Passive Displacement Cooling (PDC) is a relatively recent technology gaining attention as a means of significantly reducing building energy consumption overheads, especially in tropical climates. PDC eliminates the use of mechanical fans, instead using chilled-water heat exchangers to perform convective cooling. In this paper, we identify and characterize the impact of several key parameters affecting occupant comfort in a 1000m2 open-floor area (consisting of multiple zones) of a ZEB (Zero Energy Building) deployed with PDC units and tackle the problem of setting the temperature setpoint of the PDC units to assure occupant thermal comfort and yet conserve energy. We tackle two key practical challenges: (a) the zone-level (i.e., occupant-experienced) temperature differs significantly, depending on occupancy levels, from that measured by the ceiling-mounted thermal sensors that drive the PDC control loop, (b) sparsely deployed sensors are unable to capture the often-significant differences in ambient temperature across neighboring zones. Using extensive real-world coarser-grained measurement data (collected over 60 days under varying occupancy conditions), (a) we first uncover the various parameters that affect the occupant-level ambient temperature, and then (b) devise a trace-based model that helps identify the optimum combination of PDC setpoints, collectively across multiple zones, while accommodating variations in the occupancy levels and weather conditions. Using this trace-based model, our OcAPO system can assure ambient temperature experienced by occupants within a tolerance of 0.3°C. In contrast, the existing approach of occupancy-agnostic, rule-based setpoint control violates this tolerance interval more than 80% of the time. However, this initial model requires unnecessary and continual database lookups and is unable to derive finer-grained setpoints, thereby potentially missing opportunities for additional energy savings. We thus collected data for another 15 days, with finer-grained setpoint control in increments of 0.2∘ under varying occupancy conditions in the second phase. To determine PDC setpoints efficiently, we subsequently used the empirical data to train a KNN-based regression model. Additional studies on our real-world testbed demonstrate the regressor-based OcAPO approach is able to assure occupant-level ambient temperature within a narrow 0.2°C tolerance. We also demonstrate that the regression version of OcAPO can reduce the opening percentage of PDC valves (an indirect proxy for energy consumption) by 58.9% under low occupancy compared to the trace-based model.