P3-like Component Research Articles

Neural mechanism for dynamic distractor processing during video target detection: Insights from time-varying networks in the cerebral cortex

In dynamic video target detection tasks, distractors may suddenly appear due to the dynamicity of the visual scene and the uncertainty of the visual information, strongly influencing participants’ attention and target detection performance. Moreover, the neural mechanism that accounts for dynamic distractor processing remains unknown, which makes it difficult to compensate for in EEG-based video target detection. Here, cortical activities with high spatiotemporal resolution were reconstructed using the source localization method. The time-varying networks among important brain regions in different cognitive phases, including information integration, decision-making, and execution, were identified to investigate the neural mechanism of dynamic distractor processing. The experimental results indicated that dynamic distractors could induce a P3-like component. In addition, there was obvious asymmetry between the two hemispheres during video target detection. Specifically, the brain responses induced by dynamic distractors were weak and more concentrated in the left hemisphere during the information integration phase; left superior frontal gyrus activity related to preparation for the presence of distractors was critical, while the attention network and primary visual network, especially in the left visual pathway, were more active for dynamic targets during the decision-making phase. These findings provide guidance for designing an effective EEG-based model for dynamic video target detection.

Unraveling the Electrophysiological Activity Behind Recognition Memory

Abstract. Traditionally, most event related potential (ERP) studies of memory retrieval have been reported during item-recognition tasks. Those studies lead to two well-known ERP memory components termed FN400 (familiarity) and LPC (recollection). Nevertheless, some critics have raised concerns regarding the actual meaning of that activity since it emerges as the result of contrasting two different memory traces (previously studied vs. seen for the first time), and it is registered after the target presentation. Therefore, they possibly depict operations not related to memory itself but some cognitive processes associated with recognition memory. Based on those critics, we propose an innovative approach to study electrophysiological activity underlying recognition memory. We compared two very similar tasks with only one of them requiring subjects to actively retrieve a “cue-target” pair of visual stimuli from memory, while the other task required subjects to recognize the target stimulus as equal/different to the cue. Because of this experimental manipulation, we assured that active memory retrieval processes take place between the presentation of the cue and the target stimuli for only one of the tasks. As a result, responses upon the targets can give us valuable information regarding ERP components associated with recognition based on memory retrieval. We found three components possibly related to brain computations necessary to achieve correct target recognition. A N200-like component linked to executive functions (inhibition) from frontal cortices, a P300-like component, related to the expectation of the target stimulus, and a P600-like component associated to recognition based on LTM retrieval. These results help us to understand the complexity behind ERP components associated with recognition memory.

P300 development from infancy to adolescence.

This article provides an overview of P300 research from infancy through adolescence. First, a brief historical overview is provided highlighting seminal studies that began exploration of the P300 component in developmental groups. Overall, these studies suggest that the P300 can be detected in children and appears to reflect similar cognitive processes to those in adults; however, it is significantly delayed in its latency to peak. Second, two striking findings from developmental research are the lack of a clear P300 component in infancy and differential electrophysiological responses to novel, unexpected stimuli in children, adolescents, and adults. Third, contemporary questions are described, which include P300-like components in infancy, alteration of P300 in atypically developing groups, relations between P300 and behavior, individual differences of P300, and neural substrates of P300 across development. Finally, we conclude with comments regarding the power of a developmental perspective and suggestions for important issues that should be addressed in the next 50years of P300 research.

Human or not human? Performance monitoring ERPs during human agent and machine supervision

Performance monitoring is a critical process which allows us to both learn from our own errors, and also interact with other human beings. However, our increasingly automated world requires us to interact more and more with automated systems, especially in risky environments. The present EEG study aimed at investigating and comparing the neuro-functional correlates associated with performance monitoring of an automated system and a human agent using a vertically-oriented arrowhead version of the flanker task. Given the influence of task difficulty on performance monitoring, two levels of difficulty were considered in order to assess their impact on supervision activity. A large N2-P3 complex in fronto-central regions was observed for both human agent error detection and system error detection during supervision. Using a cluster-based permutation analysis, a significantly decreased P3-like component was found for system compared to human agent error detection. This variation is in line with various psychosocial behavioral studies showing a difference between human-human and human-machine interactions, even though it was not clearly anticipated. Finally, the activity observed during error detection was significantly reduced in the difficult condition compared to the easy one, for both system and human agent supervision. Overall, this study is a first step towards the characterization of the neurophysiological correlates underlying system supervision, and a better understanding of their evolution in more complex environments. To go further, these results need to be replicated in other experiments with various paradigms to assess the robustness of the pattern and decrease during system supervision.

Cholinergic Mechanisms of Target Oddball Stimuli Detection: The Late "P300-Like" Event-Related Potential in Rats.

Event-related potentials (ERPs) and oscillations (EROs) provide powerful tools for studying the brain's synaptic function underlying information processing. The P300 component of ERPs indexing attention and working memory shows abnormal amplitude and latency in neurological and psychiatric diseases that are sensitive to pharmacological agents. In the active auditory oddball discriminant paradigm, behavior and auditory-evoked potentials (AEPs) were simultaneously recorded in awake rats to investigate whether P300-like potentials generated in rats responding to rare target oddball tones are sensitive to subcutaneous modulation of the cholinergic tone by donepezil (1 mg/kg) and scopolamine (0.64 mg/kg). After operant training, rats consistently discriminate rare target auditory stimuli from frequent irrelevant nontarget auditory stimuli by a higher level of correct lever presses (i.e., accuracy) in target trials associated with a food reward. Donepezil attenuated the disruptive effect of scopolamine on the level of accuracy and premature responses in target trials. Larger P300-like peaks with early and late components were revealed in correct rare target stimuli trials as compared to frequent tones. Donepezil enhanced the peak amplitude of the P300-like component to target stimuli and evoked slow theta and gamma oscillations, whereas scopolamine altered the amplitude of the P300-like component and EROs to target stimuli. Pretreatment with donepezil attenuated effects of scopolamine on the peak amplitude of the P300-like component and on EROs. This study provides evidence that AEP P300-like responses can be elicited by rats engaged in attentive and memory processing of target stimuli and outline the relevance of the cholinergic system in stimulus discrimination processing. The findings highlight the sensitivity of this translational index for investigating brain circuits and/or novel pharmacological agents, which modulate cholinergic transmission associated with increased allocation of attentional resources.

Development of the P300 from childhood to adulthood: a multimodal EEG and MRI study.

Maturation of attentional processes is central to cognitive development. The electrophysiological P300 is associated with rapid allocation of attention, and bridges stimulus and response processing. P300 is among the most studied and robust electrophysiological components, but how different subcomponents of the P300 develop from childhood to adulthood and relate to structural properties of the cerebral cortex is not well understood. We investigated age-related differences in both early visual and P300 components, and how individual differences in these components are related to cortical structure in a cross-sectional sample of participants 8-19years (n = 86). Participants completed a three-stimulus visual oddball task while high-density EEG was recorded. Cortical surface area and thickness were estimated from T1-weighted MRI. Group-level blind source separation of the EEG data identified two P300-like components, a fronto-central P300 and a parietal P300, as well as a component reflecting N1 and P2. Differences in activity across age were found for the parietal P300, N1 and P2, with the parietal P300 showing stronger activity for older participants, while N1 and P2 were stronger for younger participants. Stronger P300 components were positively associated with task performance, independently of age, while negative associations were found for P2 strength. Parietal P300 strength was age-independently associated with larger surface area in a region in left lateral inferior temporal cortex. We suggest that the age differences in component strength reflect development of attentional mechanisms, with increased brain responses to task-relevant stimuli representing an increasing ability to focus on relevant information and to respond accurately and efficiently.

The time is “right:” Electrophysiology reveals right parietal electrode dominance in time perception

In the present study, healthy undergraduates were asked to identify if a visual stimulus appeared on screen for the same duration as a memorized target (2 s) while event-related potentials (ERP) were recorded. Trials consisted of very short (1.25 s), short (1.6 s), target (2 s), long (2.5 s) or very long (3.125 s) durations, and a yes or no response was required on each trial. We examined behavioral response as signal detection (d′) and response bias via a Generalized Accuracy Coefficient (GAC). We examined the mean amplitude as well as the change in amplitude of the initial Contingent Negative Variation (iCNV) and overall CNV (oCNV) and P350 (a P300-like component that follows stimulus extinction) potentials in paired, lateralized posterior electrodes. Results showed a bias to identifying shorter trials as the target more than longer trials via negative GAC scores. The slope and amplitudes of the iCNV and oCNV were consistently greater in right parietal electrodes. Also in right parietal electrodes, the iCNV correlated to d′ scores while greater P350 amplitudes in the short condition correlated with more negative GAC scores. The results indicate dominance in the right hemisphere in temporal processing for durations exceeding 1 s. The P350 should also be studied further.

A Randomized Controlled ERP Study on the Effects of Multi-Domain Cognitive Training and Task Difficulty on Task Switching Performance in Older Adults.

Executive functions are subject to a marked age-related decline, but have been shown to benefit from cognitive training interventions. As of yet, it is, however, still relatively unclear which neural mechanism can mediate training-related performance gains. In the present electrophysiological study, we examined the effects of multi-domain cognitive training on performance in an untrained cue-based task switch paradigm featuring Stroop color words: participants either had to indicate the word meaning of Stroop stimuli (word task) or perform the more difficult task of color naming (color task). One-hundred and three older adults (>65 years old) were randomly assigned to a training group receiving a 4-month multi-domain cognitive training, a passive no-contact control group or an active (social) control group receiving a 4-month relaxation training. For all groups, we recorded performance and EEG measures before and after the intervention. For the cognitive training group, but not for the two control groups, we observed an increase in response accuracy at posttest, irrespective of task and trial type. No training-related effects on reaction times were found. Cognitive training was also associated with an overall increase in N2 amplitude and a decrease of P2 latency on single trials. Training-related performance gains were thus likely mediated by an enhancement of response selection and improved access to relevant stimulus-response mappings. Additionally, cognitive training was associated with an amplitude decrease in the time window of the target-locked P3 at fronto-central electrodes. An increase in the switch positivity during advance task preparation emerged after both cognitive and relaxation training. Training-related behavioral and event-related potential (ERP) effects were not modulated by task difficulty. The data suggest that cognitive training increased slow negative potentials during target processing which enhanced the N2 and reduced a subsequent P3-like component on both switch and non-switch trials and irrespective of task difficulty. Our findings further corroborate the effectiveness of multi-domain cognitive training in older adults and indicate that ERPs can be instrumental in uncovering the neural processes underlying training-related performance gains.

V21. Electrophysiological correlates of auditory change detection: A simultaneous depth and scalp EEG study

Introduction Attentive monitoring of the environment is fundamental for efficient detection of relevant stimuli and is well investigated for cortical regions. However, subcortical network circuitry and the involvement of these structures in the context of detection of relevant stimuli, involuntary attention and distractibility is not well understood. The P300 component is frequently used in electroencephalographic (EEG) studies as a measure for attentional and cognitive functions and is supposed to give further insight into context-specific processes of subcortical structures. Methods In this ongoing study, simultaneous recordings of local field potentials (LFPs) and event-related potentials (ERPs) from scalp EEG were obtained in 14 patients (mean age = 51.6 ± 21.7 years) undergoing deep brain stimulation (DBS). These patients were implanted bilaterally with quadripolar electrodes in the subthalamic nucleus (STN; n = 5; Parkinson disease), the thalamic ventral intermediate nucleus (VIM; n = 5; essential tremor and cervical dystonia), or the globus pallidus internus (GPi; n = 4; segmental dystonia, Parkinson disease and Tourette syndrome). Within five days after surgery, patients performed an auditory three-class oddball paradigm with externalized DBS electrodes. ERPs from scalp and DBS electrodes were analyzed upon presentation of one frequent standard stimulus (900 Hz; 72%) and two infrequent stimuli, either being a relevant (1200 Hz; 14%) or a distractor (600 Hz; 14%) stimulus. Stimuli were presented for 62 ms with an interstimulus interval of 800–1200 ms. The patients were asked to press a button to the relevant stimulus. Results Analysis reveals high accuracy in all patients (84.25%±15.14). Preliminary EEG results show a P300 component over parietal regions that was largest upon presentation of target stimuli compared with distractor and standard stimuli. A similar P300-like component was also found in depth recordings, suggesting stimulus-specific responses of subcortical structures. Here, STN showed shorter latencies and larger amplitudes compared to GPi or Vim. Discussion The P300 reflects attentional processes that require stimulus detection and discrimination. The present results suggest that, in particular, the STN may play a pivotal role in context-specific processes.

Less Efficient Neural Processing Related to Irregular Sleep and Less Sustained Attention in Toddlers

The current study used event-related potentials to examine a candidate process through which sleep difficulties affect attentional processing in toddlers. Fifteen toddlers participated in an auditory Oddball task while neurophysiological data were collected. Sleep deficits were assessed using actigraphs, and attention was examined with a sustained attention task. A P3-like component was elicited from the toddlers, and longer target P3 latencies were associated with poorer sustained attention and irregular sleep. Findings suggest that irregular sleep is associated with less efficient attentional processing as reflected by the P3 component, and that longer target P3 latencies are associated with poorer sustained attention.

An averaging technique for the P300 spatial distribution.

This article is part of the Focus Theme of Methods of Information in Medicine on "Biosignal Interpretation: Advanced Methods for Neural Signals and Images". The main objectives of the paper regard the analysis of amplitude spatial distribution of the P300 evoked potential over a scalp of a particular subject and finding an averaged spatial distribution template for that subject. This template, which may differ for two different subjects, can help in getting a more accurate P300 detection for all BCIs that inherently use spatial filtering to detect P300 signal. Finally, the proposed averaging technique for a particular subject obtains an averaged spatial distribution template through only several epochs, which makes the proposed averaging technique fast and possible to use without applying any prior training data as in case of data enhancement technique. The method used in the proposed framework for the averaging of spatial distribution of P300 evoked potentials is based on the statistical properties of independent components (ICs). These components are obtained by using independent component analysis (ICA) from different target epochs. This paper gives a novel averaging technique for the spatial distribution of P300 evoked potentials, which is based on the P300 signals obtained from different target epochs using the ICA algorithm. Such a technique provides a more reliable P300 spatial distribution for a subject of interest, which can be used either for an improved spatial selection of ICs, or more accurate P300 detection and extraction. In addition, the experiments demonstrate that the values of spatial intensity computed by the proposed technique for P300 signal converge after only several target epochs for each electrode allocation. Such a speed of convergence allows the proposed algorithm to easily adapt to a subject of interest without any additional artificial data preparation prior the algorithm execution such in case of data enhancement technique. The proposed technique averages the P300 spatial distribution for a particular subject over all electrode allocations. First, the technique combines P300-like components obtained by the ICA run within a target epoch in order to obtainan averaged P300 spatial distribution. Second, the technique averages spatial distributions of P300 signals obtained from different target epochs in order to get the final averaged template. Such an template can be useful for any BCI technique where spatial selection is used to detect evoked potentials.

Temporal characteristics of online syntactic sentence planning: an event-related potential study.

During sentence production, linguistic information (semantics, syntax, phonology) of words is retrieved and assembled into a meaningful utterance. There is still debate on how we assemble single words into more complex syntactic structures such as noun phrases or sentences. In the present study, event-related potentials (ERPs) were used to investigate the time course of syntactic planning. Thirty-three volunteers described visually animated scenes using naming formats varying in syntactic complexity: from simple words (‘W’, e.g., “triangle”, “red”, “square”, “green”, “to fly towards”), to noun phrases (‘NP’, e.g., “the red triangle”, “the green square”, “to fly towards”), to a sentence (‘S’, e.g., “The red triangle flies towards the green square.”). Behaviourally, we observed an increase in errors and corrections with increasing syntactic complexity, indicating a successful experimental manipulation. In the ERPs following scene onset, syntactic complexity variations were found in a P300-like component (‘S’/‘NP’>‘W’) and a fronto-central negativity (linear increase with syntactic complexity). In addition, the scene could display two actions - unpredictable for the participant, as the disambiguation occurred only later in the animation. Time-locked to the moment of visual disambiguation of the action and thus the verb, we observed another P300 component (‘S’>‘NP’/‘W’). The data show for the first time evidence of sensitivity to syntactic planning within the P300 time window, time-locked to visual events critical of syntactic planning. We discuss the findings in the light of current syntactic planning views.

Left temporal alpha-band activity reflects single word intelligibility

The electroencephalographic (EEG) correlates of degraded speech perception have been explored in a number of recent studies. However, such investigations have often been inconclusive as to whether observed differences in brain responses between conditions result from different acoustic properties of more or less intelligible stimuli or whether they relate to cognitive processes implicated in comprehending challenging stimuli. In this study we used noise vocoding to spectrally degrade monosyllabic words in order to manipulate their intelligibility. We used spectral rotation to generate incomprehensible control conditions matched in terms of spectral detail. We recorded EEG from 14 volunteers who listened to a series of noise vocoded (NV) and noise-vocoded spectrally-rotated (rNV) words, while they carried out a detection task. We specifically sought components of the EEG response that showed an interaction between spectral rotation and spectral degradation. This reflects those aspects of the brain electrical response that are related to the intelligibility of acoustically degraded monosyllabic words, while controlling for spectral detail. An interaction between spectral complexity and rotation was apparent in both evoked and induced activity. Analyses of event-related potentials showed an interaction effect for a P300-like component at several centro-parietal electrodes. Time-frequency analysis of the EEG signal in the alpha-band revealed a monotonic increase in event-related desynchronization (ERD) for the NV but not the rNV stimuli in the alpha band at a left temporo-central electrode cluster from 420–560 ms reflecting a direct relationship between the strength of alpha-band ERD and intelligibility. By matching NV words with their incomprehensible rNV homologues, we reveal the spatiotemporal pattern of evoked and induced processes involved in degraded speech perception, largely uncontaminated by purely acoustic effects.

Electrophysiological Indicators of Visuomotor Planning: Delay-Dependent Changes

A visuomotor task was used to investigate the influence of a varying response delay on the evoked activity measured during motor planning. Participants performed one-dimensional hand movements to visual targets after 200-, 1,000-, and 5,000- msec. delays with respect to the target offset. In response to an imperative go signal, similar deflections were observed over motor areas in all delay conditions. In contrast, activity at posterior electrodes was strongly delay-dependent. During the shortest delay condition, evoked alpha oscillations were pronounced at occipitoparietal recording sites and were accompanied by P300-like positive waves. In contrast, when the delay was either 1,000 or 5,000 msec., lateral occipitotemporal deflections (N1) were observed. Also, during the longest delay condition another P300-like component was measured, which was entirely absent when the delay was 1,000 msec. These results suggest that neurophysiological processes underlie motor planning, change depending on the time of response.

Rapid Automatized Naming and Lexical Decision in Children from an Electrophysiological Perspective

Rapid Automatized Naming (RAN) deficits have been associated with less developed orthographic abilities that may affect lexical decisions. The effects of Spanish-speaking children's RAN performance on lexical decisions were evaluated by analyzing ERP and behavioral measures. Based upon their naming speed in four RAN tasks, 28 normal IQ, right-handed, 7-year-old children were selected and divided uniformly into two groups: average-naming (AN), and slow-naming (SN). ERPs were obtained during a lexical decision task consisting of 100 strings of four sequentially-presented letters that completed words (50 trials) or pseudowords (also 50 trials). The SN group showed major reading difficulties when compared to the AN group, as well as a significantly lower number of correct responses and slower reaction times in the lexical task. Two main ERP components were observed: parietal N320, interpreted as analogous to N170/N200; and a subsequent P3-like component (P500) with a higher amplitude for pseudowords, which probably reflects higher cognitive demands. Better reading comprehension and fewer misread pseudowords correlated with minor N320 latencies, while lower N320 amplitudes for words correlated with faster reading speeds, lower naming times and fewer errors while reading a text. The present results suggest that naming speed and ERP seem to be valuable in distinguishing early orthographic stored code retrieval abilities through a lexical decision task. Moreover, RAN and ERP emerge as accurate tools for evaluating reading processes in the early stages of reading acquisition.

Neural Correlates of Generic versus Gender-specific Face Adaptation

The perception of facial gender has been found to be adaptively recalibrated: adaptation to male faces causes participants to perceive subsequent faces as more feminine and vice versa [Webster, M. A., Kaping, D., Mizokami, Y., & Duhamel, P. Adaptation to natural facial categories. Nature, 428, 557-561, 2004]. In an event-related brain potential (ERP) study, Kovács et al. [Kovács, G., Zimmer, M., Banko, E., Harza, I., Antal, A., & Vidnyanszky, Z. Electrophysiological correlates of visual adaptation to faces and body parts in humans. Cerebral Cortex, 16, 742-753, 2006] reported reduced N170 amplitudes and increased latencies for test faces following female gender adaptation compared to control stimulus (a phase randomized face) adaptation. We examined whether this N170 attenuation to test faces was related to the adaptor's gender, or to adaptation to face exposure in general. We compared N170 effects after adaptation to either male or androgynous faces. Additionally, we investigated cross-modal adaptation for the same test faces following male or androgynous voice adaptors. Visual adaptation to face gender replicated previously reported aftereffects in classifying androgynous faces, and a similar trend was observed following adaptation to voice gender. Strikingly, N170 amplitudes were dramatically reduced for faces following face adaptors (relative to those following voice adaptors), whereas only minimal gender-specific adaptation effects were seen in the N170. By contrast, strong gender-specific adaptation effects appeared in a centroparietal P3-like component (approximately 400-600 msec), which in the context of adaptation may reflect a neural correlate of the detection of perceptual novelty.

Identification of rat P3-like processes in the anterior cingulate cortex and hippocampus

The purpose of this study was to investigate whether the rat P3-like potential reflects “attention processes” rather than “arousal level”. After controlling for arousal levels, event-related potentials (ERPs) of the rat were recorded at the anterior cingulate cortex and hippocampal CA1 during active and passive oddball paradigms. The arousal level of the passive group was equivalent to that of the active group, while the amplitude of the P3-like potential during the active paradigm was greater than that during the passive paradigm for both sites. These results provide evidence that the rat P3-like component reflects “attention processes”, which is also the case for the human P3 component. Rats can provide a useful model for investigation of the neural mechanisms of the P3 in humans.

Processing of Auditory Location Changes after Horizontal Head Rotation

Under natural conditions, our sound localization capabilities enable us to move constantly while keeping a stable representation of our auditory environment. However, since most auditory studies focus on head-restrained conditions, it is still unclear whether neurophysiological markers of auditory spatial processing reflect representation in a head-centered or an allocentric coordinate system. Therefore, we used human electroencephalography to test whether the spatial mismatch negativity (MMN) as a marker of spatial change processing is elicited by changes of sound source position in terms of a head-related or an allocentric coordinate system. Subjects listened to a series of virtually localized band-passed noise tones and were occasionally cued visually to conduct horizontal head movements. After these head movements, we presented deviants either in terms of a head-centered or an allocentric coordinate system. We observed significant MMN responses to the head-related deviants only but a change-related novelty P3-like component for both head-related and allocentric deviants. These results thus suggest that the spatial MMN is associated with a representation of auditory space in a head-related coordinate system and that the integration of motor output and auditory input possibly occurs at later stages of the auditory "where" processing stream.

Non-musicians’ perception of phrase boundaries in music: A cross-cultural ERP study

The present study investigates neural responses to musical phrase boundaries in subjects without formal musical training, with special emphasis on the issue of cultural familiarity (i.e., the relation between the enculturation of the subjects and the cultural style of the presented music). German and Chinese non-musicians listened to Western and Chinese melodies which contained manipulated phrase boundaries while event-related potentials (ERP) were measured. The behavioral data clearly showed that melodic phrase boundary perception is influenced by cultural familiarity. The ERP revealed a series of positive and negative peaks with latencies between 40 ms and 550 ms relative to the phrase boundary offset, all of which were influenced by the phrase melodic structure type. In contrast, cultural familiarity only influenced phrase boundary processing at longer latencies, reflected by a P3-like component peaking at 280 ms. At about 450–600 ms post phrase boundary offset, we observed a slightly right-lateralized music closure positive shift (CPS), which has been reported as a marker for phrase boundary processing in musicians in earlier studies. This study demonstrates for the first time that the music CPS can be elicited in non-musicians, suggesting that the underlying phrase boundary processing does not require formal musical training.

Risk-Taking and the Feedback Negativity Response to Loss among At-Risk Adolescents

Event-related brain potentials were examined in 32 adolescents (50% female) from a high-risk sample, who were exposed to cocaine and other drugs prenatally. Adolescents were selected for extreme high- or low-risk behavior on the Balloon Analog Risk Task, a measure of real-world risk-taking propensity. The feedback error-related negativity (fERN), an event-related potential (ERP) that occurs when an expected reward does not occur, was examined in a game in which choices lead to monetary gains and losses with feedback delayed 1 or 2 s. The fERN was clearly visible in the fronto-central scalp region in this adolescent sample. Feedback type, feedback delay, risk status, and sex were all associated with fERN variability. Monetary feedback also elicited a P300-like component, moderated by delay and sex. Delaying reward feedback may provide a means for studying complementary functioning of dopamine and norepinephrine systems.