Para La Salud Research Articles

Sperm and leukocyte telomere length are related to sperm quality parameters in healthy men from the Led-Fertyl study.

Could sperm and leukocyte telomere length (TL) be associated with sperm quality parameters and reproductive health in men from the general population? A positive association between sperm and leukocyte TL with sperm concentration and total count has been demonstrated. Male factors account for almost half of cases of couple infertility, and shorter TLs have been observed in sperm from men with impaired sperm parameters. However, evidence in men from the general population is limited. A total of 200 volunteers of reproductive age were recruited between February 2021 and April 2023 to participate in the Lifestyle and Environmental Determinants of Seminogram and Other Male Fertility-Related Parameters (Led-Fertyl) cross-sectional study. TLs in sperm and leukocytes were measured using quantitative polymerase chain reaction (qPCR) in 168 and 194 participants, respectively. Sperm parameters, including concentration, total count, motility, vitality, and morphology, were analyzed using a computer-assisted sperm analysis (CASA) SCA® system according to the World Health Organization (WHO) 2010guidelines. Multivariable regression models were performed to assess the associations between sperm and leukocyte TL, either in tertiles or as continuous variables, and sperm quality parameters while adjusting for potential confounders. Participants in tertiles 2 (T2) and 3 (T3) of sperm TL showed a higher sperm concentration (β: 1.09; 95% CI: 0.09-2.09 and β: 2.06; 95% CI: 1.04-3.09 for T2 and T3, respectively; P-trend < 0.001), compared to those in the reference tertile (T1). Participants in the highest tertile of sperm TL showed higher total sperm count (β: 3.83; 95% CI: 2.08-5.58 for T3 vs T1; P-trend < 0.001). Participants in the top tertile of leukocyte TL showed higher sperm concentration (β: 1.49; 95% CI: 0.44-2.54 for T3 vs T1; P-trend = 0.004), and total count (β: 3.49; 95% CI: 1.62-5.35 for T3 vs T1; P-trend < 0.001) compared with participants in T1. These results remained consistent when sperm and leukocyte TL were modelled as continuous variables. One limitation is the impossibility of establishing a cause-effect relationship due to the cross-sectional study design. Additionally, the sample size of the study cannot be considered large. Sperm and leukocyte TLs are associated with sperm quality parameters in the general population. Additional determinations and further studies with larger sample sizes are needed to clarify the mechanisms underlying these associations and to investigate the further implications. The Led-Fertyl study was supported by the Spanish government's official funding agency for biomedical research, Instituto de Salud Carlos III (ISCIII), through the Fondo de Investigación para la Salud (FIS) and co-funded by the European Union ERDF/ESF, 'A way to make Europe'/'Investing in your future' (PI21/01447), and the Diputació de Tarragona (2021/11-No.Exp. 8004330008-2021-0022642). J.S.-S., senior author of the present study, is partially supported by ICREA under the ICREA Academia program. M.F.d.l.P. was supported by a predoctoral grant from the Rovira i Virgili University and Diputació de Tarragona (2020-PMF-PIPF-8). C.V.-H. received a predoctoral grant from the Generalitat de Catalunya (2022 FI_B100108). M.Á.M. was supported by the Sara Borrell postdoctoral fellowship (CD21/00045-Instituto de Salud Carlos III (ISCIII)). All authors declare that they have no conflicts of interest. N/A.

Ultra-processed food consumption and semen quality parameters in the Led-Fertyl study.

Is ultra-processed food (UPF) consumption associated with semen quality parameters? Higher UPF consumption was inversely associated with total sperm count, sperm concentration, and total motility in men of reproductive age. The consumption of UPF, which has been rising during the last decades, has been demonstrated to be positively associated with several chronic diseases such as diabetes or cardiovascular diseases. However, the scientific evidence on its potential impact on semen quality remains notably limited. A cross-sectional analysis was conducted using data from 200 healthy men (mean age 28.4 ± 5.5 years) enrolled in the Led-Fertyl (Lifestyle and Environmental Determinants of Seminogram and Other Male Fertility-Related Parameters) study between February 2021 and April 2023. UPF consumption (% of energy from UPF) was estimated according to the NOVA classification system using a validated 143-item semi-quantitative food frequency questionnaire. Total sperm count, sperm concentration, sperm vitality, total motility, progressive motility, and normal sperm forms were set as the main outcomes. Microscopic parameters were analyzed using a phase-contrast microscope and a computer-assisted sperm analysis (CASA) system. Semen samples were collected and tested according to World Health Organization 2010 standards. Multivariable linear regression models were fitted to estimate the associations between UPF tertile and semen quality parameters. Sperm concentration (β: -1.42 × 106 spz./ml; 95% CI: -2.72 to -0.12) and motility (β: -7.83%; 95% CI: -15.16 to -0.51) were lower in participants in the highest tertile of UPF compared to the lowest. A similar association was observed for sperm count when UPF was analyzed per 10% increment of energy from UPF consumption (β: -1.50 × 106 spz.; 95% CI: -2.83 to -0.17). Theoretically replacing 10% of energy from UPF consumption with 10% of energy from unprocessed or minimally processed food consumption was associated with a higher total sperm count, sperm concentration, total motility, progressive motility, and normal sperm forms. Cross-sectional studies do not permit the drawing of causal inferences. Measurement errors and reporting bias cannot be entirely ruled out. This work suggests that consumption of UPF may have an impact on certain semen quality parameters. Furthermore, opting for unprocessed or minimally processed foods instead of UPFs could potentially benefit semen quality. If these results are replicated in future epidemiological studies with different long-term designs, these novel findings could provide valuable insights for updating or even designing preventive and interventional programs to address infertility among men of reproductive age. This study was supported by the Spanish government's official funding agency for biomedical research, ISCIII, through the Fondo de Investigación para la Salud (FIS), the European Union ERDF/ESF, 'A way to make Europe'/'Investing in your future' [PI21/01447], and the Diputació de Tarragona (2021/11-No.Exp. 8004330008-2021-0022642). J.S.-S. gratefully acknowledges the financial support of ICREA under the ICREA Academia program. C.V.-H. received a predoctoral grant from the Generalitat de Catalunya (2022 FI_B100108). M.Á.M. was supported by the Sara Borrell postdoctoral fellowship (CD21/00045-Instituto de Salud Carlos III (ISCIII)). M.F.d.l.P. was supported by a predoctoral grant from the Rovira i Virgili University and Diputació de Tarragona (2020-PMF-PIPF-8). All authors have no conflict of interest to declare. N/A.

1039. Clinical and Economic Impact of COVID-19 and Serologic Protection among Farm Workers: Results from the Guatemala Agricultural Workers and Respiratory Illness Impact (AGRI) Study

Abstract Background In the Guatemala AGricultural workers and Respiratory Impact (AGRI) study, we evaluated the clinical and socioeconomic burdens of respiratory disease in a cohort of Guatemalan banana farm workers. Methods All eligible workers were offered enrollment from June 15–December 30, 2020, and annually, then followed for influenza-like illnesses (ILI) through: 1) self-reporting to study nurses, 2) sentinel surveillance at health posts, and 3) absenteeism. Workers with ILI submitted nasopharyngeal swabs for influenza, RSV, and SARS-CoV-2 testing, then completed surveys at days 0, 7, and 28. Enrollment and acute-illness serum samples were tested for anti-SARS-CoV-2 nucleocapsid IgG (anti-N, Roche Elecsys®), and neutralizing antibodies (NAb) were tested in a subset using a lentivirus-based pseudovirion assay. Results Through October 10, 2021, 1,833 workers were enrolled. The majority were male (84%), young (mean 31 years), and healthy (&amp;lt; 13% had comorbidity). Through October 10, 2021, 1,833 workers developed 169 ILIs (12.0/100 person-years) and 43 (25.4%) of these ILIs were laboratory-confirmed SARS-CoV-2 (3.1/100 person-years). Workers with SARS-CoV-2-positive ILI reported more anosmia (p&amp;lt; 0.01), dysgeusia (p&amp;lt; 0.01), difficulty concentrating (p=0.01), and irritability (p=0.01), and greater clinical and well-being severity scores (Flu-iiQ) than test-negative ILIs (Fig 1); they also had greater absenteeism (p&amp;lt; 0.01) and lost income (median US$127.1, p&amp;lt; 0.01). Among 1334 workers enrolled in 2020, 616 (46.2%) had anti-N IgG suggestive of prior SARS-CoV-2 infection. COVID-19 incidence density for IgG-seropositive workers was 0.4/100 Person ̶ Years (P ̶ Y), lower than those who were seronegative (2.3/100 P ̶ Y) (Fig 2). At enrollment, anti-N IgG titers in serum correlated with neutralizing antibody titers (R2=0.26, p&amp;lt; 0.0001). Notably, in &amp;lt; 6 months from enrollment, most workers with follow-up NAb testing (65/77, 84%) exhibited a 95% decrease in neutralizing antibody titers. Conclusion Guatemalan farm workers suffered a significant burden of COVID-19, including more severe clinical and economic outcomes than other respiratory illnesses. Ongoing vaccination programs and longitudinal serology will provide additional insight into long-term immunity. Disclosures Daniel Olson, MD, Pfizer: Grant/Research Support|Roche: Grant/Research Support Diva M Calvimontes, MD, Pfizer: Grant/Research Support Molly Lamb, PhD, Pfizer: Grant/Research Support Edwards Kathryn, MD, Bionet: Advisor/Consultant|IBM: Advisor/Consultant|Merck: Data Monitoring Committee|Moderna: Data Monitoring Committee|Pfizer: Data Monitoring Committee|Roche: Data Monitoring Committee|Sanofi: Data Monitoring Committee|Seqirus: Data Monitoring Committee|X-4 Pharma: Data Monitoring Committee Edwin J. Asturias, MD, Curevac: DSMB Member|Fundacion para la Salud Integral de los Guatemaltecos: Board Member|Inovio: DSMB Member|Merck: Honoraria|Pfizer: Grant/Research Support.

314. Performance of Saliva Compared to Nasopharyngeal Swab in Detection of SARS-CoV-2 at a Field Site in Rural Guatemala Using the Roche Cobas® Liat® Point-of-Care Assay

Abstract Background Saliva samples are less invasive but not considered the gold standard for detecting SARS-CoV-2, and they are not validated for the Roche Cobas® Liat® platform. We aimed to evaluate the performance of a saliva sample compared to nasopharyngeal (NP) swab in the detection of SARS-CoV-2 on the Roche Cobas® Liat® platform at a research site in rural Guatemala. Methods Adults in an existing cohort study with influenza-like illness (ILI) provided clinical data and underwent NP swab (Copan) collection by trained nurses. Swabs were immediately placed into universal transport media (UTM), stored at 2-8 °C for less than 30 minutes and then tested on the Cobas Liat platform for SARS-CoV-2. Consenting subjects who had not eaten or drank in the last 2 hours were asked to provide a 5-mL saliva sample directly into an RNAse free container. The saliva sample remained at 2-8 °C for 24 hours, then diluted 1:2 with 0.85% saline (to reduce viscosity) and run on the same assay. We used descriptive statistics to compare the performance of saliva to NP swabs. Results Of the 28 subjects screened (1/10/22 - 4/26/22), 23 (82%) were consented and enrolled. The majority of subjects were male (78.3%) with a mean age of 31 years (range: 18-59 years). Of the 23 subjects enrolled, 14 (30.4%) reported fever and cough, 16 (34.8%) reported cough only, 14 (30.4%) reported fever only, and 2 (4.3%) reported cough and nasal congestion. The median symptom duration was 3.0 days (IQR: 1.5-5 days). Of the 23 subjects, 5 (23.7%) tested positive for SARS-CoV-2 in both sample types (NP swab and saliva); 3 (13%) were discordant, including 1 (4.3%) saliva-positive only and 2 (8.7%) NP-positive only. Compared to NP swab, preliminary performance of saliva in detection of SARS-CoV-2 included a sensitivity, specificity, accuracy, positive predictive value, and negative predictive value of 71.4%, 93.7%, 87%, 83.3%, and 88.2%, respectively. The Fisher’s exact test p-value (0.003) shows concordance between both tests. Conclusion Our preliminary results show good precision between NP and saliva samples in detection of SARS-CoV-2 on the Roche Cobas® Liat® platform. Ongoing data collection will provide greater insight on the discordant results, but our findings support the continued use of saliva in the detection of SARS-CoV-2 in this population. Disclosures Molly Lamb, PhD, Pfizer: Grant/Research Support Edwin J. Asturias, MD, Curevac: DSMB Member|Fundacion para la Salud Integral de los Guatemaltecos: Board Member|Inovio: DSMB Member|Merck: Honoraria|Pfizer: Grant/Research Support Diva Calvimontes, n/a, Pfizer: Grant/Research Support Daniel Olson, MD, Fundacion para la Salud Integral de los Guatemaltecos: Board Member|Pfizer: Grant/Research Support|Roche: Grant/Research Support.

La construcción del Diseño curricular del Profesorado Universitario en Biología de la Universidad Nacional de Misiones y del trayecto formativo de Educación para la Salud y el Ambiente

The aim of this paper is to share the results of the process of formulating the curriculum for the 2016 University Teacher Training in Biology at the Faculty of Exact, Chemical and Natural Sciences of the National University of Misiones (UNaM) based on a collective construction among various stakeholders in the educational community and especially the proposal of the formative pathway of Education for Health and the Environment (EpSyA). The research used a qualitative and interpretative methodology based on the analysis of curricular documents, institutional agreements, national regulations, interviews and classroom observations. The different instances of discussion in the reformulation of the curricular project are reconstructed chronologically, the macro-decisions in the construction of the formative path of EpSyA are analysed and the hourly loads and minimum contents of the subjects and the teaching strategies are made explicit.

La murta (Ugni molinae) y sus propiedades benéficas para la salud: Una revisión

Currently there is a great demand for food products containing functional properties and/or bioactive compounds. One of the fruits that has been widely studied is the murta (Ugni molinae), which appears to contain various beneficial health properties. This review compiles scientific information on the functional and beneficial properties of murta for human health, such as the main components associated with anti-inflammatory activity, antimicrobial activity, antioxidant activity, nutritional composition, other uses of murta, economic aspects, and current and future challenges of murta, all based on updated scientific work.

COVID-19: Un gran desafío para la salud pública y la economía en Colombia

La pandemia Covid- 19 está generando una gran crisis global en la que los países en desarrollo parecen ser los más afectados; en América Latina y el Caribe resulta preocupante dadas las precarias condiciones laborales y al alto índice de pobreza. El mercado laboral colombiano está seriamente perjudicado por el aislamiento social adoptado para desacelerar los contagios de COVID-19, sin embargo, son incontables las pérdidas humanas y económicas por esta pandemia que no discrimina. Enfrentar este enemigo invisible con prudencia y sensatez será la hazaña más grande de nuestra historia y la forma de lograrlo será nuestro más preciado legado para las generaciones venideras.

La importancia de las colecciones biológicas para la salud pública: El caso de la colección de Triatominae del Museo del Instituto de Zoología Agrícola “Francisco Fernández Yépez”, Venezuela

Entomological collections help scientists to rapidly identify invasive insects that affect agriculture, forestry, and human and animal health and to infer about global change biology. There are several collections with deposited Chagas disease vectors that are distributed throughout the world, but most of them present in Brazil. Faced with the need to disclose the biological material deposited in these collections, Brazilian articles were published compiling the information about the Triatomines Collections of the Oswaldo Cruz Institute, the Collection of Chagas Disease Vectors, the Entomologic collections of the Faculty of Public Health of the University of Sao Paulo, and the Entomological Collection of Instituto Butantan. The Museum of the Institute of Agricultural Zoology “Francisco Fernández Yépez” (MIZA) in Venezuela has more than four million arthropods deposited in its collection, being more than 4,500 holotypes. Based on the importance of disseminating to the world the richness of species deposited in biological collections, with emphasis on the entomological collections of vectors that can present important epidemiological information on the distribution of the vector-borne diseases, the present work compiles all the information related to triatomines deposited in MIZA. Through the analysis of the triatomines deposited in the MIZA was possible to highlight that there are over one thousand triatomines deposited in the entomological collection, distributed in 39 species grouped in four tribes: Bolboderini (two species), Cavernicolini (one species), Rhodniini (seven species) and Triatomini (29 species). In additional, eleven new occurrence points were described for Venezuelan states, namely, Miranda (Cavernicola pilosa and Eratyrus mucronatus), Amazonas (Rhodnius pictipes and E. mucronatus), Aragua (R. robustus), Federal District (E. mucronatus), Barinas (Panstrongylus geniculatus), Bolívar (P. rufotuberculatus), Carabobo (Triatoma nigromaculata), Falcón (T. nigromaculata) and Táchira (T. nigromaculata). The analysis of the entomological collection of MIZA allowed to group important information on the richness of biological material deposited for the subfamily Triatominae, as well as for the epidemiology of Chagas disease in the States of Venezuela, emphasizing the importance of the dissemination of information on biological collections to the scientific community in the form of manuscripts or official sites aiming the internationalization and valuation of collections and deposited material.

Epidemias, virus y activos para la salud del barrio

Epidemias, virus y activos para la salud del barrio

Lúcuma (Pouteria lucuma): Composición, componentes bioactivos, actividad antioxidante, usos y propiedades beneficiosas para la salud

Lucuma is a superfruit of Andean origin, with ovoid shape, greenish yellow color, nice smell, and intense sweet taste. In recent years this superfruit has won great popularity in the international market, and its demand tends to increase exponentially in the future, due to its properties as a functional food for its bioactive components like β-carotens, niacin, phenolic components, phytosterols, among others that give this fruit beneficial properties for health, such as its anti-inflammatory action, antioxidant effect, antihypertensive action, antibacterial, energizing, healing, and its use as a natural sweetener. Currently, research is being carried out about its influence on metabolism, its antidiabetic, anti-cancer capacity and its use to prevent heart disease and counteract Alzheimer's. The properties of lucuma are still under study and greater benefits and applications are expected. The objective of this work was to announce the components and beneficial properties of lucuma known from the point of view of health.

Virus emergentes y reemergentes: un nuevo reto para la salud mundial del milenio

Virus emergentes y reemergentes: un nuevo reto para la salud mundial del milenio

Desarrollo de la investigación para la salud en Latinoamérica y el Caribe. Colaboración, publicación y aplicación del conocimiento

Desarrollo de la investigación para la salud en Latinoamérica y el Caribe. Colaboración, publicación y aplicación del conocimiento

Alfabetización para la salud, más que información

Alfabetización para la salud, más que información

Incidence, mortality, and prevalence of end-stage chronic renal disease in the Bajo Lempa region of El Salvador: A ten-year community registry

The Bajo Lempa is an impoverished rural coastal region of El Salvador affected by the chronic kidney disease (CKD) epidemic known as Mesoamerican nephropathy. The local community organisation Fondo Social de Emergencia para la Salud (FSES) (Emergency social fund for health) is helping to fight the epidemic in 42 communities of the region (19,223 inhabitants; average age 26.7 years; 48.5% male; 40.2% <18 years). ObjectivesTo report annual rates of end-stage renal disease (ESRD) incidence and patient mortality in these communities during a 10-year period (2004–2013), and the prevalence of patients receiving renal replacement therapy (RRT) as of 31 December 2013. MethodsThe FSES recorded new ESRD cases, basic patient history, form of RRT if received and patient deaths. ResultsWe registered 271 new ESRD cases (annual average 27.1; 89% male; average age 55.6 years, four <18 years). Average annual ESRD incidence rate: 1409.8 per million population (pmp). Two-thirds did not report diabetes or hypertension. 94 patients (34.7%) received RRT: 58 in the Ministry of health, 26 in private services, 9 in social security and 1 in the military health system. 246 patients died (annual average 24.6 deaths; 89.4% male; average age 56.1 years; 92.3% at home). Average annual mortality rate: 128/100,000 population. Prevalence of patients receiving RRT in 2013: 1300.5pmp (N=25; 84% male; average age 51 years). ConclusionsThis region has a high incidence of ESRD. Few receive RRT. Patient mortality is high even with RRT. Most patients are male (9:1). Social determinants influence the high mortality.

De compras para la salud: Cereales de desayuno

It is no secret that breakfast is an important meal. Eating breakfast provides you with physical and mental energy to start the day, along with vitamins and minerals. Cereal is a quick, versatile, and budget-friendly breakfast choice. The benefits of eating a healthy cereal include increased fiber intake and lower body weight. But navigating the cereal aisle at your local grocery store can be an overwhelming experience. This 3-page fact sheet is the Spanish-language version of FSHN15-11/FS274: Shopping for Health: Breakfast Cereals. Written by Jenna Seckar and Wendy J. Dahl, and published by the Food Science and Human Nutrition Department, May 2016. FSHN15-11S/FS280: De compras para la salud: Cereales de desayuno (ufl.edu)

Incidencia, mortalidad y prevalencia de enfermedad renal crónica terminal en la región del Bajo Lempa, El Salvador: 10 años de registro comunitario

The Bajo Lempa is an impoverished rural coastal region of El Salvador affected by the chronic kidney disease (CKD) epidemic known as Mesoamerican nephropathy. The local community organisation Fondo Social de Emergencia para la Salud (FSES) (Emergency social fund for health) is helping to fight the epidemic in 42 communities of the region (19,223 inhabitants; average age 26.7 years; 48.5% male; 40.2% <18 years). ObjectivesTo report annual rates of end-stage renal disease (ESRD) incidence and patient mortality in these communities during a 10-year period (2004-2013), and the prevalence of patients receiving renal replacement therapy (RRT) as of 31 December 2013. MethodsThe FSES recorded new ESRD cases, basic patient history, form of RRT if received and patient deaths. ResultsWe registered 271 new ESRD cases (annual average 27.1; 89% male; average age 55.6 years, four <18 years). Average annual ESRD incidence rate: 1409.8 per million population (pmp). Two-thirds did not report diabetes or hypertension. 94 patients (34.7%) received RRT: 58 in the Ministry of health, 26 in private services, 9 in social security and 1 in the military health system. 246 patients died (annual average 24.6 deaths; 89.4% male; average age 56.1 years; 92.3% at home). Average annual mortality rate: 128/100,000 population. Prevalence of patients receiving RRT in 2013: 1300.5 pmp (N=25; 84% male; average age 51 years). ConclusionsThis region has a high incidence of ESRD. Few receive RRT. Patient mortality is high even with RRT. Most patients are male (9:1). Social determinants influence the high mortality.

Estrés laboral: implicaciones para la salud física y mental

Estrés laboral: implicaciones para la salud física y mental

Desarrollo de neumoconiosis y trabajo bajo la modalidad tercerización en trabajadores peruanos del sector minero

The aim of this study is to evaluate the association between the time of outsourced work and the development of pneumoconiosis in Peruvian miners who attended the "Centro Nacional de Salud Ocupacional y Protección al Ambiente para la Salud" between 2008 and 2011. Retrospective case-control study. Cases were defined as workers diagnosed of pneumoconiosis under standardized criteria. Outsourced work was defined as the time (in months) of work in a company that does not own the primary mining project. The project owner company was registered in the Mining Companies Directory (Ministerio de Energía y Minas). We used multiple logistic regression with crude and adjusted ORs. The study comprised 391 cases and 1519 controls. In both groups, most of the study subjects had a level of education lower than complete high school and were born and currently lived in the Peruvian highlands. There was statistically significant association between more frequency of pneumoconiosis and working 10 or more years in an outsourced company (OR: 1.50; 95%CI: 1.05-1.14; p=0.026). Miners with pneumoconiosis were more likely not to have education (OR: 3.07; 95%CI: 1.55-6.08; p=0.001), be currently living at the Peruvian highlands (OR: 1.40; 95%CI: 1.10-1.78; p=0.007) and to have more than 20 years of underground work history (OR: 8.92; 95%CI: 4.53-18.25; p<0.001). A statistically significant association was found between pneumoconiosis and the time of outsourced work. Not having education, residing in the Peruvian highlands and the time of underground work were associated risk factors.

Los microorganismos desde una perspectiva de los beneficios para la salud

Fil: del Coco, Valeria Fernanda. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Conicet - La Plata; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Medicas. Departamento de Articulacion de Ciencias Basicas y Clinicas. Catedra de Microbiologia y Parasitologia; Argentina

A comparison of a social support physical activity intervention in weight management among post-partum Latinas.

BackgroundWeight gain during the childbearing years and failure to lose pregnancy weight after birth contribute to the development of obesity in postpartum Latinas.MethodsMadres para la Salud [Mothers for Health] was a 12-month, randomized controlled trial exploring a social support intervention with moderate-intensity physical activity (PA) seeking to effect changes in body fat, fat tissue inflammation, and depression symptoms in sedentary postpartum Latinas. This report describes the efficacy of the Madres intervention.ResultsThe results show that while social support increased during the active intervention delivery, it declined to pre-intervention levels by the end of the intervention. There were significant achievements in aerobic and total steps across the 12 months of the intervention, and declines in body adiposity assessed with bioelectric impedance.ConclusionsSocial support from family and friends mediated increases in aerobic PA resulting in decrease in percent body fat.Trial registrationClinicalTrials.gov Identifier: NCT01908959.