This research advances current efforts to develop 3rd gen concentrated solar power (CSP) systems, addressing current research and practical implementation gaps. It focuses on key challenges identified by the academic community: advanced power cycles and utilising waste heat effectively to enhance efficiency. This research introduced a novel system comprising a direct parabolic trough with supercritical carbon dioxide (sCO2) Brayton cycle, and a Direct Contact Membrane Distillation (DCMD) desalination system, aiming to overcome these barriers. The methodology entailed developing a mathematical model and conducting thermodynamic analyses to evaluate system efficiencies, the impact on water production, and the number of DCMD units needed under various conditions. The results reveal that both thermal and exergetic efficiencies decline with decreasing direct normal irradiance across all pressure ratios with the optimal efficiency observed at pressure ratios of approximately 3.1 to 3.2 with exergetic efficiency of around 0.383. Higher bulk temperature differences increased water production and reduced need for direct contact membrane distillation units. However, an initial decline and subsequent rise in water production at bulk temperature differences of 10 °C and 20 °C indicates that feed temperature alone does not determine water production capacity. The existence of an inverse correlation between the cycle’s efficiency and water production prompted the introduction of a unifying coefficient, the Integrated Performance Coefficient (IPC), peaking at 50.32 between pressure ratios of 3.1 and 3.2. High bulk feed temperatures combined with low bulk permeate temperatures enhance water production but also increase its vulnerability to variations in direct normal irradiance. Conversely, increased bulk permeate temperatures lessen the effect of direct normal irradiance changes on water production, albeit with a reduced output.