Ovary In Children Research Articles

Impact of Surgical Timing (Primary, Delayed, or Second Look) on Surgical Morbidity and Outcomes in Malignant Germ Cell Tumor of the Ovary in Children

BackgroundMalignant ovarian germ cell tumors (MOGCT) are rare in children. Surgery with or without chemotherapy is the primary treatment approach. This study aimed to analyze the impact of primary and delayed surgery on surgical morbidity and outcomes. Second-look surgery after inadequate surgical staging and the various components of surgical staging were also evaluated. MethodsChildren below 15 years with MOGCT treated between 2006 and 2022 were analyzed. A comparison of patients undergoing primary, delayed, and second-look surgery was performed. Results118 patients with a median age of 12 (0.11–15) years were eligible. Forty patients underwent primary, 51 delayed, and 27 second-look surgeries. Overall complications, including tumor rupture, blood loss, and adjacent organ removal, were significantly higher in the primary compared to the delayed surgery group (p = 0.0001). Second-look surgery conceded more blood loss (p = 0.0001), extended duration (p = 0.03), and complications (p = 0.004) than delayed surgery. The compliance with surgical guidelines was 100% for most components, with a positive yield rate of 10–80%. At a median follow-up of 5.2 years, the 5-year event-free survival (EFS) and overall survival (OS) for the entire cohort are 86% and 89%, respectively. The OS and EFS did not differ by the timing of surgery, although the second-look surgery demonstrated relatively inferior outcomes consequential to initial suboptimal surgery. ConclusionsMOGCT shows favorable outcomes. Delayed surgery after chemotherapy in appropriately selected patients minimizes the morbidity of surgery with similar outcomes compared to primary surgery. An optimal initial surgery is essential since second-look surgery produces significant morbidity.Prognosis Study, Level II evidence

Research

The February 2024 Research Roundup360 looks at: If you use a surgical helmet, you should seal your gown-glove interface; The use of iodophor-impregnated drapes in patients with iodine-related allergies: a case series and review of the literature; Location of the ovaries in children and efficacy of gonadal shielding in hip and pelvis radiography; Prehospital tranexamic acid administration does not improve outcomes in severe trauma patients; Silver-coated distal femur megaprosthesis in chronic infections with severe bone loss: a multicentre case series.

Location of the ovaries in children and efficacy of gonadal shielding in hip and pelvis radiography

BackgroundPatients with hip disorders undergo multiple radiographic examinations, so gonadal radiation risk should be minimized. Inaccurate shield placement, including obscuring landmarks, has been widely reported, and some studies reported that covering the true pelvis was inappropriate to shield young girls’ ovaries. However, no reports on ovaries in Asian patients identified on magnetic resonance imaging exist. We aimed to identify the location of the ovaries in Japanese children and assess the efficacy of gonadal shielding. MethodsFemale patients aged ≤16 years who underwent magnetic resonance imaging for hip disorders that displayed at least one ovary were included. Sixty ovaries from 31 patients were classified into two age groups: <2 years and >2 years, and the ovaries' position was classified according to the following four zones on the anteroposterior pelvic radiograph: zone 1 (true pelvis) — area surrounded by the line of the anterior superior iliac spines, inner side walls of the ilium, and symphysis pubis; zone 2 — areas lateral to zone 1; zone 3 — sacral area superior to zone 1; and zone 4 — areas lateral to zone 3. The ovaries’ position was analyzed according to age group. ResultsThirty-one ovaries in 16 patients were <2 years, and 29 ovaries in 15 patients were >2 years. Thirteen ovaries in the true pelvis, 18 ovaries in the false pelvis were <2 years, and 27 in the true pelvis and 2 in the false pelvis were in >2 years. In girls aged <2 years, most ovaries in the false pelvis were located in zone 3. ConclusionsGirls aged >2 years mostly have their ovaries in the true pelvis, and ovaries in infants tend to be located superior to the true pelvis. Covering the true pelvis is plausible for shielding ovaries. Shields should be placed slightly more cranially than the true pelvis for infants.

Unilateral Cystic Teratoma of the Ovary in Children: A Case Report

Teratoma is a type of extracranial germ cell tumor that often occurs and correlates with age and anatomical location. Mature Cystic Teratoma (MCT) is the most common ovarian tumor in children and adolescents. The most common sites for teratomas are the sacrococcygeal region and the ovaries. Laparoscopy is by far the surgical treatment of choice for teratomas. We report a case of a 9-year-old girl with a chief complaint of left lower quadrant abdominal pain 1 week before hospital admission. The patient appears weak and has decreased appetite, accompanied by weight loss, and painful urination. Physical examination of abdominal distension (+), tenderness, and release in the left lower quadrant (+). The patient had not menstruated, and a history of vaginal discharge was denied. On MSCT-scan examination of the abdomen with contrast, a cystic mass was found that adhered to and pushed the surrounding bowel structures in the lower abdominal region. On histopathological examination taken from the left ovary preparation, a macroscopic examination found cyst tissue of 9.5 x 6.5 x 5 cm. The cyst is gray-black, filled with blood and a white pulp mass with hair. On microscopic examination found cysts with fibrous connective tissue stroma containing vascular. The treatment is in the form of laparoscopy and after surgery, currently, the patient is in good condition and will be followed up again every 3 months.

“Follow the Fallopian tube”: A technique to improve sonographic identification of ovaries in children

Ovary detection is the first step in confirming ovarian lesions. The daughter cyst sign is widely used for this purpose; however, it is not always applicable. Recent improvements in image resolution allow Fallopian tube delineation, which can serve as a guide to identify the ovary. This anatomical approach ("follow the Fallopian tube" technique) comprises three steps: (1) confirm the uterus; (2) follow the Fallopian tube; and (3) find the ovary. Other applications of this approach include the differentiation between nonovarian and ovarian masses and ruling out ovarian torsion and an auto-amputated ovary.

Assessment of ovarian reserve using serum anti-Müllerian hormone after ovarian torsion surgery.

The aim of this study was to determine ovarian reserve using serum anti-Müllerian hormone (AMH) level in children who had undergone either ovarian-preserving surgery or oophorectomy because of ovarian torsion. Patients aged > 10 years who had undergone surgery for unilateral ovarian torsion were contacted for the study with ethics committee approval. Seventeen patients agreed to be included. A total of 10 patients had undergone ovarian detorsion and seven had undergone oophorectomy. Mean age at operation was 11.6 ± 2.23 years (range, 8-15 years) and 13.2 ± 2.17 years (range, 10-16 years), respectively (P = 0.46). Ovarian torsion was isolated in four patients in the first group, and in three in the second. The remainder had associated benign masses. At the time of this study, mean patient age was 18 ± 2.11 years (range, 14-21 years) with a mean postoperative follow up of 5.9 ± 2.8 years (range, 2-10.5 years). Echogenicity of all preserved ovaries was normal on pelvic Doppler ultrasonography, with presence of antral follicles in six. Three ovaries were smaller than expected for age, although two of these had antral follicles. Mean AMH was 5.54 ± 2.25 ng/mL in the detorsion group and 2.70 ± 2.11 ng/mL in the oophorectomy group (P = 0.04). The presence of follicles in preserved ovaries after detorsion has been reported previously. AMH is expressed in granulosa cells of growing follicles and its serum level is valuable in assessing the quantitative aspects of ovarian reserve. Preservation of the ovary in children with torsion is justified in terms of future ovarian reserve.

Torsion of otherwise healthy ovary Has a worse prognosis than torsion of pathologic ovary in children

IntroductionTo evaluate if torsion of an otherwise healthy ovary (THO) has a different prognosis than torsion with an underlying ovarian mass (TUOM) in children. Material and methodsChildren with an ovarian torsion who were treated in our department from 1997 to 2016 were studied retrospectively. Patients with prenatal ovarian torsion and isolated oviduct torsion were excluded. Trophicity of the ovary was assessed by ultrasonography at the end of follow-up. ResultsFifty-four girls were included. Twenty-seven presented a TUOM; the others had a THO. Beside the deleterious effect of late surgical management, another prognostic factor was identified. THO was more prone to an ovarian hypotrophy or atrophy than TUOM (n = 20 vs n = 5, p < 0.01). This was confirmed by logistic regression analysis (OR = 5.08, p = 0.01). To explain this finding, we further compared TUOM and THO. The diagnosis of TUOM was more frequently suspected on US at the first visit (p = 0.005). TUOM also occurred more often after puberty (>12 years, 52.9% vs 11.1%, p < 0.001) than THO. ConclusionTHO is more frequently associated with an ovarian atrophy or hypotrophy than TUOM. A less obvious diagnosis at US and the early occurrence of THO before puberty with a less favorable hormonal climate may explain this finding. Level of evidenceIII.

Review of Laparoscopic Management of Mature Cystic Teratoma of Ovaries in Children.

Ovarian cystic mature teratomas (OCMTs) are the most frequent ovarian tumors in childhood. This review aimed to determine the feasibility and safety of laparoscopic management of OCMT. Literature was searched for terms “mature,” “ovarian,” “teratomas,” and “laparoscopy.” Primary endpoints were age at surgery, laparoscopic and surgical technique, intraoperative complications, postoperative morbidity, and associated pathology. Literature search revealed 11 articles published between 1998 and 2014 that met the inclusion criteria. There were 105 (n = 95 unilateral; n = 10 bilateral) patients for this analysis, with mean age at surgery being 13 years. Four laparoscopic approaches were opted: gasless transumbilical laparoendoscopic single-site (LESS) surgery (n = 19), gasless multiport surgery (n = 24), single-incision laparoscopic surgery (SILS) (n = 3), and pneumoperitoneum multiport laparoscopy (n = 59). The 10 patients with bilateral OCMT underwent ovary-sparing surgery: LESS-assisted extracorporeal bilateral cystectomy in which tumors were punctured by a balloon catheter (n = 2), intracorporeal cystectomy for gasless multiport laparoscopy (n = 5) with use of endobags to prevent spillage, and transperitoneal multiport laparoscopy (n = 3). OCMT was associated with ipsilateral and unilateral ovarian torsion in five and bilateral ovarian torsion in one patient with bilateral OCMT. In four patients with unilateral OCMT, salpingo-oophorectomy was performed. Intraoperative complications were laceration of utero-ovarian ligament and bladder injury during a suprapubic port placement. The mean follow-up was 31.9 months. Patients with unilateral or bilateral OCMT can be offered ovarian-sparing surgery laparoscopically with one of the following techniques: LESS, SILS or multiport laparoscopy with pneumoperitoneal or gasless. Long-term follow-up of these techniques has shown no recurrence with low postoperative morbidity and low intraoperative complications.

ЗАКОНОМЕРНОСТИ СТРУКТУРНО-КЛЕТОЧНОГО СТРОЕНИЯ ЯИЧНИКОВ В ОНТОГЕНЕЗЕ

The article presents the examination of the ovaries of embryos, ovaries of human feti and ovaries of children of the tender&#x0D; age. The researches revealed the increase of the surface of follicles, nucleus and primary oocyte’s cytoplasm that tells&#x0D; about the fact that further follicular maturation continues in the ovaries of a child of 2–4 months old. Also we registered&#x0D; the increase of nuclear cytoplasmic ratio, appearance of single mature follicles with cumulus oophorus that testifies to&#x0D; the fact that the ovary is functionally mature. Furthermore the research revealed increased content of lipids and DNA in&#x0D; follicular epithelium that also tells about functional maturity of the ovary. It was found that incretory activity of an ovary&#x0D; during the first year of life is provided by the cells originated from the connective tissue membrane of atresic follicles.

Unusual malignant neoplasms of ovary in children: two cases report.

Sex cord tumors with annular tubules are known to originate from the sex cord of embryonic gonads that synthesize Sertoli cells, Leydig cells, granulosa cells, and theca cells of the ovarian stroma, while ovarian small cell carcinoma of the hypercalcemic type is a type of neuroendocrine tumor. Both these tumors are uncommon, potentially malignant neoplasms in children. We report the case of a sex cord tumor with annular tubules in an 11-year-old girl and a case of small cell carcinoma of the hypercalcemic type in a 10-year-old girl. We also discuss the prognosis and management of these tumors.

Epithelial Tumors of the Ovary in Children and Teenagers: A Prospective Study from the Italian TREP Project

Study ObjectiveTo report the clinical findings and treatment results of a series of patients with epithelial tumors of the ovary, registered and treated prospectively in a multi-institutional Italian network (TREP project) on rare tumors in children and adolescent between 2000 and 2014. Design, Setting, and ParticipantsData on 16 patients, aged 22 to 206 months, from 7 centers were reviewed. All patients were grouped on the basis of the results of the first surgical approach, according to the Children Oncology Group staging system. ResultsThe most frequent symptom was abdominal pain; 3 patients were hospitalized for acute pain after ovarian torsion. Initial surgical treatment was complete in 15 of 16, and a biopsy was performed in 1 of 16. The histology examination revealed 8 benign tumors (7 mucinous cystadenomas and 1 serous cystadenoma) and 8 borderline tumors (2 serous and 6 mucinous). Fifteen of 16 patients maintained the complete remission after surgical treatment alone; 1 affected by Proteus syndrome died consequent to the progression of a synchronous Wilms tumor, after a delayed incomplete surgery. ConclusionOur analysis documented the rarity of these tumors in children and adolescents. No malignant histologies were found. Surgery alone was effective to cure the majority of patients. Considering the rarity of malignant entities, ovary-sparing surgery may be planned when an epithelial tumor is suspected on the basis of the preoperative work-up and intraoperative findings.

Sex cord stromal tumors of the ovary in children: A clinicopathological report from the Italian TREP project

Ovarian sex-cord stromal tumors (SCST) are rare in childhood and include a variety of neoplasms with different clinical features and biologic behavior. Aim of the analysis was to report the clinical findings and treatment results of a series of patients with SCST of the ovary, registered in a multi-institutional Italian network on rare tumors in children and adolescent between 2000 and 2009. Data on 23 patients, 5-176 months old, from 13 Centers were reviewed. All patients were grouped on the basis of the results of the first surgical approach, according to the Children Oncology Group staging system. A cisplatin based chemotherapy was recommended in patients with a localized disease, who had undergone an incomplete excision/initial biopsy, and in case of metastatic spread. A frequent symptom was abdominal pain; 9/23 cases had signs of hormonal secretion and two patients were hospitalized for acute pain following ovarian torsion. Twelve patients had a Juvenile-Granulosa Cell tumor, six a Sertoli-Leydig Cell tumor, three a Fibrothecoma, and two a Sclerosing-Stromal tumor. Twenty-one patients maintained the complete remission (follow-up: 9-91 months), 2 with a ST II Sertoli-Leydig Cell tumor relapsed and one of them died. Immonohistochemical studies could be done in 10 cases. Completeness of resection and histology were important prognostic factors; in our series the Sertoli-Leydig Cell tumor was the most aggressive variety. Hormonal signs (precocious puberty, telarca, menarche) were common in younger patients and led to an early diagnosis. Cisplatin based chemotherapy seemed to be effective for locally advanced tumors.

Minilaparotomy Approach for Giant Mucinous Cystadenoma of the Ovary in Children: Report of Two Cases

Minilaparotomy Approach for Giant Mucinous Cystadenoma of the Ovary in Children: Report of Two Cases

P-218B Two cases of giant mucinous cystadenoma of the ovary in children(Oncology, 44th Annual Meeting of Japanese Society of Pediatric Surgeons)

P-218B Two cases of giant mucinous cystadenoma of the ovary in children(Oncology, 44th Annual Meeting of Japanese Society of Pediatric Surgeons)

Outcome and staging evaluation in malignant germ cell tumors of the ovary in children and adolescents: an intergroup study

Purpose The aim of this study was to perform an evaluation of outcome and the role of surgical staging components in malignant germ cell tumors (GCT) of the ovary in children and adolescents. Methods From 1990 to 1996, 2 intergroup trials for malignant GCT were undertaken by Pediatric Oncology Group (POG) and Children’s Cancer Study Group (CCG). Stage I-II patients were treated with surgical resection and 4 cycles of standard dose cisplatin (100 mg/m 2/cycle), etoposide, and bleomycin (PEB) chemotherapy. Stage III-IV patients were treated with surgical resection and randomly assigned to chemotherapy with PEB or high-dose cisplatin (200 mg/m 2/cycle) with etoposide and bleomycin (HDPEB). Patients unresectable at diagnosis had second-look operation after 4 cycles of chemotherapy if residual tumor was seen on imaging studies. IRB approval of the protocols was obtained at each participating institution. An analysis of outcome data, operative notes, and pathology reports in girls with ovarian primary site was done for this report. Results There were 131 patients with ovarian primary tumors of 515 entered on these studies. Mean age was 11.9 years (range, 1.4 to 20 years). Six-year survival rate was stage, I 95.1%; stage II, 93.8%; stage III, 98.3%; stage IV, 93.3%. In only 3 of 131 patients were surgical guidelines followed completely. Surgical omissions resulting in protocol noncompliance resulted from failure to biopsy bilateral nodes (97%), no omentectomy (36%), no peritoneal cytology (21%), no contralateral ovary biopsy (59%). More aggressive procedure than recommended by guidelines included total hysterectomy and bilateral salpingo-oophorectomy in 6 patients and retroperitoneal node dissection in 10 patients. Correlation of gross operative findings with pathology results was carried out for ascites, lymph nodes, implants, omentum, and contralateral ovary. Conclusions Pediatric ovarian malignant GCT (stages I-IV) have excellent survival with conservative surgical resection and platinum-based chemotherapy. Survival appears to have been unaffected by deviations from surgical guidelines. New surgical guidelines are proposed based on correlation of gross findings, histology, and outcome in these intergroup trials.

Juvenile granulosa cell tumors of the ovary in children and adolescents: Results from 33 patients registered in a prospective cooperative study: Calaminus G.; Wessalowski R.; Harms D.; Gobel U. DEU Gynecol Oncol 1997 65/3 (447–452)

International Journal of Gynecology & ObstetricsVolume 60, Issue 1 p. 100-101 Citations from the literature Oncology Juvenile granulosa cell tumors of the ovary in children and adolescents: Results from 33 patients registered in a prospective cooperative study Calaminus G.; Wessalowski R.; Harms D.; Gobel U. DEU Gynecol Oncol 1997 65/3 (447–452) First published: 18 May 2004 https://doi.org/10.1016/S0020-7292(98)90465-9AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat No abstract is available for this article. Volume60, Issue1January 1998Pages 100-101 RelatedInformation

Juvenile Granulosa Cell Tumors of the Ovary in Children and Adolescents: Results from 33 Patients Registered in a Prospective Cooperative Study

Clinical and pathological data from 33 prospective registered patients who suffered from juvenile granulosa cell tumors (JGCT) were evaluated according to treatment and outcome. The median age at the time of diagnosis was 7.6 years (range, 6 months to 17.5 years). Fourteen patients showed signs of a pseudo-precocious puberty. In 1 patient premenarcheal bleeding was the only clinical symptom of the disease. A pelvic tumor or an abdominal distention was found in 6 children, revealing signs of an acute abdomen in 3 children. Tumor staging was performed according to the FIGO (International Federation of Gynecology and Obstetrics) classification for ovarian tumors. Twenty children and adolescents were classified as FIGO stage Ia; 8 children had stage Ic tumors. In 4 patients stage IIc and in 1 patient stage IIIc tumors were observed. For local tumor control all 33 patients underwent tumor resection and oophorectomy, which was complete in 28 patients. Adjuvant combination chemotherapy was used in 1 girl who presented with high mitotic pathological index features in FIGO stage Ia. In 8 other children between FIGO stage Ic and IIIc, treatment was also intensified by multidrug chemotherapy. After a follow-up period of 168 months, an event-free survival of 0.75 ± 0.07 was observed. From our data we conclude that multidrug chemotherapy including cisplatin-based regimens may be useful to enhance treatment results of JGCT, especially in advanced FIGO stages.

Wandering calcified ovary in children

A case of a mobile, calcified, intrapelvic mass representing an autoamputated ovary in an asymptomatic girl is presented. There was no previous history of acute abdominal pain indicating possible torsion of the adnexa. The diagnosis should be suspected when radiological investigations show a freely mobile, calcified intraperitoneal mass incidentally in young females with absent adnexa. The diagnostic and therapeutic role of laparoscopy in this case is emphasised.

Wandering calcified ovary in children

A case of a mobile, calcified, intrapelvic mass representing an autoamputated ovary in an asymptomatic girl is presented. There was no previous history of acute abdominal pain indicating possible torsion of the adnexa. The diagnosis should be suspected when radiological investigations show a freely mobile, calcified intraperitoneal mass incidentally in young females with absent adnexa. The diagnostic and therapeutic role of laparoscopy in this case is emphasised.

Laparoscopic ovariopexy for paediatric pelvic malignancies

Ovariopexy can prevent radiation damage to the ovaries in children undergoing pelvic irradiation, and should be considered prior to radical curative radiotherapy. We report two children who have had successful laparoscopic ovariopexy, and advocate its use in conjunction with local radiotherapy in childhood malignancy. It reduces iatrogenic trauma significantly and assists with staging and managing paediatric pelvic malignancies.