This study presents active sensing methods in structural health monitoring, for detecting cracks and debonds in metallic and composite structures, which can be potentially implemented into airframe structures. First, a pitch-catch method using a pair of piezoelectric actuator and sensor is introduced to generate a damage indeX which can be used to characterize damage at a known location. Tests on airbus fuselage panels are conducted to verify the method and damage indeX. The damage indeX relates changes in the energy content of a specific Lamb wave mode selected by group velocity analysis to the eXtent of damage. Second, an imaging method based on multiple pitch-catch information, a network of piezoelectric actuator/sensors, is presented for characterizing damage (location and size) without need for a structural or damage model. The imaging method with an autofocusing feature is applied to aluminum plates and a stiffened composite panel for method verification.