Tumor Of Palate Research Articles

舌の小腫りゅうにより診断が確定した原発性アミロイドーシスの１症例

Amyloidosis is a disease characterized by progressive irreversible deposition ofamyloid in the body.A case of oral amyloidosis as initial symptom of systemic primary amyloidosis is described. A 67 year old man, who complained of multiple hard nodules on the dorsal surface of the tongue, was first seen in the Oral Surgery clinic May, 1986, and the biopsy was carried out.Histology showed extensive deposition of pale eosinophilic amorphous material. Congo red stains were positive for amyloid and the typical apple green birefringences were noted on polarisation.Routine laboratory tests were initiated and Bence Jones protein (κ) was positive in urine. Bone marrow aspiration from sternum revealed plasmacytosis. Amyloid depositions were noted later on the face skin, hands and hard palate. Amyloid tumor of the hard palate as vaporized by CO2 LASER. Chemotherapy (Melphalan, predonine and DMSO) was carried out, but the effect was poor and the patient died of cerebral infarction Feb, 1985.

口蓋弁による軟口蓋再建の２例

Two cases of immediate reconstruction using palatal flap for defect following excision of the soft palatal tumor were reported.A reconstruction for palatal defect of the soft palate using palatal island flap was very useful in following advantages. The flap was able to transfer from adjacent hard palate. There were no functional disturbances in the hard palate and no necrosis of the flap because of excellent blood supply. The flap was very movable so that it could transfer even to posterior border of the soft palate. This procedure which could achieve in only one stage without delay was easier than in other flaps.On the other hand, in a reconstruction for defect of the entier soft palate, atrophy of the flap was remarkable after 2 or 3 months so that it should be simultaneously used with pharyngeal flap.

当科におけるレーザー手術症例の検討

Sixteen patients with various head and neck tumors (laryngeal papilloma, lymphangioma, malignant melanoma, others) were treated by CO2 laser. A lymphanigioma of the tongue, seen in a child, was well cured; the patient was able to take food orally immediately after surgery. Because of easy surgical manipulation, little bleeding and less chanse of the tumor cell dissemination, laser surgery seemed to be the most beneficial tool for treatment of malignant melanoma. The patients with malignant melanoma, who underwent laser surgery, did not complain of pain, and no recurrent signs were observed for one year follow-up. Bone necrosis occurred in a case of hard palate tumor. However there was no life threatening complication in laser surgery.

Tumours of the minor (oropharyngeal) salivary glands: a demographic study of 336 cases.

There are 2410 primary epithelial salivary gland tumours in the files of the British Salivary Gland Tumour Panel. Of these tumours, 336 (14%) involved the minor (oropharyngeal) salivary glands, and these were studied in the present investigation. Individual tumours were diagnosed according to the WHO Classification. The percentage of malignant or potentially malignant tumours (46%) was much higher than in major glands (18%), and in some of the less common intraoral sites all the tumours were malignant. The principal sites were the palate (54%), lips (21%) and buccal mucosa (11%), and, in these sites, pleomorphic adenoma was the most common tumour. Monomorphic adenomas accounted for 6% of palatal tumours, but 30% of lip salivary gland tumours. The most common malignant tumour was the adenoid cystic carcinoma. The results are compared with several other large surveys and with tumours of major salivary glands.

Treatment and prognosis of mucoepidermoid carcinoma in the pediatric age group.

Although mucoepidermoid carcinoma is the most common malignant salivary neoplasm in adults, it occurs rarely in the pediatric age group. A retrospective study of 15 pediatric cases from 1954 to 1984 showed that 13 of the patients were 10 to 15 years old, and 11 were female. The parotid (11/15) and the palate (4/15) were the sites involved. Tumors were graded into three categories: well differentiated (grade I), moderately differentiated (grade II), and poorly differentiated (grade III). Tumor grade influenced the method and outcome of treatment. Wide local composite resection was used for palatal tumors, and total parotidectomy (with or without nerve resection) and nodal dissection was the technique selected for parotid tumors. No nodal or distant metastases were present in the poorly differentiated tumor category (2/15). A follow-up period of ten years or more was possible in 90% of the cases. The prognosis for those studied is excellent, and there have been no deaths attributable to the malignant process.

軟口がいに発生したせん様のう胞がんの１例

Recently we came across a case of adenoid cystic carcinoma in the soft palate rarely found in past medical literature. The patient, a 56-year-old woman, was treated by surgical resection of palatal tumor with immediate reconstruction of the palate after radio therapy and chemotherapy. The most difficult part was repairing the defects of the soft palate. Reconstruction was done by using a mucoperiosteal flap of hard palate. Detailed procedures of reconstruction are described and discussed in the paper.Postoperative recovery was uneventful and, after 17 months, no evidence of recurrence or metastasis has been observed. Pronunciation disturbance was not serious and was much less than expected. No further complications nor adverse results due to the operation were observed.

External and iridium-192 interstitial irradiation in the treatment of tonsillar region and soft palate tumors

External and iridium-192 interstitial irradiation in the treatment of tonsillar region and soft palate tumors

Oral surgery and hemodialysis

A case of a hemodialysis patient with a palatal tumor is presented. The problems requiring surgical management were as follows: anemia, hyperkalemia, bleeding tendency, delayed wound healing and usage of drugs, especially antibiotics. The palatal tumor was diagnosed histologically as monomorphic adenoma.

骨形成性エプーリスの１例

A case of epulis fibro-osteoplastica. Although epulis is a phyma of relatively high incidence in the oral mucosa, less reports an epulis with bone formation in fibrous tissues have been so far available. We recently experienced a case of epulis fibro-osteoplatica and the clinical couse is described in this paper. A 45 year old female noticed a swelling of the palate of the maxillary incisors around April, 1981. Under the diagnosis of palatal tumor, an incision was given, resulted in a temporal reduction in the tumor size. However, the tumor gradually increased in size on and after October and the patient was then referred to our department.The phyma was perdiculated having the base in the palate at 3|2 portion and the elastic hard, smooth surface without tenderness. The surrounding mucosa was normal. The tumor including its surrounding mucosa was removed and alveolar rearrangement was performed followed by a tentative suture and closure. The size of tumor thus extirpated was 25×15×12 mm, and the cut surface was grayish white, solid and elastic hard with many hard tissues.Pathologically, irregularly shaped bone formation was noted among many proliferated fibrous tissues suggestive epulis fibro-osteoplastica. The prognosis is evenful without any tendency of relapse as of 2 years lapsed after operation.

Granular cell tumor of the hard palate

A case of granular cell tumor of the hard palate is reported. The lesion, which rarely occurs in this site, presented as an ulcerated mass. Histologically and ultrastructurally it showed features typical of this entity. A case of granular cell tumor of the hard palate is reported. The lesion, which rarely occurs in this site, presented as an ulcerated mass. Histologically and ultrastructurally it showed features typical of this entity.

The effect of iron deficiency on experimental oral carcinogenesis in the rat.

The effect of iron deficiency on oral carcinogenesis was investigated in 30 young adult male Charles River white rats. In 15 animals, prior to the start of carcinogen treatment, iron deficiency anaemia was produced and subsequently maintained by a combination of low iron diet (12 mg Fe2+ kg-1 diet) and repeated venesection. Fifteen control animals were fed the same diet supplemented with iron to approximately 140 mg FE2+ kg-1 diet. All animals were treated with the carcinogen 0.5% 4-Nitroquinoline-N-oxide in propylene glycol which was painted on the palate 3 times weekly. Animals were killed when tumours were grossly evident. The mean haemoglobin levels at the start of carcinogen applications were 10.1 g dl-1 in the anaemic group and 14.1 g dl-1 in the control group, and at the time of killing were 8.2 g dl-1 in anaemic animals and 13.8 g dl-1 in controls. The incidence of animals developing squamous cell carcinomas was similar in both groups, but tumour development was significantly earlier in iron-deficient animals (mean 183 days) compared to controls (mean 229 days). Iron-deficient animals showed a significantly greater incidence of tongue tumours and control animals showed a significantly greater incidence of palatal tumours.

Adenocarcinoma of the palate associated with nephrotic syndrome and epimembranous carcinoembryonic antigen deposition

A 42-year-old male presented with adenocarcinoma of the palate and nephrotic syndrome. Renal biopsy demonstrated membranous glomerulopathy in which carcinoembryonic antigen was demonstrated. Carcinoembryonic antigen was also found in the palatal tumor. This is the first instance of this association with this particular tumor.

The Application of Speech Aid Appliance to Speech Disorders after Exision of the Soft Palate Tumor : A Case Report

The Application of Speech Aid Appliance to Speech Disorders after Exision of the Soft Palate Tumor : A Case Report

Mucoepidermoid carcinoma of the oral cavity.

From 1950 through 1975, 54 patients with mucoepidermoid carcinoma of the oral cavity were treated at the Mayo Clinic. Metastatic disease occurred in 13 patients; nine patients died of their disease. Mucoepidermoid tumors of the hard palate should be treated by partial maxillectomy. Complete neck dissection is necessary for tumors larger than 2 cm in the base of the tongue. Other intraoral mucoepidermoid carcinomas are treated by wide surgical excision.

Salivary gland tumors in Malawi.

A study of 190 tumors of major and minor salivary glands seen in Malawi over a nine-year period showed an overall incidence rate similar to that in Western countries. However, submandibular and palatal tumors are relatively more common, parotid tumors more likely to be malignant, and submandibular tumors less likely to be malignant than in Western countries. No adenolymphomas were seen. Despite the long history given by many patients with pleomorphic adenomas, the rate of malignant change in these tumors was not high; the majority of carcinomas (16% of all tumors) appeared to rise de novo. Histologic features were similar to those of tumors from other countries but the occurrence of tyrosine crystals in 20% of the pleomorphic adenomas was unusual. Melanocyte colonization of a mucoepidermoid tumor and a carcinoma, both in the primary site and in metastases of a salivary gland tumor, has not been previously reported.

Fast neutron teletherapy for advanced carcinomas of the oral cavity and soft palate.

A retrospective study was performed to determine the efficacy of using fast neutron radiation for treating advanced squamous cell carcinomas of the oral cavity and soft palate. The majority of patients were judged to have less than a 10% 5-year survival with conventional medical treatment. Fifteen patients with oral cavity tumors were treated for cure with neutrons alone and six were treated with a combination of neutrons and photons as part of a mixed beam fractionation scheme. In the neutron-only group, the complete regression rate was 33% in the mixed beam group, the rate was 50%. Five patients who had squamous cell carcinomas of the soft palate were treated for cure, one with neutrons alone and four with a mixed beam regimen. The complete regression rate was 100%. The two-year NED results are comparable with literature results for more selected groups of patients with oral cavity and soft palate tumors treated by conventional photon therapy. The acute treatment morbidity was perhaps somewhat greater in the subgroup of patients treated with neutrons alone, and this subgroup later developed a more pronounced subcutaneous fibrosis. Morbidity associated with the mixed beam treatment regimen was comparable to that associated with conventional radiotherapy.

Fabricating cone locating devices for radiation treatment of tumors of the soft palate

T 1 umors of the head and neck region are frequently treated with the megavoltage electron beam alone, or in conjunction with the photon beam, chemotherapy, or surgery. The 6 to 18 million electron-volt (MEV) beam has the following characteristics: 1. The radiobiologic effectiveness (RBE) ratio is near 1.0 when compared with the photon megavoltage beam. 2. The dose reached within 1 cm depth of tissue is close to lOO%, exhibiting modest skin-sparing ability.’ 3. .4 high dose level is maintained to a depth determined by the energy beam, with the dose decreasing sharply beyond this depth. Because of the rapid buildup and homogeneity of the dose distribution, the electron beam may be indicated in intraoral lesions which are relatively superficial.’ Constriction of the useful portion of the beam, particularly at high energies and with small fields, requires extra care in centering the beam on the lesion.’ For this reason, a cone locating device is essential to assure the correct position of the patient relative to the direction of the beam. An acrylic resin cone locating device designed for an individual patient aids significantly in simplifying and improving intraoral radiation therapy.:‘, ’ The acrylic resin cone locating device may be fabricated by obtaining casts of both dental arches, mounting them on an articulator, waxing a pattern to orient the cone head, and processing the wax pattern in heat-curing acrylic resin.” However, this method is time consuming, and a simplified method for obtaining a cone locating device is desirable. This article describes an improved technique for rapid and accurate fabrication of such devices.

A malignant salivary gland tumor of palate with interesting histological findings; Report of a case

A malignant salivary gland tumor of palate with interesting histological findings; Report of a case

Experimental cryogenic injury of the palate: Observations pertinent to cryosurgical destruction of tumors

In experiments using cryosurgical apparatus to freeze the canine palate in situ, observations were made on techniques of producing tissue destruction. Several time-temperature schedules of freezing were studied. The results showed the great tolerance of palatal tissues to extremely low temperatures for short time periods. Melanocytes were extraordinarily sensitive to cold injury. Tissue necrosis increased with duration of freezing, but repeated freezing was lethal and obviously critical for successful cryosurgical destruction. Thermocouples must be used in clinical cryosurgery to insure that lethal tissue temperatures (colder than −50 °C) are attained. The incidence of sequestration in the canine palate showed the need for use of proper technique and suitable precautions in the cryosurgical treatment of human palatal tumors.

Surgical treatment of submucosal tumors of the hard palate

Two cases have been presented to illustrated to illustrate the principles of total excisional biopsy for palatal tumors and the postoperative management of the resulting defect with the use of palatal splints. Total excisional biopsy is curative for benign tumors and for some malignant-grade tumors, and is the preferred method of treatment when possible. Total excision of the lesion with adequate margins negates the possibility of seeding the tumor into surrounding tissue or of leaving behind residual tumor.