Paradoxical Adipose Hyperplasia Research Articles

54780 Paradoxical Adipose Hyperplasia in Cool Sculpting: A Review of Current Literature

54780 Paradoxical Adipose Hyperplasia in Cool Sculpting: A Review of Current Literature

Paradoxical Adipose Hyperplasia Following Cryolipolysis.

Cryolipolysis (CL) is a noninvasive technique that uses applicators to cool tissue to temperatures that selectively destroy adipocytes. Since its introduction to the market, it has rapidly become one of the leading non-surgical modalities to reduce fat in the aesthetic industry. Paradoxical Adipose Hyperplasia (PAH) is an adverse reaction to CL, whereby there is initial reduction in fat volume, followed by abnormal fat growth exceeding the original volume in the treated area. The incidence of PAH is thought to be underreported, and its pathophysiology and management remains unclear. The objective of this study was to present a series of PAH cases and review efficacy of management modalities.

Literature review of adverse events associated with cryolipolysis.

Cryolipolysis is a noninvasive procedure for localized fat reduction and body contouring. This technique utilizes controlled cooling to induce adipocyte apoptosis without damage to overlying skin and other tissue. Although the procedure was once thought to be relatively harmless, recent studies have shed light on the risks of adverse effects (AEs). The aim of this article was to review AEs in cryolipolysis as published in clinical data. A comprehensive search was performed in PubMed, using relevant keywords such as "cryolipolysis," "CoolSculpting," "adverse effects," "complications," and "side effects" with no set data range. The search was limited to studies published in English. The selected studies encompassed a variety of study designs, including randomized controlled trials, prospective cohort studies, case series, case reports, and reviews. Since its FDA approval in 2010, our understanding of the potential risks and complications associated with cryolipolysis has grown significantly, and shown that the procedure may not be as harmless as once thought. Continued post-market surveillance of cryolipolysis devices combined with documenting of AE cases help providers better understand the true risks associated with this procedure. As "cryolipolysis" and "CoolSculpting" are often used interchangeably, further research is needed to understand if AEs such as paradoxical adipose hyperplasia (PAH) that occur both inside and outside the United States are CoolSculpting cases or linked to other devices. Additionally, further studies are needed to understand the pathophysiology of such sequelae as PAH, and to better recognize the risks and potential complications associated with cryolipolysis so that we can more accurately inform patients.

A review of research for a cryolipolysis technology.

Obesity and excess body fat are known health issues and a major aesthetic concern. Numerous modalities have been developed to address unwanted deposits of adiposity, including the development of various noninvasive methods overcoming the limitations and risks of invasive alternatives. Cryoadipolysis, also known commonly as cryolipolysis, involves the harnessing of selective cryolysis, the selective cold-based damaging of subcutaneous fat cells which die via apoptosis, and are removed naturally by the body over time. To provide a brief but comprehensive summary of the literature supporting two related cryoadipolysis devices that are only available outside of North America, Cooltech and Cooltech Define (Sinclair). Review of 10 available clinical studies evaluating the two devices, specifically, showed both devices to be safe, with side effects profiles comparable to those of similar platforms in the armamentarium. Both operate by non-invasively lowering the temperature of localized subcutaneous fat and maintaining it at or below a threshold that causes disruption of adipocytes via crystallization, inducing apoptosis (programmed cell death). Over time, clinically significant reductions in fat thickness and circumference of the treated area were noted. Patient satisfaction is high. The literature also highlights the necessity of adherence to patient selection and device use guidelines to minimize potential for rare paradoxical adipose hyperplasia and maximize patient satisfaction.

Assessing the benefits and drawbacks of cryolipolysis as a noninvasive body sculpting technique: risks, side effects, and future research – an editorial

This article discusses cryolipolysis, a noninvasive body sculpting method that freezes and removes fat cells. It explores the historical context of fat reduction treatments and the development of noninvasive techniques as alternatives to invasive liposuction. Cryolipolysis gained popularity after U.S. Food and Drug Administration (FDA) approval and has become one of the most frequently utilized noninvasive cosmetic procedures globally. The abstract delves into case reports and complications associated with cryolipolysis, such as persistent lumps, frostbite lesions, and skin necrosis, highlighting potential risks and limitations. It also addresses common side effects like erythema, numbness, and bruising, as well as more severe adverse events such as dysesthesia and paradoxical adipose hyperplasia. Safety considerations and relative contraindications are discussed, emphasizing the importance of consulting qualified medical professionals who adhere to pretreatment and posttreatment instructions and use FDA-approved technology. Patience and a healthy lifestyle are stressed for optimal outcomes. In conclusion, cryolipolysis offers a safe and convenient fat removal option with long-lasting benefits. However, it may not be suitable for significant fat loss or certain medical conditions. Consulting medical experts and considering personal preferences are essential in making an informed decision about cryolipolysis as a body sculpting option.

Cryolipolysis for fat reduction using Cooltech® Define technology: A large-sample retrospective clinical study.

Cryolipolysis is a noninvasive technique for localized fat reduction, which induces selective apoptosis of the adipocytes using controlled exposure to intense cold. During the past 10 years, this technique has been shown to be safe and effective and its application has significantly increased. In this context, Cooltech® devices have been widely used around the world. The purpose of this retrospective study was to evaluate the efficacy and safety of the removal of localized fatty tissue in different body areas using the new Cooltech® Define controlled cooling system. This single-center study was carried out on 287 patients, both female and male, treated with Cooltech® Define on different body areas for a total of 1118 procedures. Follow-up evaluations were conducted to estimate efficacy and safety. Efficacy was evaluated through plicometry and photographs. Side effects were also reported. Fold thickness showed a significant reduction (-69.91 ± 12.55%) after cryolipolysis treatment (fold thickness before: 35.33 ± 8.41 mm; fold thickness after: 10.69 ± 5.27 mm). Few side effects were reported, they included posttreatment pain (1.70%) and one case of paradoxical adipose hyperplasia (0.09%). The Cooltech® Define cryolipolysis device is a safe, effective, and well-tolerated nonsurgical procedure for reducing localized fat.

Paradoxical Adipose Hyperplasia after Cryolipolysis CoolSculpting.

Paradoxical Adipose Hyperplasia after Cryolipolysis CoolSculpting.

84. An Unfortunate Series: Characteristics of Patients Diagnosed With Paradoxical Adipose Hyperplasia After Cryolipolysis

84. An Unfortunate Series: Characteristics of Patients Diagnosed With Paradoxical Adipose Hyperplasia After Cryolipolysis

Paradoxical adipose hyperplasia after cryolipolysis

<h3></h3> Описаны клинический случай и лечение редкого осложнения после безоперационной редукции жировой ткани — парадоксальной адипоцитарной гиперплазии, также представлен обзор научной литературы. Парадоксальная адипоцитарная гиперплазия чаще развивается у мужчин. Данный клинический случай представляет особый интерес ввиду развития указанного состояния у женщины, а также недостаточности информации о патогенезе парадоксальной адипоцитарной гиперплазии.

Submental Paradoxical Adipose Hyperplasia Following Cryolipolysis: A Report and Management Recommendations.

Submental Paradoxical Adipose Hyperplasia Following Cryolipolysis: A Report and Management Recommendations.

Alternative Cosmetic and Medical Applications of Injectable Deoxycholic Acid: A Systematic Review.

Beyond submental fat reduction, injectable deoxycholic acid (DCA) has gained popularity in recent years for various minimally invasive lipolysis applications. To summarize and evaluate the evidence of off-label uses of injectable DCA. MEDLINE, Embase, CINAHL, Web of Science, and CENTRAL were searched. The outcomes measured included applications of DCA, treatment regimen, and its efficacy. An overall success rate for each condition was calculated based on the improvement defined in the included studies. Eleven studies evaluated the cosmetic use of DCA for excess adipose tissue on various anatomical locations. The outcomes were evaluated at time points ranging from 1 to 21 months post-treatment, with overall success rates over 85%. Eight case reports and series reported the success of using DCA treating lipomas, xanthelasmas, paradoxical adipose hyperplasia, fibrofatty residue of infantile hemangioma, piezogenic pedal papules, and HIV-associated lipohypertrophy. Although the preliminary efficacies were high, the overall recommendations for off-label uses are weak because of the lack of high-level studies. The review emphasizes the diversity of injectable DCA as a minimally invasive technique for lipolysis. Further high-level studies demonstrating consistent treatment regimens and methods of evaluation are warranted to make more definitive recommendations regarding off-label DCA use.

Commentary on: A Multicenter Evaluation of Paradoxical Adipose Hyperplasia Following Cryolipolysis for Fat Reduction and Body Contouring: A Review of 8658 Cycles in 2114 Patients.

Commentary on: A Multicenter Evaluation of Paradoxical Adipose Hyperplasia Following Cryolipolysis for Fat Reduction and Body Contouring: A Review of 8658 Cycles in 2114 Patients.

Response to: Shockwave Therapy for the Prevention of Paradoxical Adipose Hyperplasia After Cryolipolysis: Myth or Reality?

Response to: Shockwave Therapy for the Prevention of Paradoxical Adipose Hyperplasia After Cryolipolysis: Myth or Reality?

Shockwave Therapy for the Prevention of Paradoxical Adipose Hyperplasia After Cryolipolysis: Myth or Reality?

Shockwave Therapy for the Prevention of Paradoxical Adipose Hyperplasia After Cryolipolysis: Myth or Reality?

Evolution of the treatment approach to cryolipolysis using the CoolAdvantage® applicator family: results from a retrospective database review

The CoolAdvantage family of CoolSculpting applicators reduces skin tension and increases tissue contact compared with the previous CoolCore system. We assessed the impact of transitioning from CoolCore to CoolAdvantage in routine practice. This was a retrospective, single-center analysis of consecutive cryolipolysis treatments conducted using the CoolSculpting procedure. Between January 2012 and January 2017, these were based on the CoolCore system; between January 2017 and July 2019, treatments used CoolAdvantage. A total of 253 patients were included (n = 196 female [77.5%]). Of these, 111 received treatment with CoolCore (130 treatment areas; 338 cycles) and 151 with CoolAdvantage (248 treatment areas; 723 cycles). With CoolCore, all treatments were to the abdomen (262 cycles) or flanks (76 cycles); with CoolAdvantage, treatments were to the abdomen (231 cycles), flanks (227 cycles), and many other areas, including the inner thighs (78 cycles), outer thighs (68 cycles), and back (30 cycles). The number of body areas treated per visit was higher with CoolAdvantage versus CoolCore (1.59 ± 1.01 vs 1.14 ± 0.34, respectively; p < 0.0001), as was the mean number of treatment cycles per visit (4.63 ± 4.30 vs 2.96 ± 1.34; p < 0.0001). There were only two significant complications: one paradoxical adipose hyperplasia (with CoolCore) and one loss of sensation (with CoolAdvantage). Transitioning to the new CoolAdvantage applicator family had no impact on safety and led to greater versatility and increased numbers of cycles per treatment. Level of evidence: Level IV, therapeutic study.

A Multicenter Evaluation of Paradoxical Adipose Hyperplasia Following Cryolipolysis for Fat Reduction and Body Contouring: A Review of 8658 Cycles in 2114 Patients.

BackgroundParadoxical adipose hyperplasia (PAH) is a rare, moderate-to-severe adverse event associated with cryolipolysis (CoolSculpting, CS).ObjectivesThe aim of this study was to describe the incidence, diagnosis, and treatment of PAH occurring after CS for nonsurgical fat reduction.MethodsA multicenter evaluation of all patients who underwent CS treatment between January 2015 and December 2019 at 8 Canadian medical centers was conducted. Data abstracted included symptoms, management strategy, outcome, operator characteristics, device characteristics, patient characteristics, body region, and CS treatment details. Incidence of PAH was calculated based on the number of treatment cycles.ResultsOur findings revealed incidence rates between 0.05% and 0.39%, which are slightly higher than the manufacturer’s quoted rate of 0.025% (1 per 4000 cycles). Incidence rates at all sites were dramatically reduced by over 75% with the implementation of newer models of CS units. Of patients who developed PAH, 55% were male and 77.8% were of European ethnic origin. The majority of cases (76.9%) were associated with older models of CS units.ConclusionsDevelopment of PAH may be related to a combination of factors, including older models of CS units and applicators, as well as individual characteristics that predispose certain patients.Level of Evidence: 4

Adverse Events Associated With Cryolipolysis: A Systematic Review of the Literature

Cryolipolysis is a popular procedure for people seeking noninvasive body contouring. As with any novel therapy, it is critical for providers to familiarize themselves with related adverse events (AEs), to provide appropriate information to patients before treatment. To describe reported complications and AEs associated with cryolipolysis. A systematic review was completed using the PubMed database and following search terms: "cryolipolysis" or "lipocryolysis" or "CoolSculpting." Only randomized clinical trials, prospective cohort studies, retrospective studies, case series, and case reports describing AEs related to cryolipolysis as well as studies written in English were included for review. Fifty-three articles were included in this review. The most common AEs associated with cryolipolysis were treatment site erythema, numbness/paresthesia, bruising, and edema. More serious complications of cryolipolysis include severe/persistent pain, dysesthesia, skin hyperpigmentation, motor neuropathy, and paradoxical adipose hyperplasia. Cryolipolysis is a safe option for patients seeking noninvasive body contouring. Most reported AEs are minimal and resolve quickly. It is important that physicians are aware of serious, irreversible AEs and are prepared to counsel patients appropriately before treatment.

Ultrasound-Assisted Liposuction and Helium-Activated Radiofrequency Skin Tightening for Treatment of Paradoxical Adipose Hyperplasia After Cryolipolysis

Paradoxical adipose hyperplasia (PAH) following cryolipolysis is a rare but deforming complication. This likely underreported adverse event has been described as being refractory to both traditional tumescent liposuction and repeated cryolipolysis treatments. Here, we present 3 isolated cases with PAH deformity created by cryolipolysis. Management of PAH on the abdomen and flanks involved 2 key elements: ultrasound-assisted liposuction (UAL) technology and helium-activated radiofrequency (RF) energy subdermal coagulation. We observed complete resolution and definitive correction of PAH deformities at 2 weeks, 1 month, and 3 months postoperatively. UAL combined with helium-activated RF subdermal coagulation is a viable surgical modality to correct contour irregularities seen in PAH following cryolipolysis.

Fat necrosis post cryolipolysis: a case report

Cryolipolysis has been marketed as a safe and effective alternative to invasive procedures for reduction of subcutaneous fat and body contouring. Some complications include erythema and paradoxical adipose hyperplasia. We present a case report of bilateral flank lumps post 2 sessions of cryolipolysis. Literature search was performed for “Cool sculpting” AND “adverse effects” OR “Side effects” OR “Complications” OR “cryolipolysis” AND “Fat necrosis”. Histopathology slides were also reviewed by a senior consultant pathologist. The mechanism of action of each non-invasive fat reduction modality differs; cryolipolysis works by apoptosis, not necrosis. However, on review of the histopathology slides, necrosis was a predominant feature of the bilateral flank lumps that were excised. This is the first known publication of fat necrosis following cryolipolysis and while fat necrosis is incongruent with known complications, we propose that in persistent lumps following cryolipolysis, fat necrosis should be part of the differential. Level of evidence: Level V, risk/prognostic study.

Paradoxical adipose hyperplasia after noninvasive radiofrequency treatment: A novel report and review

The past decade has experienced a surge in the frequency of nonsurgical procedures, including injectables, skin rejuvenation, and nonsurgical fat reduction. Nonsurgical fat reduction methods include cryolipolysis (Coolsculpting), ultrasound (Vaser Shape), laser (Liposonix), and radiofrequency (Vanquish). These methods generally produce good results, with cryolipolysis gaining much popularity over the past few years. Multiple reports of paradoxical adipose hyperplasia have been reported with Coolsculpting, with an incidence of 0.025% to 1%. This entity has never been reported with other methods of nonsurgical fat reduction, including noninvasive radiofrequency (Vanquish). We present a case of paradoxical adipose hyperplasia in a 57-year-old male following treatment with noninvasive radiofrequency (Vanquish) to the abdomen. He was treated with power-assisted liposuction to the abdomen and flanks. This is the first case in the literature of paradoxical adipose hyperplasia in a patient treated with this form of noninvasive fat reduction.