To effectively combat the re-infestation of boll weevils (Anthonomus grandis L.) in cotton fields, it is necessary to address the detection of volunteer cotton (VC) plants (Gossypium hirsutum L.) in rotation crops such as corn (Zea mays L.) and sorghum (Sorghum bicolor L.). The current practice involves manual field scouting at the field edges, which often leads to the oversight of VC plants growing in the middle of fields alongside corn and sorghum. As these VC plants reach the pinhead squaring stage (5–6 leaves), they can become hosts for boll weevil pests. Consequently, it becomes crucial to detect, locate, and accurately spot-spray these plants with appropriate chemicals. This paper focuses on the application of YOLOv5m to detect and locate VC plants during the tasseling (VT) growth stage of cornfields. Our results demonstrate that VC plants can be detected with a mean average precision (mAP) of 79% at an Intersection over Union (IoU) of 50% and a classification accuracy of 78% on images sized 1207 × 923 pixels. The average detection inference speed is 47 frames per second (FPS) on the NVIDIA Tesla P100 GPU-16 GB and 0.4 FPS on the NVIDIA Jetson TX2 GPU, which underscores the relevance and impact of detection speed on the feasibility of real-time applications. Additionally, we show the application of a customized unmanned aircraft system (UAS) for spot-spray applications through simulation based on the developed computer vision (CV) algorithm. This UAS-based approach enables the near-real-time detection and mitigation of VC plants in corn fields, with near-real-time defined as approximately 0.02 s per frame on the NVIDIA Tesla P100 GPU and 2.5 s per frame on the NVIDIA Jetson TX2 GPU, thereby offering an efficient management solution for controlling boll weevil pests.
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