ObjectivesCoronavirus COVID-19 is spreading very fast in Brazil, requiring innovative strategies for the fast deployment of disinfectants. Panic in population triggered by COVID-19 has caused a shortage of alcohol-based hand sanitizers and disinfectants in many cities of Brazil. Despite the governmental reaction against the outbreak, a risk of shortage of disinfectants still exists. The objective of this research is to investigate an alternative method for the fast deployment of alcohol-based disinfectants to protect the population against COVID-19. Methods and resultsThis research highlights the feasibility of disinfectant production from common ethanol available in Brazilian gas stations, as a last resort. A four-by-one (4:1) ratio of common alcohol diluted in water meets the minimum requirements set by health agencies for the alcoholic concentration of disinfectants. Risks factors on alcohol dilution process are associated with corresponding measures of risk mitigation for public health and safety. Conclusions and perspectivesThis research proposes a process for the production and deployment of ethanol-based disinfectant from gas stations. However, the implementation is not timely possible for the COVID-19 pandemic due to complexities in the productive process. For the post-COVID-19 period, the authors give three perspectives: (a) future investigation of human dermal toxicity of common ethanol, (b) establishment of a program for the ethanol decontamination, and (c) countries such as the US, Sweden, Thailand, and Colombia to rethink their energy policy for the adoption of biofuel E100 (ethanol and water) instead of E85 (blend of ethanol, gasoline, and water), as part of their biodefense strategy.