Otoacoustic Emission Phase Research Articles

Otoacoustic Estimate of Astronauts' Intracranial Pressure Changes During Spaceflight.

To investigate the potential correlation between prolonged exposure to microgravity on the International Space Station and increased intracranial fluid pressure, which is considered a risk factor for the astronauts' vision, and to explore the feasibility of using distortion product otoacoustic emissions as a non-invasive in-flight monitor for intracranial pressure changes. Distortion product otoacoustic emission phase measurements were taken from both ears of five astronauts pre-flight, in-flight, and post-flight. These measurements served as indirect indicators of intracranial pressure changes, given their high sensitivity to middle ear transmission alterations. The baseline pre-flight ground measurements were taken in the seated upright position. In-flight measurements revealed a significant systematic increase in otoacoustic phase, indicating elevated intracranial pressure during spaceflight compared to seated upright pre-flight ground baseline. Noteworthy, in two astronauts, strong agreement was also observed between the time course of the phase changes measured in the two ears during and after the mission. Reproducibility and stability of the probe placement in the ear canal were recognized as a critical issue. The study suggests that distortion product otoacoustic emissions hold promise as a non-invasive tool for monitoring intracranial pressure changes in astronauts during space missions. Pre-flight measurements in different body postures and probe fitting strategies based on the individual ear morphology are needed to validate and refine this approach.

A cochlea with three parts? Evidence from otoacoustic emission phase in humans.

The apical and basal regions of the cochlea appear functionally distinct. In humans, compelling evidence for an apical-basal transition derives from the phase of otoacoustic emissions (OAEs), whose frequency dependence differs at low and high frequencies. Although OAEs arising from the two major source mechanisms (distortion and reflection) both support the existence of an apical-basal transition-as identified via a prominent bend (or "break") in OAE phase slope-the two OAE types disagree about its precise location along the cochlea. Whereas distortion OAEs at frequency 2f1-f2 suggest that the apical-basal transition occurs near the 2.5 kHz place, reflection OAEs locate the transition closer to 1 kHz. To address this discrepancy, distortion and reflection OAEs were measured and analyzed in 20 young human adults from 0.25-8 kHz and at eight primary-frequency ratios f2/f1 in the range 1-1.5. Break frequencies and OAE phase-gradient delays were estimated by fitting segmented linear models to the unwrapped phase. When distortion- and reflection-OAE phase are considered as functions of ln f2-that is, as linear functions of the location of their putative site of generation within the cochlea-the analysis identifies not just two but three main cochlear segments, meeting at transition frequencies of approximately 0.9 and 2.6 kHz, whose locations are largely independent both of primary-frequency ratio and emission type. A simple model incorporating an abrupt transition from wave- to place-fixed behavior near the middle of the cochlea accounts for key features of distortion-OAE phase.

Distortion-product otoacoustic emission phase shift test (Shift-DPOAE) – methodology of measurements and interpretation of results in example cases

Aim: The aim was to present methodology and interpretation of results of phase shift distortion-product otoacoustic emissions (Shift-DPOAE) in healthy subjects and patients with Meniere’s disease in remission stage and at the time of attack. Material and methods: Shift-DPOAE was performed in two healthy subjects without any otologic or neurologic problems and in six patients diagnosed with Meniere’s disease. Results obtained in eight subjects are oresented. The following tests were performed in all subjects: detailed otoscopy, impedance audiometry, pure tone audiometry, DPOAE, and Shift-DPOAE. Results: The normal Shift-DPOAE results obtained in two healthy subjects as well as the normal (two subjects) and abnormal (four subjects) Shift-DPOAE results obtained in patients with Meniere's disease are presented in order to thoroughly discuss the methodology and interpretation of the Shift-DPOAE study. Conclusions: The Shift-OAE is a promising diagnostic tool with great clinical potential in the diagnosis and monitoring of Meniere's disease in patients whose hearing has not yet been damaged. This examination is completely non-invasive, it can be carried out immediately after an attack of the disease with symptoms present at the time of the test, and it takes just a few minutes.

Medial olivocochlear influence on stimulus-frequency otoacoustic emission input-output functions

Modulation of cochlear mechanics by the medial olivocochlear efferent system is characterized by a reduction in active, outer hair cell-mediated amplification of basilar membrane motion. This increases cochlear thresholds and linearizes basilar membrane input-output functions for low-to-moderate stimulus levels. Significant efferent effects have also been observed for responses to higher stimulus levels, potentially reflecting changes in the mechanical properties of the cochlear partition. In humans, sound activated changes in stimulus-frequency otoacoustic emissions have been used as a tool for investigating the dynamics of the medial olivocochlear reflex. However, the degree to which the amplitude and phase of otoacoustic emissions are related to those of basilar membrane motion is not entirely clear. For the purposes of comparison with invasive physiological measurements in animals, stimulus-frequency otoacoustic emission input-output functions were obtained from human subjects in the presence and absence of contralateral acoustic stimulation. Medial olivocochlear effects were quantified in terms of the absolute change in emission level as well as the vector change, which incorporates changes in emission phase. The extent to which efferent modulation of emissions in humans reflects that observed in previous reports of basilar membrane motion will be discussed.

Level dependence of distortion product otoacoustic emission phase is attributed to component mixing

Distortion product otoacoustic emissions (DPOAEs) measured in the ear canal represent the vector sum of components produced at two regions of the basilar membrane by distinct cochlear mechanisms. In this study, the effect of stimulus level on the 2f(1) - f(2) DPOAE phase was evaluated in 22 adult subjects across a three-octave range. Level effects were examined for the mixed DPOAE signal measured in the ear canal and after unmixing components to assess level effects individually on the distortion (generated at the f(1), f(2) overlap) and reflection (at f(dp)) sources. Results show that ear canal DPOAE phase slope becomes steeper with decreasing level; however, component analysis further explicates this result, indicating that interference between DPOAE components (rather than a shift in mechanics related to distortion generation) drives the level dependence of DPOAE phase measured in the ear canal. The relative contribution from the reflection source increased with decreasing level, producing more component interference and, at times, a reflection-dominated response at the lowest stimulus levels. These results have implications for the use of DPOAE phase to study cochlear mechanics and for the potential application of DPOAE phase for clinical purposes.

Differences in distortion product otoacoustic emission phase recorded from human neonates using two popular probes

DPOAE (2f(1)-f(2)) phase was measured across a 3-octave frequency range from two groups of newborns using ER10B+ and ER10C probe microphones. A marked phase shift was noted in the mid-to-high frequency range for newborn data recorded with the ER10C only. In contrast, the ER10B+ produced phase that was approximately invariant as a function of frequency for most of the range. Probe-related phase shifts can be effectively eliminated by correcting for variations in the phases of the primary tones. Results highlight the importance of detecting and correcting for system-related phase shifts so they are not misinterpreted as cochlear in origin.

Distortion product otoacoustic emission phase and component analysis in human newborns

Apical distortion product otoacoustic emissions (DPOAEs) are comprised of at least two components, as evidenced by the interference pattern of alternating maxima and minima known as fine structure. DPOAE fine structure is produced by the shifting phase relationship in the ear canal, between the generator and characteristic frequency (CF) component of the response. Each component arises from a different cochlear region and, according to theory, reflects a distinct generation mechanism. The analysis of DPOAE components and phase in newborns may provide a window into targeted aspects of cochlear physiology during development. 2f(1)-f(2) DPOAE fine structure was recorded from 15 adults and 14 newborns using a swept-tone technique. DPOAE group delay, as well as magnitude and phase of each component, was compared between age groups. Results show narrower fine structure spacing, a longer group delay (steeper phase gradient) in low frequencies, and a stronger relative contribution from the CF component in newborns. The prolonged group delay for low-frequency DPOAEs could indicate immature basilar membrane motion in the apex of the cochlea and warrants further investigation. The enhanced contribution from the CF component may have implications for clinical practice as well as for theories of cochlear maturation.

Multicomponent acoustic distortion product otoacoustic emission phase in humans. II. Implications for distortion product otoacoustic emissions generation

Phase characteristics and latency of 2f1-f2, 3f1-2f2, and 2f2-f1 acoustic distortion product otoacoustic emissions (DPOAEs) recorded in normally hearing adults have been described in a companion paper [Moulin and Kemp, "Multicomponent acoustic distortion product otoacoustic emission phase in humans. I. General characteristics," J. Acoust. Soc. Am. 100, 1617-1639 (1996)]. Phase-versus-frequency functions (PFF) have been recorded using two methods, depending whether f1 or f2 was swept in frequency, defining, respectively, an "f1 sweep" and an "f2 sweep" method. The present study compares 2f1-f2, 3f1-2f2, 4f1-3f2, and 2f2-f1 DPOAEs phase characteristics, and latencies obtained by these two methods. For lower sideband DPOAEs, the f2 sweep gave consistently longer latencies than the f1 sweep method, whereas no difference was obtained for the 2f2-f1 DPOAE. This suggests that the lower sideband DPOAEs and the 2f2-f1 DPOAE do not come from the same aspect of the traveling wave. The longer delay obtained with an f2 sweep is suggested to be due to an additional delay added by the proximity of the peak of the f2 traveling wave. The place-fixed and the wave-fixed models of DPOAE generation are discussed, and an "intermediate" model of DPOAE generation is introduced to explain such additional delay and the existence of phase irregularities which were observed in the PFF. The ratio of the latencies obtained by the two sweep methods is frequency dependent and a relation to cochlear frequency selectivity is suggested. Finally, analysis of the differences in latency of the different lower sideband DPOAE components allowed an estimation of the return latency of DPOAEs.

Multicomponent acoustic distortion product otoacoustic emission phase in humans. I. General characteristics.

Phase characteristics and latency of 2f1-f2, 3f1-2f2, and 2f2-f1 acoustic distortion product otoacoustic emissions (DPOAEs) have been analyzed in 12 adults with normal hearing. Phase-versus-frequency functions (PFF) have been recorded at each of ten pairs of primary frequencies, by two methods, depending on which one of the primary frequencies f1 or f2 was swept in frequency. Whichever sweep method was used, local phase irregularities were found in the PFF and were shown to be independent of the phase variability due to the measured noise, to be reproducible and frequency specific. Phase irregularities were significantly greater in subjects exhibiting spontaneous otoacoustic emissions. The latency calculation was unaffected by phase irregularities provided that a suitably large range of f2/f1 ratio was used. The DPOAE latencies that were obtained at low ratios of primaries were significantly longer than those obtained at higher ratios. For all DPOAE components and sweep methods used, the latency decreased as frequency increased from 750 Hz to 6 kHz. Substantial intersubject differences were found. They might be due to two main factors: differences in middle ear acoustic properties and in cochlea mechanical characteristics. The influence of pressure in the outer ear canal increased the DPOAE latencies recorded with both the f1 and f2 sweep methods at low frequencies. Men showed significantly longer 2f2-f1 DPOAE latencies than women, especially at low frequencies, which can be attributed to the difference in length of the cochlea according to gender. Lastly, the latencies measured using the f2 sweep were consistently longer than the latencies obtained using an f1 sweep for lower sideband DPOAEs, but no difference was observed for upper sideband DPOAEs.