In this paper we develop a closed-form mathematical solution for the resonance frequency of the axisymmetric irregular shaped visco-acoustic Helmholtz cavity problem. The solution is based on a conformal mapping that transforms the governing visco-acoustic equations of motion for the irregular cavity geometry into a new domain described by a set of orthogonal curvilinear coordinates. These orthogonal curvilinear coordinates have an important characteristic relative to the transformation of the physical boundary: the mapped domain is constructed such that the locus of all points for the length-wise profile of the physical boundary coincides with a constant value for a (quasi radial) coordinate in the new mapped domain. In these orthogonal curvilinear coordinates we obtain an analytical solution for the visco-acoustic equations of motion and exactly satisfy the no-slip fluid boundary conditions over the irregular shaped cavity walls by matching the coefficients of an orthogonal Legendre polynomial series representation for the non-uniform velocity on the cavity walls. The mathematical solution is an approximation to the extent that the scale factors chosen for the mapping consist of strictly the mutual-coupling terms of the true scale factors. Thus we analyze some results to understand the correlation of the analytical solution frequency response spectra with numerical finite element analyses of the idealized boundary conditions with various irregular shaped cavity geometries. The results for fundamental resonance frequency were found to exhibit good correlation with the results of finite element analyses over a significant range of fluid properties with different irregular cavity geometries. As the primary motivation for the derivation stems from the lack of a rapid yet accurate alternative to computationally intensive MultiPhysics FEA in the formulation of acoustic trendlines for sensor development, the solution’s acoustic impedance was applied as dispersive loading in a simple lumped parameter model of a fluid identification sensor for comparison. The resulting acoustic trendlines of the reduced (5 DOF) model were found to exhibit good correlation with the results of the MultiPhysics FEA (>105 DOF). Thus the solution was found to enable a closed-form analytical method for rapid construction of parametric studies in the practical design of fluid analysis sensors based on complex resonant cavity geometries.