Oxidative Amidation Of Alcohols Research Articles

Cu42Ge24Na4—A Giant Trimetallic Sesquioxane Cage: Synthesis, Structure, and Catalytic Activity

Unprecedented germanium-based sesquioxane exhibits an extremely high nuclearity (Cu42Ge24Na4) and unusual encapsulation features. The compound demonstrated a high catalytic activity in the oxidative amidation of alcohols, with cost-effective catalyst loading down to 400 ppm of copper, and in the oxidation of cyclohexane and other alkanes with H2O2 in acetonitrile in the presence of nitric acid. Selectivity parameters and the mode of dependence of initial cyclohexane oxidation rate on initial concentration of the hydrocarbon indicate that the reaction occurs with the participation of hydroxyl radicals and alkyl hydroperoxides are formed as the main primary product. Alcohols have been transformed into the corresponding ketones by the catalytic oxidation with tert-butyl hydroperoxide.

ChemInform Abstract: TEMPO‐Catalyzed Oxidative Amidation of Alcohols via Hexafluoroisopropyl Esters.

AbstractThe title synthesis is compatible with many functional groups including acid‐sensitive protecting groups.

Copper-catalyzed one-pot oxidative amidation of alcohol to amide via C–H activation

Copper-catalyzed one-pot oxidative amidation of both aliphatic and aromatic alcohols with N-chloramines, prepared in situ from many types of primary and secondary amines, to form amides under mild conditions.

ChemInform Abstract: Copper‐Catalyzed Synthesis of Weinreb Amides by Oxidative Amidation of Alcohols.

AbstractThe efficient reaction protocol delivers various aryl and hetaryl substituted Weinreb amides in high yields.

Emerging Catalytic Methods for Amide Synthesis†

Amide is the key functional group in organic and biological chemistry as it is present in many natural products of therapeutic importance, peptides and polymers. There is continuous exploration of methodologies that can facilitate the user to choose the method of its interest regarding the availability of substrates and high atom economy. In this review, the catalytic methods developed in the past decade mainly focusing on oxidative amidation of alcohols, aldehydes, ketones and esters, aminocarbonylation of aryl halides, alkanes, alkenes and alkynes using transition metals such as Ru, Rh, Fe, Cu, Co, Pd, Ag, Au, Ir and Zr based catalysts have been discussed to highlight the emerging methodologies and expansion of research. The methods developed for the conversion of nitriles and oximes to corresponding amides have also been discussed. Keywords: Amides, aminocarbonylation, catalytic methods, nitrile hydration, oxidative amidation, transamidation

Oxidative Amidation of Alcohols with Amines Catalyzed by Au/DNA

Oxidative Amidation of Alcohols with Amines Catalyzed by Au/DNA