Overtraining Syndrome Research Articles

The sports performance improving effects of konjac glucomannan with varying molecular weights in overtrained mice

Overtraining affects individuals engaged in high-volume training, potentially hindering athletic performance and revealing shortcomings in suggested solutions. This study evaluated the impact of konjac glucomannan (KGM) with varying molecular weights on the gut microbiome, endurance, and strength in mice subjected to excessive training. The native KGM (1.82 × 107 Da) was enzymatically degraded using endo-1,4-β-mannanase to generate moderate molecular weight KGM (KGM-EM, 1.89 × 105 Da) and low molecular weight KGM (KGM-EL, 1.34 × 104 Da). These fractions were characterized and compared with the native KGM regarding their effects on mice undergoing excessive training. The results demonstrated a positive correlation between KGM's molecular weight and its capacity to mitigate the adverse impacts of excessive training on strength or/and endurance (a significant increase of 55.57 % and 55.70 % by the native KGM compared with the excessive training group). In addition, the native KGM exhibited superior preservation of microbial diversity and composition in fecal samples against excessive training-induced shifts, along with increased production of individual and total short-chain fatty acids in plasma compared with the two degraded products. Overall, these results highlight the potential benefits of high molecular weight KGM for preventing overtraining syndrome and enhancing athletic performance in animal models.

Rapid Liquid Chromatography-Tandem Mass Spectrometry Method for Determination of Total and Free Testosterone in Human Serum and Its Application to Monitoring Biomarker Response of Elite Athletes.

Total testosterone (TT) and free testosterone (FT) are important biochemical markers for anabolism of the human body, and can also serve as early screening indicators for overtraining syndrome (OTS). Presently, there is no fast and reliable serum TT and FT determination method in the field of sport science that can meet the requirements of sports research. Thus, a rapid and accurate determination method for serum TT and FT to fill the gap is needed urgently in sports training. Herein, a simple and reliable liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for the simultaneous determination of TT and FT in serum was developed and fully validated, followed by the application of professional athletes in training monitoring. Efficient pretreatments based on only one-step liquid-liquid extraction (LLE) for TT and one-step LLE after a 20 min ultrafiltration for FT were adopted in this study, and the isotope internal standard of testosterone-13C3 was used to ensure the reliability of the whole procedure. A linear range of four orders of magnitude with 0.02-100 ng/mL can meet the concentration range requirement between a higher limit for male TT and a lower limit for female FT. The accuracy, precision, stability, and matrix effect were all within the limits of the guidelines. The serum TT and FT levels of 200 professional athletes (98 male athletes and 102 female athletes) were investigated by this method. Serum TT, FT, and FT/TT levels of professional athletes were significantly higher than the general population, and serum TT levels were significantly higher by LC-MS/MS than by a chemiluminescence immunoassay. In conclusion, the LC-MS/MS method for TT and FT measurement developed in this study is time-saving and easy to operate, which can be used as a reliable method for the determination of serum TT and FT in sports training, offering valuable information for monitoring anabolism of athletes and screening OTS in the early stage.

Analyzing the theoretical trajectory of “staleness” and its relevance to modern sports psychiatry

Abstract: Introduction: Despite recent advancements in sports medicine and sports psychiatry, a lack of clarity remains in understanding the pathogenesis and etiology of Overtraining Syndrome (OTS). Early research on endurance athletes in high volume/intensity cycles of training described a condition of “staleness”, which could be detected using psychometric assessments on mood. Associated with both physical and psychological symptoms, “staleness” was found to be dose responsive and tended to abate with a reduction in training. Subsequent study of OTS has not revealed reliable or reproducible measurements for ascertaining or treating the condition. Methods: We reviewed historical literature discussing “staleness”, summarizing its theoretical trajectory in academic domains, and comparing this with more recent work that emphasizes the physiological parameters of OTS. We also consider the sociocultural context surrounding these terminological shifts. Results: Though the term “staleness” has fallen out of favor, past work into this topic may have relevance in attempts to define, diagnose, and treat OTS. Further, sports psychiatry may be in a unique position to revisit the literature and emphasize the utility of psychometric assessment in screening, as well as underlining the importance of maintaining mental health among high performing athletes. Conclusion: Research and psychometric assessments designed to discuss “staleness” still remain relevant, particularly in sports psychiatry, and may deserve to be revisited as well as expanded.

A Narrative Review on Adipose Tissue and Overtraining: Shedding Light on the Interplay among Adipokines, Exercise and Overtraining.

Lifestyle factors, particularly physical inactivity, are closely linked to the onset of numerous metabolic diseases. Adipose tissue (AT) has been extensively studied for various metabolic diseases such as obesity, type 2 diabetes, and immune system dysregulation due to its role in energy metabolism and regulation of inflammation. Physical activity is increasingly recognized as a powerful non-pharmacological tool for the treatment of various disorders, as it helps to improve metabolic, immune, and inflammatory functions. However, chronic excessive training has been associated with increased inflammatory markers and oxidative stress, so much so that excessive training overload, combined with inadequate recovery, can lead to the development of overtraining syndrome (OTS). OTS negatively impacts an athlete's performance capabilities and significantly affects both physical health and mental well-being. However, diagnosing OTS remains challenging as the contributing factors, signs/symptoms, and underlying maladaptive mechanisms are individualized, sport-specific, and unclear. Therefore, identifying potential biomarkers that could assist in preventing and/or diagnosing OTS is an important objective. In this review, we focus on the possibility that the endocrine functions of AT may have significant implications in the etiopathogenesis of OTS. During physical exercise, AT responds dynamically, undergoing remodeling of endocrine functions that influence the production of adipokines involved in regulating major energy and inflammatory processes. In this scenario, we will discuss exercise about its effects on AT activity and metabolism and its relevance to the prevention and/or development of OTS. Furthermore, we will highlight adipokines as potential markers for diagnosing OTS.

Subjective Indicators of Overtraining and Their Relationship to Sport Fitness: A 1-year Observation of Elite Athletes

This study explores the relationships among indicators of overtraining in adolescent athletes. The research employed widely-accepted tools for subjective overtraining indicator detection, as identified through a systematic review. Two groups of athletes were observed, comprising 13 athletes with bi-weekly assessments and 66 athletes with assessments every 3 months over a one-year period. The study analyzed relationships between variables using repeated measures correlations. A correlation matrix was subjected to principal component analysis. Three fundamental groups of indicators, reflecting negative emotionality (accompanied by sleep problems), self-concept characteristics, and core symptoms of overtraining syndrome captured through subjective sport fitness and vigor. This research emphasizes the intrinsic link between emotional and physical aspects in the lives of elite athletes, shedding light on the complex interplay of overtraining indicators in the context of adolescent developmental period.

The Impact of Inadequate Sleep on Overtraining Syndrome in 18-22-Year-Old Male and Female College Athletes: A Literature Review.

Both male and female athletes experience acute fatigue and decreased performance from intense training sessions and training cycles with inadequate recovery. The concept of training with insufficient recovery time is known as overtraining syndrome (OTS). Primary stressors leading to OTS include excessive training, environmental factors, and inadequate levels of sleep. Sleep is a critical component of rest, recovery, memory, and cognitive function in collegiate athletes, known as male and female athletes between 18 and 22 years old. Collegiate athletes are more prone to inadequate levels of sleep, which can lead to elevated levels of fatigue, a lack of energy, motivation, alertness, and a weakened immune system. Additionally, inadequate levels of sleep lead to decreased glycogen stores in the body, affecting the functioning of physiological pathways. The processes of removing toxins and the release of growth hormones (GHs) are also impacted. GH is secreted as the rapid eye movement (REM) phase alternates with the non-REM phase and continues to rise until it peaks in the REM sleep stage, which is important for physical recovery, memory formation, and emotional regulation. This literature review aims to summarize current research on overtraining and the physiological changes that are present in both males and females from inadequate levels of sleep, emphasizing its importance in body homeostasis.

Recovery and stress monitoring in elite ice hockey: A longitudinal pilot-study

Introduction
 Young athletes in high-level sports experience a greater risk for injury and illness during phases of increased training and competitive load. When recovery is too sparse under these circumstances, psychological and physical health problems could emerge. These are referred to as nonfunctional overreaching or overtraining syndrome, OTS (Daly et al., 2022; Jones et al., 2017; Kiely, 2018). OTS is typically characterized by a reduction in athletic performance that lasts for several weeks to months, accompanied with mood and sleep disturbances, feelings of depression, respiratory tract infections, weight loss, and other symptoms. The prevalence of this condition is high with approxymately 10-20 % of young adult and about 29 % of young athletes from various sports beeing affected (Matos et al., 2011). To our knowledge, no scientifically valid and reliable measurement system currently exists, which would allow the preventive, early diagnosis of overreaching states that might lead to OTS (Weakley et al., 2022). The aim of this study is to develop and evaluate a multiparameter measurement system to assess the recovery and stress state of high-level athletes.
 Methods
 Twenty-five male ice hockey players from the highest level Swiss leagues at their respective age group participated (i.e., National League, NL, n = 11, age = 24.8 ± 4.1 years and U20, n = 14, age = 18.5 ± 1.5 years). Over 5-10 weeks during the in-season (i.e., competition phase) measurements were performed on 10 separate days, either after 1 day of passive recovery (T1) or after a day with match/intensive training (T2). The measurement battery included counter movement jump (CMJ), heart rate variability (HRV), executive functions (EF), tympanic temperature (Temp), and Stress Recovery Short Scale (SRSS).
 Results
 Independent Student’s t-tests showed significant differences (p < 0.05) between timepoints T1 and T2 for CMJ (peak power per body mass), HRV (sympathic and parasympatic indexes), and SRSS (recovery, stress, total score); but not for CMJ (jump height), EF and Temp.
 Discussion/Conclusion
 We conclude that various measurment parameters, including CMJ performance, HRV indices, and subjective ratings of recovery and stress could provide valuable feedback for athletes, coaches, and medical staff regarding a potential overreaching or OTS state.
 References
 Daly, E., Pearce, A. J., Esser, P., & Ryan, L. (2022). Evaluating the relationship between neurological function, neuromuscular fatigue, and subjective performance measures in professional rugby union players. Frontiers in Sports and Active Living, 4, Article 1058326. https://doi.org/10.3389/fspor.2022.1058326
 Jones, C. M., Griffiths, P. C., & Mellalieu, S. D. (2017). Training load and fatigue marker associations with injury and illness: A systematic review of longitudinal studies. Sports Medicine, 47(5), 943-974. https://doi.org/10.1007/s40279-016-0619-5
 Kiely, J. (2018). Periodization theory: Confronting an inconvenient truth. Sports Medicine, 48(4), 753-764. https://doi.org/10.1007/s40279-017-0823-y
 Matos, N. F., Winsley, R. J., & Williams, C. A. (2011). Prevalence of nonfunctional overreaching/overtraining in young English athletes. Medicine & Science in Sports & Exercise, 43(7), 1287-1294. https://doi.org/10.1249/MSS.0b013e318207f87b
 Weakley, J., Halson, S. L., & Mujika, I. (2022). Overtraining syndrome symptoms and diagnosis in athletes: Where is the research? A systematic review. International Journal of Sports Physiology and Performance, 17(5), 675-681. https://doi.org/10.1123/ijspp.2021-0448

Up-to-date understanding of overtraining syndrome and overlap with related disorders

Abstract: Introduction: The rigorous training regimens of elite athletes are, by nature, emotionally, physically, and mentally demanding. These regimens can result in marked improvements in athletic performance when they incorporate adequate intervals of rest and recovery. Continued training in the absence of adequate recovery progresses to a constellation of symptoms that affect medical and mental health, which is referred to as overtraining syndrome (OTS). Method: A literature review was conducted using PubMed, a database of reference on medical research maintained by the US national Library of Medicine and the National Institute of Health. Search terms included “overtraining syndrome”, “Unexplained Underperformance” (UUPS), “Burnout” in athletes. Results: The collection of the published work provides insight into the multidimensional composition and complexity of OTS in athletes. OTS progresses along a continuum without adequate recovery. Conclusion: Decreased athletic performance in the setting of increased training intensity without appropriate recovery, often accompanied by changes in mood, motivation, and general well-being are the distinctive features of OTS. OTS is preceded by stages of underperformance that are reversable and preventable, highlighting the importance of recognizing, managing, and preventing overtraining in athletes in order to prevent long-term negative outcomes is a maladaptive response to an imbalance between exercise and recovery.

Monitoring training, performance, biomarkers, and psychological state throughout a competitive season: a case study of a triathlete.

Ironman triathletes undergo high workloads during competition preparation which can result in nonfunctional overreaching or overtraining syndrome if not matched with adequate recovery. The purpose of this case study was to observe changes in physiological and psychological status over the course of a competitive season in a free-living triathlete. The subject was a 41-year-old triathlete competing in three 113.1-km events. Over the course of a 40-week period, the participant arrived at the laboratory every 4weeks and underwent body composition testing via air displacement plethysmography, a blood draw for analysis of various biomarkers, and a treadmill-based lactate threshold test. Workload during training and competitions was monitored via a wearable heart rate-monitoring device. Throughout the season, training volume remained high (12.5 ± 3.4h/week) and body mass and fat-free mass (FFM) continuously decreased, while biomarkers including cortisol, testosterone, and markers of immunological status exhibited minor changes. Laboratory performance remained relatively consistent, while competition performance continually improved. Following the completion of the competitive period, training volume decreased, FFM remained below baseline levels, free cortisol increased, and both free and total testosterone decreased. Workload and recovery seem to have been properly managed throughout the season, evidenced by minimal fluctuations in endocrine and immunological markers. The reason for changes observed in testosterone, cortisol, and body composition following the last competition is unclear, though it may be attributed to changes in stressors and recovery practices outside of training. It is recommended that athletes follow a structured plan during the transition period into the offseason to ensure recovery of physiological state and to set up a productive offseason.

Overtraining Syndrome as a Risk Factor for Bone Stress Injuries among Paralympic Athletes.

Background and Objectives: In this review, we have explored the relationship between overtraining syndrome (OTS) and bone stress injuries among paralympic athletes. OTS is a complex condition that arises from an imbalance between training volume, nutrition, and recovery time, leading to significant negative effects on paralympic athlete's performance and overall well-being. On the other hand, bone stress injuries occur when abnormal and repetitive loading is applied to normal bone, resulting in microdamage accumulation and potential. The prevalence of overtraining syndrome and bone stress injuries among athletes highlights the need for a better understanding of their relationship and implications for prevention and management strategies. Methods: A literature review from the PubMed, Web of Science, and Google Scholar databases including the MeSH keywords "overtraining syndrome", "bone", and "paralympic athletes". Results: Studies have consistently shown that athletes engaged in endurance sports are particularly susceptible to overtraining syndrome. The multifactorial nature of this condition involves not only physical factors, but also psychological and environmental determinants. In addition, the diagnosis and management of OTS and bone stress injuries present challenges in clinical practice. Conclusions: Currently, there are no definitive biochemical markers for overtraining syndrome. The diagnosis is based on a combination of subjective measures such as questionnaires, symptoms checklists, and objective biomarkers, including hormone levels, inflammatory markers, and imaging studies. However, these diagnostic approaches have limitations regarding their specificity and sensitivity.

Vitamin D deficiency contributes to overtraining syndrome in excessive trained C57BL/6 mice

Vitamin D deficiency contributes to overtraining syndrome in excessive trained C57BL/6 mice

The Potential Role of Nutrition in Overtraining Syndrome: A Narrative Review

Competition between athletes and an increase in sporting knowledge have greatly influenced training methods while increasing the number of them more and more. As a result, the number of athletes who have increased the number and intensity of their workouts while decreasing recovery times is rising. Positive overtraining could be considered a natural and fundamental process when the result is adaptation and improved performance; however, in the absence of adequate recovery, negative overtraining could occur, causing fatigue, maladaptation, and inertia. One of the earliest forms of fatigue is overreaching. It is considered to be an accumulation of training that leads to reduced sports performance, requiring days or weeks to recover. Overreaching, if followed by adequate recovery, can lead to an increase in athletic performance. Nonetheless, if overreaching becomes extreme, combined with additional stressors, it could lead to overtraining syndrome (OTS). OTS, caused by systemic inflammation, leads to central nervous system (CNS) effects, including depressed mood, further inflammation, central fatigue, and ultimately neurohormonal changes. There are therefore not only physiological, biochemical, and immunological but also psychological symptoms or markers that must be considered, independently or together, being intrinsically linked with overtraining, to fully understand OTS. However, to date, there are very few published studies that have analyzed how nutrition in its specific food aspects, if compromised during OTS, can be both etiology and consequence of the syndrome. To date, OTS has not yet been fully studied, and the topic needs further research. The purpose of this narrative review is therefore to study how a correct diet and nutrition can influence OTS in all its aspects, from prevention to treatment.

Konjac Glucomannan Counteracted the Side Effects of Excessive Exercise on Gut Microbiome, Endurance, and Strength in an Overtraining Mice Model.

Excessive exercise without adequate rest can lead to overtraining syndrome, which manifests a series of side effects, including fatigue, gut dysbiosis, and decremental sports performance. Konjac glucomannan (KGM) is a plant polysaccharide with numerous health-improving effects, but few studies reported its effects on the gut microbiome, endurance, and strength in an overtraining model. This study assessed the effect of KGM on gut microbiome, endurance, and strength in mice with excessive exercise. Three doses of KGM (1.25, 2.50, and 5.00 mg/mL) were administrated in drinking water to mice during 42 days of a treadmill overtraining program. The results showed that excessive exercise induced a significant microbial shift compared with the control group, while a high dose (5.00 mg/mL) of KGM maintained the microbial composition. The proportion of Sutterella in feces was significantly increased in the excessive exercise group, while the moderate dose (2.50 mg/mL) of KGM dramatically increased the relative abundance of Lactobacillus and SCFA production in feces. Additionally, the moderate dose and high dose of KGM counteracted the negative effects of excessive exercise on strength or/and endurance (43.14% and 39.94% increase through a moderate dose of KGM, Bonferroni corrected p < 0.05, compared with the excessive exercise group). Therefore, it suggests that KGM could prevent overtraining and improve sports performance in animal models.

Stress Management: from Sports Science to People Management

The deterioration of physical and mental performance in physical, work, or personal activities is the main outcome and is a consensual factor for finding accumulated stress, chronic fatigue, overtraining, or burnout syndrome, for example. However, energy depletion and partial impairment of performance can be managed and lead to overcompensation of physiological adaptations. In this context, it is essential to monitor the effect of chronic stress, but there is no consensus on which tools to use due to inaccuracies, difficult interpretations, and inconclusions. Therefore, the objective of this review is to share conceptual information about stress, and its role in the development of chronic fatigue, pointing out limitations, gaps, and future perspectives regarding monitoring possibilities. For the construction of arguments and presentation of possible solutions, examples from exercise and sport sciences were used. It is expected that the understood knowledge can guide actions in different areas of professional activity, favoring the management of human resources.

Vitamin D deficiency contributes to overtraining syndrome in excessive trained C57BL/6 mice.

Overtraining syndrome is a condition resulting from excessive training load associated with inadequate recovery and poor sleep quality, leading to performance decrements and fatigue. Here we hypothesized that vitamin D (VitD) deficiency is a lead factor in the development of the overtraining syndrome. To test this hypothesis, two groups of 60-week-old C57BL/6 mice followed a 16-week excessive eccentric-based overtraining by excessive downhill running with or without dietary VitD depletion (EX and EX-D- groups). Two control groups were trained by uphill running at the same load with or without VitD depletion (CX and CX-D- groups). Handgrip strength decreased throughout the protocol for all groups but the decrease was sharper in EX-D- group (VitD × training, p = 0.0427). At the end of the protocol, the mass of Triceps brachii muscle, which is heavily stressed by eccentric contractions, was reduced in eccentric-trained groups (training effect, p = 0.0107). This atrophy was associated with a lower concentration of the anabolic myokine IL-15 (training effect, p = 0.0314) and a tendency to a higher expression of the atrogene cathepsin-L (training effect, p = 0.0628). VitD depletion led to a 50% decrease of the fractional protein synthesis rate in this muscle (VitD effect, p = 0.0004) as well as decreased FGF21 (VitD effect, p = 0.0351) and increased osteocrin (VitD effect, p = 0.038) concentrations that would lead to metabolic defects. Moreover, the proportion of anti-inflammatory Th2 lymphocytes was significantly decreased by the combination of eccentric training with VitD depletion (vitD × training, p = 0.0249) suggesting a systemic inflammation. Finally, exploratory behavior time of mice was decreased by VitD depletion (VitD effect, p = 0.0146) suggesting a cognitive dysfunction. Our results suggest that VitD deficiency exacerbates the effects of overtraining.

Диагностика, лечение и профилактика синдрома перенапряжения у спасателей МЧС России

Summary. The aim of the study is to evaluate modern scientific views on the problem of diagnosis, treatment and prevention of syndromes associated with physical and emotional overstrain in rescue workers of the Russian Ministry of Emergency Situations. Study materials and methods. An analysis of domestic and foreign literature data was performed. The search was performed using the Google Academy search engine and electronic databases PubMed, MEDLINE, Embase, Scopus, Web of Science, eLIBRARY for the period from 2017 to 2022. Results of the study and their analysis. Currently, early diagnosis of overexertion syndrome (overtraining) is quite complicated. It is caused by the absence of clear diagnostic criteria, gradual development of the pathology and nonspecificity of its symptoms. That is why a complex approach is important for timely and high-quality diagnosis of overexertion, which includes a set of diagnostic measures, such as collecting anamnesis and visual examination, completing psychological questionnaires, examination of hormone levels at rest and after exercise tests, examination of blood biochemical characteristics (determination of total protein concentration, lipoproteins, glucose, cholesterol, etc.) and instrumental examination. The main ways to fight against overtraining syndrome are emotional rest, gentle training regime, adequate replenishment of energy and plastic substrates, and a sufficient amount of sleep. Usage of manual therapy, therapeutic physical training and physiotherapy is also possible.

An Investigation of the Psychological Status of Amateur Athletes Before and After a Triathlon Competition

Triathlon is a multisport, endurance event which places significant psychological demands on athletes. To date, few studies have compared psychological states of triathletes before and after competition. Furthermore, there is a lack of research assessing psychological indicators of overtraining in triathletes. This study aimed to create a psychological profile of amateur athletes before and after a triathlon competition, and to investigate psychological symptoms of overtraining syndrome. Forty amateur triathletes were recruited to participate in this study. Participants completed the Profile of Mood States (POMS), Passion Scale (PS), Pittsburgh Sleep Quality Index (PSQI), and General Self-Efficacy Scale (GES). Questionnaires were administered the day before a triathlon event, and then repeated the day after the competition. Athletes reported poor sleep quality, and mood states followed the iceberg profile (i.e., high vigor, and low anxiety, depression, anger, fatigue, tension, and confusion). Significantly higher pre-competition scores emerged for tension (pre: 8.85±5.4, post: 4.18±5.0, p &lt; 0 .001) and anger (pre: 3.57±3.8, post: 2.80±4.1, p = 0 .021). Correlational analyses performed using Spearman’s rank correlation coefficient revealed that pre-competition sleepquality (r = -0.37, p = 0.019) and tension (r = -0.34, p = 0.031) were related to self-efficacy, and that tension (r = 0.47, p = 0.002), and fatigue (r = 0.57, p &lt; 0.001) were related to pre-competition sleep quality. Lower scores for pre-competition vigor (r = -0.40, p = 0.010) were associated with poorer sleep quality. The study highlights significant relationships with sleep quality, and potential indicators of overtraining syndrome in amateur triathletes. Experimental research analyzing the effects of interventions to target the highlighted psychological characteristics in amateur triathletes is recommended. Coaches and practitioners should monitor athletes’ sleep quality before competition to optimize performance and prevent overtraining syndrome.

Evaluation of the effect of oxidative stress on dynamics of cardiac biomarkers in Georgian elite athletes with overtraining syndrome

Abstract Funding Acknowledgements Type of funding sources: None. Background Training of professional athletes comprises of repetitive overloading to initiate structural and functional changes for favorable adaptation to the workouts, but with an inadequate recovery overloading may produce non-functional overreaching(NFO) and then overtraining syndrome(OTS). It is important to study chronic effects of exercises via responses of biomarkers for understanding of muscle fatigue and cardiac damage to identify athletes at risk of poor adaptation to training[3,4]. The purpose was to study the effects of oxidative stress on dynamics of cardiac biomarkers in Georgian elite athletes with OTS. Methods On the initial stage in 43 athletes(37 with NFO, 6 with OTS) study of relationship between oxidative stress and OTS revealed imbalance between oxidant production and antioxidant protection via attenuation of antioxidant capacity in athletes with OTS[1,2]. On the current stage of our study,in 43 NFO/OTS athletes and 40 age-matched controls without NFO/OTS pre-season serum creatine kinase myocardial band(CK-MB) and cardiac troponin I(cTnI) were measured, followed by in-season evaluation of the dynamic of their changes(HUMAN,Germany). In-season levels of CK-MB and cTnI were obtained 24hrs before strenuous sport-specific exercise of peak-season intensity, immediately after the work-load,after 6, 48,and 72hrs. Baseline and post-execise clinical assessment and transthoracic echocardiography(TTE) were performed in 6 and 48hrs after strenuous session(6 hrs corresponds to the time when cTnI is typically detectable in ischemic models;48 hrs-CK concentrations recovery time). Results Similar rising trend of CK-MB and cTnI levels was observed immediately after exercise, reaching peak values after 6hrs in all athletes, though, significantly greater in NFO/OTS athletes than in controls, and slightly exceeded reference range of cTnI (in NFO 0.128±0.092ng/ml, in OTS 0.137±0.061ng/ml). After 48hrs of recovery CK-MB and cTnI in NFO/OTS athletes were significantly higher than on entry, showing slower recovery,though normalized in 72hrs. TTE didn’t reveal any sustained alterations of systolic and diastolic functions, or clinically threatening myocardial damage, only minor diastolic changes due to adaptation to the post-exercise haemodynamic in OTS athletes(E/A pre-exercise:1.47±0.25, post-exercise:in 6hrs 1.06±0.14,in 48hrs 1.40±0.09,p&amp;lt;0,05). Elevated cardiac markers after strenuous exercise can be linked to increased cellular permeability and cardiac troponin leakage, amplified by oxidative stress existent in OTS athletes. Conclusions In our study intensive exercise caused transient increase of the CK-MB and cTnI in NFO/OTS athletes, without irreversible pathophysiological and clinical consequences, suggesting mostly benign cardiac involvement, though amplified by existent oxidative stress in athletes with OTS. Monitoring responses via alterations of biochemical parameters can be helpful to guide athletic training and prevent OTS.

Exercise-related changes in the anabolic index (testosterone to cortisol ratio) and serum amyloid A concentration in endurance and racehorses at different fitness levels.

Increased training loads in both human and equine athletes are generally implemented to improve their physical performance. These loads are tolerated only within appropriate training periodization with regard to recovery time. Otherwise, training overload causes failure in the systemic adaptation, which at first leads to overreaching, and progressively to overtraining syndrome (OTS). Exercise endocrinology, and anabolic/catabolic balance as an indicator of athlete performance status and OTS has continued to attract attention. In human medicine, changes in testosterone and cortisol levels, as well as the testosterone to cortisol ratio (T/C; anabolic index), are suggested to be sensitive stress markers. However, there is a lack of research investigating these parameters for use in equine sports medicine. The aim of the study was to investigate the differences in testosterone, cortisol, and T/C in response to a single training session in two types of equine sports: endurance and race, together with serum amyloid A (SAA), the main acute phase response indicator of physical effort, and the overall health status in horses. Two groups of horses were enrolled in the study: endurance (n = 12) and racehorses (n = 32) of different fitness level. Blood samples were obtained before and after the exercise. On average, T increased 2.5 times after the race training in experienced racehorses and dropped in endurance horses regardless the fitness level (p < 0.05). In endurance horses, a decrease in T/C occurred after training in inexperienced horses (p < 0.05). In racehorses, a T/C decrease occurred in the inexperienced group (p < 0.05) and an increase in the experienced (p < 0.01). In conclusion, T/C ratio was found to be a potentially reliable indicator of fitness status especially in racing horses. These findings provide insight into the physiological response of the horses to different types of exercise and the potential use of hormone levels as markers of performance and adaptation.

Intrafasciomembranal Fluid Pressure: A Novel Approach to the Etiology of Myalgias, Part II.

The fascia forms a hierarchy of spaces (small and large compartments) that contain and enclose muscle fibers, fiber bundles, skeletal muscles, and compartments of several skeletal muscles. Solid fascia serves as a membrane that enables an increased volume and fluid pressure within such a fasciomembrane, an intrafasciomembrial fluid pressure (IFMFP). Increased IFMFP provides a theoretical model and a common explanation for the etiology of the myalgias: trigger point (TrP), chronic exertional compartment syndrome (CECS), overtraining syndrome (OTS), and delayed onset muscle soreness (DOMS). Many myalgias and their symptoms are poorly understood, and this review aims to provide an extension to this theoretical model and novel approach. This review suggests that the swelling from elevated IFMFP also likely leads to a longitudinal shortening of the same affected tissue. This model of swelling and shortening provides additional explanations for the changes in the lines of force through the body that can lead to changes in the body's posture and, thus, to compensatory movements. This new approximation also provides a biomechanical explanation for the thickening of the fascia and referred pain, and also suggests that IFMFP is a factor in weather-related pain.