Solar energy is the ideal energy source for activating photocatalysis. However, due to the solar motion, achieving 24-hour solar-powered efficient photocatalytic reactions remains a challenge. In this study, a Sunlight Adjustable Parabolic Trough Reactor (SA-PTR) integrated with flexible parabolic mirror and solar panel was developed. During the daytime, flexible parabolic mirror could be rolled up under sunny condition or expanded under cloudy condition, thus providing optimal light irradiance (1500 W·m−2) and temperature (rises yet below 55 ℃) for photocatalysis. Additionally, the solar panel behind the flexible parabolic mirror could generate solar-electricity. At night, the stored solar-electricity could meet 100 % power demands of UV lamp, enabling a 24-hour solar-powered photocatalytic process. Compared with traditional parabolic trough reactor and inclined plate collector, SA-PTR exhibited higher treatment efficiency against carcinogenic organic dyes (Rhodamine B, Methylene Blue, Methyl Orange), antibiotic (Tetracycline) and pathogenic bacteria (Escherichia coli) during day and night. Moreover, SA-PTR exhibited superior global deployability, economic advantage, safety and lifetime. Therefore, SA-PTR, as a novel solar controllable 24-hour operational photoreactor, is promising to be employed in real wastewater treatment plant.