Introduction. We investigate a multidimensional (in terms of spatial variables) parabolic-type integro-differential equation with nonhomogeneous first-order boundary conditions. The locally one-dimensional finite difference scheme developed herein can be applied to solve various applied problems leading to multidimensional parabolic-type integro-differential equations. Examples include mathematical modelling of cloud processes, addressing the issue of active intervention in convective clouds to prevent hail and artificially enhance precipitation, as well as describing the droplet mass distribution function due to microphysical processes such as condensation, coagulation, fragmentation, and freezing of droplets in convective clouds.Materials and Methods. In this study, an approximate solution to the initial-boundary value problem is constructed using the locally one-dimensional scheme of A.A. Samarsky with a specified order of approximation О(h2 +τ). The primary research method employed is the method of energy inequalities.Results. A priori estimates have been obtained in the discrete interpretation, from which uniqueness, stability, and convergence of the solution of the locally one-dimensional difference scheme to the solution of the original differential problem follow, with a convergence rate equal to the order of approximation of the difference scheme.Discussion and Conclusions. The research findings can be utilized for further development of boundary value problem theory for parabolic equations with variable coefficients. Additionally, they may find applications in the fields of difference scheme theory, computational mathematics, and numerical modelling.