AbstractThe India–Eurasia collision has produced a number of Cenozoic deep intracontinental basins, which bear important information for revealing the far‐afield responses to the remote collision. Despite their significance, their subsiding mechanism remains the subject of debate, with end‐member models attributing it to either orogenic or sedimentary load. In this study, we conduct flexural subsidence modeling with a two‐dimensional finite elastic plate model on the Hotan–Mazatagh section along the southern Tarim Basin, which defines a key region in the foreland of the West Kunlun Orogen, along the NW margin of the Tibetan Plateau. The modeling results indicate that the orogenic load of West Kunlun triggers the southern Tarim Basin to subside by up to less than ∼6 km, with its impact weakening towards the basin interiors until ∼230 km north from the Karakax fault. The sedimentary load, consisting of Cenozoic strata, forces the basin to subside by ∼2 to ∼7 km. In combination with the retreat of the proto‐Paratethys Sea and the paleogeographic reorganization of the Tarim Basin, we propose that surface processes, in particular a shift from an exorheic to an endorheic drainage system associated with the consequent thick sedimentary load, played a decisive role in forming deep intracontinental basins in the context of the India–Eurasia collision.