Orthostatic Blood Pressure Testing Research Articles

Orthostatic Hypotension in Parkinson's Disease: The Relation of Blood Pressure Tests and Symptoms in Daily Life.

Orthostatic hypotension (OH) is common in Parkinson's disease (PD), but the relation between the results of orthostatic blood pressure tests and orthostatic symptoms in daily life is not clear. We performed a cross-sectional study in an incident nontertiary care cohort of PD patients with additional recruitment of PD patients from our own outpatient clinic. We recruited sex- and age-matched controls. All participants underwent orthostatic blood pressure tests using continuous blood pressure measurements. Orthostatic symptoms experienced in daily life were assessed using autonomic symptom questionnaires (SCOPA-AUT and COMPASS-31). A total of 83 PD patients and 35 controls were included. Mean patient age was 69.2 years (standard deviation [SD]: 10.0). Mean disease duration was 6.6 years (SD, 0.8). The estimated prevalence of OH in PD was 24.1% (95% confidence interval: 16.2-34.3). There was no significant difference between PD patients with and without OH regarding reported daily orthostatic symptoms. Alternative OH criteria did not substantially improve this. Perceived orthostatic symptoms in daily life have no clear association with the results of a single orthostatic blood pressure test. Better diagnostic strategies are needed.

Orthostatic blood pressure test for risk stratification in patients with hypertrophic cardiomyopathy.

BackgroundHypertrophic cardiomyopathy (HCM) is the most common cause of sudden cardiac death (SCD) in young adults, mainly ascribed to ventricular tachycardia (VT). Assuming that VT is the major cause of (pre-) syncope in HCM patients, its occurrence is essential for SCD risk stratification and primarily preventive ICD-implantation. However, evidence of VT during syncope is often missing. As the differentiation of potential lethal causes for syncope such as VT from more harmless reasons is crucial, HCM patients were screened for orthostatic dysregulation by using a simple orthostatic blood pressure test.MethodsOver 15 months (IQR [9;20]) 100 HCM patients (55.8±16.2 yrs, 61% male) were evaluated for (pre-)syncope and VT (24h-ECGs, device-memories) within the last five years. Eighty patients underwent an orthostatic blood pressure test. Logistic regression models were used for statistical analysis.ResultsIn older patients (>40 yrs) a positive orthostatic test result increased the chance of (pre-) syncope by a factor of 63 (95%-CI [8.8; 447.9], p<0.001; 93% sensitivity, 95%-CI [76; 99]; 74% specificity, 95%-CI [58; 86]). No correlation with VT was shown. A prolonged QTc interval also increased the chance of (pre-) syncope by a factor of 6.6 (95%-CI [2.0; 21.7]; p=0.002).ConclusionsThe orthostatic blood pressure test is highly valuable for evaluation of syncope and presyncope especially in older HCM patients, suggesting that orthostatic syncope might be more relevant than previously assumed. Considering the high complication rates due to ICD therapies, this test may provide useful information for the evaluation of syncope in individual risk stratification and may help to prevent unnecessary device implantations, especially in older HCM patients.

Comprehensive geriatric assessment decreases prevalence of orthostatic hypotension in older persons

Orthostatic hypotension (OH) is associated with significant morbidity and mortality among older people. We have studied whether its prevalence can be reduced by a Comprehensive Geriatric Assessment (CGA). 1000 randomly-selected persons aged ≥75 years were divided into intervention (n = 500) and control groups (n = 500). We focused on those subjects in whom an orthostatic blood pressure test had been performed at least once during the study period (2004-2007) (n = 365 and 332 for intervention and control groups, respectively). A CGA, including evaluation of the adequacy of the medication, was performed annually in the intervention group but not in the control group. We conducted Markov models to study change in the OH profiles and the effect of CGA on it. Competing risk of mortality was modeled as an absorbing state to avoid attrition bias. Over 3 years, the prevalence of OH decreased (35.0% → 28.0%) in the intervention group, whereas its prevalence increased in the control group (32.8% → 40.8%). By Markov models it was shown that CGA had a statistically significant effect on recovering from OH. In addition, CGA was shown to protect from developing OH. Repeated CGA performed annually can reduce the prevalence of OH.

The Comparative Usefulness of Orthostatic Testing and Tilt Table Testing in the Evaluation of Autonomic-Associated Dizziness

To elucidate the usefulness of clinical orthostatic blood pressure testing (COBP) as a screening tool for autonomic dysfunction. In this retrospective case review, the records of 156 consecutive patients with nonotologic dizziness as the primary complaint seen in an academic neurotology clinic between 2005 and 2009 were reviewed. The objective of this study was accomplished by comparing the diagnostic yield of COBP with that of head-upright tilt table testing (HUT) and assessing the sensitivity and specificity of COBP in predicting an abnormal HUT in patients with nonotologic dizziness. Ambulatory tertiary referral center. Patients presenting to the clinic with dizziness without otologic cause. Clinical evaluation, orthostatic blood pressure testing, and HUT. The primary outcome assessed in this study was patient blood pressure. Blood pressures were measured in the clinic in the following order: supine, sitting, and standing. Positive COBP was defined as a reduction in systolic or diastolic blood pressure greater than 20 or 10 mm Hg, respectively, or both, within 3 minutes of sitting from supine or standing from sitting. For comparison, HUT was used as the gold standard. A positive HUT was defined as a reduction in systolic or diastolic blood pressure greater than 20 or 10 mm Hg, respectively, or both, relative to baseline at any point after initiation of HUT. Forty patients were referred for HUT. Twenty-four (61.5%) of these patients were deemed to have a positive response. Thirty-three patients (85%) referred to HUT were initially evaluated with COBP, which revealed orthostatic hypotension (OH) in 8 patients (24%). COBP was calculated to have sensitivity and specificity of 21% and 71%, respectively, when asymptomatic OH was included in the positivity criteria. When asymptomatic OH was excluded from the positivity criteria, the sensitivity and specificity remained similar at 25% and 76%, respectively. However, the exclusion of asymptomatic OH from the positivity criteria resulted in a decrease in the positive predictive value from 50% to 25% and an increase in the negative predictive value from 40% to 76%. Overall, HUT detected 16 patients with an abnormal result that were missed by COBP testing. Evaluation for autonomic dysfunction should be part of the comprehensive evaluation of a dizzy patient, involving, at a minimum, orthostatic testing of blood pressure and heart rate. Patients with nonotologic dizziness and light-headedness with a normal neurotologic evaluation can reasonably be referred for HUT, even in the presence of normal in-office orthostatic testing.

Autonomic nervous system function in Huntington's disease

Objective: To investigate whether Huntington's disease (HD) affects autonomic nervous system (ANS) functioning. Methods: Twenty patients with HD who had positive genetic test results underwent standardised ANS function tests including...

Evaluation of orthostatic blood pressure testing as a discharge criterion from PACU after spinal anesthesia

Discharge readiness from a Phase I PACU after spinal anesthesia is frequently determined by recovery of sensory/motor function. However, no data exist indicating that recovery of sensory/motor function adequately predicts hemodynamic stability after spinal anesthesia. The conservative practice of waiting until the sensory/motor effects of spinal anesthesia have completely worn off often requires patients to remain in PACU for prolonged periods of time. The purpose of this study was to determine the safety and efficacy of using orthostatic blood pressure (BP) testing as a discharge criterion from PACU after spinal anesthesia. This study used a prospective, descriptive design to measure changes in mean arterial pressure (MAP) during orthostatic BP testing at 30-minute intervals after admission to the PACU following spinal anesthesia. A convenience sample of 121 patients admitted through the Same Day Surgery (SDS) unit was used. Results show that orthostatic BP criterion was safe and effective as an alternative to sensory/motor criteria in assessing hemodynamic stability and reducing the amount of time patients spend in the PACU after spinal anesthesia. This is a U.S. government work. There are no restrictions on its use.

Evaluation of orthostatic blood pressure testing as a discharge criterion from PACU after spinal anesthesia

<h2>Abstract</h2> Discharge readiness from a Phase I PACU after spinal anesthesia is frequently determined by recovery of sensory/motor function. However, no data exist indicating that recovery of sensory/motor function adequately predicts hemodynamic stability after spinal anesthesia. The conservative practice of waiting until the sensory/motor effects of spinal anesthesia have completely worn off often requires patients to remain in PACU for prolonged periods of time. The purpose of this study was to determine the safety and efficacy of using orthostatic blood pressure (BP) testing as a discharge criterion from PACU after spinal anesthesia. This study used a prospective, descriptive design to measure changes in mean arterial pressure (MAP) during orthostatic BP testing at 30-minute intervals after admission to the PACU following spinal anesthesia. A convenience sample of 121 patients admitted through the Same Day Surgery (SDS) unit was used. Results show that orthostatic BP criterion was safe and effective as an alternative to sensory/motor criteria in assessing hemodynamic stability and reducing the amount of time patients spend in the PACU after spinal anesthesia. This is a U.S. government work. There are no restrictions on its use.

Mianserin: cardiovascular effects in elderly patients.

Cardiovascular effects of the tetracyclic antidepressant drug mianserin were examined in a prospective study including ten elderly depressed patients (age 60-77 years). During 1 week on placebo and 5 weeks on mianserin, 60 mg per day, orthostatic blood pressure testing, recording of standard electrocardiogram, 24-h electrocardiographic recording and systolic time intervals were carried out along with frequent monitoring of plasma levels of mianserin (13-57 micrograms/l) and the primary metabolite desmethylmianserin (7-27 micrograms/l). Mianserin caused a significant increase in orthostatic systolic blood pressure drop, and this correlated well with the plasma mianserin levels (rs = 0.70). There were no significant changes in supine blood pressure or in orthostatic changes in heart rate. No cardiac conduction disturbances or arrhythmias were provoked, but mianserin caused changes in systolic time intervals indicating impairment of left ventricular contractility and performance. Like tricyclic antidepressants mianserin should thus be used with caution in patients with latent or overt cardiovascular disease.