FS-guided procedure. The primary-endpoint was effective PFO-closure (residual-shunt grade 0/1 at 6-month follow-up). The secondary-endpoints included procedural safety/efficacy and major adverse cardiovascular events during hospital stay and at the 6-month follow-up. Two hundred-three patients (mean age 51.8 ± 12.5 years, 39.4% women, Risk of Paradoxical Embolism score = 7 [IQR = 6-7]) underwent PFO closure with FS-only guidance (88 patients, 43.3%) or TOE/FS guidance (115 patients, 56.7%). The main indications for PFO closure were cryptogenic stroke (179 patients, 88.2%) and peripheral embolism (13 patients, 6.4%). At baseline, a right-to-left shunt of grade 2 or higher was present in 199 patients (98%). The procedure time in the FS group was shorter (13 minutes in the FS group vs 16.5 minutes in the TOE/FS group, P = .002). The immediate procedural success was 99.5%. At 6 months, effective closure was achieved in 195 patients (96.1% [FS group: 97.7% vs TOE/FS group 97.8%, P = .29]). The rates of atrial fibrillation and recurrent thromboembolic events were not different among the procedural strategies (3.9% [P = .47] and 0.5% [P = .43]). After comprehensive pre-procedural echocardiography workup, PFO closure with FS guidance only seems equally safe and effective as TOE/FS guidance. A standardized pre-procedural echocardiography protocol facilitates procedural planning with excellent echocardiographic and clinical outcomes.

Paradoxical and bimodal immune-mediated dermatological side effects of TNF-α inhibitors: A comprehensive review.

Due to the increasing prevalence of immune-mediated diseases such as psoriasis, lichen planus, rheumatoid arthritis and inflammatory bowel disease, dermatologists have turned to new biologic drugs known as DMARDs (disease-modifying anti-rheumatic drugs) in recent years. In this study, we evaluate the immune-mediated dermatological side effects of DMARDS by reviewing and analyzing previous peer-reviewed research on the effects of TNF-α inhibitors in the treatment of skin diseases, as well as adverse effects of these drugs and some of the main causes of these effects. DMARDs are very effective in improving control of the above diseases. TNF-α inhibitors are an important group of DMARDs that are widely used. The paradoxical adverse events (PAEs) associated with the use of TNF-α inhibitors are divided into three categories: true paradoxical, borderline paradoxical, and non-paradoxical. True PAEs include conditions for which TNF-α inhibitors are approved for treatment. Borderline PAEs are considered to occur with this class of drugs for which there is no definite approval but for which there is sufficient evidence. Although these events are rare, early recognition of the accused drug and appropriate decision-making may prevent progression of complications and irreversible side effects.

Amplatzer or Figulla Flex II Occluder: a comparative study of outcomes after transcatheter patent foramen ovale closure.

Percutaneous closure of a patent foramen ovale (PFO) for the prevention of recurrent paradoxical thromboembolic events has been shown to be safe and effective in randomized controlled trials. However, it remains uncertain if differences in the structure and design of the occluder devices impact the outcomes. The aim of this study was to compare results of percutaneous PFO closure using 2 widely used double-disc occluders. Consecutive patients who underwent percutaneous PFO closure with the Abbott Amplatzer occluder (APO) or the Occlutech Figulla-Flex-II occluder (OPO) at the Heart Center Lucerne between February 2017 and December 2022 were included in a registry. The primary endpoint was effective closure of the PFO, defined as a residual shunt grade 0 or 1, assessed by contrast echocardiogram at 6-month follow-up. Secondary endpoints included procedural efficacy/safety and major adverse cardiovascular events during the hospital stay and at 6-month follow-up. One hundred ninety-three consecutive patients (mean age 51.7 ± 12.5 years; 39% women; Risk of Paradoxical Embolism (RoPE) score = 7, IQR = 6-8) underwent percutaneous PFO closure with the APO (120 patients, 62.2%) or the OPO (73 patients, 37.8%). Main indications for closure were crypotogenic stroke in 168 patients (87.1%) and peripheral embolism in 13 patients (6.7%). At baseline, right-to-left shunt (RLS) greater than or equal to grade 2 was present in 189 patients (97.9%). Immediate procedural success was 99.5%. In 1 patient, an air embolism occurred during positioning of the APO occluder with transient chest pain and electrocardiogram changes, but without further sequelae to the patient. At 6-month follow-up, effective closure was achieved in 185 patients (95.8%; APO: 96.6% vs OPO: 94.5%, P = .30). Rates of atrial fibrillation and recurrent thromboembolic events were 4.2 and 0.5%, respectively. PFO closure is safe and effective when performed with either the self-expanding Abbott Amplatzer or Occlutech Figulla Flex II PFO occluder.

Improving cell-specific recombination using AAV vectors in the murine CNS by capsid and expression cassette optimization

The production of cell-type- and age-specific genetically modified mice is a powerful approach for unraveling unknown gene functions. Here, we present a simple and timesaving method that enables adeno-associated virus (AAV)-mediated cell type- and age-specific recombination in floxed mice. To achieve astrocyte-specific recombination in floxed Ai14 reporter mice, we intravenously injected blood-brain barrier-penetrating AAV-PHP.eB vectors expressing Cre recombinase (Cre) using the astrocyte-specific mouse glial fibrillary acidic protein (mGfaABC1D) promoter. However, we observed non-specific neuron-predominant transduction despite the use of an astrocyte-specific promoter. We speculated that subtle but continuous Cre expression in non-astrocytic cells triggers recombination, and that excess production of Cre in astrocytes inhibits recombination by forming Cre–DNA aggregates. Here, we resolved this paradoxical event by dividing a single AAV into two mGfaABC1D-promoter-driving AAV vectors, one expressing codon-optimized flippase (FlpO) and another expressing flippase recognition target-flanked rapidly degrading Cre (dCre), together with switching the neuron-tropic PHP.eB capsid to astrocyte-tropic AAV-F. Moreover, we found that the FlpO – dCre system with a target cell-tropic capsid can also function in neuron-targeting recombination in floxed mice.

Kūnas krikščionybėje remiantis kūniškumo krize šiuolaikinėje kultūroje

Relevance of the topic. The article is devoted to the meanings and practises of the body in Christian culture and the issue of preserving and continuing this tradition in contemporary culture. Since it is about the semantic contexts of the body, the article uses the phenomenological method in combination with hermeneutic analysis. The authors consistently deploy several logical lines. The first line is related to the description of such a direction as hesychasm, its practises and attitude to the body. At the same time, the ethical potential of hesychasm and the pathos of physicality as an instrument of morality are emphasised. The second line revolves around the practical attitude to the body in modern culture: the preservation of the Christian tradition, the natural characteristics of the body, and understanding the meaning of the body. The third line is connected with the loss of the “sanctity” of the body and the unawareness of this loss on the part of the common citizen and, as a result, the erosion of the ethical and natural meaning of the body. According to the authors, history will show how terrible these changes in meaning can be. The “distortion” of the meaning of the body in modern cultures makes it possible to emphasise the emergence of the phenomenon of unconsciousness of paradoxical events, the enormity of the consequences of which few people still understand. The problem. Today, the events that unfold around the topic of the corporeal directly and indirectly touch on the topic of human relations and, as a result, there is a need to once again talk about the role and significance of the body in the Christian tradition and about the consequences of ignoring the biblical commandments in modern everyday life. The purpose. To clarify the meanings of the corporeal, based on the tradition of hesychasm. Research object. The role and significance of the body in the Christian tradition and about the consequences of ignoring the biblical commandments in modern everyday life. Results. In the article, it was shown that the body and its meaning have a special ethical pathos because its understanding was formed under the enormous influence of Christianity, which laid the foundations for the formation of the context of the general civilisational development of mankind. Modern culture “distorts” the meaning of the body, and the actual material of sports competitions makes it possible to record the phenomenon of unawareness in most people that there is a departure from universal values (this is what is called a crisis of culture). History moves in such a way that sometimes it is impossible to trace the trajectories of its development. And yet, despite the incomprehensible lines of development, does the question of the relationship with the Absolute remain relevant for a man? If the Christian meanings of the body fade into the background of life, then what other religion will be able to promote the ideas of ethics and morality? Keywords. Hesychasm, Christian tradition, meanings of the body, transgender, sports competitions, the pathos of the body, contemporary culture.

History and Cartography meet youth through Digital Technology

Through collaboration between the Onassis Foundation, the Historical Archive of the National Bank of Greece, and the Vocational Senior High School of Kamatero, an innovative digital project was developed that is both trendy and geared towards youth. This project showcases how a concept aimed at emphasizing the historical significance of the Capital of Greece inspired students to merge the disciplines of Computer Science and History, resulting in the creation of a 3D game on a popular platform. Additionally, this project demonstrates how Project-based learning can be achieved through collaborative and inquiry-based learning, real-world connections, initiative, and the satisfaction of creating something new. The impetus for the cooperation was the Panhellenic Student Competition of the Onassis Foundation, "Hack the Map: Imaginary Worlds." This competition invited schools to promote the cultural heritage of Greece, especially cartographic exhibits/evidence of the old days, through students' digital projects. The Historical Archive of the National Bank of Greece, which is a significant resource for studying Modern Greek History through primary sources, reached out to the Vocational Senior High School of Kamatero, located in the western sector of Athens, to work on a project. The school has an IT department, among other disciplines. In close collaboration, they developed a scenario that is about the civil war that occurred in Athens during the Interregnum period (October 1862-October 1863) after the dethronement of Greece's first king, Otto I. The scenario highlights the bloody events that took place between political factions in the city. In these conflicts, the implication of "Kyriakos," a dangerous leader of robbers, is a paradoxical historical event that stimulated the 2nd-grade Informatics students' imagination. Therefore, they created a 3D digital game entitled "Thieves and Policemen in the newly established Greek city-state: Iouniana." This presentation intends to demonstrate how the students' team of the Vocational School of Kamatero rebuilt Athenian monuments related to Kyriakos' action in a 3D environment; how they reconstructed the cartography of the capital's center during the second half of the 19th century based on these monuments and how they utilized digital resources (maps, photos, and texts) and books proposed by NBG Historical Archives; how a single player, via Kyriakos' persona, has to accomplish missions-battles and match parts of Athens' map of that era; and finally, how students narrated a historical event in a game constructed in Roblox platform inviting other young people to involve history knowledge.

Skin Related Paradoxical Adverse Events (Mainly Psoriasis) During Il-17 Blockage: A Systematic Review

Background: Paradoxical Adverse Events (PAEs) during biological therapy are characterized by the onset of a new inflammatory disease or by the exacerbation of the preexisting condition (with a different morphology or localization) while treating the patient with a class-agent proven efficacious for both conditions. They can be divided in two subgroups: “true PAE” characterized by the previously proven efficacy of the biological agent for the PAE and “borderline PAE” defined by the development of an inflammatory condition where the biological agent has not a proven efficacy. Methods: systematic search of English databases in order to identify true and borderline-skin PAE under anti IL-17 therapy. Results: We retrieved 58 patients affected by skin-PAE during anti-IL-17 therapy, 40 cases classified as True-PAE and 18 as Borderline-PAE., with a mean age of onset of 51 years. Secukinumab was the most frequent agent associated to skin-PAE and mean onset of the skin-PAE was 18 weeks. Conclusion: True-skin-PAE occur during anti Il-17 therapy, the underlaying immunological mechanism is not yet known, but pustular variants of psoriasis seem to be more prevalent; withdrawal of the anti-IL-17 therapy has been mainly performed and other therapies such as antiIL-23 biologics seem to control both the underlying disease and the true-skin-PAE. Further studies are needed in order to better understand the immunological mechanism involved.

Biologics-Induced Immunophenotypic Cross-Switching in Patients with Psoriasis and Atopic Dermatitis.

Antibody-based therapies that inhibit pro-inflammatory cytokine signalling are commonly used in dermatology. Paradoxically, these biological agents may induce or exacerbate paradoxical reactions. Recently, it has been reported that the treatment of eczema with dupilumab can lead to the development of psoriasiform eruptions, which we called psoriasiform paradoxical reactions (P-PRs). Conversely, cases of eczematous paradoxical reactions (E-PRs) have also been described in patients with psoriasis treated with biologics. To summarise the case characteristics and disease features of phenotypic transition between psoriasis and eczematoid dermatitis, and to explore the mechanism or connection related to biological agents or patients' genetic characteristics, a systematic review was conducted for P-PRs in atopic dermatitis and E-PRs in patients with psoriasis treated with corresponding biological agents, respectively. We identified a series of P-PRs in 42 atopic dermatitis cases treated with dupilumab. The time to onset of P-PRs typically ranged from weeks to months, with a mean latency period of 22.65 weeks. Almost all patients presented with new-onset P-PRs. Simultaneously, we reviewed 22 articles reporting 51 patients with psoriasis with biological agent-induced E-PRs, which occurred on average at 24.47 weeks, 72.55% of them induced by IL-17A inhibitors. 48.98% (24/49) of cases reported a positive personal history of atopy, which may suggest an increased risk of biological agent-induced paradoxical eruptions. Overall, the improvement or resolution upon discontinuation of the inciting biologics was relatively common, and further studies are needed to estimate the real prevalence and unveil the pathophysiological mechanisms of these paradoxical events.

Extensive Bowel Necrosis in a Case of COVID-19 Disease Despite Warfarin Toxicity: A Paradoxical Event

Background: Coronavirus disease 2019 (COVID-19) involves multiple organs, including the gastrointestinal tract. It also causes frequent thromboembolic events because of its thrombogenicity. This study reports a COVID-19 case of extensive bowel necrosis despite using warfarin. Case Presentation: A 52-year-old homeless addict male was brought via Emergency Medical Services with a chief complaint of abdominal pain for two days and loss of consciousness since the day before. He had a history of cough and dyspnea for seven days and had been using warfarin after mitral valve replacement three years earlier. On admission, he had low oxygen saturation, tachycardia, and fever. Because of his respiratory signs and symptoms, a chest CT scan was performed, and evidence of COVID-19 infection was detected. He had nausea, and on abdominal examination, there was generalized tenderness, rebound tenderness, and guarding. Following physical examination and abnormal laboratory test results, he underwent an emergent laparotomy. Extensive necrosis made surgical intervention impossible, and he died shortly after the surgery. Conclusion: COVID-19-associated coagulopathy raises many challenges nowadays, and according to the present case, even using anticoagulants may not prevent it.

Epileptiform EEG discharges during sevoflurane anesthesia in children: A meta-analysis

ObjectiveTo investigate the overall incidence and associated factors of epileptiform discharges in children during sevoflurane anesthesia. MethodsOur group systematically searched the PubMed, Cochrane library (Central) and EMBASE for the relevant trials from their inception until September 2020. The primary endpoint was the incidence of epileptiform discharges during sevoflurane induction. The secondary endpoints were the incidence of different types of epileptiform discharges, factors associated with these epileptiform events, and other adverse events such as seizure-like movements. ResultsAfter screening of 713 records, eleven studies involving 448 participants were included into the final analysis. Meta-analysis indicated that the overall incidence of Epileptiform EEG discharges was 38.1% (95%confidence interval [CI], 19.1%-59.2%) during sevoflurane anesthesia in children. Subgroup analysis showed that the incidence of these EEG patters was lower when participants were inducted by using the low initial concentration of sevoflurane, compared with the high initial concentration sevoflurane (1.7%, 95%CI, 0.0% to 8.4% versus 47.7%, 95%CI, 25.5% to 70.3%, P < 0.05). The longer exposure (>3 min) of high concentration sevoflurane during induction showed higher rate of epileptiform discharges than a shorter exposure (≤3 min) (48.4%, 95%CI, 20.1% to 77.3% versus 5.7%, 95%CI, 0.00% to 23.5%; P < 0.05). No significant difference for the incidence of epileptiform discharges was observed in subgroup analysis of addition of nitrous oxide (69.2%, 95%CI, 34.0% to 95.7% versus 41.3%, 95%CI, 15.6% to 69.7%, P﹥0.05) and type of EEG monitoring (26.9%, 95%CI, 3.8% to 60.7% versus 53.1%, 95%CI, 25.4% to 79.8%, P﹥0.05). ConclusionsThe incidence of epileptiform EEG events in children during sevoflurane anesthesia varied from 19.1%-59.2%. The low initial concentration technique and shorter exposure time of high concentration sevoflurane may be associated with a decreased incidence of these epileptiform discharges in EEG. SignificanceEpileptiform EEG discharges during sevoflurane anesthesia in children should arouse clinicians’ attention. The use of low initial concentration technique and shorter exposure time of high concentration sevoflurane may be associated with a lower occurrence of these paradoxical events.

Magical realism as an aesthetic phenomenon – Givi Margvelashvili miniatures

The report discusses the miniatures of German-speaking Georgian writer Givi Margvelashvili in the context of magical realism as an aesthetic phenomenon. Magical realism, the same as magical realism, is a kind of narrative strategy in fiction that, in the face of paradoxical and supernatural events, graphically depicts the mystery of reality. It, as a current and style, is mostly a Latin American phenobenon and is related to e. with writers of the B.Boom era. Since the 1960s, magical realism has been spreading around the world and becoming a link between cultural eras.Direct or indirect protest of dictatorship, unification of worldly and non-worldly, ordinary and ususual, dream and obvious, reality and unreality, hard, extraordinary biography and so called “deficit identity”, which became neither fatal nor fatal the basis of the magical realism of the work of the German-Georgian writer Givi Margvelashvili.

Paradoxical Hidradenitis Suppurativa during Biologic Therapy, an Emerging Challenge: A Systematic Review.

Hidradenitis suppurativa (HS) is a chronic, inflammatory skin disease usually occurring after puberty with painful, deep-seated, inflammatory lesions in the apocrine gland-bearing areas of the body. Although HS pathogenesis is still unproven, recent major research advantages have increased our knowledge of the mechanisms behind HS lesions. Particularly, follicular occlusion followed by follicular rupture has been shown to be crucial to HS development, leading to immune response activation, and resulting in typical clinical HS lesions. Moreover, an increased and imbalanced cytokine production, such as interleukin (IL) 17 and tumor necrosis factor (TNF) α, may play a role in HS. In recent years, paradoxical adverse events have been described during treatment. Since the recent increased use of biologic treatments in HS, an increased number of paradoxical HS occurrences have been reported. In this review, we analyzed all current data on paradoxical HS triggered by biological drugs.

Adalimumab Biosimilar-Induced Severe Paradoxical Palmoplantar Pustulosis in a Patient with Psoriasis and Psoriatic Arthritis Successfully Treated with Ixekizumab

Psoriasis vulgaris is a chronic immune-mediated inflammatory disease of the skin. Biologic therapy has been available for more than 10 years and has become one of the standard treatments for patients with moderate to severe psoriasis. Initially, only biologics against tumour necrosis factor alpha (TNF-α) were used, and only later did drugs against different interleukins (ILs), including IL-17 or IL-23, became available. The side effects of biologic therapy include paradoxical adverse events (PAEs), such as palmoplantar pustular reaction, especially with anti-TNF-α drugs. We present the case of a 49-year-old female patient with diabetes and psoriasis and psoriatic arthritis treated with an adalimumab biosimilar who developed a severe PAE of the palmoplantar pustular type. Treatment with adalimumab was stopped and the patient switched to ixekizumab which was successful. When a paradoxical reaction develops during biologic therapy, especially when it is severe as in our patient, switching to another class of biologics is advised.

A Review on Quantum Entanglement

Erwin Schrodinger first used the phrase “quantum entanglement” in 1935 to describe a mechanical phenomenon at the quantum level where two (or more) particles’ quantum states must be defined in relation to one another even if they may be geographically apart. This paradoxical event has confounded us for a very long time. Entangled particle behavior appears to be mysterious, illogical, and akin to sorcery at work. The successful and dependable principle of locality has led us to the achievements of twentieth-century physics. However, some theorists may doubt the locality itself due to the “spooky” and nonlocal effects of the local laws of quantum theory. Could there truly be an instant connection between two subatomic particles located on the extreme edges of the universe? Is there a theory that predicts such a relationship that is fundamentally faulty or lacking? Are the outcomes of the experiments that show this connection being read incorrectly? These questions challenge our most fundamental understanding of space and time. The universe is currently being disassembled by modern physics, and it will never be the same. Utilizing cutting-edge technology, quantum entanglement will have a positive impact on society. The history of quantum entanglement is outlined in this work, along with several hypotheses regarding the puzzling behavior of entangled particles. Quantum entanglement may also be an instance of nonlocality in action, in which what occurs in one location affects what occurs in another. Entanglement can also be compared to a situation in which a light switch is used to control two (or more) light bulbs, causing them to turn on at the same time when the switch is switched on. The key question is whether one of the aforementioned theories actually accounts for the odd behavior of entangled particles, in which case experimental evidence would unquestionably support the theory.

Paradoxical Reaction in Lymph Node Tuberculosis Presented as Shoulder Osteomyelitis

Paradoxical reactions (PRs) can be viewed as an abnormal immune response toward the anti-tubercular treatment (ATT). It is characterized by clinical worsening of the patient's symptoms and signs following an initial improvement despite definitive treatment with ATT. Tubercular lymphadenitis is the most common extrapulmonary manifestation seen under PR. Other sites of involvement include the pleura, central nervous system, bones, and muscle. Although some paradoxical events may not require any intervention, studies have shown to have good outcomes using glucocorticoid therapy. This case reports a PR that involves tubercular lymphadenitis and osteomyelitis, which showed marked improvement of patient ailment following a 1-month course of oral steroid.

Multiple simultaneous embolic cerebral infarctions 11 months after COVID-19

BackgroundThe coronavirus disease (COVID-19) pandemic has led to an unprecedented worldwide burden of disease. However, little is known of the longer-term implications and consequences of COVID-19. One of these may be a COVID-19 associated coagulopathy that can present as a venous thromboembolism (VTE) and further, as multiple paradoxical cerebral emboli.Case presentationA 51 year old man presented to the emergency department with multiple simultaneous embolic cerebral infarctions 11 months after mild COVID-19. In the subacute phase of the COVID-19 illness the patient developed increasing shortness of breath and was found to have an elevated D-dimer and multiple bilateral segmental pulmonary emboli. He was subsequently treated with 3 months of anticoagulation for a provoked VTE. The patient then presented 11 months after the initial COVID-19 diagnosis with multiple simultaneous cerebral infarctions where no traditional underlying stroke etiology was determined. A patent foramen ovale (PFO) and an elevated D-dimer were found suggesting a paradoxical thromboembolic event due to an underlying coagulopathy.ConclusionsThis case report highlights the one of the potentially more serious complications of long-term COVID-19 where VTE due to a persistent coagulopathy is seen almost a year after the initial illness. Due to the highly prevalent nature of PFO in the general population, VTE due to COVID-19 associated coagulopathy could lead to ischemic stroke. This case report highlights the possibility for an underlying COVID-19 associated coagulopathy which may persist for many months and beyond the initial illness.

New Biologics for the Treatment of Atopic Dermatitis: Analysis of Efficacy, Safety, and Paradoxical Atopic Dermatitis Acceleration.

Atopic dermatitis (AD) is a chronic, inflammatory skin disease with an eczematous rash and itching. Due to undesired adverse effects of traditional systemic treatment, there is still an unmet need for safe and effective long-term therapy for refractory AD. As our understanding of the pathogenesis underlying AD grows, novel treatments targeting specific molecules have been developed. Here, we discuss the efficacy and safety profiles of these drugs in recent clinical trials. Among their adverse effects, of particular note is AD acceleration. Although there is still debate about whether certain adverse reactions can be said to be paradoxical adverse events (PAEs), a wide range of PAEs have been reported during biological treatment for chronic immune-mediated diseases. Close surveillance of novel biologics is crucial to detect new undescribed paradoxical reactions and to shed light on the convoluted pathogenesis of AD.

AESTHETIC IMPERMANENCE HERO STORY “КӨНЕ ЖҰРТ”

This article analyzes in detail the story of Zhumeken Nazhimedenov “Көне жұрт”. The analysis of the story is carried out from the point of view of the author's concept, from the point of view of the artistic structure. In artistic details-inappropriate use. The path and shape type are determined. A psychoanalyst is created for the main character. We also analyzed the manifestations of psychoanalysis in the modern literary process. It is analyzed from a meaningful and formal point of view, and an overview of the artistic world is given. Weak points of plot connections are shown. On the basis of Sigmund Freud's philosophical platform "vision of color", a psychoanalyst of the hero is created. The significance of the article lies in the analysis of the artistic structure of Zhumeken's stories, which were not analyzed in the prose of past eras. Defining ways to create the main character, comparing the advantages and disadvantages of stories from that period. To reveal the essence of the aesthetics of helplessness through a thorough analysis of the state of the soul and mind, the hero's exit from the psychological category into a duel of consciousness with paradoxical events. In a social phenomenon, an action that carries consciousness is a demonstration that the brutal treatment of the hero, who was left in the captivity of powerlessness, led the main character to the aesthetics of helplessness.

The Eventful Character of Bibikhin's Philosophical Thought

The article deals with the event-related aspects of V.V. Bibikhin's philosophical activities on the material of his lectures, texts and communication with contemporaries (S.S. Horuzhy, S.S. Averintsev and A.V. Akhutin). The eventfulness of the transfer of knowledge from teacher to student, as well as the unity of thought, word and life are the principles of teaching philosophy derived from the pedagogical experience of V.V. Bibikhin. He was a follower of A.F. Losev and M. Heidegger focusing his thoughts on clarifying ontological problems. Ontological thought is paradoxical in its own nature. This is revealed in the reading and interpretation of Bibikhin's writings, as well as in the evidence of his polemical communication with colleagues. One of the brightest ontological disputes of recent times is the discussion of V.V. Bibikhin and S.S. Horuzhy about the concept of energy which is an essential ontological category. These prominent Russian thinkers had a long-term friendship that included an element of intellectual rivalry. The author calls such communication “friendship in struggle” which has a paradoxical character. The philosophical definition of friendship presented in the book “The Pillar and Statement of Truth” by P.A. Florensky which has an antinomic character is used in the text. The paradoxical event and the polemic nature of V.V. Bibikhin's thought manifests itself in his works and correspondence with friends. The article provides illustrative examples of these moments of his intellectual creativity. V.V. Bibikhin is one of those thinkers who preserve the Russian philosophical tradition in the context of its disputes with other national traditions.

Событийный характер философской мысли В. Бибихина

The article deals with the event-related aspects of V.V. Bibikhin's philosophical activities on the material of his lectures, texts and communication with contemporaries (S.S. Horuzhy, S.S. Averintsev and A.V. Akhutin). The eventfulness of the transfer of knowledge from teacher to student, as well as the unity of thought, word and life are the principles of teaching philosophy derived from the pedagogical experience of V.V. Bibikhin. He was a follower of A.F. Losev and M. Heidegger focusing his thoughts on clarifying ontological problems. Ontological thought is paradoxical in its own nature. This is revealed in the reading and interpretation of Bibikhin's writings, as well as in the evidence of his polemical communication with colleagues. One of the brightest ontological disputes of recent times is the discussion of V.V. Bibikhin and S.S. Horuzhy about the concept of energy which is an essential ontological category. These prominent Russian thinkers had a long-term friendship that included an element of intellectual rivalry. The author calls such communication “friendship in struggle” which has a paradoxical character. The philosophical definition of friendship presented in the book “The Pillar and Statement of Truth” by P.A. Florensky which has an antinomic character is used in the text. The paradoxical event and the polemic nature of V.V. Bibikhin's thought manifests itself in his works and correspondence with friends. The article provides illustrative examples of these moments of his intellectual creativity. V.V. Bibikhin is one of those thinkers who preserve the Russian philosophical tradition in the context of its disputes with other national traditions.