Oxford Academic Research Articles

Book Review

Journal Article Ludwig van Beethoven: A Very Short IntroductionMark Evan Bonds Get access Ludwig van Beethoven: A Very Short Introduction. By Mark Evan Bonds. Pp. 168. Very Short Introductions. ( Oxford University Press, New York and Oxford, 2022. ISBN 978–0–19–005173–0, $11.95.) Barry Cooper Barry Cooper University of Manchester Search for other works by this author on: Oxford Academic Google Scholar Music and Letters, gcad049, https://doi.org/10.1093/ml/gcad049 Published: 20 June 2023 Article history Editorial decision: 15 June 2023 Received: 15 June 2023 Corrected and typeset: 20 June 2023 Published: 20 June 2023

Thymus as Incontrovertible Target of Future Immune Modulatory Therapeutics.

Thymus plays a crucial role in cellular immunity by acting as a warehouse for proliferating and differentiating lymphocytes. Thymic stromal cells educate T-cells to differentiate self from non-self antigens while nurse cells and thymoproteasome play a major role in the maturation and differentiation of T-cells. The thymic conditions dictate T-cells to cope with the risk of cancer development. A study was designed to demonstrate potential mechanisms behind the failure to eliminate tumors and impaired immune surveillance as well as the impact of delay in thymus regression on cancer and autoimmune disorders. Scientific literature from Pubmed; Scopus; WOS; JSTOR; National Library of Medicine Bethesda, Maryland; The New York Academy of Medicine; Library of Speech Rehabilitation, NY; St. Thomas' Hospital Library; The Wills Library of Guys Hospital; Repository of Kings College London; and Oxford Academic repository was explored for pathological, physiological, immunological and toxicological studies of thymus. Studies have shown that systemic chemotherapy may lead to micro inflammatory environment within thymus where conventionally and dynamically metastasized dormant cells seek refuge. The malfunctioning of the thymus and defective T and Treg cells, bypassing negative selection, contributes to autoimmune disorders, while AIRE and Fezf2 play significant roles in thymic epithelial cell solidity. Different vitamins, TCM, and live cell therapy are effective therapeutics. Vitamin A, C, D, and E, selenium and zinc, cinobufagin and dietary polysaccharides, and glandular extracts and live cell injections have strong potential to restore immune system function and thymus health. Moreover, the relationship between different ages/stages of thymus and their corresponding T-cell mediated anti-tumor immune response needs further exploration.

Local participants and uninvolved citizens: life beyond participatory research

ABSTRACT Participatory ethnography brings together strands of academic and local knowledge, transforming the positionality of both academic and local participants in the research site. The extent of citizen involvement in participatory (action) research and the ethical dilemmas for both academic and civil researchers have long been the subject of debate [Lenette, Caroline. 2022. Participatory Action Research: Ethics and Decolonization. New York: Oxford Academic]. Our paper focuses on how local participants manage their new knowledge and transformed ideologies in a local reality that remains highly (in)securitised. The research site presented in this paper is a small town in Hungary with a large Romani-speaking community. We organised monthly workshops in the town with the participation of academics, local Hungarian-Romani bilingual and Hungarian monolingual citizens. The present study is based on the findings of these workshops and on ethnographic work conducted by the academic participants with citizens not involved in the workshops. We draw attention to the fact that the dissemination of workshop results in the locality can be successful only if local citizens succeed in developing a transformative voice of their own which disrupts conventionalised discourse repertoires. The intersubjective dynamics between local v. non-local and participating v. non-participating actors determines the long-term sustainability and impact of participatory research projects.

Supplementary protection of intellectual property rights for medicines

The article discusses the issue of extending the legal protection of intellectual property rights for medicines. The research aims to provide a comprehensive overview of the problems related to the implementation of Supplementary Protection Certificates (SPCs) in national legislation and possible solutions. The study also seeks to draw conclusions and make proposals for improving the regulatory framework for the SPCs of medicines. The work utilizes general scientific and specialized methods of scientific cognition, including dialectical, formal-logical, systemic-structural, comparative legal, as well as modeling, analysis, and synthesis methods, which collectively contributed to the organization, planning, and conduct of the research. The study is based on scientific publications from databases and search systems (PubMed, JAMA, Scopus, Springer, BMC, Oxford Academic), international and national regulatory acts, statistical studies by international organizations (Precedence Research), patents for inventions related to medicines, recommendations by national government bodies, as well as prescriptions and guidelines from international and national experts. Considering the analysis of statistical data on the development and implementation of medicines, it has been determined that original biological medicines are a major factor in the rising prices of treating conditions such as diabetes, oncological diseases, and others. Examples of patents for medicines owned by global pharmaceutical companies (Gilead, Bayer Intellectual Property Gmbh, etc.) that have ensured their commercial success and competitive advantages are examined. It has been established that patent protection provides the right holder with the opportunity to maintain a monopoly in the market, thereby compensating for the time spent on the development and research of original medicinal products. Legislative approaches to regulating relationships concerning the supplementary protection of inventions related to medicines in the form of SPCs in Ukraine and the EU are identified. The exclusivity periods for regulatory data protection for medicines in the EU are outlined. Based on the conducted research, it is concluded that the application of the SPC mechanism is a tool to achieve a balance between the protection of intellectual property rights and access to original medicines. Timely entry of generics and biosimilars to the market contributes to reducing market prices but negatively impacts the profitability of manufacturers of original medicines. Attention is drawn to problematic aspects of the legislative implementation of the SPC mechanism in Ukraine, which leads to incorrect interpretation and implementation of relevant provisions and necessitates updating. In light of the aforementioned, there is an urgent need in Ukraine to implement, update, and improve the legislative mechanism for regulating SPCs.

Celebrating BHL Australia through the Eye of the (Tasmanian) Tiger

BHL Australia, the Australian branch of the Biodiversity Heritage Library (BHL), was launched in 2010 and began operation with a single organisation, Museums Victoria in Melbourne. Since then, it has grown considerably. Funded by the Atlas of Living Australia, BHL Australia now digitises biodiversity literature on behalf of 42 organisations across the country. These organisations include museums, herbaria, state libraries, royal societies, government agencies, field naturalist clubs and natural history publishers, many of whom lack the resources to do this work themselves. BHL Australia’s national consortium model, which makes biodiversity literature accessible on behalf of so many organisations, is unique amongst the BHL global community. Most BHL operations digitise material on behalf of a single organisation. BHL Australia has now made over 530,000 pages of Australia’s biodiversity knowledge freely accessible online. The BHL Australia Collection includes both published works (books and journals) and unpublished material (collection registers, field diaries and correspondence). The pages of these works are filled with species descriptions, references to historically significant people and, most importantly, scientific data that is critical to ongoing research and conservation efforts. Providing access to materials published as far back as the 1600s and as recently as the current year, the collection chronicles the scientific discovery and understanding of Australia’s biodiversity. BHL Australia also leads the global initiative to bring the world's historic biodiversity and taxonomic literature into the modern linked network of scholarly research by incorporating article data into BHL and retrospectively assigning DOIs (Digital Object Identifiers) (Kearney et al. 2021). BHL has now assigned more than 162,000 DOIs to historic publications, making them persistently citable and trackable, both within BHL and beyond. This paper will celebrate the achievements of BHL Australia by journeying through the (now accessible, discoverable and DOI'd) Tasmanian Tiger literature. It will showcase: previously elusive descriptions (and beautiful illustrations) of Thylacines, including those by Gerhard Krefft (1871) https://doi.org/10.5962/p.314741, and John Gould (1863) https://doi.org/10.5962/p.312790; the invaluable creation of links to open access versions from paywalled publications that should be in the public domain, such as the first description of the Thylacine (Harris 1808): open access on BHL; paywalled by Oxford Academic; the many citations of historic taxonomic descriptions that are now appearing as clickable DOI links in modern scholarly articles, taxonomic databases, social media, and Wikipedia (Kearney and Page 2022); and the efforts being made to encourage more authors to cite the authoritative source of taxonomic names (Benichou 2022). previously elusive descriptions (and beautiful illustrations) of Thylacines, including those by Gerhard Krefft (1871) https://doi.org/10.5962/p.314741, and John Gould (1863) https://doi.org/10.5962/p.312790; the invaluable creation of links to open access versions from paywalled publications that should be in the public domain, such as the first description of the Thylacine (Harris 1808): open access on BHL; paywalled by Oxford Academic; the many citations of historic taxonomic descriptions that are now appearing as clickable DOI links in modern scholarly articles, taxonomic databases, social media, and Wikipedia (Kearney and Page 2022); and the efforts being made to encourage more authors to cite the authoritative source of taxonomic names (Benichou 2022). The extinction of the Thylacine is a stark reminder of the irreversible consequences that arise from a lack of understanding and appreciation of the natural world. Similarly, a lack of access and/or the inability to find biodiversity knowledge hinders our capacity to learn from the past, impeding scientific progress and conservation efforts. The Biodiversity Heritage Library was created “to address a major obstacle to scientific research: lack of access to natural history literature” (BHL 2019). BHL Australia has made a substantial contribution to this global mission and has played a significant role in BHL’s transition to a fully searchable, persistently linkable component of the biodiversity knowledge graph (Kearney 2020, Page 2016).

Digital Libraries and Personalised Learning Experiences of Final-year Economics Education Students in Public Universities in Lagos State, Nigeria

This study examined the influence of educational tools in digital libraries on the personalised learning experiences of final-year economics education students in public universities in Lagos State, Nigeria. A descriptive research design was employed, with the use of a questionnaire tagged Digital Libraries and Personalised Learning Experiences of Students Questionnaire (DLPLESQ) as an instrument of data collection. A total of 212 final-year economics education students were selected for the study using the snowball sampling technique. Descriptive statistics such as frequency distribution, percentage, mean, and standard deviation were used to provide answers to research questions. Additionally, inferential statistics in the form of regression analysis was used to test the relevant hypothesis. The findings revealed that digital library tools have a significant positive impact on students’ personalised learning experiences of students ( = 2.002; P<0.05). The study also demonstrated that final-year Economics education students are “Not Aware” of the resources in digital libraries in public universities in Lagos State, Nigeria. Out of the 13 digital library resources listed, sampled students seem to be “Aware” of only three resources which are “Google Scholar,” “Oxford Academic,” and “Research4life”. Furthermore, the study showed that final-year Economics education students make use of the digital library resources “Monthly”. Based on these findings, the study recommended strategies to enhance the utilisation of digital libraries, such as improving access to devices and internet connectivity, providing training programs to enhance digital literacy skills, and integrating digital library resources into the economics education curriculum

Association of vitamin D levels with severity and outcome of COVID-19 infection among inward patients at a tertiary care unit in Sri Lanka

Introduction: A link between vitamin D and COVID-19 infection has been expressed by many experts. In this study, we aim to investigate the association of the prevalence of vitamin D deficiency with the severity and outcome of COVID-19 infection in patients who are admitted to Teaching Hospital Batticaloa, Sri Lanka. Methods: A retrospective cross-sectional study was conducted among COVID-19 patients over a period of one month in May 2021. All patients who tested positive for COVID-19 were included. Patients with chronic kidney disease, known vitamin D deficiency, and patients on vitamin D supplements were excluded from the study. The vitamin D deficiency was defined according to the Oxford Academic Endocrine Society guidelines. The severity of the COVID-19 was defined according to the Provisional Clinical Practice Guidelines on COVID-19 suspected and confirmed patients. Primary endpoints of this study were 'recovered from COVID-19' or 'death'. Data was analysed to report the proportion of patients with different vitamin D levels and disease severity. Chi-squared and Fisher's exact tests were used to analyse the results. A p-value of <0.05 was considered as statistically significant. Results: Out of 141, 58% were males. Mild, moderate, and severe COVID-19 were observed in 29.8%, 48.2%, and 22.0% of patients respectively. Only 30.5% of the population had normal vitamin D levels while the rest had some degree of vitamin D insufficiency. None of the patient population had severe vitamin D deficiency status. A 52.9% in the moderate category of COVID-19 severity had insufficient levels of vitamin D levels. Those that recovered from COVID-19 were 93.6%. No significant association was observed between the severity of COVID-19 and vitamin D deficiency (p=.1041 ). Interestingly hypoxia was significantly prevalent among those with normal vitamin D levels (p=.0005). vitamin D deficiency does not impact the mortality rate among COVID-19 patients (p=.6559). Conclusions: The association of vitamin D levels with COVID-19 severity and mortality was not statistically significant.

Music in World War II: Coping with Wartime in Europe and the United States Pamela M Potter Christina Baade , and Roberta Montemorra Marvin

Journal Article Music in World War II: Coping with Wartime in Europe and the United StatesPamela M Potter Christina Baade and Roberta Montemorra Marvin Get access Music in World War II: Coping with Wartime in Europe and the United States. Ed. by Pamela M Potter, Christina Baade, and Roberta Montemorra Marvin. Pp. 318. ( Indiana University Press, Bloomington and Indiana, 2020. ISBN 978-0-253-05025-0, $85.) Michelle Meinhart Michelle Meinhart Trinity Laban Conservatoire of Music and Dance, London Search for other works by this author on: Oxford Academic Google Scholar Music and Letters, gcad045, https://doi.org/10.1093/ml/gcad045 Published: 22 June 2023 Article history Editorial decision: 15 June 2023 Received: 15 June 2023 Corrected and typeset: 22 June 2023 Published: 22 June 2023

The Way of the Moderns: Six Perspectives on Modernism in Music Antoni Piza

Journal Article The Way of the Moderns: Six Perspectives on Modernism in MusicAntoni Piza Get access The Way of the Moderns: Six Perspectives on Modernism in Music. Ed. by Antoni Piza. Pp. 172. ( Brepols Publishers n.v., Turnhout, 2022. ISBN 978-2-503-599773-7, €80.) Björn Heile Björn Heile University of Glasgow Search for other works by this author on: Oxford Academic Google Scholar Music and Letters, gcad041, https://doi.org/10.1093/ml/gcad041 Published: 19 June 2023 Article history Editorial decision: 15 June 2023 Received: 15 June 2023 Corrected and typeset: 19 June 2023 Published: 19 June 2023

Musical Notation in the West James Grier

Journal Article Musical Notation in the WestJames Grier Get access Musical Notation in the West. By James Grier. Pp. xvi + 269. Cambridge Introductions to Music. ( Cambridge University Press, Cambridge, 2021. ISBN 978-0-521-72643-9, £18.99.) Nicolas Bell Nicolas Bell Trinity College, Cambridge Search for other works by this author on: Oxford Academic Google Scholar Music and Letters, gcad044, https://doi.org/10.1093/ml/gcad044 Published: 19 June 2023 Article history Editorial decision: 15 June 2023 Received: 15 June 2023 Accepted: 15 June 2023 Corrected and typeset: 19 June 2023 Published: 19 June 2023

Sondheim in Our Time and His W. Anthony Sheppard

Journal Article Sondheim in Our Time and HisW. Anthony Sheppard Get access Sondheim in Our Time and His. Ed. by W. Anthony Sheppard. Pp. 456. ( Oxford University Press, New York and Oxford, 2022. ISBN 978-0-19-760320-8, $125.) John Snelson John Snelson Goldsmiths, University of London Search for other works by this author on: Oxford Academic Google Scholar Music and Letters, gcad039, https://doi.org/10.1093/ml/gcad039 Published: 20 June 2023 Article history Editorial decision: 15 June 2023 Received: 15 June 2023 Accepted: 15 June 2023 Corrected and typeset: 20 June 2023 Published: 20 June 2023

The Impact of Covid-19 Pandemic on Child Routine Immunization Programs: A Systematic Review

Immunization is one of the most successful, most accepted and proven cost-effective public health preventive interventions in the world and has saved 2 to 3 million children from immunization-preventable diseases. The COVID-19 outbreak and the effort being made to overcome the outbreak could cause negative impacts on the utilization of basic immunization services. During the outbreak, basic immunization coverage rate in various regions had decreased. This article conducted a comprehensive and systematic literature search in electronic databases (PubMed, ScienceDirect, Sage Journal, SpringerLink, ClinicalKey, and Oxford Academic) with articles published in the last 5 years and adjusted according to inclusion and exclusion criteria. This systematic review use PRISMA (Preferred, Reporting Items for Systematic Review and Meta-analysis). There were 2 studies that met the final inclusion criteria. The results showed a significant reduction of basic immunization coverage happen especially during the early period of pandemic. Six themes are identified related to the decrease: 1) Covid-19 lockdown; (2) motivation for childhood immunization; (3) availability of biosafety procedures and personal protective equipment (PPE); (4) service adjustments and guidelines during the pandemic; (5) the availability of vaccines; and (6) the resilience of the immunization program in view of COVID-19. Childhood routine immunization coverage rate significantly decreased during the early period of the pandemic. Interventions for providers and parents is required to ensure adequate catch-up of delayed/missed immunizations in order to prevent potential outbreaks of vaccine-preventable diseases.

Wisdom of the Established Pattern

Wisdom of the Established Pattern

Dynamic ultrasound examination painting the picture of omohyoid muscle strain and associated suprascapular nerve entrapment.

Journal Article Accepted manuscript Dynamic Ultrasound Examination Painting the Picture of Omohyoid Muscle Strain and Associated Suprascapular Nerve Entrapment Get access Wei-Ting Wu, Wei-Ting Wu Department of Physical Medicine and Rehabilitation, National Taiwan University Hospital, Bei-Hu Branch, Taipei, TaiwanDepartment of Physical Medicine and Rehabilitation, National Taiwan University College of Medicine, Taipei, Taiwan Search for other works by this author on: Oxford Academic PubMed Google Scholar Kamal Mezian, Kamal Mezian Department of Rehabilitation Medicine, First Faculty of Medicine and General University Hospital, Charles University, in Prague, Prague, Czech Search for other works by this author on: Oxford Academic PubMed Google Scholar Vincenzo Ricci, Vincenzo Ricci Physical and Rehabilitation Medicine Unit, Luigi Sacco University Hospital, ASST Fatebenefratelli-Sacco, Milan, Italy Search for other works by this author on: Oxford Academic PubMed Google Scholar Chia-Shiang Lin, Chia-Shiang Lin Department of Anesthesiology, Shuang Ho Hospital, Ministry of Health Welfare, New Taipei City, TaiwanDepartment of Anesthesiology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan Search for other works by this author on: Oxford Academic PubMed Google Scholar Ke-Vin Chang, Ke-Vin Chang Department of Physical Medicine and Rehabilitation, National Taiwan University Hospital, Bei-Hu Branch, Taipei, TaiwanDepartment of Physical Medicine and Rehabilitation, National Taiwan University College of Medicine, Taipei, TaiwanCenter for Regional Anesthesia and Pain Medicine, Wang-Fang Hospital, Taipei Medical University, Taipei, Taiwan Correspondence: Ke-Vin Chang, Department of Physical Medicine and Rehabilitation, National Taiwan University Hospital Bei-Hu Branch, No. 87, Nei-Jiang Rd., Wan-Hwa District, Taipei 108, Taiwan, E-mail: kvchang011@gmail.com phone: +886223717101-5309. Search for other works by this author on: Oxford Academic PubMed Google Scholar Levent Özçakar Levent Özçakar Department of Physical and Rehabilitation Medicine, Hacettepe University Medical School, Ankara, Turkey Search for other works by this author on: Oxford Academic PubMed Google Scholar Pain Medicine, pnad085, https://doi.org/10.1093/pm/pnad085 Published: 24 June 2023 Article history Received: 26 April 2023 Revision received: 03 June 2023 Accepted: 21 June 2023 Published: 24 June 2023

Peripartum thrombotic microangiopathy-a enigma.

Journal Article Accepted manuscript Peripartum Thrombotic Microangiopathy- A enigma Get access Jasmine Sethi, MD/DM Jasmine Sethi, MD/DM Assistant Professor. Department of Nephrology. Post Graduate Institute of Medical Education and Research Chandigarh, India Corressponding author Dr Jasmine Sethi. MD/DM Assistant Professor. Department of Nephrology. Post Graduate Institute of Medical Education and Research Chandigarh. India. Pin code-160012 Mail id-jasmine227021@gmail.com Phone no-91-9855422270 Search for other works by this author on: Oxford Academic PubMed Google Scholar QJM: An International Journal of Medicine, hcad148, https://doi.org/10.1093/qjmed/hcad148 Published: 24 June 2023 Article history Received: 03 June 2023 Published: 24 June 2023

Let us start a dialogue about interprofessional research.

Journal Article Let us start a dialogue about interprofessional research Get access Joon Soo Park, Joon Soo Park International Research Collaborative—Oral Health and Equity, University of Western Australia, Crawley, Western Australia, AustraliaUWA Dental School, University of Western Australia, Nedlands, Western Australia, AustraliaSchool of Allied Health, University of Western Australia, Crawley, Western Australia, AustraliaInstitute for Sustainable Industries & Liveable Cities, Victoria University, Melbourne, Victoria, Australia Correspondence: Joon Soo Park, International Research Collaborative—Oral Health and Equity, University of Western Australia, Crawley, Western Australia, Australia. Email: alex.park@uwa.edu.au https://orcid.org/0000-0002-2052-558X Search for other works by this author on: Oxford Academic Google Scholar Manorika Ratnaweera Manorika Ratnaweera UWA Dental School, University of Western Australia, Nedlands, Western Australia, Australia Search for other works by this author on: Oxford Academic Google Scholar International Journal of Pharmacy Practice, riad039, https://doi.org/10.1093/ijpp/riad039 Published: 24 June 2023

Response to: Peripartum thrombotic microangiopathy: an enigma.

Journal Article Accepted manuscript Response to: Peripartum Thrombotic Microangiopathy- A enigma Get access Taro Horino, MD, PhD, Taro Horino, MD, PhD Department of Endocrinology, Metabolism and Nephrology, Kochi Medical School, Kochi University, Oko-cho, Kochi, 783-8505, Japan, Kohasu, Nankoku Address correspondence to: Taro Horino, MD, PhD, Department of Endocrinology, Metabolism and Nephrology, Kochi Medical School, Kochi University, Kohasu, Oko-cho, Nankoku, Kochi 783-8505, Japan. Tel: +81-88-880-2343 Fax: +81-88-880-2344 email: horinott@yahoo.co.jp https://orcid.org/0000-0003-0695-7981 Search for other works by this author on: Oxford Academic PubMed Google Scholar Yoshio Terada, MD, PhD Yoshio Terada, MD, PhD Department of Endocrinology, Metabolism and Nephrology, Kochi Medical School, Kochi University, Oko-cho, Kochi, 783-8505, Japan, Kohasu, Nankoku Search for other works by this author on: Oxford Academic PubMed Google Scholar QJM: An International Journal of Medicine, hcad149, https://doi.org/10.1093/qjmed/hcad149 Published: 24 June 2023 Article history Received: 16 June 2023 Published: 24 June 2023

Aesthetic Life and Why it Matters

Journal Article Aesthetic Life and Why it Matters Get access Aesthetic Life and Why it Matters Dominic McIver Lopes, Bence Nanay, and Nick Riggle Oxford: oxford university press, 2022. pp. 128. £41.99 (hbk). Robbie Kubala Robbie Kubala The University of Texas at Austin, USA rkubala@utexas.edu https://orcid.org/0000-0002-9648-6572 Search for other works by this author on: Oxford Academic Google Scholar The British Journal of Aesthetics, ayad013, https://doi.org/10.1093/aesthj/ayad013 Published: 23 June 2023

Aqua-Spectrality, Submerged Perspectives, and Chinese Exclusion in Shawna Yang Ryan’sWater Ghosts

Journal Article Aqua-Spectrality, Submerged Perspectives, and Chinese Exclusion in Shawna Yang Ryan’s Water Ghosts Get access Yen Loh Yen Loh E-mail: lohy@denison.edu Search for other works by this author on: Oxford Academic Google Scholar ISLE: Interdisciplinary Studies in Literature and Environment, isad033, https://doi.org/10.1093/isle/isad033 Published: 23 June 2023 Article history Received: 06 November 2022 Editorial decision: 11 June 2023 Revision received: 11 June 2023 Accepted: 12 June 2023 Published: 23 June 2023

Has the GDPR killed e-government? The “once-only” principle vs the principle of purpose limitation

Journal Article Has the GDPR killed e-government? The “once-only” principle vs the principle of purpose limitation Get access Monika Mikiver, Monika Mikiver Guest Lecturer in Administrative Law, University of Tartu, School of Law, 10142 Tallinn, Estonia Search for other works by this author on: Oxford Academic Google Scholar Paloma Krõõt Tupay Paloma Krõõt Tupay Paloma Krõõt Tupay, Associate Professor in Constitutional Law, University of Tartu, School of Law, 10142 Tallinn, Estonia Email: palomakreet.tupay@ut.ee Search for other works by this author on: Oxford Academic Google Scholar International Data Privacy Law, ipad010, https://doi.org/10.1093/idpl/ipad010 Published: 23 June 2023