An approach to design analog building blocks based on digital standard cells is presented in this work. By ensuring that every CMOS inverter from a standard-cell library operates with a well-defined quiescent current and output voltage, the suggested method makes it possible to construct analog circuits that are resistant against PVT variations. The method uses the local supply voltages connected to the source terminals of the p-channel and n-channel MOS transistors of the standard-cell inverters as control inputs. It is based on adaptive supply voltage generator (ASVG) reusable blocks, which are comparable to those used in digital applications to handle process variations. All of the standard-cell inverters used for analog functions receive the local supply voltages produced by the ASVGs, which enable setting each cell’s quiescent current to a multiple of a reference current and each cell’s static output voltage to an appropriate reference voltage. Both the complete custom design of the ASVG blocks and a theoretical study of the feedback loop of the ASVG are presented. An application example through the design of a fully synthesizable two-stage operational transconductance amplifier (OTA) is also provided. The TSMC 180 nm CMOS technology has been used to implement both the OTA and the ASV generators. Simulation results have demonstrated that the proposed approach allows to accurately set the quiescent current of standard-cell inverters, dramatically reducing the effect of PVT variations on the pmain performance parameters of the standard-cell-based two-stage OTA.