Organic farming is gaining momentum nowadays and the demand for organic food is increasing day by day. Field investigations were carried out during five consecutive summer seasons (2016, 2017, 2018, 2019, and 2020) at the Regional Research Station, Vridhachalam to optimize the organic inputs and to develop an organic production package for sesame. The field experiment comprised eight treatments with different organic inputs [farm yard manure (FYM), neem cake, biofertilizers, panchakavya] applied in different forms. The experiment was laid out in a randomized complete block design replicated thrice. The experimental results showed that the application of FYM @ 12.5 t/ha + seed treatment (Azospirillum + Phosphobacteria + PGPR each @ 600 g/ha of seed) + soil application of biofertilizer (Azospirillum + Phosphobacteria + PGPR each @ 2 kg/ha of seed) and foliar application of 3% panchagavya at 35 and 45 DAS recorded a higher seed yield (783 kg/ha).