Introduction-Diabetic foot ulcers are most commonly occurring complication in patients of diabetes mellitus who have poor glycaemic control. It's also the common cause for osteomyelitis of foot, amputation of lower extremities. About 60% of patients develop neuropathy eventually leads to formation of foot ulcers. Staphylococcus is common infective organism which cause ulcers over the foot. Objective-To study efcacy of topical Sucralfate in healing of diabetic ulcer, in terms of number of days needed for healing, rate of reduction in mean ulcer surface area. Also, to assess the bacterial load by culture & sensitivity of wound swabs before and after application of Sucralfate and conventional dressing. Methodology-The present prospective study was conducted at Dr. D.Y. Patil Medical College Hospital Research Institute, Kolhapur. Atotal of 30 patients from OPD & IPD with diabetic foot ulcers of Wagner grade- I&II having size less than 15x15cm were included in study. All patients were evaluated and investigated by a standard protocol for the management of the ulcer. The dressings were changed everyday morning in both groups for 6-weeks and appearance of the healthy granulation tissue is observed daily. The nal area is measured on 43rd day by planimetry using a transparent graph sheet and subjected to statistical analysis. Result-Sucralfate on daily application to wounds increases thickness of granulation tissue and promotes rapid epithelialization of second-degree burns. An ideal dressing that promotes chronic ulcer healing without any complications. Conclusions-The results of the study showed signicant effect in area of reduction, negative culture rate and weeks for recovery are seen in study group, suggesting that topical Sucralfate dressing can effectively increase the wound healing in diabetic foot ulcer compared to conventional dressing.