Bitter gourd is a versatile vegetable that brings health-promoting benefits to consumers. To maintain its high nutrition values and ensure year-round availability, proper post-harvest processes are essential for preserving its original properties. However, there is limited knowledge regarding how pretreatment methods impact the physicochemical properties of pretreated bitter gourd and the performance of subsequent hot air-assisted radio frequency drying (HARFD) process. In the present study, bitter gourd underwent osmotic dehydration (OD) and ultrasonic-assisted osmotic dehydration (UAOD) pretreatment with different ultrasound power levels (400, 800, and 1200 W). The physicochemical properties of the pretreated samples, such as mass transfer behavior, water migration status, dielectric loss factor, and others, were compared. The drying duration, energy consumption, and various quality attributes (e.g., color index, rehydration, nutritional compositions, antioxidant activity, etc.) of the HARFD dried products were also examined. The microstructure observations demonstrated that acoustic waves induced the structural changes and created microchannels. Additionally, physicochemical properties of the pretreated samples showed that OD and UAOD methods significantly facilitated water migration status and increased the dielectric loss factor. Compared to control and OD methods, three UAOD methods successfully reduced the drying duration by 7.9%–30.3% and total energy consumption by 5.8%–28.3% for the entire processing steps. Furthermore, UAOD methods improved the total phenolic content, total chlorophyll retention, DPPH and ABTS values of dried bitter gourds by 32.3%–36.7%, 12.6%–20.3%, 23.4%–31.6%, and 20.7%–26.3%, respectively, compared to the control methods. Overall, UAOD-400 W samples after drying exhibited improved quality characteristics, including reduced color difference, increased retention of bioactive compounds, higher rehydration ratio, and enhanced antioxidant capacity. This study underscores the effectiveness of UAOD application in improving both processing efficiency and quality of bitter gourds produced by HARFD.
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