Oxygen Equivalent Research Articles

The effect of staged versus rapid immersion on the cardio-respiratory components of the cold-shock response

Drowning is one of the leading causes of accidental death. Sudden cold-water immersion (CWI) leads to the stimulation of cutaneous cold receptors causing the cold-shock response (CSR) which includes a gasp, hyperventilation, and tachycardia for several minutes. Only one study has investigated staged CWI (Hayward and French, 1989, Av Space Env Med, 60, 1163-1165) and found a reduction in minute ventilation (V̇E) and respiratory frequency (fB) occurred when immersed to the waist for 30 s followed by to the shoulders. However, it is unclear whether a staged entry with a longer or shorter period at the waist would elicit a greater or lesser CSR. Thus, the aim of this study is to establish whether a staged immersion with a longer period immersed to the waist would attenuate the initial cardio-respiratory responses associated with CWI, when compared with rapid immersion. Ethical approval was gained from the University of Portsmouth Science Faculty Research Ethics Committee (SHFEC 2020-070). Seven male participants completed two, 5 min immersions that occurred at the same time of day (± 2 h) to avoid circadian variation in internal body temperature: a staged immersion (immersion to the iliac crest for 2 min prior to immersion to the acromion process); a rapid immersion (immersion to the acromion process for 5 min). Participants were lowered into stirred water (15°C) at a rate of 4 s to the waist, 4 s to the shoulder. Inspiratory and expiratory data were collected using a ventilatory turbine module and Douglas bags, respectively, whilst heart rate data was collected using a three-lead ECG. Variables were analysed over the first 30 s of immersion by a one-way ANOVA and a Tukey post hoc test. Effect sizes were calculated using Cohen’s d. Staged immersion to the waist resulted in a significantly lower fB (P < 0.05; d = 1.54) and V ̇E (P < 0.01; d = 1.96) over the first 30 s epoch, when compared to rapid immersion. Staged immersion to the shoulders resulted in a lower ventilatory equivalent of oxygen (P < 0.005; d = 1.95). There was no difference in heart rate between immersions. A staged immersion to the waist resulted in a 36.2% lower V̇E and 29.4% lower fB, potentially due to fewer cutaneous cold receptors being stimulated. This reduces the potential to aspirate water due to a lower ventilatory drive, therefore, could reduce drowning incidence attributed to the CSR.

Field-training in young two-year-old thoroughbreds: investigating cardiorespiratory adaptations and the presence of exercise induced pulmonary hemorrhage

BackgroundComparatively little is known regarding the initial cardiorespiratory response of young racehorses to training. The objectives were to compare physiological parameters before and after introductory training and determine whether young Thoroughbreds show endoscopic signs of exercise-induced pulmonary hemorrhage (EIPH). Ten Thoroughbreds (20–23 months) underwent 12-weeks of introductory training, including weekly speed sessions. Two 600 m high-speed exercise tests (HSET) were performed following weeks 4 and 12 while wearing a validated ergospirometry facemask. Peak oxygen consumption (V̇O2pk) and ventilatory parameters (tidal volume, VT; peak inspiratory and expiratory flow, PkV̇I, PkV̇E; respiratory frequency, Rf; minute ventilation, V̇E) were measured. The ventilatory equivalent of oxygen (V̇E/V̇O2) and the aerobic and anaerobic contributions to energy production were calculated. Maximal heart rate (HRmax) and HR at maximal speed (HRVmax) were determined. Post-exercise hematocrit, plasma ammonia and blood lactate were measured. Evidence of EIPH was investigated via tracheobronchoscopy post-exercise. Results were compared (paired t-test, P < 0.05).ResultsHorses were faster following training (P < 0.001) and V̇O2pk increased 28 ml/(kg total mass.min) (28 ± 16%; P < 0.001). Ventilatory (V̇E, P = 0.0015; Rf, P < 0.001; PkV̇I, P < 0.001; PkV̇E, P < 0.001) and cardiovascular parameters (HRmax, P = 0.03; HRVmax, P = 0.04) increased. The increase in V̇E was due to greater Rf, but not VT. V̇E/V̇O2 was lower (26 ± 3.6 vs 23 ± 3.7; P = 0.02), indicating improved ventilatory efficiency. Anaerobic contribution to total energy production increased from 15.6 ± 6.1% to 18.5 ± 6.3% (P = 0.02). Post-exercise hematocrit (P < 0.001), plasma ammonia (P = 0.03) and blood lactate (P = 0.001) increased following training. Horses showed no signs of EIPH.ConclusionsYoung two-year-old Thoroughbreds responded well to introductory training without developing tracheobronchoscopic evidence of EIPH.

Calculation of a conversion factor for estimating the glycolytic contribution in exercise from post-exercise blood lactate concentration.

Purpose: Often, the glycolytic contribution in a bout of heavy or severe intensity exercise is estimated by multiplying the increase in blood lactate concentration above resting levels that is engendered by the exercise (in mM) by 3.3 (or 3) mL·kg-1 per mM. Our purpose was to verify the value of this conversion factor, using methods that were completely different from those of the original studies. Methods: Six women (mean ± SD), age, 23 ± 1year; VO2max, 46 ± 4mL·kg-1·min-1) and three men (23 ± 0years; 54 ± 8mL·kg-1·min-1) completed 6min of heavy intensity exercise in conditions of normoxia and hypoxia (FIO2, ∼12%). VO2 was measured throughout the exercise and 7min of recovery. The increase in glycolytic contribution was estimated as the reduction in aerobic contribution in hypoxia, after correction for the effects of hypoxia on the oxygen demand and on the contribution from phosphocreatine. The peak post-exercise blood lactate concentration was measured in fingerstick blood samples. Results: The ratio between the increase in estimated glycolytic contribution (in mL·kg-1) in hypoxia and the increase in peak blood lactate concentration (in mM) yielded an oxygen equivalent of 3.4 ± 0.4mL·kg-1 per mM (range, 2.6mL·kg-1 per mM to 4.0mL·kg-1 per mM) for cycle ergometer exercise. Conclusion: These results generally support the use of a common conversion factor to calculate the glycolytic contribution from post-exercise blood lactate concentrations. However, there is some inter-individual variability in the conversion factor.

Wastewater Characterization: Chemical Oxygen Demand or Total Organic Carbon Content Measurement?

The long time (2 h) required for measurement, expensive chemicals (Ag2SO4), and toxic reagents (K2Cr2O7, HgSO4) limit the application of the standard method for measuring the oxygen equivalent of organic content in wastewater (chemical oxygen demand, COD). In recent years, the COD has increasingly been replaced by the total organic carbon (TOC) parameter. Since the limit values of the pollution levels are usually given in terms of the COD, efforts are being made to find the correlation between these parameters. Several papers have published correlation analyses of COD and TOC for industrial and municipal wastewater, but the relationship has not been discussed for individual chemicals. Here, this relationship was investigated using 70 contaminants (laboratory chemicals, pharmaceuticals, and pesticides). The calculated COD values, in most cases, agreed, within ~10%, with the experimental ones; for tetracyclines and some chloroaromatic molecules, the measured values were 20-50% lower than the calculated values. The COD/TOC ratios were between 2 and 3: for macrolides, they were ~3; for fluoroquinolones and tetracyclines, they were ~2. The molecular structure dependence of the ratio necessitates the establishing of the correlation on an individual basis. In advanced oxidation processes (AOPs), the ratio changes during degradation, limiting the application of TOC instead of COD.

Isothiocyanates: happy-go-lucky reagents in organic synthesis.

Owing to their unique structural features, isothiocyanates (ITCs) are a class of highly useful and inimitable reagents as the -NCS group serves both as electrophile and nucleophile in organic synthesis. ITCs share a rich legacy in organic, medicinal, and combinatorial chemistry. Compared to their oxygen equivalents, isocyanates, ITCs are easily available, less unpleasant, and somewhat less harmful to work with (mild conditions) which makes them happy-go-lucky reagents. Functionalized ITCs can finely tune the reactivity of the -NCS group and thus can be exploited in the late-stage functionalization processes. This review's primary aim is to outline ITC chemistry in the construction and derivatization of heterocycles through the lens of sustainability. For ease and brevity, the sections are divided based on reactive centers present in functionalized ITCs and modes of cyclisation. Scrutinizing their probable unexplored directions for future research studies is also addressed.

Validation of the AC[La]+EPOCfast Method in Sprinters and Middle-distance Runners.

The anaerobic capacity (AC[La]+EPOCfast) method is of interest as it can differentiate between the contributions of phosphocreatine (PCr) and glycolytic energy, assess the anaerobic metabolism during a single effort, and evaluate various exercise modalities. However, no previous studies have investigated whether the superiority of the PCr and glycolytic systems can be assessed in athletes with high anaerobic capacity. This study aimed to compare the AC[La]+EPOCfast method in seven sprinters (SP) and seven middle-distance runners (MD). The participants underwent a graded exercise test and constant-load exercise at 115% ˙VO2max until exhaustion using a bicycle ergometer. AC[La]+EPOCfast was calculated as the sum of oxygen equivalents from the phosphagen (EPCr) and glycolytic (ELa) pathways. This study reveals that there was no significant difference in AC[La]+EPOCfast or maximal accumulated oxygen deficit (MAOD) between the two groups. Although EPCr was not significantly different between groups, ELa was significantly higher in the SP group than in the MD group. In conclusion, the AC[La]+EPOCfast method can be used to evaluate high and low anaerobic capacities. However, further studies on athletes with high aerobic capacity are required.

The Identity of Nickel Peroxide as a Nickel Superoxyhydroxide for Enhanced Electrocatalysis.

Nickel peroxides are a class of stoichiometric oxidants that can selectively oxidize various organic compounds, but their molecular level structure remained elusive until now. Herein, we utilized structural prediction using the Stochastic Surface Walking method based on a neural network potential energy surface and advanced characterization using the as-synthesized nickel peroxide to unravel its chemical identity as the bridging superoxide containing nickel hydroxide, or nickel superoxyhydroxide. Superoxide incorporation tunes the local chemical environment of nickel and oxygen beyond the conventional Bode plot, offering a 6.4-fold increase in the electrocatalytic activity of urea oxidation. A volcanic dependence of the activity on the oxygen equivalents leads to the proposed active site of the Ni(OO)(OH)Ni five-membered ring. This work not only unveils the possible structures of nickel peroxides but also emphasizes the significance of tailoring the oxygen environment for advanced catalysis.

Long-term effects of physical training on cardiopulmonary exercise parameters in young patients with congenital heart diseases.

Physical activity is recognised as an important intervention in patients with CHD. However, more data on the actual magnitude of physical training impact on functional capacity in this group of patients are still warranted. We aim to assess effort tolerance in a contemporary cohort of patients with congenital heart disease, regularly following a training programme, in comparison with a matched control group. Patients with CHD followed at the sports medicine department, who had undergone cardiopulmonary exercise test between 2011 and 2019, were included. Variables recorded were maximum workload, absolute and indexed maximum oxygen consumption, maximum heart rate, absolute and indexed maximum O2 pulse, ventilatory equivalent of CO2 and oxygen consumption/Work. Trend of cardiopulmonary parameters was analysed over time. Maximal workload, maximum oxygen consumption and ventilatory equivalent of CO2 were compared with a control group of patients with a more sedentary lifestyle, matched for diagnosis, gender, age, and body mass index. Among one hundred and eleven patients, 73 males (66%) were analysed. Median age was 14 (12-17) years. Twenty-nine patients (27%) were practising sports at competitive level. Maximum oxygen consumption and oxygen consumption % of maximum predicted were not significantly different at follow-up as compared with baseline. Follow-up of maximum oxygen consumption was 38.2 ± 9 ml/kg/min versus 38.6 ± 9.2 ml/kg/min (p = NS) and follow-up of %oxygen consumption was 88 ± 20 versus 87 ± 15 (p = NS). Ventilatory equivalent of CO2 significantly improved in the last test as compared with the baseline: 30 ± 4 versus 33 ± 5 (p = 0.002). As compared with the control group, trained patients displayed a significantly higher maximum workload and oxygen consumption, while ventilatory equivalent of CO2 was not significantly different. In our cohort, patients following a regular training programme displayed a significantly higher functional capacity as compared with not trained control group, irrespective of NYHA class. Objective functional capacity was stable over a median follow-up of 3 years.

The Reliability of a Single-Trial Measurement of Maximal Accumulated Oxygen Deficit Determined via Perceptually-Regulated Exercise

ABSTRACT Purpose: The aim of this study was to evaluate the reliability of a single-trial determination of maximal accumulated oxygen deficit (MAOD) achieved via the aid of perceptually-regulated incremental exercise. Methods: 14 trained male cyclists (age: 45 ± 8 yrs; height: 1.82 ± 0.06 m; mass: 79.7 ± 6.7 kg; V ˙ O 2 max : 4.09 ± 0.57 L·min−1) performed three trials of a submaximal incremental cycling test followed by a test to exhaustion at 116% of predicted V ˙ O 2 max . The intensity for each stage of the incremental test was regulated by participants to elicit perceived exertion levels of 9–15 on the Borg (6–20) scale. Linear regression was used to estimate V ˙ O 2 max at a perceived exertion level of 19. MAOD was calculated from the difference between predicted and actual oxygen demand in the test to exhaustion, reported in oxygen equivalents (O2 eq). A separate incremental test was used to measure V ˙ O 2 max directly. Results: Correlation coefficients between perceived exertion and V ˙ O 2 across trials were strong (r ≥0.99), and there were no between-trial differences in predicted V ˙ O 2 max (4.03 ± 1.04, 3.76 ± 0.53, and 3.69 ± 0.64 L·min−1, respectively; p = .142) or MAOD (2.75 ± 2.28, 2.50 ± 1.53, and 2.93 ± 1.40 L O2 eq, respectively; p = .633). Nevertheless, the coefficients of variation for predicted V ˙ O 2 max (14.2%) and MAOD (142.8%) were poor. Conclusions: The prediction of V ˙ O 2 max from perceptually-regulated exercise displays a level of test-retest reliability which prevents its use as a means of evaluating MAOD reliably in a single-trial.

Influence of oxygen equivalent on molten salt oxidation efficiency of mixed resin in Li2CO3-Na2CO3-K2CO3 melt

The disposal of spent radioactive ion exchange resin generated during the operation of nuclear facilities has always been a conundrum. The molten salt oxidation (MSO) for the treatment of mixed resin (MR) shows obvious superiority. In this work, ternary carbonate (Li2CO3-Na2CO3-K2CO3) and MR was used as the molten salt system and the oxidation target, respectively. The oxidation behavior of MR was analyzed by varying the temperature and oxygen equivalent during the MSO process. By studying the effect of different oxygen equivalents on the oxidation efficiency, the oxygen equivalent of 125% could make the oxidation efficiency of MR reach 99.99% at 800 °C. The composition of C, N and S containing exhaust gas produced through MSO process of MR with temperature were almost consistent with the simulation results. The exhaust gas was successfully adsorbed by molten carbonate to produce nitrate and sulfur compounds. The carbonate has good absorption to harmful gases such as SO2, CO, NO, etc. The content of SO2 from the highest 0.32% to 0, and 71.23% of sulfur in MR was trapped by molten carbonate as the form of sulfate. This work has important implications for reducing the potential harm of radioactive waste resin to the environment.

Directed-energy deposition of Ti-6Al-4V alloy using fresh and recycled feedstock powders under reactive atmosphere

This research studies the directed-energy deposition of Ti-6Al-4V (wt%) in an argon atmosphere containing 9–9500 ppm oxygen (from air), using both fresh and recycled feedstock powders. For fresh powder builds, when exposed to a 3500 ppm oxygen-containing atmosphere, a yield strength (YS) of 1061 ± 0.6 MPa and an elongation-to-fracture (ETF) of 10.5 ± 1.6 % are obtained. The oxygen pickup in the build deposit tends to plateau at 1000 ppm beyond 3500 ppm oxygen exposure. Conversely, the nitrogen pickup shows an increasing trend, reaching 1000 ppm for the air exposure range investigated. Recycled powder builds are stronger but less ductile than equivalent fresh powder builds made under comparable atmospheres. A higher degree of interstitial element pickup with no apparent saturation is identified for builds made from recycled powders, due to their smaller average particle size and a correspondingly larger specific surface area. The resulting microstructure for all samples made with air exposure comprises full lamellar α + β, formed through the in-situ decomposition of martensite at a temperature close to 600 °C. This conclusion is supported by the β volume fraction at 600°C as predicted by Thermo-Calc agreeing with image analysis data. The α lath thickness is found to increase with air exposure level. The increased β-transus temperature and martensite start temperature, and the accelerated diffusion-driven phase transformation due to the presence of elevated interstitial element contents accounts for the α lath thickening behaviour. YS and ultimate tensile strength (UTS) are found to increase linearly with oxygen equivalent. Solid solution strengthening from nitrogen and oxygen pickup is responsible for this increase. YS and UTS models based on oxygen equivalent are proposed. Nitrogen and oxygen in the builds dictate the ETF, with nitrogen content being the more potent factor.

Repeatability of ventilatory, metabolic and biomechanical responses to an intermittent incremental swimming protocol

Objective. This study aimed to determine the repeatability of ventilatory, metabolic and biomechanical variables assessed at a large spectrum of front crawl swimming intensities. We hypothesized a strong agreement (combined with a small range of variation) between a typical step protocol performed in two experimental moments. Approach. Forty competitive swimmers performed a 7 × 200 m front crawl intermittent incremental protocol (0.05 m·s−1 velocity rises and 30 s intervals) on two different occasions (48–72 h apart). Pulmonary gas exchange and ventilation were continuously measured breath-by-breath, metabolic variables were assessed during the intervals and biomechanical analysis was done at every protocol step. Main results. Concomitantly with the velocity increment, oxygen uptake, carbon dioxide production, ventilation, respiratory frequency, respiratory exchange ratio, averaged expiratory concentrations, end tidal oxygen and ventilatory equivalents for oxygen and carbon dioxide and blood lactate concentrations rose (p < 0.001), averaged expiratory concentrations and end tidal carbon dioxide and duration of inspiration, expiration and total breathing cycle decreased (p < 0.001), while tidal volume and volumes of oxygen and carbon dioxide expired maintained constant. Stroke frequency and stroke length increased and decreased (respectively) with the swimming velocity raise. No differences between experimental moments were observed in most of the assessed variables (p > 0.05), with a low dispersion (0.49%–9.94%) except for lactate concentrations and inspiration and expiration durations (11.00%–17.16%). Moderate-nearly perfect direct relationships and a good-excellent degree of reliability between moments were verified for all the assessed variables (r = 0.50–1.00, ICC = 0.76–1.00, p < 0.001), except for respiratory exchange ratio. Significance. The reliability analysis confirmed the repeatability of the assessed ventilatory, metabolic and biomechanical variables, with the obtained data well representing swimmers physiological condition when monitoring performance through a commonly used step protocol.

Status of LBNF/DUNE near site liquid argon proximity and external cryogenics systems development.

The Deep Underground Neutrino Experiment (DUNE) near site located at Fermilab will host the neutrino beam complex. It includes a high voltage liquid argon time projection chamber located 60-meter underground used as beamline instrumentation. The LAr cryogenic system provided by the Long-Baseline Neutrino Facility (LBNF) regulates thermohydraulic conditions of the membrane cryostat hosting the detector with 285 Ton purified LAr. The purification system uses molecular sieve and copper oxide pellets to manage the argon contamination below 100 ppt (parts per trillion) oxygen equivalent. The detector and its cryogenics are capable to move a stroke of 30 meters on/off beam. The cryogenic system modes of operation include the cryostat pressure test, purge in open loop, detector cooldown, cryostat fill, closed loop purification, liquid empty, and purification system activation/regeneration process. The system design status and schedule, and technical details such as operating modes and interfaces are reported in this paper.

Energetics contribution during no-gi Brazilian jiu jitsu sparring and its association with regional body composition.

We used measurements of metabolic perturbation obtained after sparring to estimate energetics contribution during no-gi Brazilian jiu-jitsu. Ten advanced grapplers performed two six-minute sparring bouts separated by 24 hours. Kinetics of recovery rate of oxygen uptake was modelled and post-combat-sparring blood-lactate concentration measured to estimate oxygen equivalents for phospholytic and glycolytic components of anaerobic energetics, respectively. Linear regression was used to estimate end-combat-sparring rate of oxygen uptake. Regional and whole-body composition were assessed using dual X-ray absorptiometry with associations between these measurements and energy turnover explored using Pearson’s correlation coefficient (significance, P < 0.05). Estimated oxygen equivalents for phospholytic and glycolytic contributions to anaerobic metabolism were 16.9 ± 8.4 (~28%) and 44.6 ± 13.5 (~72%) mL∙kg-1, respectively. Estimated end-exercise rate of oxygen uptake was 44.2 ± 7.0 mL∙kg-1∙min-1. Trunk lean mass was positively correlated with both total anaerobic and glycolytic-specific energetics (total, R = 0.645, p = 0.044; glycolytic, R = 0.692, p = 0.027) and negatively correlated with end-exercise rate of oxygen uptake (R = -0.650, p = 0.042). There were no correlations for any measurement of body composition and phospholytic-specific energetics. Six minutes of no-gi Brazilian jiu-jitsu sparring involves high relative contribution from the glycolytic component to total anaerobic energy provision and the link between this energetics profile and trunk lean mass is consistent with the predominance of ground-based combat that is unique for this combat sport. Training programs for Brazilian jiu-jitsu practitioners should be designed with consideration given to these specific energetics characteristics.

Cardiorespiratory, Metabolic and Muscular Responses during a Video-Recorded Aerobic Dance Session on an Air Dissipation Platform.

Background: Aerobic dance (AD) is an appropriate physical activity for improving cardiorespiratory fitness. This study aimed to compare cardiorespiratory and metabolic responses, and muscle fatigue between an air dissipation platform (ADP) and a hard surface during a video-recorded AD session. Methods: 25 healthy young women (23.3 ± 2.5 years) completed three sessions. In session 1, participants performed an incremental test to exhaustion on a treadmill. One week after session 1, participants were randomly assigned in a crossover design to perform video-recorded AD sessions on an ADP and on a hard surface (sessions 2 and 3). Cardiorespiratory and metabolic responses were assessed during AD sessions. Muscular fatigue was measured before and after AD sessions by a countermovement jump test. Results: Significantly higher heart rate, respiratory exchange ratio, pulmonary ventilation, ventilatory oxygen equivalent, and ventilatory carbon dioxide equivalent were observed on an ADP than on a hard surface (p < 0.05). Despite a significant increase in lactate levels on an ADP (p ≤ 0.01), muscular fatigue and perceived exertion rating were similar on both surfaces (p > 0.05). Conclusions: Video-recorded AD on an ADP increased the cardioventilatory and metabolic responses compared to a hard surface, preventing further muscle fatigue.

Design of a thermally resistant core@shell/halloysite catalyst with optimized structure and surface properties for a Pd-only three-way catalyst

In this study, two types of core@shell nanoparticles, CeO2@Pd and inverse Pd@CeO2 nanoparticles, were synthesized by sequential deposition and electrostatic attraction-induced deposition method, respectively. Then, the core@shell nanoparticles supported on halloysite were thermally treated at different temperatures, and the nascent core@shell/H-x catalysts were characterized and evaluated for their three-way catalytic performance. During the thermal treatment (650 °C, 800 °C, and 1100 °C), the CeO2@Pd/H-x catalysts showed strong temperature sensitivity, resulting in aggregation of the active metal particles, degradation of the textural properties, and weak interactions between the active sites and support, accompanied by the deactivation of the three-way reaction. Remarkably, Pd@CeO2/H-800 exhibits excellent catalytic performance because it has an appropriate Pd-CeO2 interaction and high thermal stability, which effectively suppresses the encapsulation and aggregation of Pd@CeO2 nanoparticles and imparts a high content of Ce3+ species and oxygen vacancies and equivalent of Pd2+/Pd° ratio.

CURRENT POSSIBILITIES OF USE OF INDIRECT CALORIMETRY IN PERIOPERATIVE ENERGY MONITORING

The purpose of the study is to develop a method of perioperative energy monitoring and to implement it in clinical practice.&#x0D; Material and methods. The study involved 125 patients who underwent various surgical interventions under general anesthesia using sevoflurane (inhalation anesthetics) and fentanyl (narcotic analgesics) in low-flow artificial lung ventilation. Methods of perioperative monitoring (International Standards for a Safe Practice of Anesthesia 2010, WFSA) were supplemented using indirect calorimetry.&#x0D; Results. Analyzing the literature data, a close correlation was found between the energy equivalent of oxygen (EEE2) and the respiratory factor (RQ). The authors obtained the corresponding one-factor linear regression formula, which had the form: EEE2 = 1.157 × RQ + 4,037. Using the basic principles of gas exchange in the lungs of Bohr-Engoff, a method of perioperative energy monitoring was developed, based on indirect calorimetry, taking into account the real values ​​of the energy equivalent of patients' oxygen. The universal formula for determining the level of metabolism of the patient (MR, cal / min) in the form of:&#x0D; MR = [0,863 × VE × (PECO2 / PaCO2) × (FiO2 - FeO2)] (1,157 × RQ + 4,037)&#x0D; where, VE - total ventilation of the lungs per minute (ml / min), PECO2, PaCO2 - partial pressure, respectively, in a mixture of gases, which is exhaled and in the arterial blood (mm Hg). FiO2 and FEO2 are the oxygen fraction in the gas mixture that is inhaled and exhaled in units (% / 100). The method is implemented as a computer program created on the basis of the developed formula. The methods of intensive perioperative therapy taking into account the level of metabolism are presented.&#x0D; Conclusion. The method of perioperative energy monitoring substantially complements the "International Standards for Safe Anesthesiology Practice", WFSA (2010) enhances the perioperative safety of patients by detecting metabolic disorders and conducting appropriate pathogenetic correction.

Net community oxygen production derived from Seaglider deployments at the Porcupine Abyssal Plain site (PAP; northeast Atlantic) in 2012–13

As part of the OSMOSIS project, a fleet of gliders surveyed the Porcupine Abyssal Plain site (Northeast Atlantic) from September 2012 to September 2013. Salinity, temperature, dissolved oxygen concentration and chlorophyll fluorescence were measured in the top 1000 m of the water column. Net community production (N) over an annual cycle using an oxygen-budget approach was compared to variations of several parameters (wind speed, mixing layer depth relative to euphotic depth, temperature, density, net heat flux) showing that the main theories (Critical Depth Hypothesis, Critical Turbulence Hypothesis, Heat-flux Hypothesis) can explain the switch between net heterotrophy to net autotrophy in different times of the year, The dynamics leading to an increase in productivity were related to shifts in regimes, such as the possible differences in nutrient concentration. The oxygen concentration profiles used for this study constitute a unique dataset spanning the entire productive season resulting in a data series longer than in previous studies. Net autotrophy was found at the site with a net production of (6.4 ± 1.9) mol m−2 in oxygen equivalents (or (4.3 ± 1.3) mol m−2 in carbon equivalents). The period exhibiting a deep chlorophyll maximum between 10 m and 40 m of depth contributed (1.5 ± 0.5) mol m−2 in oxygen equivalent to the total N. These results are greater than most previously published estimates.

DETERMINATION OF INDIVIDUAL GLUCOSE THRESHOLD USING PHARMACY PORTABLE BLOOD GLUCOSE METER

ABSTRACT Introduction The individual glucose threshold (IGT) has been used to estimate the anaerobic threshold with low-cost analyses and shorter times. However, the reliability of the glycemic analysis using a portable pharmacy glucose meter has received little attention. Objective To identify the IGT using a portable glucose meter and to compare it with the ventilatory threshold (VT). Methods Fourteen active, healthy men (25.9 ± 3.2 years; %BF = 17.9 ± 3.7%) performed an incremental treadmill test. The anaerobic threshold was identified by two different methods: (1) IGT, corresponding to the intensity of the lowest glucose value during the test; and (2) VT, corresponding to the break in linearity of the ventilation curve and an increase in the respiratory oxygen equivalent, without an equivalent increase in carbon dioxide. Results There were significant differences between VT (9.9 ± 1.2 km/h) and IGT (9.5 ± 1/1 km/h), corresponding to 75.4 ± 9.2 and 72.5 ± 10.4 %VO2max, respectively. The methods presented high correlation (r = 0.82, p = 0.002) and the Bland-Altman technique showed agreement between IGT and VT, with a mean difference of 0.5 km/h. Conclusion It was possible to determine the intensity of IGT by the glycemic response in the incremental test using a portable glucose meter. The IGT underestimated the intensity of VT by approximately 0.5 km/h, but with a high correlation and agreement between them. Level of evidence III, Case-Controle Study.

Medical Therapy for Systemic Right Ventricles: A Systematic Review (Part 1) for the 2018 AHA/ACC Guideline for the Management of Adults With Congenital Heart Disease: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines.

Patients with systemic morphological right ventricles (RVs), including congenitally corrected transposition of the great arteries and dextro-transposition of the great arteries with a Mustard or Senning atrial baffle repair, have a high likelihood of developing systemic ventricular dysfunction. Unfortunately, there are a limited number of clinical studies on the efficacy of medical therapy for systemic RV dysfunction. We performed a systematic review and meta-analysis to assess the effect of angiotensin-converting enzyme (ACE) inhibitors, angiotensin-receptor blockers (ARBs), beta blockers, and aldosterone antagonists in adults with systemic RVs. The inclusion criteria included age ≥18 years, systemic RVs, and at least 3 months of treatment with ACE inhibitor, ARB, beta blocker, or aldosterone antagonist. The outcomes included RV end-diastolic and end-systolic dimensions, RV ejection fraction, functional class, and exercise capacity. EMBASE, PubMed, and Cochrane databases were searched. The selected data were pooled and analyzed with the DerSimonian-Laird random-effects meta-analysis model. Between-study heterogeneity was assessed with Cochran's Q test. A Bayesian meta-analysis model was also used in the event that heterogeneity was low. Bias assessment was performed with the Newcastle-Ottawa Scale and Cochrane Risk of Bias Tool, and statistical risk of bias was assessed with Begg and Mazumdar's test and Egger's test. Six studies met the inclusion criteria, contributing a total of 187 patients; treatment with beta blocker was the intervention that could not be analyzed because of the small number of patients and diversity of outcomes reported. After at least 3 months of treatment with ACE inhibitors, ARBs, or aldosterone antagonists, there was no statistically significant change in mean ejection fraction, ventricular dimensions, or peak ventilatory equivalent of oxygen. The methodological quality of the majority of included studies was low, mainly because of a lack of a randomized and controlled design, small sample size, and incomplete follow-up. In conclusion, pooled results across the limited available studies did not provide conclusive evidence with regard to a beneficial effect of medical therapy in adults with systemic RV dysfunction. Randomized controlled trials or comparative-effectiveness studies that are sufficiently powered to demonstrate effect are needed to elucidate the efficacy of ACE inhibitors, ARBs, beta blockers, and aldosterone antagonists in patients with systemic RVs.