Throughout history, Pakistan and the United States have experienced a complex and evolving relationship. This relationship has witnessed periods of cooperation, strain, and scrutiny, particularly concerning formal engagement, financial collaboration, military ties, and regional security matters. This study is critical because it illustrates the evolving geopolitical landscape by revealing how military aid and nuclear concerns have affected South Asian security. By highlighting strategic interactions between global powers and regional entities, this research contributes to the international relations discourse. To assess the state of US-Pakistan relations post-9/11, this study investigates counterterrorism, nonproliferation, and regional geopolitics. It examines how Pakistan's counterterrorism operations and regional security are influenced by US military support, as well as the impact of regional geopolitics on the partnership. Employing mixed methods research, the study reveals diverse perspectives on the impact of aid, including both cooperation and concerns regarding conditional assistance. Regional dynamics, such as Afghanistan's stability and India-Pakistan tensions, emerge as critical factors influencing the partnership's evolution. Challenges stemming from divergent interests and perceptions are also highlighted. Furthermore, the quantitative aspect indicates that gender influences the outcome variable, suggesting potential behavioral or attitudinal differences between men and women regarding the studied environment.