Zeotropic mixture utilization enhances the performance of the Organic Rankine cycle (ORC) significantly. For geothermal ORC power plants, the zeotropic mixture flow boiling correlation plays a vital role in both evaporator design and system performance evaluation. Based on the screened zeotropic mixture R1224yd(Z)/R1234ze(E) (0.452/0.548), a comparative analysis of 4 flow boiling correlations is performed to assess their impact on both evaporator design and system performance under off-design conditions. The results underscore a substantial impact of these correlations on determining the plate length, with the largest relative difference being 53.8%, consequently resulting in uncertainties of 31.7% and 23.4% for the evaporator exergy loss and cost, respectively. Under off-design working conditions, the relative difference in net power output varies from 16.43% to 7.67%. The exergy efficiency variation is up to 11.82% and the electricity production cost (EPC) uncertainty is up to 11.2% at the working condition with the maximum difference in net output work. This study provides valuable insights for selecting the appropriate zeotropic mixture flow boiling correlation in practical evaporator design and evaluating the off-design performance of ORC systems.