Soil salinization significantly impacts agricultural lands and crop productivity in the study area. Moreover, freshwater scarcity poses a significant obstacle to soil reclamation and agricultural production. Therefore, eco-friendly strategies must be adopted for agro-ecosystem sustainability under these conditions. A study conducted in 2022 and 2023 examined the interaction effects of various soil mulching materials (unmulched, white plastic, rice straw, and sawdust) and chitosan foliar spray application (control, 250 mg L-1 of normal chitosan, 125 mg L-1 of nano chitosan, and 62.5 mg L-1 of nano chitosan) on the biochemical soil characteristics and productivity of common beans in clay-saline soil. Higher organic matter, available nutrient content, and total bacteria count in soils were found under organic mulching treatments (rice straw and sawdust). In contrast, the white plastic mulching treatment resulted in the lowest values of soil electrical conductivity (EC) and the highest soil water content. Conversely, chitosan foliar spray treatments had the least impact on the chemical properties of the soil. Plants sprayed with 62.5 mg L-1 of nano chitosan exhibited higher chlorophyll content, plant height, fresh weight of shoots and roots, seed yield, and nutrient content compared to other chitosan foliar spray applications. All treatments studied led to a significant reduction in fungal communities and Na% in plants. The combined effect of organic mulch materials and foliar spray application of 62.5 mg L-1 nano chitosan appeared to enhance biochemical saline soil properties and common bean productivity.