Outer Band Research Articles

Retinal Pigment Epithelium Curvature Can Predict Late Age-Related Macular Degeneration.

Outer retinal band integrity strongly predicts late age-related macular degeneration (AMD). However, it is often assessed subjectively as "continuity" using inconsistent definitions. Alternatively, "curvature" of the outer retinal bands is a quantitative metric that strongly correlates with AMD biomarkers and can screen for intermediate AMD. We evaluated the prognostic ability of retinal pigment epithelium (RPE) and ellipsoid zone (EZ) curvature for late AMD against outer retinal band continuity, pigmentary abnormalities, reticular pseudodrusen, and drusen volume. Consecutive patients with intermediate AMD who progressed to late AMD (n = 17) or remained stable (n = 42) were recruited. RPE and EZ curvature were quantified as a ratio of their lengths over Bruch's membrane using the sinuosity method of assessing river curvature, where a ratio of ∼1 indicates no outer retinal pathology. RPE, EZ, and Bruch's membrane were manually segmented and their lengths automatically extracted. The primary outcomes were outer retinal sinuosity and the odds ratio of predicting late AMD. Mean follow-up time for progressors and nonprogressors was 4.4 and 3.6 years. RPE sinuosity was strongly associated with pigmentary abnormalities (P = 0.001) and drusen volume (P = 0.004) but not reticular pseudodrusen (P = 0.28). RPE sinuosity >1.03 was the strongest predictor of late AMD developing within 5 years (15 [2.9-75]) and across the study period (25 [2.3-282]). Drusen volume >0.03 mm3 was the strongest predictor of progression within 2 years (33 [2.5-426]), and RPD could not independently predict progression within any time frame. RPE curvature is a promising, quantitative outer retinal biomarker that can prognosticate late AMD and potentially enhance prognostic models.

IMAGING PREDICTORS OF FUNCTIONAL OUTCOMES AFTER RHEGMATOGENOUS RETINAL DETACHMENT REPAIR.

To evaluate the microstructural optical coherence tomography and fundus autofluorescence imaging predictors of visual acuity, metamorphopsia, and aniseikonia following rhegmatogenous retinal detachment repair. This is a multicenter retrospective study of patients with primary rhegmatogenous retinal detachment who underwent repair. Best-corrected visual acuity, metamorphopsia, and aniseikonia were formally tested at 3 months postoperatively. Metamorphopsia and aniseikonia were quantitatively assessed with M-CHARTS and the New Aniseikonia Test, respectively. High-resolution spectral-domain optical coherence tomography and fundus autofluorescence images were obtained at 3 months postoperatively. Images were assessed for discontinuity of the outer retinal bands on optical coherence tomography and retinal displacement detected by retinal vessel printings on fundus autofluorescence by two masked graders with disagreements adjudicated by a third senior masked grader. Multiple linear regression models were used to determine the predictors of postoperative visual acuity, metamorphopsia, and aniseikonia. Six hundred fourteen eyes of 614 patients were included in this study. Regression analysis indicated that significant early postoperative (at 3 months) imaging predictors of visual acuity were discontinuity of the external limiting membrane (P = 0.001) and the presence of retinal vessel printings on fundus autofluorescence (P = 0.033). Discontinuity of interdigitation zone was a significant predictor of metamorphopsia [horizontal metamorphopsia (P =0.004); vertical metamorphopsia (P = 0.056); average of horizontal metamorphopsia + vertical metamorphopsia (P = 0.008)], and presence of retinal vessel printings was a significant predictor of aniseikonia (P = 0.04). Discontinuity of the external limiting membrane and retinal displacement were significant predictors of postoperative visual acuity following rhegmatogenous retinal detachment repair. Discontinuity of the interdigitation zone and retinal displacement were significant predictors of metamorphopsia and aniseikonia, respectively.

Examining Outer Band Supercell Environments in Landfalling Tropical Cyclones Using Ground-Based Radar Analyses

Abstract Supercells in landfalling tropical cyclones (TCs) often produce tornadoes within 50 km of the coastline. The prevalence of TC tornadoes near the coast is not explained by the synoptic environments of the TC, suggesting a mesoscale influence is likely. Past case studies point to thermodynamic contrasts between ocean and land or convergence along the coast as a possible mechanism for enhancing supercell mesocyclones and storm intensity. This study augments past work by examining the changes in the hurricane boundary layer over land in the context of vertical wind shear. Using ground-based single- and dual-Doppler radar analyses, we show that the reduction in the boundary layer wind results in an increase in vertical wind shear/storm-relative helicity inland of the coast. We also show that convergence along the coast may be impactful to supercells as they cross the coastal boundary. Finally, we briefly document the changes in mesocyclone vertical vorticity to assess how the environmental changes may impact individual supercells.

Photoreceptor outer segment reflectivity with ultrahigh resolution visible light optical coherence tomography in systemic hydroxychloroquine use.

To evaluate outer retinal organization in normal subjects and those using hydroxychloroquine (HCQ) with ultrahigh resolution visible light optical coherence tomography (VIS-OCT). Forty eyes of 22 adult subjects were recruited from a tertiary care retina practice including controls (20 eyes, 12 subjects, mean age 40±22yrs, mean logMAR BCVA 0.19, 90% female) and subjects with a history of HCQ use (20 eyes, 10 subjects, mean age 62±17yrs, mean logMAR BCVA 0.03, 67% female). Each subject was imaged using a custom-built VIS-OCT device (axial resolution 1.3μm) and FDA-approved OCT devices. Using VIS-OCT, control subjects demonstrate 5 and 6 hyperreflective bands in the foveal and parafoveal regions, respectively, between the outer nuclear layer and Bruch's membrane. These bands demonstrate intensity profiles complementary to the known histopathologic distribution of rods and cones. In comparison to controls, subjects taking HCQ demonstrate blunting of all bands, particularly bands 2-4. In all cases of suspected or known toxicity, VIS-OCT demonstrated attenuation of band 3i and in no cases was there attenuation of other bands that was more severe than band 3i, suggesting that changes in the reflectivity of Band 3i may be the earliest identifiable sign of HCQ toxicity. VIS-OCT of the outer retina demonstrates a unique outer retinal banding pattern corresponding to photoreceptor density profiles. There is a notable attenuation of the photoreceptor outer segment reflectivity profile associated with early HCQ toxicity. This finding may be an early, and possibly reversible, sign of HCQ toxicity, primarily impacting the cones.

Analysis of the Antarctic Marginal Ice Zone Based on Unsupervised Classification of Standalone Sea Ice Model Data

AbstractThe Antarctic marginal ice zone, the regularly wave‐affected outer band of the sea ice covered Southern Ocean, typically contains an unconsolidated ice cover comprised of smaller, thinner floes than the inner ice pack. Thus, it is a highly dynamic region and susceptible to rapid expansion and contraction, making it a focal area for understanding and predicting the response of Antarctic sea ice to a changing climate. This novel study uses unsupervised statistical clustering of sea ice data simulated by a global sea ice model (standalone CICE6 combined with a wave propagation module and prescribed ocean) to address the outstanding challenge of separating the marginal ice zone from the inner ice pack in sea ice data sets. The method identifies a marginal ice zone with the desired characteristics and floe size is shown to be the key variable in the classification. Simulated marginal ice zone widths are similar to those derived from satellite observations of wave penetration distances, but contrast with those using the standard 15%–80% areal sea ice concentration proxy, particularly during austral winter. The simulated marginal ice zone is found to undergo a seasonal transition due to new ice formation in winter, increased drift in spring, and increased rates of wave‐induced breakup and melting in summer. The understanding gained from the study motivates incorporation of wave and floe‐scale processes in sea ice models, and the methods are available for application to outputs from high‐resolution and coupled sea ice–ocean–wave models for more detailed studies of the marginal ice zone (in both hemispheres).

Polarization-resolved analysis of outer retinal bands: investigating ballistic and multiply scattered photons using full-field swept-source optical coherence tomography.

Precise interpretation of the anatomical origins of outer retinal optical coherence tomography (OCT) presents technical challenges owing to the delicate nature of the retina. To address this challenge, our study introduces a novel polarization-sensitive full-field swept-source OCT (FF-SS-OCT) that provides parallel-polarization and cross-polarization OCT measurements, predominantly capturing ballistically reflected photons and multiply scattered photons, respectively. Notably, parallel-polarization OCT unveils layer-like structures more effectively, including the inner plexiform layer (IPL) sub-layers, outer plexiform layer (OPL) sub-layers (in rod-dominant regions), and rod/cone outer segment (OS) tips, compared to cross-polarization OCT, where such sub-layers are not visible. Through a comparative analysis of parallel-polarization and cross-polarization OCT images of the outer retina, we discovered that the 2nd outer retinal OCT band results from contributions from both the ellipsoid zone (EZ) and the inner segment/outer segment (IS/OS) junction. Similarly, the 3rd outer retinal OCT band appears to reflect contributions from both the interdigitation zone (IZ) and photoreceptor OS tips. This polarization-sensitive approach advances our understanding of the origins of outer retinal OCT signals and proposes potential new biomarkers for assessing retinal health and diseases.

LONG-TERM PRESERVATION OF VISUAL ACUITY AFTER RESORPTION OF ACQUIRED VITELLIFORM LESIONS IN AGE-RELATED MACULAR DEGENERATION.

To report the long-term (23 years) clinical and multimodal imaging features of acquired vitelliform lesions (AVLs) associated with nonneovascular age-related macular degeneration. Retrospective case report. Color and red-free fundus photographs, high-resolution optical coherence tomography, fluorescein and indocyanine green angiography, and optical coherence tomography-angiography were performed. A 58-year-old man presented with bilateral AVLs in the setting of nonneovascular age-related macular degeneration. At baseline, his best-corrected visual acuity was 20/30 in his right eye and 20/20 in his left eye. Red-free fundus photographs showed AVLs with cuticular drusen in both eyes corresponding to a "stars-in-the-sky" pattern on fluorescein. Indocyanine green angiography showed no evidence of macular neovascularization. Throughout the 23-year follow-up, the patient reported consuming 20 mg/day of lutein supplement. At the end of follow-up, his best-corrected visual acuity was 20/20 in both eyes. Color fundus photographs showed resorption of the AVLs in both eyes and High-Res optical coherence tomography showed relative preservation of the outer retinal bands in the fovea. Optical coherence tomography-angiography confirmed the absence of macular neovascularization. In nonneovascular age-related macular degeneration, spontaneous resorption of AVLs may be associated with long-term maintenance of visual acuity and relative preservation of the outer retinal morphology.

Parametric Optimization of System Modes for Nozzle Turbine Vane by Means of Costimulated Artificial Immune System

One requirement posed by customers is to achieve adequate durability levels as described in technical requirement documents. Modal analysis is one of the design assessments aimed at identifying the risks of high cycle fatigue (HCF). This article presents a novel application of an artificial immune system (AIS) in the optimization of a nozzle guide vane’s modal characteristics. The aim is to optimize the system’s natural frequencies in the vibration vane and adjacent hardware (turbine casing). The geometrical characteristics accounted for in the optimization process include the shell thicknesses on the turbine casing side and the nozzle outer band features (hook thickness, leaning and position). The optimization process is based on a representative model established from FEM analysis results. The framework is robust because of the applied metamodel and does not require time-consuming FEM analysis in order to evaluate the fitness function. The aim is to minimize the model area (a derivative of the system weight) with constraints imposed on the frequency (a penalty function). The optimum design is given as the solution with an increased shell thickness in the turbine casing and leaning nozzle outer band hooks to obtain the maximum stiffness of the system. The results obtained by means of the artificial immune system (AIS) and a novel variant based on an additional costimulation procedure (CAIS) are compared with the solution obtained by means of a genetic algorithm implemented in the commercial CAE software (Ansys version 19.2).

OCT Intensity of the Region between Outer Retina Band 2 and Band 3 as a Biomarker for Retinal Degeneration and Therapy.

Optical coherence tomography (OCT) is widely used to probe retinal structure and function. This study investigated the outer retina band (ORB) pattern and reflective intensity for the region between bands 2 and 3 (Dip) in three mouse models of inherited retinal degeneration (Rs1KO, TTLL5KO, RPE65KO) and in human AMD patients from the A2A database. OCT images were manually graded, and reflectivity signals were used to calculate the Dip ratio. Qualitative analyses demonstrated the progressive merging band 2 and band 3 in all three mouse models, leading to a reduction in the Dip ratio compared to wildtype (WT) controls. Gene replacement therapy in Rs1KO mice reverted the ORB pattern to one resembling WT and increased the Dip ratio. The degree of anatomical rescue in these mice was highly correlated with level of transgenic RS1 expression and with the restoration of ERG b-wave amplitudes. While the inner retinal cavity was significantly enlarged in dark-adapted Rs1KO mice, the Dip ratio was not altered. A reduction of the Dip ratio was also detected in AMD patients compared with healthy controls and was also positively correlated with AMD severity on the AMD score. We propose that the ORB and Dip ratio can be used as non-invasive early biomarkers for retina health, which can be used to probe therapeutic gene expression and to evaluate the effectiveness of therapy.

Potential Structural Biomarkers in 3D Images Validated by the First Functional Biomarker for Early Age-Related Macular Degeneration - ALSTAR2 Baseline.

Lack of valid end points impedes developing therapeutic strategies for early age-related macular degeneration (AMD). Delayed rod-mediated dark adaptation (RMDA) is the first functional biomarker for incident early AMD. The relationship between RMDA and the status of outer retinal bands on optical coherence tomography (OCT) have not been well defined. This study aims to characterize these relationships in early and intermediate AMD. Baseline data from 476 participants was assessed including eyes with early AMD (n=138), intermediate AMD (n=101), and normal aging (n=237). Participants underwent volume OCT imaging of the macula and rod intercept time (RIT) was measured. The ellipsoid zone (EZ) and interdigitation zone (IZ) on all OCT B-scans of the volumes were segmented. The area of detectable EZ and IZ, and mean thickness of IZ within the Early Treatment Diabetic Retinopathy Study (ETDRS) grid were computed and associations with RIT were assessed by Spearman's correlation coefficient and age adjusted. Delayed RMDA (longer RIT) was most strongly associated with less preserved IZ area (r=-0.591; P<0.001), followed by decreased IZ thickness (r=-0.434; P<0.001), and EZ area (r=-0.334; P<0.001). This correlation between RIT and IZ integrity was not apparent when considering normal eyes alone within 1.5 mm of the fovea. RMDA is correlated with the status of outer retinal bands in early and intermediate AMD eyes, particularly, the status of the IZ. This correlation is consistent with a previous analysis of only foveal B-scans and is biologically plausible given that retinoid availability, involving transfer at the interface attributed to the IZ, is rate-limiting for RMDA.

Immunohistochemical, functional, and anatomical evaluation of patients with idiopathic epiretinal membrane

PurposeThe main purpose of this study was to perform an immunohistochemical, functional, and anatomical evaluation of patients with idiopathic epiretinal membrane (ERM).MethodsTwenty-four specimens of idiopathic ERM from 24 consecutive patients who underwent 23 G pars plana vitrectomy for ERM and internal limiting membrane (ILM) peeling at the San Juan University Hospital in Alicante (Spain) in 2019 were analyzed. All patients underwent a complete ophthalmological examination including measurement of best corrected visual acuity (BCVA) and macular analysis by spectral-domain optical coherence tomography (SD-OCT) at the time of diagnosis and 3 months after surgery. Specific glial fibrillar acid protein antibodies (GFAP) and S100 calcium-binding protein β (S100β) immunostaining markers were used to identify the macroglial component of the ERM, Müller cells, and astrocytes. Ionized calcium-binding adapter molecule 1 protein (Iba1) antibodies were used as specific markers for inflammatory cells, such as microglia and macrophages.ResultsMean preoperative BCVA measured with Snellen chart was 0.3 and 0.6 preoperatively and at 3 months after surgery, respectively. SD-OCT identified 15 patients (62.5%) with a disruption of the outer retinal hyperreflective bands. The immunohistochemical study showed the presence of Müller cells in almost all cases (91.6%), as well of abundant microglia and macrophages. Microglia and macrophages were more frequently present in earlier stages of ERM. Microglia were present in ERM independently of the outer retinal hyperreflective bands integrity as measured by SD-OCT. A greater presence of macrophages was found in those ERMs with no outer retinal hyperreflective band disruption.ConclusionsMüller cells seem to be the most frequent cell group in ERMs, with also presence of microglia cells and macrophages. Astrocytes were more frequently found in early stages of ERMs. Microglia and macrophages were most frequent in ERMs with early stage (1, 2, or 3) than in advanced stages (4).

TOWARD AN IMAGING-CENTRIC DEFINITION OF NONPARANEOPLASTIC AUTOIMMUNE RETINOPATHY.

To explore characteristic imaging features of nonparaneoplastic autoimmune retinopathy (npAIR) to augment diagnostic criteria. This is a retrospective cohort study of patients with npAIR evaluated at the Emory Eye Center between 2013 and 2019. Multimodal fundus images were evaluated to characterize the evolution of the disease. Twenty-one eyes of 12 patients were classified as having npAIR. Five patients (42%) were female, with median (range) age of 59 years (45-85 years). Median baseline visual acuity was 20/30 (20/20 to hand motions). Disease was asymmetric in 11 patients (92%). Common imaging findings included absence of bone spicules (86% of affected eyes), presence of attenuated vessels (86%), and speckled hypoautofluorescence in perimacular and perivenular regions. Three eyes were noted to present early with subtle splotchy fundus autofluorescence abnormality, ultimately developing characteristic speckled perimacular hypoautofluorescence. On optical coherence tomography, 18 eyes (86%) had loss of outer retinal bands with relative foveal sparing and a tapered transition zone. Many eyes with npAIR exhibit a subacute, asymmetric, generalized photoreceptor degeneration featuring outer retinal atrophy with relative foveal sparing, retinal vascular attenuation, absence of bone spicules, and speckled hypoautofluorescence often in a perimacular and perivenular distribution. Findings of this study augment diagnostic criteria to improve specificity and accessibility of testing for npAIR.

The Baltic Agenda in the Strategies of Russia’s Baltic Regions and Municipalities

Quantitative content analysis was employed to examine 63 strategies for the socioeconomic development of regions and municipalities within Russian Baltic territories. The aim was to assess the extent to which the ‘Baltic agenda’ – themes specific to this area – manifest themselves in the documents. Strategies developed between 2010 and 2023 and in force as of February 2024 were analysed. Indices of manifestation (IM) were calculated based on the number of mentions of 77 marker words. The formula for IM calculation includes the absolute number of mentions of words, adjusted for their significance, which was determined by their frequency of use and location within the text of the strategy. The IM was computed for three interrelated directions: Baltic, European and global. The maximum values of IM are characteristic of the strategy of the Kaliningrad region, which, in addition to objective factors, is due to the unusual voluminosity of the document. At the municipal level, the most impressive performances on this measure are seen in municipalities of the Kaliningrad region (Kaliningrad, Zelenogradsk, Gusev, Slavsk, Baltiysk and Bagrationovsk), Vyborg in the Leningrad region and Pskov. For Kaliningrad and Vyborg, two strategy versions were examined, making it possible to observe changes in the volume and focus on Baltic issues: the strategies are becoming shorter, with diminishing attention given to the Baltic agenda. A map diagram was drawn to illustrate the division of municipal strategies into five groups for each direction. Spatial differentiation is evident: the average IM value for the documents of the inner band of the Russian Baltic area is 2.7 times that for strategies of the outer band.

POSTOPERATIVE PHOTORECEPTOR INTEGRITY AND ANATOMICAL OUTCOMES BASED ON PRESENTING MORPHOLOGIC STAGE OF RHEGMATOGENOUS RETINAL DETACHMENT.

To evaluate outer retinal recovery on postoperative optical coherence tomography (OCT) based on presenting morphologic stage of rhegmatogenous retinal detachment (RRD). Retrospective cohort of consecutive primary fovea-involving RRDs, referred from January 2012 to September 2022. Baseline OCTs were assessed for morphologic stage of RRD. Postoperative OCT scans were graded at 3, 6, and 12 months for external limiting membrane, ellipsoid zone and interdigitation zone discontinuity, epiretinal membrane formation and severity, and residual subfoveal fluid. Three hundred and fifty-one patients were included. Increasing baseline morphologic stage of RRD was significantly associated with external limiting membrane, ellipsoid zone, and interdigitation zone discontinuity at all time points postoperatively ( P < 0.001) and was shown to be an independent predictor of foveal photoreceptor integrity after adjusting for height of detachment, time to surgery, and duration of fovea involvement ( P < 0.001). Earlier stages were associated with residual subfoveal fluid ( P < 0.001). There was no association between the stages of RRD and epiretinal membrane severity. However, late stages presented with earlier development of epiretinal membrane ( P = 0.012). Increasing morphologic stage of RRD is associated with delayed recovery of outer retinal bands in the first year and faster development of epiretinal membrane after RRD repair. The results of this study suggest that the stages may serve as a prognostic biomarker for postoperative photoreceptor recovery.

Autoimmune Retinopathy in a Patient with Stiff-Person Syndrome: A Case Report.

To describe a patient who developed retinal degeneration associated with autoimmune retinopathy (AIR) and who was also found to have anti-glutamic acid decarboxylase (GAD65) autoantibodies and the diagnosis of stiff-person syndrome (SPS). Ophthalmologic workup consisted of clinical examination, multi-modality retinal imaging, and electrophysiologic testing. Further neurologic assessment including relevant serum and cerebrospinal fluid studies was also conducted. We highlight the case of a 45-year-old patient who developed subacute, sequential vision loss, along with bilateral lower extremity weakness. On initial presentation, optical coherence tomography (OCT) of the left eye was notable for diffuse attenuation of the outer retinal bands. Fundus autofluorescence demonstrated a ring of hyper-autofluorescence encircling the fovea of the left eye. At fifteen-month follow-up, the right eye also became similarly affected. He was found to have elevated serum and cerebrospinal anti-GAD65 autoantibodies and was diagnosed with both SPS and AIR. There is a potential association of anti-GAD65 autoantibodies with the development of AIR.

Evaluating the clinical relevance and reliability of outer retinal band length on optical coherence tomography in retinal disease: a cross-sectional study

ObjectivesHyper-reflective outer retinal band (HORB) disruptions are reported across a range of retinal disease, yet a reliable, easily implemented assessment method and thorough evaluation of their association to retinal disease...

Characterization and pathogenicity of Pratylenchus vandenbergae stat. nov. (Tylenchina: Pratylenchidae), a highly pathogenic root‐lesion nematode parasitizing crops in Kenya and South Africa

AbstractA highly fecund root‐lesion nematode parasitizing a variety of crops was discovered and found to be widespread in Kenya and South Africa. These populations were molecularly identical to Pratylenchus teres teres and P. teres vandenbergae based on D2‐D3 of 28S rDNA and Hsp90 sequences. However, based on morphological differences with the original description of P. teres and its different geographical distribution, Pratylenchus vandenbergae stat. nov., previously known as subspecies P. teres vandenbergae, is recognized as a separate species. This species is characterized by a slightly offset labial region with three annuli, en face morphology belonging to Group II, lateral field with four incisures with two outer bands areolated as observed under a light microscope and the inner band also partially areolated at the vulva region as observed in scanning electron microscopy view, a robust stylet (14–17 μm) with rounded knobs and subcylindrical tail with annulated tail tip. This important and common species remained largely under the radar, probably due to identifications based only on sequence similarity, including mislabelled Pratylenchus bolivianus sequences in GenBank. Pathogenicity of P. vandenbergae stat. nov. in finger millet roots was confirmed through acid fuchsin staining, and reproduction and pathogenicity tests in maize, soybean, sunflower and tomato plants demonstrated its capacity to affect crop growth. Life cycle comparison with P. penetrans in vitro showed a similar life cycle length but significantly higher fecundity. Finally, significant differences in pathogenicity and reproduction of P. vandenbergae stat. nov. were found both at genotype level (finger millet genotypes OKHALE‐1 &amp; KNE1034) and crop level (maize, soybean, sunflower and tomato plants).

U–Pb Dating of Fibrous Dolomite in the Hydrothermal Dolostone of the Dengying Formation, Central Sichuan Basin, and Its Response to Supercontinent Breakup

Super-deep drilling in the central Sichuan Basin encountered volcanic rocks of the Suxiong Formation, which are overlain by multiple hydrothermal alterations within the upper section of the Ediacaran Dengying Formation. This provides an excellent research opportunity to understand the pre-Cambrian hydrothermal activity and geological evolution of the western margin of the Yangtze Craton. Observations revealed the development of a series of hydrothermal dolomite aggregates characterized by the presence of brown sphalerite within fractures and pores of the carbonate rock. Microscopically, the dolomite exhibited fibrous columnar crystallization, forming radial bands with a gradual decrease in crystallization intensity from the center to the periphery. Cathodoluminescence analysis revealed the presence of approximately eight dolomite bands within the aggregate. U–Pb dating from the inner to outer bands yielded isotopic ages of 781 ± 12 Ma for the second band, 683 ± 12 Ma for the fifth, 562 ± 12 Ma for the sixth, and 545.4 ± 6.9 Ma for the seventh. The in situ rare earth element (REE) distribution patterns of the 781 and 683 Ma dolomite bands exhibited similarities. They both showed low total REE content (∑REE), with significant fractionation between light and heavy REEs. Additionally, they exhibited negative anomalies in cerium (Ce) and europium (Eu), while heavy REEs were relatively enriched. The dolomite bands at 562 and 545 Ma also exhibited similar REE characteristics, with low ∑REE and weak fractionation between light and heavy REEs. They also displayed distinct negative anomalies in Ce and Eu, indicating similar distribution patterns. These findings suggested that formation of the banded hydrothermal dolostone occurred during different tectonic events, and the presence of heavy REE-enriched hydrothermal fluids suggested a deep-seated origin. This study has provided preliminary evidence that the Dengying Formation, previously considered to be of the Ediacaran age, has undergone multiple episodes of deep-seated fluid infiltration and alteration since the Mesoproterozoic Era. Importantly, these events coincide with the rifting of the Rodinia and Pannotia supercontinents, aligning with their respective timeframes. This finding raises questions regarding the stratigraphic division and correlation of the formations in the deeply buried core area of the basin.

Drivers of Antarctic sea ice advance

Antarctic sea ice is mostly seasonal. While changes in sea ice seasonality have been observed in recent decades, the lack of process understanding remains a key challenge to interpret these changes. To address this knowledge gap, we investigate the processes driving the ice season onset, known as sea ice advance, using remote sensing and in situ observations. Here, we find that seawater freezing predominantly drives advance in the inner seasonal ice zone. By contrast, in an outer band a few degrees wide, advance is due to the import of drifting ice into warmer waters. We show that advance dates are strongly related to the heat stored in the summer ocean mixed layer. This heat is controlled by the timing of sea ice retreat, explaining the tight link between retreat and advance dates. Such a thermodynamic linkage strongly constrains the climatology and interannual variations, albeit with less influence on the latter.

Acute Idiopathic Blind Spot Enlargement Syndrome (AIBSES) in the Era of OCT - a Review.

There are only about 100 case reports on the Acute Idiopathic Blind Spot Enlargement Syndrome (AIBSES). This is characterised by the eponymous visual field loss in the blind spot area, acute onset photopsia, and funduscopically little or no change in the optic disc area, with conspicuous outer retinal bands on optical coherence tomography (OCT). Typical is the unilateral occurrence. Predominantly young women are affected. While previous reviews of AIBSES either predate the introduction of OCT or focus on differentiation from potentially related outer retinal conditions (e.g., multiple evanescent white dot syndrome and acute zonal occult outer retinopathy), the present review will concentrate on the current perspective and treatment strategies that have been developed and will aim to help increase awareness. Since the first description of AIBSES in the late 1980s, the introduction of OCT has simplified the diagnosis and characterisation of AIBSES as a disease of the outer retina. Nevertheless, misdiagnosis remains common in the spectrum of optic neuritis, as AIBSES may be ignored in differential diagnosis.