Background: The study is based on the Quality of life in patients operated with total knee replacement between 50 to 65 years. Total knee replacement is one of the common procedures performed globally and is considered cost-effective with excellent long-term survivorship. Although most patients have a favorable clinical outcome after TKR, several studies have reported that more than 20% of patients are dissatisfied with the outcome after the procedure. Therefore, measuring patients' Quality of life and their perception of the procedure is paramount to improving this procedure and increasing the proportion of patients who have successful outcomes and improved Quality of life. Methods: Patients operated with total knee replacement were included in the study and were screened with inclusion and exclusion criteria. A total of 20 individuals were assessed by using the Oxford knee score questionnaire, and their responses were noted. The result was found by descriptive statistical analysis. Result: On analysis using descriptive statistical analysis, the mean score of Oxford Knee Score is 30.95. Hence, the Quality of Life is considered fair in patients at 2 months after total knee replacement. Conclusion: From the results, we conclude that Quality of life remains fair in patients at 2 months after being operated with total knee replacement at a tertiary care hospital.