Objective To identify characteristics of clinical research projects that influence patients' willingness to participate in research. Study Design and Setting We surveyed all patients discharged during 1 month from a Swiss public teaching hospital. We described four hypothetical studies and asked patients whether they would agree to participate. We randomly manipulated three study attributes in each vignette, using a factorial design. Results All studies were not equally acceptable to the 1,277 respondents. A higher willingness to participate was found when a new drug had no side effects, no additional visit was required, balanced information was given, results were in the public domain, and the project was approved by a research ethics committee. In contrast, destruction of blood samples at the end of the project, use of placebo controls, and random allocation to study arms were associated with a lower likelihood of participation. The origin of funds, financial reward, the need to complete a questionnaire, and clinical vs. economic purpose of the study did not influence willingness to participate. Conclusion Patients valued safety, convenience, oversight, and open communication in research. However, they were put off by some aspects that are valued by health care professionals. Educating the public about research methods may improve participation.
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