Papular Granuloma Annulare Research Articles

Papular mucinosis (papular lichen myxedematosus): Clinical and histopathological evaluation

Background: Papular mucinosis is a variety of mucinosis characterized by excessive production of mucin by fibroblasts and deposition in the dermis. It manifests itself with fleshy papules or plaques in different sites of the body and taking different clinical morphological cutaneous features. Objective: The objective is to report and evaluate the different clinical and histopathological features of the disease in Iraqi patients. Patients and Methods: This is a case series and a clinical descriptive study in which ten patients with papular mucinosis were reported during the period from 2012 through 2019. The age ranged from 4 to 56 years, with seven females and three males. Clinical evaluation regarding histories of the disease and examination was carried out. General investigation was done and skin biopsy for histopathological assessment was conducted. Results: Nine patients were adults, with their age ranging from 20 to 56 years, a mean of around 35 years, and only one 4-year-old child. It is a disease with a female predominance, as observed in 7 (70%) females. The common sites of involvement were the face but the rash may extend to affect the neck and upper arms. The rash appeared in the form of skin-colored or red fleshy papules and plaques or in diffuse erythematous orange peel-like forms. The rash was asymptomatic in most patients. The pathology of the disease clarified the diffuse deposition of mucin in the dermis, as was demonstrated with H&E staining. Conclusion: Papular mucinosis is a rare disease characterized by mucin deposition in the skin affecting mostly adult females. The face is commonly involved together with other areas such as the neck and upper arms, but the trunk and lower limbs are spared. It manifests itself with different clinical morphological cutaneous features. Papular granuloma annulare must be considered as an important differential diagnosis in all cases of papular mucinosis.

Unilateral papular granuloma annulare in a type I diabetic child: a case report and literature review.

Unilateral papular granuloma annulare in a type I diabetic child: a case report and literature review.

Generalized papular granuloma annulare

Granuloma annulare is a benign skin condition that typically consists of grouped papules in an enlarging annular shape. It affects patients of all ages and is generally asymptomatic. The lesions rarely occur on the palms, soles, face, and mucous membranes. In this study, we present the case of a 47-year-old woman with lesions over her chest, bilateral forearms, and upper back, diagnosed as having generalized papular granuloma annulare.

Papular Granuloma Annulare of Palms and Soles.

Papular Granuloma Annulare of Palms and Soles.

Localized papular granuloma annulare in an adult: A new clinical variant?

Localized papular granuloma annulare in an adult: A new clinical variant?

Papular granuloma annulare of palms and soles: case report of a rare presentation.

We report the case of a 44-year-old Indian male patient who presented with mildly tender isolated papular lesions confined to the palms of the hands and soles of the feet. The histopathology was characteristic of granuloma annulare. There was an excellent response with 4-week treatment with a potent topical steroid ointment and no recurrence was reported at the follow-up one year later. This report is interesting because of the rare presentation of a common disease.

English

We report a Case of Disseminated Granuloma Annulare which Mimicked Sarcoidosis. A 77 year old man presented with 1 month history of closely set, shiny, skin coloured, firm smooth pruritic papules on trunk and proximal limbs. Considering the histopathological findings with well demarcated areas of degenerated collagen surrounded by histiocytes and lymphocytes, diagnosis of granuloma annulare was made and patient responded very well to oral acitretin. Disseminated papular Granuloma Annulare appears to be a distinct variant that may be difficult to diagnose.

Granuloma Annulare

Granuloma annulare is a benign, usually self-limited granulomatous disease of the dermis and subcutaneous tissue. Several distinct subtypes have been recognized, namely localized granuloma annulare, generalized or disseminated granuloma annulare, subcutaneous granuloma annulare, papular granuloma annulare, interstitial or patch granuloma annulare, and perforating granuloma annulare. Localized granuloma annulare is the most common form in children and comprises 75% of cases. Clinically, the condition is characterized by asymptomatic, flesh-colored or erythematous-brown papules, frequently arranged in a ring or annular pattern on the distal extremities. It is estimated that 0.1 to 0.4% of new patients attending dermatologic clinics have granuloma annulare. Most cases of granuloma annulare occur before the age of 30 years. A delayed hypersensitivity and cell-mediated immune response to an antigen contributes to the pathogenesis. Histologic examination of the lesion shows central collagen degeneration and mucin deposition surrounded peripherally by palisading histiocytes and inflammatory cells. Most cases of granuloma annulare are asymptomatic and self-limited; and reassurance is often sufficient. Treatment is mainly for cosmetic purposes and various modalities of treatment options are discussed.

Granuloma annulare - Remission with puvasol

A 64-year-old man with generalized papular granuloma annulare of four years duration with frequent relapses and remissions presented with persistent lesions while on 15 mg prednisolone and achieved complete remission with PUVASOL therapy using solarium.

Papular Granuloma Annulare with Subcutaneous Granulomatous Reaction Induced by a Bee Sting

Sir, Granuloma annulare (GA) is a benign granulomatous disease of unknown aetiology. The most common clinical manifestation is the appearance of skin-coloured small dermal nodules arranged in an annular configuration; however, several clinical variants are known, including papular (1), perforating (2), linear (3), and subcutaneous types (4, 5). We report here a case with papular GA accompanied by an extensive subcutaneous granulomatous reaction that had peculiar clinical features that were trig gered by a bee sting. CASE REPORT A 63-year-old man noticed a reddish, oedematous, painful swelling of the left middle finger immediately after a bee sting. The oedema was transient, but a few days after the bee sting, diffuse swelling without ten derness re-appeared and gradually, within one month, spread to both hands and all fingers. The patient was treated unsuccessfully with systemic corticosteroids (prednisolone 15 mg/day). Two months after the bee sting, he was admitted to our hospital.

Papular Granuloma Annulare and Diabetes Mellitus

Three patients with widespread papular granuloma annulare lesions and previously undetected diabetes mellitus are described. A peculiar clinical feature included serpiginous papules on the dorsa of the hands along with typical granuloma annulare lesions. Utilizing a standard glucose tolerance or cortisone glycosuria tests defined the underlying diabetic state.