Abstract Observational and modeling efforts have explored the formation and maintenance of mesovortices, which contribute to severe hazards in quasi-linear convective systems (QLCSs). There exists an important interplay between environmental shear and cold-pool-induced circulations which, when balanced, allow for upright QLCS updrafts with maximized lift along storm outflow boundaries. Numerical simulations have primarily tested the sensitivity of squall lines to zonally varying low-level (LL) shear profiles (i.e., purely line-normal, assuming a north–south-oriented system), but observed near-storm environments of mesovortex-producing QLCSs exhibit substantial LL hodograph curvature (i.e., line-parallel shear). Therefore, previous QLCS simulations may fail to capture the full impacts of LL shear variability on mesovortex characteristics. To this end, this study employs an ensemble of idealized QLCS simulations with systematic variations in the orientation and magnitude of the ambient LL shear vector, all while holding 0–3-km line-normal shear constant. This allows for a nuanced examination of how line-parallel shear modulates system structure, as well as mesovortex strength, size, and longevity. Results indicate that hodographs with LL curvature support squall lines with prominent bowing segments and wider, more intense rotating updrafts. Shear orientation also impacts mesovortex characteristics, with curved hodographs favoring cyclonic vortices that are stronger, wider, deeper, and longer-lived than those produced with straight-line wind profiles. These results provide a more complete physical understanding of how LL shear variability influences the generation of rotation in squall lines. Significance Statement Research related to linear storms has largely focused on vertical changes in winds (i.e., shear) oriented perpendicular to squall lines given its ability to balance storm cold pools and keep updrafts upright, thus promoting long-lived storms that presumably can go on to produce rotation. However, squall lines that produce a great deal of rotation often have a component of low-level shear oriented parallel to storms. This study gauges the sensitivity of simulated squall lines to changes in the direction and strength of shear close to the surface. We find that shear oriented parallel to linear storms creates stronger and larger updrafts that in turn support the development of intense and persistent rotation with characteristics supportive of tornadoes. These insights have impacts on both our physical understanding and prediction of the rotation and associated hazards of linear storms.