Despite the reduction in the overall prevalence of cigarette smoking in the US, use has remained high among Hispanics/Latinos (H/Ls), particularly Puerto Ricans (33.7%) and Cuban/Cuban Americans (27.2%) (HCHS/SOL Databook, 2013). There is limited understanding about H/Ls knowledge, attitudes and behaviors (KAB) toward the use of other tobacco products such as e-cigs and hookah and how they may differ across diverse ethnic backgrounds, SES and acculturation. Objective: To assess KAB and perception of risk about the use of tobacco products among H/Ls that can inform the development of a culturally appropriate campaign to reduce prevalence. Methods: During the summer of 2014, 26 English and Spanish-speaking focus groups (6-10 persons per group, N = 182) were conducted among smokers and non-smokers, young (18-35) and old (36-65), men and women, of different SES and acculturation levels in: Chicago (Central and South Americans), New York City (Puerto Ricans and Dominicans), San Diego (Mexican/Mexican Americans) and Miami (Cubans). During 1 ½ hrs. discussion, participants were asked about: tobacco use problem in the community, type of tobacco use, health consequences of tobacco use, tobacco industry policy, second hand smoke, efforts to quit cigarette use, and channels of communication, including information technology. Data were analyzed using Atlas.ti for prevalent themes, perceptions and KAB. Results: Regardless of ethnic background, Latino smokers were most likely to use regular cigarettes, e-cigs and hookah. Older H/Ls (36+) and Spanish-speaking immigrants were most likely to use regular cigarettes while younger adults (women and men), US-born or more acculturated, were most likely to report using e-cigarette and/or hookah. Users stated that easy access, appeal of the different flavored tobacco taste & smell, no restrictions in their use, and socializing with others, made these products attractive. Differences did emerge in KAB and perceptions of tobacco risk by specific H/L group, smoking status, city, SES and acculturation. Conclusion: Tobacco use continues to be a serious problem in the H/L communities with growing use and acceptance of e-cigarettes and hookah among younger and more acculturated H/Ls.