The lithofacies architecture and depositional evolution of the Lower Mississippian (Tournaisian) Pekisko Formation in the subsurface of the Hawk Hills area in northwestern Alberta have been established by integrating detailed core work and well log data. The formation is composed of skeletal-peloidal limestones and argillaceous limestones that were deposited along the northern flank of the Peace River Embayment, a semi-restricted and tectonically active oceanic re-entrant located along the western margin of Laurasia at low paleolatitude. Lithofacies associations recognized in the study area include the outer ramp to slope (LA 1), outer ramp (LA 2) and mid ramp (LA 3), which are stacked into three decameter-scale, deepening-upward and aggradational cycles that are of regional extent and have meter-scale deepening and shallowing-upward trends. A previously unrecognized paleosol horizon at the top of decameter-scale cycle 2, indicating widespread subaerial exposure of the ramp, is interpreted as a sequence boundary that divides the Pekisko and Shunda formations in the study area (and possibly elsewhere in the Peace River Embayment) into two third-order sequences, each consisting of transgressive and highstand systems tracts. The Pekisko Formation in the study area is interpreted to represent a low-energy, temperature-stratified ramp that was mainly homoclinal, but with transient, distal steepening occurring in the southern part of the study area. Ramp deposition was strongly affected by basement-fault reactivation causing differential subsidence and uplift in the Peace River Embayment. The paleogeography and paleoceanographic conditions of the embayment favored upwelling currents and development of a temperature-stratified ramp, as well as the formation of heterozoan carbonate deposits and mid ramp facies of predominantly packstones and wackestones. This depositional scenario is atypical, as most other documented examples of the Pekisko Formation and other Lower Mississippian ramp successions in western North America and western Europe are characterized by moderate to high-energy, mid to inner ramp facies deposited in open-ocean conditions. The results of this study contribute to an improved understanding of the range of depositional settings along the western margin of Laurasia during the Early Mississippian and demonstrate the applicability of the thermocline-stratified ramp model, with some modification, to ramps in semi-restricted embayments and other low energy settings.