PAGE System Research Articles

Abstract 83: Early Notification Using a Novel Three-Tiered Code Stroke System Reduces Neurointerventional Team Activation Times

Background: Although Code Stroke group page systems are essential to accelerate endovascular therapy (EVT), their design and implementation has not been well-studied. We assessed a novel 3-tiered system crafted to facilitate prompt, stepped activation. Methods: An escalating 3-tiered system was designed to provide salient services with both an a) alert-be ready page, and a b) go-go-go page while minimizing false alarms. Group page levels are: 1) pre-arrival notification of possible stroke by EMS to Neurology; 2) notification of possible large vessel occlusion (LVO) by Neurology (based on cortical signs) to Neurointerventional+/Anesthesia; and 3) post-imaging notification of confirmed LVO and angiosuite decision to all services. System performance was assessed over a 1 year period September 2022 to August 2023. Results: Among 798 Code Strokes, 75 (9.4%) patients received EVT, including 45 who were EMS-arriving. Among the 45 LVO strokes treated with EVT, 26 (58%) had an early notification (EN) Level 2 page pre-imaging and 19 (42%) only a late notification (LN) Level 2 page post-imaging. Patients in the EN vs LN group were nominally older (84 vs 74), more often female (61.5% vs 47.3%), and more severely affected (NIHSS 16 vs 13). Time metrics are presented in Table 1 and Figure 1. The EN group had a near 40 minute decrease in door-to-puncture (DTP) and 50 minute decrease in door-to-reperfusion (DTR) times. Conclusion: All levels of a 3-tier (pre-arrival, pre-imaging, and post-imaging) Code Stroke group page system were activated frequently in EVT patients and pre-imaging early notification of neurointerventional and anesthesia teams was associated with markedly reduced DTP and DTR times.

IMPLEMENTATION OF RT / RW NET HOTSPOT NETWORK WITH MIKROTIK-BASED VOUCHER SYSTEM AT UNITEX BOGOR HOUSING

Technological developments are currently growing very rapidly, especially the use of computer networks. The use of the internet is increasing because it makes it easier for everyone to dig up existing information from the internet world, internet access has become a basic need for society. One effective way to provide internet access to the public is through the RT/RW Net network. However, there are still several obstacles in managing the RT/RW Net network in the Unitex housing complex in Bogor City, such as use that is not well controlled, many users who are not interested and do not have the right to use hotspot facilities by knowing the password for the Wi-Fi network in the housing complex. Unitex. To overcome these obstacles, the author proposes implementing an RT/RW Net network with a MikroTik-based voucher system. MikroTik is a network device that has reliable routing, switching and wireless capabilities. By utilizing MikroTik, RT/RW Net network managers can better manage and control internet access for users. By implementing the hotspot voucher login web page system provided by the Hotspot Server on the Mikrotik Router, to provide authentication features for users who will use the Hotspot/Wi-Fi network. So registered users are required to enter their username and password on the web login page provided by Mikrotik to be able to access the internet via the RT/RW Net Hotspot network. The research methods used in this research are observation, questionnaires, and literature studies, as well as the Network Development Life Cycle (NDLC) Method which is used to analyze needs in implementing the Rt/Rw Net Hotspot Network in the Unitex housing complex in the city of Bogor

Weighted ensemble classifier for malicious link detection using natural language processing

Purpose The internet has completely merged into contemporary life. People are addicted to using internet services for everyday activities. Consequently, an abundance of information about people and organizations is available online, which encourages the proliferation of cybercrimes. Cybercriminals often use malicious links for large-scale cyberattacks, which are disseminated via email, SMS and social media. Recognizing malicious links online can be exceedingly challenging. The purpose of this paper is to present a strong security system that can detect malicious links in the cyberspace using natural language processing technique. Design/methodology/approach The researcher recommends a variety of approaches, including blacklisting and rules-based machine/deep learning, for automatically recognizing malicious links. But the approaches generally necessitate the generation of a set of features to generalize the detection process. Most of the features are generated by processing URLs and content of the web page, as well as some external features such as the ranking of the web page and domain name system information. This process of feature extraction and selection typically takes more time and demands a high level of expertise in the domain. Sometimes the generated features may not leverage the full potentials of the data set. In addition, the majority of the currently deployed systems make use of a single classifier for the classification of malicious links. However, prediction accuracy may vary widely depending on the data set and the classifier used. Findings To address the issue of generating feature sets, the proposed method uses natural language processing techniques (term frequency and inverse document frequency) that vectorize URLs. To build a robust system for the classification of malicious links, the proposed system implements weighted soft voting classifier, an ensemble classifier that combines predictions of base classifiers. The ability or skill of each classifier serves as the base for the weight that is assigned to it. Originality/value The proposed method performs better when the optimal weights are assigned. The performance of the proposed method was assessed by using two different data sets (D1 and D2) and compared performance against base machine learning classifiers and previous research results. The outcome accuracy shows that the proposed method is superior to the existing methods, offering 91.4% and 98.8% accuracy for data sets D1 and D2, respectively.

To the Editor: Actions More Powerful Than Words-An Impactful Approach to Overcoming Page Burden.

I would like to thank Armendariz et al for their contribution to understanding the root characteristics of rounding interruptions inherent to medical learners in the inpatient teaching environment.1 As noted in the study conclusion, proactive communication with nursing staff holds merit for most team-based improvement strategies. However, based on anecdotal experience, simple discussions with nursing staff resulted in trivial long-term change. An effective, actionable plan is needed for residency programs to address inappropriately timed pages and improve paging etiquette during inpatient rounding.Inpatient medicine has trended toward algorithmic-based patient care under the banners of improved patient outcomes and hospital efficiency. Examples within this trend include antibiotic prescribing practices, pathology-directed power plans, and sepsis triage goals.2 Standardization for interprofessional communication, however, remains largely unchanged and differs across the spectrum of the US health care system. This leads to increased stress, burnout rates, and frustrations during rounding periods among medical trainees.3An algorithm-based text page system for nursing staff would improve communication and rounding efficiency by utilizing a decision tree model. This tree would include the initial decision of page appropriateness during rounding times. If it meets criteria for paging, the algorithm will require important triaging information for the text page, including urgency level (routine, urgent, emergent); patient room number; paging staff role and name; category (lab, clinical status change, medication question, disposition, diet request, family request, etc); and time requested for response (within 1 hour, 30 minutes, 5 minutes, or ASAP). Similar interventions in the pediatric ICU setting demonstrated a 42% reduction in pages per patient, improved resident well-being and nursing satisfaction, and maintained patient safety while using a text page system.4Implementing standardized, algorithm-based text page systems can improve the resident learning experience while decreasing page burden during inpatient rounds.

Açık ve Uzaktan Öğrenmede Özel Gereksinimli Öğrencilerin Kullandıkları Web Sayfası ve Öğrenme Ortamına Yönelik Kullanıcı Deneyimlerinin ve Gereksinimlerinin İncelenmesi: Anadolu Üniversitesi Örneği

E-learning systems with its flexible structure offer learning environments independent of time and place for students with special needs. The effectiveness of these environments for students with special needs depends on the creation of designs that consider their individual needs. The aim of this research is to reveal the needs, difficulties, and solution suggestions by determining the user experiences for the "e-Campus" system as the web page of the Anadolu University Open Education System "Barrier-Free Open Education Faculty (OEF)", which provides services to most university students with special needs in Turkey, and the online learning environment. For this purpose, a case study design, in which qualitative and quantitative data collection techniques are used together, was used. A total of 9533 students, including 9513 students with special needs and 20 visually impaired students, participated in the quantitative stage of the study. According to the findings of the research, students with special needs reported that the web page and e-Campus system they use are easy to use, they can easily find the content they are looking for, they can access other services from the web page and offer useful content. On the other hand, difficulties in using the mobile application login screen, accessing the call center, and accessing some content on the e-Campus were mentioned among the issues encountered. The visually impaired participants requested support for facilitating access to live lectures, enlarging the texts in online exams, and giving additional time, adding voice prompts to the entry page, and increasing audio narrations. In line with these supports required by the participants and the literature, solution suggestions to overcome the difficulties were discussed

Efektifitas Metode Muraja’ah dalam Menghafal Al-Qur’an pada Santri Pondok Pesantren

This article aims to present the results of a qualitative research that explores the impact of muraja'ah method in memorizing the Qur'an and to determine the supporting and inhibiting factors during its application in one of the Islamic boarding schools in East Java. Data was collected through observation, interviews, and documentation. The results of data analysis showed that the implementation of memorizing the Qur'an with the Muraja'ah method in this study was using the One Day One Page system with memorizing new muraja'ah to the ustadzah, muraja'ah the previous memorization with pairs, muraja'ah the previous memorization to the teacher, and the memorization test. In this study, the muraja'ah method was considered effective. The supporting factors in this research are discipline, memorization targets, motivation from parents and teachers, achievement logs, prayers for success in memorizing the Qur’an. The inhibiting factors for the application of the muraja'ah method in this study were the forgotten verses, feeling lazy, or tired. The solution to overcome these obstacles is rote repetition, self-motivation, and time management. Keywords: Islamic boarding school; memorization; muraja’ah; One Day One Page; student

Involving End Users in Adapting a Spanish Version of a Web-Based Mental Health Clinic for Young People in Colombia: Exploratory Study Using Participatory Design Methodologies.

BackgroundHealth information technologies (HITs) hold enormous promise for improving access to and providing better quality of mental health care. However, despite the spread of such technologies in high-income countries, these technologies have not yet been commonly adopted in low- and middle-income countries. People living in these parts of the world are at risk of experiencing physical, technological, and social health inequalities. A possible solution is to utilize the currently available HITs developed in other counties.ObjectiveUsing participatory design methodologies with Colombian end users (young people, their supportive others, and health professionals), this study aimed to conduct co-design workshops to culturally adapt a Web-based Mental Health eClinic (MHeC) for young people, perform one-on-one user-testing sessions to evaluate an alpha prototype of a Spanish version of the MHeC and adapt it to the Colombian context, and inform the development of a skeletal framework and alpha prototype for a Colombian version of the MHeC (MHeC-C).MethodsThis study involved the utilization of a research and development (R&D) cycle including 4 iterative phases: co-design workshops; knowledge translation; tailoring to language, culture, and place (or context); and one-on-one user-testing sessions.ResultsA total of 2 co-design workshops were held with 18 users—young people (n=7) and health professionals (n=11). Moreover, 10 users participated in one-on-one user-testing sessions—young people (n=5), supportive others (n=2), and health professionals (n=3). A total of 204 source documents were collected and 605 annotations were coded. A thematic analysis resulted in 6 themes (ie, opinions about the MHeC-C, Colombian context, functionality, content, user interface, and technology platforms). Participants liked the idea of having an MHeC designed and adapted for Colombian young people, and its 5 key elements were acceptable in this context (home page and triage system, self-report assessment, dashboard of results, booking and video-visit system, and personalized well-being plan). However, to be relevant in Colombia, participants stressed the need to develop additional functionality (eg, phone network backup; chat; geolocation; and integration with electronic medical records, apps, or electronic tools) as well as an adaptation of the self-report assessment. Importantly, the latter not only included language but also culture and context.ConclusionsThe application of an R&D cycle that also included processes for adaptation to Colombia (language, culture, and context) resulted in the development of an evidence-based, language-appropriate, culturally sensitive, and context-adapted HIT that is relevant, applicable, engaging, and usable in both the short and long term. The resultant R&D cycle allowed for the adaptation of an already available HIT (ie, MHeC) to the MHeC-C—a low-cost and scalable technology solution for low- and middle-income countries like Colombia, which has the potential to provide young people with accessible, available, affordable, and integrated mental health care at the right time.

The chloroplast metalloproteases VAR2 and EGY1 act synergistically to regulate chloroplast development in Arabidopsis.

Chloroplast development and photosynthesis require the proper assembly and turnover of photosynthetic protein complexes. Chloroplasts harbor a repertoire of proteases to facilitate proteostasis and development. We have previously used an Arabidopsis leaf variegation mutant, yellow variegated2 (var2), defective in thylakoid FtsH protease complexes, as a tool to dissect the genetic regulation of chloroplast development. Here, we report a new genetic enhancer mutant of var2, enhancer of variegation3-1 (evr3-1). We confirm that EVR3 encodes a chloroplast metalloprotease, reported previously as ethylene-dependent gravitropism-deficient and yellow-green1 (EGY1)/ammonium overly sensitive1 (AMOS1). We observed that mutations in EVR3/EGY1/AMOS1 cause more severe leaf variegation in var2-5 and synthetic lethality in var2-4 Using a modified blue-native PAGE system, we reveal abnormal accumulations of photosystem I, photosystem II, and light-harvesting antenna complexes in EVR3/EGY1/AMOS1 mutants. Moreover, we discover distinct roles of VAR2 and EVR3/EGY1/AMOS1 in the turnover of photosystem II reaction center under high light stress. In summary, our findings indicate that two chloroplast metalloproteases, VAR2/AtFtsH2 and EVR3/EGY1/AMOS1, function coordinately to regulate chloroplast development and reveal new roles of EVR3/EGY1/AMOS1 in regulating chloroplast proteostasis in Arabidopsis.

Design and Development of A Single Page and Web-based Responsive E-learning System for Higher Education Institutions

Students now use not only computers or laptops, but also small devices such as mobile phones. The students at higher education institutions spent a lot of time on the internet to find the course materials. Sometimes the teacher sends the materials, but the students who are willing to take a specific course of a semester cannot get a brief concept of the course on before starting the semester. There is now a lot of online education systems on the Internet, but few are a single page and responsive. The purpose of this research is to develop a single page, responsive and web-based e-learning system. The method used in this research is the Rapid Application Development approach which has six stages of the development process, namely Planning, Analysis, Design, Implementation, Testing, and Maintenance. This research was conducted in the Faculty of Technology and Vocational Education, Universitas Pendidikan Indonesia. The students and teachers from the Department of Mechanical Engineering Education participated in this research. The results of this research indicate that with fully functional live chat, the OpenCourseWare system has a high usability test score, highly responsive and awesome features. The OpenCourseWare system is responsive and ajax-based mobile-friendly system that can be used by higher education institutions as an e-learning system based on the results obtained.

Using Participatory Design Methodologies to Co-Design and Culturally Adapt the Spanish Version of the Mental Health eClinic: Qualitative Study.

BackgroundThe Mental Health eClinic (MHeC) aims to deliver best-practice clinical services to young people experiencing mental health problems by making clinical care accessible, affordable, and available to young people whenever and wherever they need it most. The original MHeC consists of home page with a visible triage system for those requiring urgent help; a online physical and mental health self-report assessment; a results dashboard; a booking and videoconferencing system; and the generation of a personalized well-being plan. Populations who do not speak English and reside in English-speaking countries are less likely to receive mental health care. In Australia, international students have been identified as disadvantaged compared with their peers; have weaker social support networks; and have higher rates of psychological distress. This scenario is acquiring significant relevance as Spanish-speaking migration is rapidly growing in Australia, and the mental health services for culturally and linguistically diverse populations are limited. Having a Spanish version (MHeC-S) of the Mental Health eClinic would greatly benefit these students.ObjectiveWe used participatory design methodologies with users (young people aged 16-30 years, supportive others, and health professionals) to (1) conduct workshops with users to co-design and culturally adapt the MHeC; (2) inform the development of the MHeC-S alpha prototype; (3) test the usability of the MHeC-S alpha prototype; (4) translate, culturally adapt, and face-validate the MHeC-S self-report assessment; and (5) collect information to inform its beta prototype.MethodsA research and development cycle included several participatory design phases: co-design workshops; knowledge translation; language translation and cultural adaptation; and rapid prototyping and user testing of the MHeC-S alpha prototype.ResultsWe held 2 co-design workshops with 17 users (10 young people, 7 health professionals). A total of 15 participated in the one-on-one user testing sessions (7 young people, 5 health professionals, 3 supportive others). We collected 225 source documents, and thematic analysis resulted in 5 main themes (help-seeking barriers, technology platform, functionality, content, and user interface). A random sample of 106 source documents analyzed by 2 independent raters revealed almost perfect agreement for functionality (kappa=.86; P<.001) and content (kappa=.92; P<.001) and substantial agreement for the user interface (kappa=.785; P<.001). In this random sample, no annotations were coded for help-seeking barriers or the technology platform. Language was identified as the main barrier to getting medical or psychological services, and smartphones were the most-used device to access the internet. Acceptability was adequate for the prototype’s 5 main elements: home page and triage system, self-report assessment, dashboard of results, booking and video visit system, and personalized well-being plan. The data also revealed gaps in the alpha prototype, such as the need for tailored assessment tools and a greater integration with Spanish-speaking services and communities. Spanish-language apps and e-tools, as well as online mental health information, were lacking.ConclusionsThrough a research and development process, we co-designed and culturally adapted, developed and user tested, and evaluated the MHeC-S. By translating and culturally adapting the MHeC to Spanish, we aimed to increase accessibility and availability of e-mental health care in the developing world, and assist vulnerable populations that have migrated to English-speaking countries.

The Nationwide Landscape of K–12 School Websites in the United States

This study sought to collect URLs (web addresses) of all K-12 schools in the United States (N = 98,477) and analyze website home page system and service data for all available U.S. institutional websites (n = 65,899). Building upon previous research related to Web 2.0 educational potentials, this first-of-its-kind study sought (a) to provide descriptive results of system and service adoption and website data for all schools in the United States and (b) to detect theorized differences based upon school demographics and service/system type (e.g., open source vs. proprietary). Results indicated that proprietary and purchased systems were much more common than free and open systems, that adoption patterns were generally not meaningfully influenced by demographic data (except for charter school status), and that K-12 institutional adoption of Web 2.0 seems to be more focused on educational uses of these tools that might not strictly be considered pedagogical (e.g., community outreach).

Energy Internet Access Equipment Integrating Cyber-Physical Systems: Concepts, Key Technologies, System Development, and Application Prospects

This paper systematically proposes a novel concept of energy Internet access equipment (AE) integrating cyber-physical systems (CPSs). First, based on the concept and characteristics of energy Internet AE, we comprehensively investigate its global system development, including overall framework and functions design, core hardware equipment development, and software system design and development. Among these, the hardware part containing five major types of equipment is used to achieve a unified connection of various distributed energy equipment; the software part, consisting of three categories of system platforms (i.e., local energy management system, cloud Web page system, and user-side APP), is applied to integrate energy management and distributed coordination control. Moreover, we carry out an initial practice for this proposed energy Internet AE. Based on this, finally, we prospect future application scenarios for the energy Internet AE from multiple aspects. As a unified interface platform, the proposed energy Internet AE is directly applied for end-users to connect various energy supply and utilization equipment to the energy Internet, so as to monitor and coordinate the distributed energy equipment in real time and, finally, to realize the bidirectional circulation of energy flow and information flow in smart grid. The biggest innovation of this paper lies in comprehensively proposing a novel concept of energy Internet AE from the perspective of the CPS, with an aim of hoping to provide some thoughts for end-users to access the energy Internet efficiently and conveniently through such equipment in the future.

A proficiency-based learning algorithm applied to e-learning system for knowledge-oriented course

In the cognitive psychology domain, the memorization of knowledge is one kind of representation of memory capability. Humans often get the knowledge with knowledge-oriented courses. These courses are composed of the question banks with the fixed knowledge-based content. Learners can obtain the required cognitive knowledge through the repeated memory process. This study proposed a proficiency-based learning algorithm to simulate this kind of learning behavior and then implement an instruction-assisted system called proficiency-based adaptive and guided e-learning system (PAGE system), in which learners can study independently through a guided mechanism. The PAGE system is quite suitable for the knowledge-oriented courses, which are designed by several items with standard answers. Obviously the study indicated the PAGE system is validated in the learning process of memorization. The experimental result proved that the PAGE system can help learners to remember efficiently. All participants got positive progress and 80% of them achieved their criterion for cognitive knowledge growth. In addition, the experiment also showed that the learning attitude and active performance are crucial factors that affect learners' learning growth.

Підбір умов для препаративного електрофорезу протеїнів сироватки молока у нативних умовах

Протеїни сироватки молока є попередниками більше сотні біоактивних пептидів. Ці пептиди можуть утворюватися в процесі травлення у шлунково-кишковому тракті, а також за дії протеаз молочнокислих бактерій і молокозгортальних препаратів. Серед них знайдено інгібітори ангіотензин-перетворювального ензиму, пептиди з опіоїдною та бактерицидною дією, імуномодуляторні та гіпохолестеролемічні пептиди, пептиди, які впливають на моторику кишечника, апетит та інші. Біоактивні пептиди з протеїнів сироватки молока становлять значний інтерес для створення функціональних продуктів або продуктів з профілактичними властивостями. Створення таких продуктів передбачає виділення біоактивних пептидів певної біологічної дії. Враховуючи специфіку їх розміщення у первинній структурі доцільним є використання для їх отримання гомогенних протеїнів-попередників з сироватки молока. Одним з методів для одностадійного розділення протеїнів сироватки молока є диск-електрофорез в нативній системі ПААГ для лужних і нейтральних протеїнів. Метою даної роботи було встановити параметри препаративного варіанту диск-електрофорезу для виділення гомогенних протеїнів сироватки молока. Дослідження проводили на модифікованому апараті Стадієра. Протеїни сироватки молока виділяли осадженням казеїнів в ізоелектричній точці. Осад казеїнів відділяли центрифугуванням. Для ідентифікації протеїнів сироватки молока використовували гомогенні фракції α–лактальбуміну(α-LA) і β-лактоглобуліну(β-LG), які отримували шляхом повторної гель-фільтрації на сефадексі G-100(fine). Гомогенність і фракційний склад протеїнів сироватки молока визначали аналітичним диск-електрофорезом у пластинах поліакриламідного гелю. Концентрацію протеїнів у зразках визначали спектрофотометрично (спектрофотометр СФ-46) при довжині хвилі λ = 280 нм.&#x0D; Отримані результати доводять доцільність використання пластинок ПААГ для препаративного фракціонування протеїнів сироватки молока. Встановлено допустиму тривалість і умови ідентифікації протеїнових фракцій. Показано, що вихід протеїнів у складі гомогенних фракцій становить 69,2%. При цьому співвідношення між кількістю отриманих фракцій (β-LG, α-LA, BSA і ІG) близьке до їх розподілу у сироватці молока.&#x0D;

The New Molecular Entity Evolocumab, One Kind of PCSK9 Inhibitor, Reduce Plasma Small Size LDL-Cholesterol Levels by Using a New Standardized Method of Measuring LDL Size

Aims: There has been no evidence on the effects of evolocumab, protein convertase subtilisin/kexin type 9 (PCSK9) inhibitor, on small size LDL. We observationally investigated the efficacy and side effects of evolocumab on the LDL subfraction particle diameter using PAGE system for lipoprotein analysis. Methods: We defined 30 patients with high-risk hyperlipidemia. As for analysis of LDL subfraction profile, we used polyacrylamide gel electrophoresis three methods: 1) 3% nondenatured poly-acrylamide gel electrophoresis method (3%PAGE), 2) 2% - 16% nondenatured poly-acrylamide gradient gel electro-phoresis method (2% - 16% GGE) and 3) 2.7% - 5% GGE. Evolocumab 140 mg/day administered together with statin significantly improved serum total cholesterol (TC), triglyceride (TG), high-dense lipoprotein-cholesterol (HDL-C), and LDL-C after four-week treatment. Results: TC, TG, HDL-C and LDL-C levels were improved by, respectively, 33%, 20%, 10%, and 54%. The mean LDL size significantly increased from 25.6 ± 0.4 nm to 26.4 ± 0.8 nm. The small dense LDL-cholesterol (sdLDL-C), large buoyant LDL-cholesterol (lbLDL-C), and mid-band lipoprotein-cholesterol were reduced, respectively. Therefore, the preliminary study on this paper can be the first step into a new insight on the world of lipid metabolism. Conclusion: Short-term administration of evolocumab addedons to statin therapy, significantly reduced small size LDL levels.

Instant Recovery with Write-Ahead Logging: Page Repair, System Restart, Media Restore, and System Failover, Second Edition

Traditional theory and practice of write-ahead logging and of database recovery focus on three failure classes: transaction failures (typically due to deadlocks) resolved by transaction rollback; system failures (typically power or software faults) resolved by restart with log analysis, redo, and undo phases; and media failures (typically hardware faults) resolved by restore operations that combine multiple types of backups and log replay. The recent addition of single-page failures and single-page recovery has opened new opportunities far beyond the original aim of immediate, lossless repair of single-page wear-out in novel or traditional storage hardware. In the contexts of system and media failures, efficient single-page recovery enables on-demand incremental redo and undo as part of system restart or media restore operations. This can give the illusion of practically instantaneous restart and restore: instant restart permits processing new queries and updates seconds after system reboot and instant restore permits resuming queries and updates on empty replacement media as if those were already fully recovered. In the context of node and network failures, instant restart and instant restore combine to enable practically instant failover from a failing database node to one holding merely an out-of-date backup and a log archive, yet without loss of data, updates, or transactional integrity. In addition to these instant recovery techniques, the discussion introduces self-repairing indexes and much faster offline restore operations, which impose no slowdown in backup operations and hardly any slowdown in log archiving operations. The new restore techniques also render differential and incremental backups obsolete, complete backup commands on a database server practically instantly, and even permit taking full up-to-date backups without imposing any load on the database server. Compared to the first version of this book, this second edition adds sections on applications of single-page repair, instant restart, single-pass restore, and instant restore. Moreover, it adds sections on instant failover among nodes in a cluster, applications of instant failover, recovery for file systems and data files, and the performance of instant restart and instant restore.

A new type of WEB-based access control method

This paper has proposed a new type of WEB-based access control method which adopted the Role-function user access control idea. Divide business functions of the page in the bottom menu on the basis of the Web page organizational structure that required by system business requirements and the user access control requirements,, then use the business function as the basic unit of permission configuration, control the user's access to the page, the html elements contained in the page, its operation and other Web system resources through configuring the relationship among user, role, page, menu and the functions. The practical application showed that the access control model can effectively control user's access to the Web system, in the meantime, it has simplified the user's operation and possess strong versatility; it has efficiently reduced the workload of Web system development.

Abstract T P342: Clot Busting: Enhancing Nursing Documentation

Background: Stroke is the leading cause of death and disability in the United States. The only FDA-approved treatment of ischemic stroke is tissue plasminogen activator (rt-PA) which dissolves the clot and improves blood flow to the compromised brain area(s). According to the National Institute of Neurological Disorders and Stroke rt-PA Study Group, 6.4% of patients treated with rt-PA experienced a hemorrhagic conversion. Thus, it is critical to closely monitor neurologic status (neurologic exam and vital signs) during treatment. During the Joint Commission Comprehensive Stroke Certification (CSC), we identified opportunities for improvement in our documentation of neurological status for our patients receiving rt-PA. Purpose: Following the Iowa Model of EBP to promote quality patient care, our purpose was to develop a standardized guideline for neurological assessment and documentation for patients following administration of rt-PA. Our goal was to attain a 90% compliance rate for appropriate neurological assessment documentation. Methods: Based on research, the American Heart Association clinical guidelines, and consultation with a CSC and our Regulatory Compliance department, we developed the standardized documentation guideline. The project included strategies addressing the four process phases required to implement and integrate EBP. Strategies included: 1) education on standards utilizing information sessions at staff meetings, tip sheets, and badge cards, 2) standardization of neurological assessment in EMR, 3) utilization of the stroke page system for patient identification, and 4) audit and feedback loops with just-in time in-servicing. Results: Prior to the implementation of this standardized guideline, of the 14 patients who received rt-PA, 14% met the threshold goal; of the 10 patients who received rt-PA after our implementation, all patients met the threshold. Conclusions: Through the implementation of our standardized protocol for neurological assessment and documentation of patients following administration of rt-PA, we were able to improve the quality of neurological assessments, meet Joint Commission requirements, and improve the quality of patient care.

Instant Recovery with Write-Ahead Logging: Page Repair, System Restart, and Media Restore

Traditional theory and practice of write-ahead logging and of database recovery techniques revolve around three failure classes: transaction failures resolved by rollback; system failures (typically software faults) resolved by restart with log analysis, “redo,” and “undo” phases; and media failures (typically hardware faults) resolved by restore operations that combine multiple types of backups and log replay. The recent addition of single-page failures and single-page recovery has opened new opportunities far beyond its original aim of immediate, lossless repair of single-page wear-out in novel or traditional storage hardware. In the contexts of system and media failures, efficient single-page recovery enables on-demand incremental “redo” and “undo” as part of system restart or media restore operations. This can give the illusion of practically instantaneous restart and restore: instant restart permits processing new queries and updates seconds after system reboot and instant restore permits resuming queries and updates on empty replacement media as if those were already fully recovered. In addition to these instant recovery techniques, the discussion introduces much faster offline restore operations without slowdown in backup operations and with hardly any slowdown in log archiving operations. The new restore techniques also render differential and incremental backups obsolete, complete backup commands on the database server practically instantly, and even permit taking full backups without imposing any load on the database server.

Antioxidant effects of carnitine supplementation on 14-3-3 protein isoforms in the aged rat hippocampus detected using fully automated two-dimensional chip gel electrophoresis

We here described the antioxidant effects of carnitine supplementation on 14-3-3 protein isoforms in the aged rat hippocampus detected using the fully automated two-dimensional chip gel electrophoresis system (Auto2D). This system was easy and convenient to use, and the resolution obtained was more sensitive and higher than that of conventional two-dimensional polyacrylamide gel electrophoresis (2-D PAGE). We separated and identified five isoforms of the 14-3-3 protein (beta/alpha, gamma, epsilon, zeta/delta, and eta) using the Auto2D system. We then examined the antioxidant effects of carnitine supplementation on the protein profiles of the cytosolic fraction in the aged rat hippocampus, demonstrating that carnitine supplementation suppressed the oxidation of methionine residues in these isoforms. Since methionine residues are easily oxidized to methionine sulfoxide, the convenient and high-resolution 2-D PAGE system can be available to analyze methionine oxidation avoiding artifactual oxidation. We showed here that the Auto2D system was a very useful tool for studying antioxidant effects through proteomic analysis of protein oxidation.