Results Of Laser Therapy Research Articles

The use of low-intensity Nd:Yag laser therapy in the complex treatment of animal bite wounds on the face.Own еxperience in the management of wounds by dog bite

This case series report describes the management of 26 patients and describes the protocol for the treatment of bite wounds. The patients underwent complex treatment, including primary surgical debridement, wound closure, tetanus prophylaxis with human tetanus immunoglobulin at a dose of 400 IU, level laser therapy (LLLT) with a short-pulse Nd:Yag laser “Aerolase Neo” (doses from 3-8 J/cm2, wavelength 1064 nm, pulse duration 650 mcs) 4 procedures, 1 week interval. The results of laser therapy are noticeable after 3-5 treatments, but treatment protocols are unique for each patient and condition. Primary correction of facial injuries from dog bites, with complex treatment, has positive results. When treating a wound from animal bites on the face, it is necessary to apply an integrated approach, surgical intervention should be applied in accordance with the criteria for aesthetic reconstructive surgery of the face. The inclusion of Nd:Yag laser in the complex of treatment procedures for animal bites leads to rapid wound healing, prevents the formation of scar tissue, and reduces inflammation and pain associated with injury. Case data have shown that Nd:Yag laser therapy is effective in open wounds from animal bites, indicating better regeneration and rapid restoration of structural and functional integrity

Imaging and Pathological Characteristics of Port-Wine Stain Patients with Tissue Hypertrophy Before Laser Therapy: Retrospective Data

Background: Port-wine stain (PWS) patients may simultaneously have accompanied soft tissue hypertrophy. The outcome of laser therapy can be poor. Objective: To study the imaging and histopathological characteristics of PWS patients with facial overgrowth. Materials and methods: We retrospectively assessed the effect of therapy on a subset of PWS patients with facial overgrowth. The degree of hypertrophy and the density of enhanced signals on T1-weighted magnetic resonance imaging (MRI) were independently graded by two radiologists using a quartile scale. Biopsies/resection of tissue deep to the facial muscle was reviewed and compared with flat PWS. Results: Thirty-two PWS patients with facial hypertrophy and 15 patients with flat PWS were included. MRI revealed a statistically significant correlation between the degree of hypertrophy and the density of enhanced signals (3.02 ± 0.92 vs. 2.47 ± 0.69; p < 0.01). Histological features of a subset of patients showed that vascular malformations existed in the dermis and also in the subcutaneous fat and muscle with much larger vessel diameters (fat, 0.048 vs. 0.020; muscle, 0.035 vs. 0.017) and thicker vessel walls (fat, 0.014 vs. 0.006; muscle, 0.010 vs. 0.006) (both p < 0.05). Conclusions: The imaging and pathological findings indicate that capillary malformation in subcutaneous tissue might be a major cause of poor therapeutic effect of laser therapy for PWS. Clinical trial registration no.: ChiCTR1800014278.

The outcome of using different surgical modalities and laser therapy in the treatment of small‐ and medium‐sized congenital melanocytic nevi: a systematic review

The purpose of this study is to review the published articles regarding different surgical modalities including laser therapy in the treatment of congenital melanocytic nevi (CMN). A systematic review was done using several databases including PubMed, Ovid Medline, Google Scholar, and Medline to search for articles related to surgical excisions and different treatment modalities of CMN. Fourteen studies were included according to the inclusion and exclusion criteria. The results have shown that the Q-switched ruby laser therapy was the most commonly used laser therapy to treat CMN. Overall, using laser therapy had positive outcomes in CMN treatment. However, limited knowledge was available regarding patient satisfaction with the outcomes of laser therapy. We concluded that the most acceptable surgical choice was using excision with tissue expanders. Laser-intense pulsed light (IPL) alone and in combination with Erbium:yttrium-aluminum-garnet (Er:YAG) has a risk of recurrence. Combination of types of the laser is more effective than a single one.

Clinical and Histopathologic Assessment of Facial Melasma After Low-Fluence Q-Switched Neodymium-Doped Yttrium Aluminium Garnet Laser.

Melasma is a frequent and difficult to treat skin disorder. Results of laser therapy are inconsistent. To determine the safety and efficacy of low-fluence Q-switched neodymium-doped yttrium aluminum garnet (QS Nd:YAG) laser for melasma treatment and assess recurrence rates and histopathologic findings before and after treatment. Twenty patients were treated with 10 weekly sessions of low-fluence 1064-nm QS Nd:YAG laser at 1-week intervals. The modified Melasma Area and Severity Index (mMASI) score was evaluated at baseline; 1 week; and 1, 3, and 6 months after treatment. Epidermal melanin quantification was performed on 10 biopsy samples and compared before and after treatment. All patients showed improvement by mMASI scores, range (21%-75%) compared with that at baseline. No permanent side effects occurred. The recurrence rate was 81%. By histopathology, a slight, nonsignificant (p = .305) decrease in melanin deposition was seen in all layers of the epidermis 1 week after the laser treatments ended. The results confirm the safety and effectiveness of low-fluence QS Nd:YAG laser for treating melasma; however, the high recurrence suggests poor long-term results when the laser is used as a monotherapy.

Outcome of laser therapy in patients with anal fissure

In the past decade, several studies have investigated the effect of laser therapy on haemorrhoids, anal fistulas and tumours but few have explored its use in acute anal fissure. Therefore, the present study aimed to evaluate the efficiency of laser therapy in treating acute anal fissure. This clinical trial was conducted on all the patients referred to Valiasr Hospital, Arak, Iran, with acute anal fissure. Patients who were unresponsive to medical treatment and in whom surgery was indicated were divided into two equal-sized groups. Age, medical treatment duration, healing time, pain relief, relapse and indication for reoperation were recorded in all patients. The mean age of the patients and the mean medical treatment duration were significantly different in the two groups. Although there were no significant differences in the mean healing time and response to pain in the first and third months after surgery and laser therapy, by month 6 the mean response to pain was significantly different in the two groups. Frequency of relapse and need for further surgery were not significantly different between the groups. Laser therapy of acute anal fissure is a simple, non-invasive and painless surgical procedure with a low rate of complications. It can be viewed as an effective treatment for patients with anal fissure. However, this procedure has some limitations.

Outcome of GreenLight HPS laser therapy in surgically high-risk patients

The aims of this study are to present our experience with GreenLight HPS laser in the treatment of benign prostatic hyperplasia (BPH) and evaluate the outcomes of laser therapy in surgically high-risk patients. This study included a total of 132 patients who were treated for BPH by using GreenLight HPS laser between August 2008 and December 2010 by the same operator. These patients were further divided into five subgroups: group A (age ≧ 80years), group B (prostate volume ≧ 80ml), group C (American Society of Anesthesiologists score = 3), group D (anticoagulant use), and group E (non-A, non-B, non-C, and non-D patients). Data on International Prostate Symptom Score, maximum flow rate (Q max), post-void residual urine, and quality-of-life score were evaluated at baseline and at 1, 12, and 24months after surgery. The result showed that group B patients required a longer lasing time during surgery. In addition, longer post-operative catheterization time and hospital stay were noted in groups B, C, and D patients. Statistically significant improvements were noted post-operatively for all functional parameters in all groups. The proportion of secondary surgery was significantly higher in group B patients. No major complication was observed in all groups. This suggested that GreenLight HPS laser is safe and effective in the treatment of surgically high-risk patients.

Results of laser therapy in twin-to-twin transfusion syndrome: our experience

Objective: The authors of this paper present the results of laser treatment in twin-to-twin transfusion syndrome. Methods: Laser photocoagulation of communicating vessels was performed on 91 patients from April 2005 to June 2010, at the Medical University of Gdansk (Poland). Results of treatment were analyzed. Results: The following results were achieved: at least one survival at delivery in 71 patients (83.5%), two survivors in 49 women (57.6%), and an overall survival rate of 70.6%. After the inclusion of neonatal deaths, at least one survival was reported in 65 women (76.5%) – 30 with two survivors (44.7%) and 27 with one survivor (31.8%). The incidence of preterm rupture of membranes (4 cases – 4.3%), dual intrauterine fetal demise (7 cases – 7.4%) and miscarriage or delivery (8 cases – 8.5%) during the first week after surgery were the main reasons of pregnancy loss in the analyzed group. The frequency of cerebral palsy diagnosed after 6 months was 7%. Conclusions: Despite a lower incidence of dual neonatal survivals than in other series, the results of the first years of experience with laser treatment of twin-twin transfusion syndrome are encouraging, and prompt us to improve our surgical skills to achieve better outcomes.

Retinopatía del prematuro. Casuística de los años 1995–2001

Retinopathy of prematurity (ROP) is a cause of neurosensorial morbidity. To study the incidence, associated risks factors, treatment, and outcome of ROP in premature infants born at less than 32 weeks in our hospital. We performed a descriptive study of patients born between the January 1, 1995, and December 31, 2001, in Sant Joan de Déu Hospital in Barcelona (Spain) at <= 32 weeks of gestation who survived until their first month of life. An ocular evaluation was performed between weeks 4 and 6 of life and was repeated every 1-2 weeks until retinal vascularization was complete. Ocular sequelae and visual function were evaluated. Bivariate comparison of groups with and without ROP was performed. Of the 324 patients evaluated, 74 presented ROP (22.8 %), of which 63 patients (21.7 %) were classified as stage 1 or 2 and 11 (3.7 %) as stage 3. An inverse correlation between the incidence of retinopathy and weight and gestational age was found. Threshold disease (3 plus) was detected in 9 patients (16 eyes; 3.1 % of the study sample and 12.1 % of the neonates with retinopathy). All of these neonates were treated with laser therapy. Ocular sequelae were mild in 2.7 % of the patients, moderate in 0.6 % and severe in 0.6 %. The visual function (n 236) of infants with ROP (n 74) was altered in 4 patients (1.7 %). Of these, alterations were severe in 2 patients (0.8 %). Bivariate analysis revealed significant differences (p < 0.001) in low birth weight, gestational age, days of oxygen therapy, days of mechanical ventilation, days of antibiotic therapy, and number of blood transfusions. In this study the incidence of ROP was similar to that in other centers. Development of ROP was strongly associated with its various risk factors. Severe stages were not seen above 30 weeks of gestational age. The results of laser therapy were optimal, with fewer alterations in ocular examination and visual function than those estimated in patients without treatment.

The results of the use of argon laser coagulation in the treatment of dibetic retinopathy

A total of 182 patients (95 men and 87 women) aged 15-49 years with insulin-dependent diabetes mellitus were treated using argon laser coagulation. Late results of laser therapy were followed up for 6 months to 3 years. In the patients with nonproliferative diabetic retinopathy (DR) on the fundus oculi the improvement consisted in partial resolution of solid exudative foci and retinal hemorrhages in 20%o of cases. In patients with preproliferative DR, soft exudative foci partially resolved and the number of retinal hemorrhages and microaneurysms decreased in 17%o of cases. In patients with proliferative DR, regressive development of proliferative tissue, desolation of newly formed vessels, and resolution of preretinal hemorrhages were observed in 13.9%o of cases. Stabilization for 3 years was attained in 75%) of patients with nonproliferative and proliferative and in 72.5%o of those with preproliferative DR.

CO2 laser skin resurfacing in oculoplastic surgery.

Although CO2 lasers have been used in medicine for almost 30 years, recent developments have changed the way they are being used. Several laser technologies have altered the CO2 laser delivery system, making it useful for the treatment of wrinkles, photoaged skin, and acne scarring. Histopathologically, the resurfacing CO2 lasers produce morphologic alterations similar to medium-depth chemical peels. Many of the same principles applied to chemical peels and dermabrasion are useful in the evaluation and treatment of patients undergoing laser resurfacing. The results of laser therapy appear to be more predictable than those from dermabrasion and chemical peeling and produce fewer sequelae. Laser resurfacing can be used alone or as an adjunct to other cosmetic surgical procedures.

Changes in rheological properties of the blood after irradiation with helium-neon laser

The effect of helium-neon (HNL) laser on the rheological properties of the blood is examinedin vitro and during the treatment of 22 patients with obliterating atherosclerosis of the leg. It is shown that irradiation with HNLin vivo induces negative changes in blood rheology which are proportional to the time of exposure. Intravascular and extracorporeal irradiation reduces blood viscosity in the body as a result of dilution of the blood, as is evidenced by the lowered hematocrit, plasma viscosity, and hemoglobin concentration. Presumably, the decrease in blood viscosity accounts for the positive clinical results of laser therapy of patients with chronic arterial insufficiency.

Calcitonin Gene–Related Peptide Increases the Blood Flow of Port-Wine Stains and Improves Continuous-Wave Dye Laser Treatment

Ten patients with port-wine stains were treated with continuous-wave dye laser before and after treatment with the vasodilatory compound calcitonin gene-related peptide. The patients were given calcitonin gene-related peptide as an intravenous infusion or as a regional intravenous infusion. Six uniformly colored test sites, each 5 x 10 mm, located within a port-wine stain were selected for clinical evaluation. Laser treatment of these areas was performed on one occasion with three different energy densities: 15, 30, and 45 J/cm2. The port-wine stain circulation was monitored with a laser Doppler flowmeter before and after calcitonin gene-related peptide infusion and immediately after laser treatment. The cosmetic result was evaluated and judged as excellent, desirable, or undesirable. It was shown that calcitonin gene-related peptide is able to induce a long-lasting increase in blood flow in the vascular bed of port-wine stains and that the immediate postlaser laser Doppler flow values may serve as an indication of the outcome of laser therapy. The cosmetic result was often better in the group treated with calcitonin gene-related peptide compared with controls, and an excellent result also was achievable with the use of lower levels of energy.

Long-term results of laser therapy in patients with bronchial asthma and chronic obstructive bronchitis

We performed a course of treatment with the helium-neon laser L G-75 in the conditions of a polyclinic for patients with bronchial asthma (170 persons) and chronic obstructive bronchitis (90). Exposure to the laser beam was made taking into account the experience of reflexotherapy. Time of exposure to each biologically active point was 10 s with irradiation power of 25 mW (course - 15-20 procedures).

Forrest 11 bleeding: indications for treatment and results of laser therapy.

Ulcers with stigmata of recent hemorrhage (SRH) but without evidence of active bleeding (Forrest 11 bleeding) are a common endoscopic finding in patients with upper gastrointestinal bleeding. This study considers the problem of identifying patients in this group at risk of further bleeding and death. The high incidence of rebleeding in patients with visible vessel and the low incidence in patients with other SRH or no SRH suggest that endoscopic therapy in the absence of active bleeding is best limited to patients with visible vessels in ulcers that have recently bled. Evidence from controlled trials of laser therapy is presented which suggests that laser therapy can reduce the incidence of rebleeding in such patients with visible vessel.