Research Outcomes Research Articles

Organoids Research for Colorectal Cancer: Promising Approach for Precision Medicine, their Applications and Future Perspectives

Background: Organoids are three-dimensional (3D) constructs designed to emulate the complexity and functionality of organs in the body. Organoids have recently been used as powerful instruments for modeling and investigating several diseases, including colorectal cancer. Colorectal cancer is caused by altering colonic epithelial cells, which produce adenomas and carcinomas. Objective: The objective of present study was to investigate impact of organoids on colorectal cancer and their therapeutic outcome in cancer research. Organoids can be grown from stem cells in vitro, which closely resemble the structure and function of the organ they are derived from. They have been used in a variety of research applications, including disease modeling, drug screening, and personalized medicine. Organoids have allowed researchers to understand better the mechanisms underlying colorectal cancer initiation, progression, and resistance to therapy. Methods: The literature review was surveyed, and keywords related to cancer management, organoids, modelling, personized medicine, 3D structures were screened for colorectal cancer management were screened in SCI-hub, SCOPUS, WOS, and ABC Journals. Results: The findings of studies suggested that organoids derived from patient tumors can recapitulate the histopathology and genetic alterations of the original tumor, making them a valuable tool for personalized medicine. Conclusion: Organoids have been used to develop high-throughput drug screening assays and investigate the tumor microenvironment's contribution to colorectal cancer progression. In this review, we summarize recent advances in the use of organoids to study colorectal cancer and discuss their potential applications in the clinic.

Functional Communication Training in Schools: A Systematic Analysis of the Evidence for Ecological Validity.

Ecological validity refers to the meaningfulness or practical significance of research outcomes in everyday settings or the extent to which an intervention can be implemented by typical people during naturally occurring opportunities. In education, ecological validity may contribute to the adoption of interventions by teachers working with students in school settings. Our purpose in this review was to examine the evidence for ecological validity of functional communication training (FCT) used to address challenging behavior in school-age individuals with disabilities. We reviewed 19 single-case experimental design (SCED) studies published between 1985 and 2023. First, we used the What Works Clearinghouse (WWC) Standards to evaluate the empirical evidence of each study. Second, we evaluated the extent to which behavioral assessment and FCT procedures were described in the 15 studies that met the WWC Standards. Third, we conducted a systematic analysis of the evidence for ecological validity of behavioral assessment and FCT. Results indicate that 95% of the SCED studies met the WWC Standards. The description of procedures was complete for 50% of the behavioral assessments and for 11% of the FCT. The overall evidence for ecological validity was moderate for 16.7% and low for 83.3% of the behavioral assessments. The evidence for ecological validity for all FCT procedures was low. Future research and implications related to ecological validity are discussed.

MRI and CT compatible asymmetric bilayer hydrogel electrodes for EEG-based brain activity monitoring

The exploration of multi-dimensional brain activity with high temporal and spatial resolution is of great significance in the diagnosis of neurological disease and the study of brain science. Although the integration of electroencephalogram (EEG) with magnetic resonance imaging (MRI) and computed tomography (CT) provides a potential solution to achieve a brain-functional image with high spatiotemporal resolution, the critical issues of interface stability and magnetic compatibility remain challenging. Therefore, in this research, we proposed a conductive hydrogel EEG electrode with an asymmetrical bilayer structure, which shows the potential to overcome the challenges. Benefiting from the bilayer structure with different moduli, the hydrogel electrode exhibits high biological and mechanical compatibility with the heterogeneous brain-electrode interface. As a result, the impedance can be reduced compared with conventional metal electrodes. In addition, the hydrogel-based ionic conductive electrodes, which are free from metal conductors, are compatible with MRI and CT. Therefore, they can obtain high spatiotemporal resolution multi-dimensional brain information in clinical settings. The research outcome provides a new approach for establishing a platform for early diagnosis of brain diseases and the study of brain science.

Peer editing and writing proficiency: an experimental study in South Korean higher education

ABSTRACT Peer editing enhances critical thinking, improves student writing, ultimately leading to a more productive learning environment (Kostopoulou and O’Dwyer 2021; Lundstrom and Baker 2009, “To give is better than to receive: The benefits of peer review to the reviewer’s own writing.” Journal of Second Language Writing 18:30–43; Storch 2018, “Written corrective feedback from sociocultural theoretical perspectives: A research agenda.” Language Teaching 51 (02): 262–277; Yao et al. 2021, “How university EFL writers’ beliefs in writing ability impact their perceptions of peer assessment: Perspectives from implicit theories of intelligence.” Assessment & Evaluation in Higher Education 46 (1): 151–167). However, reservations toward peer feedback in a university EFL setting persist due to the accuracy of L2 feedback (Braine, 2003; Erdel 2023, “Student feedback literacy (SFL) profiles in an L2 writing classroom and the influence of peer feedback on the SFL features.” International Journal of Education and Literacy Studies 11 (3): 112–125.). This study utilized a pretest-posttest writing assessment to analyze differences in writing outcomes in an academic research writing course at two universities in Seoul, South Korea. The researchers also examined the accuracy of the L2 peer-editing feedback. The sampling consisted of five randomized classes of university undergraduates. Two control groups received feedback via the instructor and two experimental groups received peer-editing feedback. A fifth mixed group was divided between the control and experimental groups but within the same context. The instructors used both in-class and online feedback tools for the control and experimental groups. The analysis used Sengupta’s (1998, “Peer evaluation: ‘I am not the teacher’.” ELT Journal 52 (1): 19–28) revision taxonomy to assess peer feedback accuracy. Participants completed separate pretest and posttest writing assessments. One at the start of the semester (pretest) and one at the end (posttest). The researchers used a MANOVA to compare the pretest and posttest mean average assessment scores between the control and experimental groups. The results show that peer feedback matches the effectiveness of professor feedback for pretest/posttest scores. Researchers also assessed 156 peer-editing assignments for feedback accuracy. Peer editors demonstrated statistically significant accuracy. This study recommends using peer feedback for its benefits to L2 learners and instructors.

Outcomes after Traumatic Brain Injury with and Without Computed Tomography.

Our recent improved understanding of traumatic brain injury (TBI) comes largely from cohort studies of TBI patients with indication for computed tomography (CT). Using CT head as an inclusion criterion may overestimate poor outcomes after TBI with Glasgow Coma Scale (GCS) 13-15. We aimed to compare outcomes after TBI in adults who had a head CT scan (with negative findings) versus those who had no CT when presenting to an emergency department. This was a secondary analysis of a trial that recruited adults with GCS = 13-15 after TBI in Vancouver, Canada. We included 493 participants (18-69 years, 54% female), after removing n = 19 with traumatic abnormalities on CT (intracranial and/or skull fracture). Outcomes were Glasgow Outcome Scale Extended (GOSE), Rivermead Post-Concussion Symptoms Questionnaire (RPQ), Patient Health Questionnaire (PHQ)-9, and generalized anxiety disorder (GAD)-7 at 6 months post-injury. Over half (55%) of participants received a CT. At 6 months, 55% of participants with CT and 49% without CT had functional limitations on GOSE; 32% with CT and 33% without CT reported severe post-concussion symptoms (RPQ ≥16); 26% (with CT) and 28% (without CT) screened positive for depression (PHQ-9 ≥ 10), and 25% (with CT) and 28% (without CT) screened positive for anxiety (GAD-7 ≥ 8). In regression adjusted for personal variables, participants with CT had somewhat higher odds of worse functioning (ordinal GOSE; 1.4, 95% CI 1.0-2.0) but similar odds of severe post-concussion symptoms (1.1, 95% CI: 0.7-1.7), and depression (1.1, 95% CI: 0.7-1.7) and anxiety (1.0, 95% CI: 0.6-1.5) symptoms. Adults with and without head CT have mostly comparable outcomes from TBI with GCS = 13-15. Requiring CT by clinical indication for study entry may not create problematic selection bias for outcome research.

An Energy-Efficient Dynamic Feedback Image Signal Processor for Three-Dimensional Time-of-Flight Sensors

With the recent prominence of artificial intelligence (AI) technology, various research outcomes and applications in the field of image recognition and processing utilizing AI have been continuously emerging. In particular, the domain of object recognition using 3D time-of-flight (ToF) sensors has been actively researched, often in conjunction with augmented reality (AR) and virtual reality (VR). However, for more precise analysis, high-quality images are required, necessitating significantly larger parameters and computations. These requirements can pose challenges, especially in developing AR and VR technologies for low-power portable devices. Therefore, we propose a dynamic feedback configuration image signal processor (ISP) for 3D ToF sensors. The ISP achieves both accuracy and energy efficiency through dynamic feedback. The proposed ISP employs dynamic area extraction to perform computations and post-processing only for pixels within the valid area used by the application in each frame. Additionally, it uses dynamic resolution to determine and apply the appropriate resolution for each frame. This approach enhances energy efficiency by avoiding the processing of all sensor data while maintaining or surpassing accuracy levels. Furthermore, These functionalities are designed for hardware-efficient implementation, improving processing speed and minimizing power consumption. The results show a maximum performance of 178 fps and a high energy efficiency of up to 123.15 fps/W. When connected to the hand pose estimation (HPE) accelerator, it demonstrates an average mean squared error (MSE) of 10.03 mm, surpassing the baseline ISP value of 20.25 mm. Therefore, the proposed ISP can be effectively utilized in low-power, small form-factor devices.

Evaluating zooplankton species diversity using environmental DNA and bulk-DNA metabarcoding in the Ulleung Basin of the Southeastern Korean Peninsula in the summer

Accurately investigating the composition of zooplankton species is crucial for monitoring changes in marine ecosystems and assessing biodiversity. In this study, we utilized bulk DNA and environmental DNA metabarcoding in the Ulleung Basin, known for its high zooplankton species diversity among the seas surrounding the Korean Peninsula. Genomic DNA extracted from samples collected during three summer seasons in the survey area was analyzed using high-throughput sequencing of the cytochrome c oxidase I barcode region. We identified 350 species, which were three to six times more than those identified by traditional morphological methods. Furthermore, we observed significant differences in species composition and diversity between bulk DNA and eDNA samples. Notably, eDNA metabarcoding effectively detected species with high swimming ability and those that were difficult to capture using traditional sampling methods. This study underscores the significant impact of sampling methods on research outcomes in zooplankton species diversity studies and highlights the importance of integrating different sampling techniques. Specifically, it suggests the need for the active adoption of non-invasive methods, such as eDNA metabarcoding, for the comprehensive monitoring of diverse biological groups in marine ecosystems.

Tunable Liquid Crystal Twisted‐Planar Fresnel Lens for Vortex Topology Determination

AbstractThe development of straightforward and effective methods to determine the topological charge of phase singular beams is crucial for broadening the applications of optical vortices. Here, a straightforward and elegant method for determining the topological charge of an optical vortex using an innovative switchable achromatic nematic liquid crystal Fresnel lens is proposed. The approach allows for the unambiguous determination of both the absolute value and the sign of the topological charge of a singular beam across a wide range of the visible spectrum, as demonstrated both experimentally and theoretically. The research outcomes are promising for applications in optical information transmission systems, cryptography, and quantum computing.

Employer Fraud and Toxic Leadership and Collusion with PMC Operations: Implications for a Dual Metro Project in UP, India

This research is concentrated on the opinions of a PMC/Engineer staff of a dual metro construction project in UP, India, in relation to project fraud and underpinned by toxic leadership of the Employer. The research study employed a qualitative/interpretive methodology focused on grounded theory to extract meaning associated with the views and practices regarding the Employer and PMC Core Group collusion to negatively affect the project performance and management competence. The research scope was PMC/Engineer staff as part of the joint venture, contracted by the Employer, to oversee the project management and construction. The targeted population was made up of eleven (11) respondents, from a Project Management JV (PMC), located across a dual metro construction project having similar experiences of toxic leadership and fraud. The research outcomes comprised of four (4) main-themes - Employer, PMC Core Group, PMC, and ED; with Fourteen sub-themes (14) – illustrated by 276 discussion targets.The research outcome has raised important issues of project Employer derived fraud, where toxic leadership was used to deflect from the fraudulent activities underpinned by a PMC Core Group, acting as sycophantic fraud “enablers”. These included harassment, creation of fear, arrogation of contract, and a sense of impunity of the Employer MD/DWI and the PMC Core Group. The lack of risk management and project governance, attributed to significant procedural failures of the project stakeholders, including the European donor, has raised clear evidence of ongoing and associated fraud.

2.Y.1. Communication in participatory health research with refugees and migrants

Abstract Innovative approaches are needed to transform public health research and address health inequities. Participatory Health Research (PHR) is one such approach, which aims to maximize the participation of those whose life or work is the subject of the research in all stages of the research process. PHR has advantages for both research outcomes, including increased relevance, meaningfulness and impact of research, as well as for those involved, in terms of ownership and empowerment to address their health priorities. PHR with migrants has potential to reduce health inequities through the active involvement of migrants in research about their health. In a framework for refugee and migrant health in the WHO European Region, MacFarlane et al. (2022) recommend the research field of migration and health to adopt PHR as the norm, for ethical reasons and to support effective research-policy-practice translation. PHR with migrants is increasingly used but is still rare and adhoc in the field of migration health research. There are also potential practical and ethical challenges that warrant critical reflection. One persistent challenge is communication, where differences in culture, language and knowledge areas need to be considered in multiple ways, for example, in the development of participatory partnerships, in the conduct of data collection that takes place as a result of such participatory partnerships and in dissemination processes. The aim of the workshop is to share different approaches on PHR with migrants and propose solutions to common challenges in communication. The workshop will be structured in a first part where presenters will draw upon their experience in PHR with refugees and migrants covering a broad range of topics relating to communication, and a second part of open discussion with presenters and the audience. The workshop will address two key questions: what challenges have we experienced, and lessons learnt. Anne MacFarlane presents emerging evidence about music and singing as culturally attuned arts based methods that can create innovative opportunities for communication for partnership building, fieldwork and dissemination. Ana Gama presents on using idea-generation workshops with vignettes representing migrants with diverse health-literacy profiles and its potential to address communication challenges. Key messages • Participatory health research with migrants warrants critical reflection around communication, ethics and partnership-building. • In participatory health research, using innovative and creative methods can create opportunities to overcome communication barriers and build meaningful collaborations. Speakers/Panelists Anne MacFarlane University of Limerick, Limerick, Ireland Ana Gama IHMT, Universidade Nova de Lisboa, Lisbon, Portugal

SUBSIDY REMOVAL AND INDEPENDENT OIL MARKETERS’ ACTIVITIES IN THE NIGERIAN DOWNSTREAM SECTOR: A CATALYST FOR PROGRESS

It is general assumed that the removal of an impediment to the development of a matter can stimulate progress. The Nigerian economy is a mono economy solely dependent on the proceeds from oil for survival Crude oil is the mainstay of the Nigerian economy attracting up to 80% of the country foreign exchange. With its pivotal role in the development of the Nigerian economy this study focuses on accessing the activities of independent oil marketers in the Nigerian downstream oil and gas sector within the context of subsidy removal with the intention of making a case for their scrapping or retention. The marketing function of distribution is at the heart of marketing which borders squarely on logistics. However, the nefarious activities of oil distributors otherwise called independent oil marketers erode this function completely. The study adopts a thematic research design wherein existing literature on the subject matter were reviewed to discover gaps and outcomes for future research. From the findings, the retention of the independent oil marketers’ activities due to its vital position in the provision of the final consumer is recommended however, an increase in the supply of crude oil within the economy through the revitalization of the dilapidated refineries in Nigeria should also be considered; this would reduce the dependency on oil and development other sectors of the economy.

Implementing patient navigation for cancer prevention among individuals with mentally ill-health

Abstract Issue In Europe, over 80 million people experience mental ill-health and there are 4 million new cancer diagnoses each year. Individuals experiencing mental ill-health exhibit higher rates of cancer morbidity and mortality, with this excess attributed to risky health behaviors and obstacles encountered when accessing often fragmented healthcare systems. Description of the problem The aim of Co-CAPTAIN is the pilot implementation and evaluation of the Patient Navigation Model (PNM) for the improvement of primary cancer prevention in individuals with mental ill-health, adapted through participatory co-design in the European context. The project will adopt a cohort-based study design, commencing data collection at baseline and succeeded by three follow-ups (6 weeks, 9 months, 18 months). It will utilize a mixed-methods approach, combining quantitative and qualitative methodologies to assess diverse outcomes of PNM, facilitating both exploratory and confirmatory research. Qualitative data will be obtained through semi-structured interviews, while quantitative data will be collected using validated questionnaires and items developed ad hoc. The project will involve four pilot sites in Europe (Austria, Greece, Poland and Spain), where the PNM will be adapted to the specificities of national healthcare and support systems. The implementation phase is expected to begin in June 2024. Results During implementation, gathering both quantitative and qualitative data will offer valuable insights into feasibility and effectiveness, establishing a baseline for reshaping health and social care policies for individuals with mental ill-health across Europe. Lessons Co-CAPTAIN project aims to reduce health disparities for individuals with mental ill-health by improving overall health and reducing cancer burdens, leading to cost reductions in European health and social care systems. Key messages • The project aims to deliver an innovative solution based on the PNM, to address health disparities among individuals with mental ill-health by reducing cancer burden. • Combination of qualitative and quantitative methodologies to assess diverse outcomes.

Clinical recommendations for polygenic risk score-enhanced breast cancer screening: Can.Heal project

Abstract Background The application of polygenic risk score (PRS) in breast cancer (BC) screening presents promising opportunities. Developing recommendations for future use and research on this topic is a key focus of the EU4Health project: Building the EU cancer and public health genomics platform (Can.Heal). We aim to provide these recommendations based on the analysis of available evidence through a transparent and rigorous development process. Methods The recommendations adopt the GRADE evidence to decision methodology, leveraging an evidence review team and a multidisciplinary panel of nine experts. A systematic review is being conducted to evaluate the evidence for PRS in BC screening, in the domains of benefits and harms, acceptability, feasibility, equity and cost-effectiveness. Results Regarding benefits and harms of adding PRS to BC standard screening, we identified 63 relevant articles. Forty-five (71%) discussed benefits, while 14 (22%) addressed harms. Forty-two (67%) were observational studies, 18 (28%) modeling studies and 1 non-randomised control trial (2%) that examined the diagnostic accuracy of PRS-enhanced screening for relative BC risk prediction using measures such as net reclassification index and area under the curve. Lastly, two modeling studies (3%) assessed the clinical utility of PRS-enhanced screening in terms of life years gained, BC deaths averted. The other domains are under examination. The panel convened to redefine the research question and outcomes of interest and will reconvene to assess the certainty of evidence collected, and subsequently to draft recommendations. Conclusions The integration of PRS into BC screening shows potential benefits in improving risk prediction. Ongoing trials, such as Wisdom and MyPEBS, are studying the clinical utility of integrating PRS in BC screening. The approach taken by the Can.Heal aims to ensure that the recommendations are based on a thorough and balanced evaluation of the available evidence. Key messages • The Can.Heal project aims to formulate policy and research recommendations for breast cancer screening using PRS through a thorough evidence review. • Upcoming PRS recommendations rely on expert opinion and modeling studies.

Sodium Vanadates for Metal-Ion Batteries: Recent Advances and Perspectives.

Rechargeable metal-ion batteries (MIBs) play a pivotal role in advancing the stable supply of renewable energy by efficiently storing and discharging electrical energy. In recent years, to propel the continuous advancement of MIB technology, numerous studies have concentrated on exploring and innovating electrode materials, aiming to engineer commercial batteries with high energy density, superior power density, and extended cycle life. Notably, sodium vanadates have garnered significant attention in the realm of MIBs owing to their distinctive crystal structures, abundant resource reservoirs, and exceptional electrochemical properties. This paper provides a prompt and comprehensive review of the research landscape for various sodium vanadates (such as NaxV2O5, Na1+ xV3O8, Na2V6O16·xH2O, etc.) in the domain of MIBs over the past five years. It delves into the structural characteristics, electrochemical performances, and energy storage mechanisms of these materials, while also proposing some effective strategies to augment their electrochemical capabilities. Building upon these insights and prevailing research outcomes, this review envisions the future developmental pathways of sodium vanadates for MIBs and aims to reveal the vast potential of sodium vanadates in the emerging energy storage field and provide researchers with clear insights and perspectives for developing optimal sodium vanadate electrodes.

3.H. Scientific session: Advancing Health and Care System Transformation with the THCS Partnership

Abstract Health and care systems across Europe are facing similar challenges. These include demographic and epidemiological changes, such as growing ageing population and increasing incidence and prevalence of chronic diseases, in addition to diminishing of budgets. These challenges can be met by innovative, evidence-based solutions, the research and development of which can be supported by several ways. The European Partnership on Transforming Health and Care Systems (THCS) is a co-fund action within the Horizon Europe Programme which supports coordinated national and regional research and innovation programs, alongside capacity building, networking, dissemination, and other activities crucial for health and care systems’ transformation. The core of THCS’s activities lies in funding research and innovation projects through transnational calls, engaging numerous research and innovation funding organisations. In addition to the funding activities, THCS develops several means for supporting the transformation towards sustainable, efficient, resilient, inclusive, innovative, and people-centred health and care systems accessible to all. This workshop aims at discussing on the trends and needs for research, development and innovation and capacity building in the European health and care systems, on leveraging research outcomes for evidence-based strategies and translating research into practice, on transferring and implementing innovative health and care practices, on fostering ecosystems, and on facilitating knowledge exchange and sharing. In the workshop the different means of the THCS partnership to support the transformation of health and care systems are presented and their further development discussed. The workshop consists of five presentations followed by a general discussion. Key messages • Participants will learn about the different means of the THCS partnership to support the transformation of health and care systems. • Participants can contribute to the further development of the THCS activities by sharing their reflections, opinions, and viewpoints.

Organoids research progress in gynecological cancers: a bibliometric analysis

Background Gynecological cancers (GC) pose a severe threat to the health and safety of women’s lives, and organoids, as in-vitro research models, have demonstrated significant advantages in simulating tissue characteristics and drug screening. In recent years, there has been a rapid increase in research outcomes related to organoids in GC. However, there has been no bibliometric study concerning.Methods Publications related to GC and organoids from 2010-2023 were retrieved from the Web of Science Core Collection (WoSCC). We conducted a bibliometric analysis and visualization using CiteSpace, VOSviewer, and the Bibliometrix R Package. This analysis included the spatiotemporal distribution, author, sources, references, and keywords.Results A total of 333 publications were included. The number of annual publications indicated an explosive phase of development since 2019. The USA was the most important country in terms of cooperation, publication output, citation and centrality. University of California system ranked first in productivity among institutions, and HIPPO Y is the most relevant author in the research field. CANCERS published the most documents, and NATURE is the most cited sources. Analysis of Keywords and References, it is possible to establish the trend, and find the hotspots in the research field.Conclusion This bibliometric analysis delineated global landscapes and progress trends in GC organoids research. This study emphasized that organoids can effectively replicate the original tissue or tumors, providing a good in-vitro model for research on tumor-related mechanisms and showing significant advantages in drug screening and efficacy clinical prediction. Additionally, as preclinical models, they provide compelling evidence for personalized therapy and prediction of patient drug responses.

Validity and reliability of a physical literacy knowledge, attitudes, self-efficacy and behaviors questionnaire for early childhood educators (PLKASB-ECE): An exploratory factor analysis.

Nurturing physical literacy in young children offers a unique opportunity to address global physical inactivity trend. Early childhood education and care (ECEC) environments, with their extensive reach into this age group, and early childhood educators, through their daily interactions with children, are strategically positioned to influence children's physical literacy development. However, enhancing educators' ability to foster physical literacy requires valid and reliable assessment tools to measure holistic physical literacy constructs (i.e., cognitive, affective, behavioral) to assess the impact of physical literacy educational interventions. The purpose of this study was to develop a holistic digital tool to measure physical literacy knowledge, attitudes, self-efficacy, and behaviors of early childhood educators (PLKASB-ECE) for both their professional teaching context as well as the educator's own personal physical literacy behaviours. This study was conducted in two phases. Phase 1 involved item generation and content validation. Phase 2 employed a cross-sectional validation study design to assess the psychometric properties of the PLKASB-ECE tool. Based on a literature review an initial 19-item instrument was developed that subsequently underwent three rounds of expert content validation. Six additional items were added, resulting in a final 25-item self-report measure with a readability score equivalent to an 8th grade reading level (Flesch-Kincaid Grade Level: 8.7). This included 1 global rating item, 2 qualitative response items, 7 knowledge items, and 15 items addressing physical literacy attitudes, self-efficacy and behaviors using a 7-point Likert response scale. The PLKASB-ECE tool was administered to 470 educators in Alberta, Canada between 2019 to 2022. The 15 items were subjected to exploratory factor analysis and resulted in a five-factor scale with one item not loading. The five-factor scale held with the final 14 items with loadings ranging from 0.481 to 0.886, Cronbach's alpha ranging from 0.70 to 0.82, with ordinal omega ranging from 0.72 to 0.82. Usability, as assessed by completion time, was 8.15 minutes. These findings demonstrate good indices of reliability and validity for the PLKASB-ECE tool. This tool will be valuable as a research outcome measure for assessing educational interventions aimed at enhancing educators' understanding, confidence, and strategies for fostering holistic concepts of physical literacy in young children within ECECs.

10.N. Scientific session: Gender and parenthood: short and long-term income, career, and health inequities

Abstract Despite the last decades’ changes in the distribution of household and child-rearing tasks, its main responsibility tends to fall on women. As such, parenting may remain an important determinant of gender inequalities in income, careers, and health and well-being. In 2022, on average, European women’s gross income was 12.7% below men’s. This income gap is, in part, explained by inequalities in full-time employment: in the EU, 31.5% of women with children worked part-time, which contrasts with 20.2% of women without children, with 4.9% of men with children, and 7.2% of men without children. These income and career impacts may occur due to the persistence of some traditional conceptions of the division of paid and nonpaid labor. These conceptions, and the subsequent inequalities in career progression and income, may be reflected in women’s living conditions, work-family conflict, chronic strain, well-being, and health. Yet, it can also be posited that men, experiencing the pressure to remain the main provider in the family and the most recent expectations to comply with childrearing roles, may also see their well-being and health affected. However, countries with higher gender equity have shown better results in life expectancy and healthy life expectancy for women and men. It can be argued that women and men, especially those who have children, benefit from countries with more progressive parental policies, such as longer and more equally divided parental leaves, accessible childcare, or flexible working schemes. It could, thus, be expected that these countries present higher gender equity in paid and nonpaid work division, career progression, and income, with a higher couple balance, and healthier family environments, with health gains for women and men who are parents and their children. This workshop aims to present and open to discussion recent research outcomes on the role of parenthood on income, career, and health inequalities across European countries. It will show results from quantitative and qualitative studies that focus on analyzing these impacts in the short- and long-term. By discussing these results, researchers and public health professionals may grasp parental, labor market, or social policies or health programs to foster gender equality in access to better living conditions and health, especially during and after parenthood. Key messages • Parenthood may widen gender inequities regarding income and career progression, contributing to the gender gap in health and well-being. • By understanding the magnitude of gender inequities and their distribution across countries, public health researchers and professionals may identify policies that effectively address the gender gap.

Study on anti-reflection of deep soft and high gas coal seam floor by deep hole controlled blasting

Addressing the practical challenges of difficult drilling for blasting-induced permeability enhancement in deep, soft, and high-gas coal seams, where fractures remain underdeveloped and prone to re-compaction, this study proposes blasting operations within the floor strata. This approach aims to enhance the permeability of soft coal seams, thereby extending the duration of effective gas extraction. A bidirectional loading gas–solid coupling blasting simulation system was established in the laboratory, enabling multi-faceted analysis of experimental models through macroscopic crack patterns, internal damage mechanisms, and strain data of coal and rock masses. Comparative experiments were conducted, contrasting various control hole spacings with conventional blasting techniques. The findings reveal that as the blasting stress wave traverses the control hole walls, tensile stress waves are reflected, facilitating crack propagation. The guiding effect of the control holes and the spatial compensation they provide significantly increase the extension distance of explosion-induced cracks, resulting in directional failure of the test specimens and heightened damage in the far field of the blast. After the blasting process, the arrangement of control holes can result in an increase of up to 133% in damage to the coal seam and a reduction of up to 167% in damage to the floorboard compared to the model without control holes. Notably, when the control holes are proximal to the coal-rock interface, the near-end coal body experiences the most pronounced effects, with peak damage and tensile strain in the d = 20 mm model being 1.93 and 1.79 times higher, respectively, than those in models without control holes. Conversely, for control holes located further from the interface, the distal coal body experiences the greatest influence, exhibiting 1.53 and 1.55 times higher peak damage and tensile strain, respectively, in the d = 80 mm model compared to uncontrolled counterparts. Field observations at the C13 coal seam of a mine within the Huainan mining area corroborate these findings, where the volume of gas extraction and its concentration experienced a rapid increase following blasting and penetration enhancement. Optimum permeability enhancement occurs when the blasting hole is situated 4 m from the extraction point, resulting in a 131% increase in gas extraction purity from 0.15 × 10–3 m3/min to 1.97 × 10–3 m3/min. Furthermore, gas concentration soars by 373%, from 5.86% to 21.86%. These research outcomes offer valuable insights and hold considerable reference significance for blasting-induced permeability enhancement in deep, soft, and high gas coal seams.

Lipidomics-based deep learning algorithms can enhance prediction of obstructive coronary artery disease

Abstract Background Lipidomics emerge as a promising research field with the potential to help in personalized risk stratification and also improve our understanding on the functional role of individual lipid species in the metabolic perturbations occurring in coronary artery disease (CAD). The existing technological challenges to detect diverse yet structurally similar lipids and their isomers, as well as the need for novel statistical and computational tools to handle the high-dimensional lipidome may be responsible for the reduced clinical translation of the very first lipidomics research outcomes. Methods To that end, this post-hoc analysis of the prospective CorLipid trial aimed to investigate the predictive capability of a lipidomics panel for obstructive CAD risk through an extreme gradient boosting (XGBoost) machine learning (ML) approach. The lipid profiles of 146 individuals with suspected CAD were investigated through liquid chromatography-mass spectrometry. Fasting blood samples were drawn prior to invasive coronary angiography execution. Obstructive CAD was defined as SYNTAX Score (SS) >0 compared to non-obstructive CAD (SS=0). Results Study participants (75.3% male, mean age: 61 ±10.5 years old) were divided into two categories based on the existence of obstructive CAD (54.8% with SS>0 and 45.2% with SS=0). In total, 517 lipid species were identified, from which 290 lipid species were finally quantified in participants’ serum [glycerophospholipids (52.1%), glycerolipids (28.6%) and sphingolipids (19.3%)]. The levels of glycerophospholipid, sphingolipid and glycerolipid classes were significantly different in patients with obstructive CAD. Finally, a ML XGBoost algorithm identified a panel of 17 serum biomarkers (5 sphingolipids, 7 glycerophospholipids, triacylglycerols, galectin-3, glucose, LDL and LDH) as totally sensitive (100% sensitivity, 62.1% specificity and 100% negative predictive value) for the prediction of obstructive CAD. Conclusions These findings provide molecular insights into the role of dysregulated lipid metabolism in the development and progression of CAD while validating the existing body of evidence from similar research studies. Further (ML-based) investigation of lipid metabolism could hold promises for novel therapeutic strategies and improvement of the existing risk stratification schemes.Lipidomics panel importance