Dengue hemorrhagic fever (DHF) or Dengue Hemorrhagic Fever (DHF) is an acute febrile disease accompanied by internal bleeding that has a tendency to cause shock or convulsions and can cause death, generally this disease attacks children younger than age. than 15 years.The method used in this study is a survey method which was conducted by distributing questionnaires and direct interviews to respondents with a case control approach. From the research survey of 198 respondents, there were 18 respondents (9.1%) who experienced the incidence of DHF and 180 respondents (90.9%) who did not. There is an analysis between the implementation of 4M Plus and the incidence of DHF in the working area of the Semen Health Center because the p-value Sig. 0.000 < 0.05, which means that H0 is rejected and H1 is accepted, then there is a relationship between the application of 4M plus and the incidence of DHF. The better the implementation of 4M plus, the lower the incidence of DHF, conversely if the implementation of 4M plus is not good, the higher the incidence of DHF.