To effectively utilize fly ash solid waste and realize fly ash resource utilization, carbon sequestration and emission reduction, as well as mine fire prevention and suppression, this paper analyses the components of fly ash by X-ray fluorescence spectrometer (XRF), rheological experiments, the CO2 sequestration experiments by the mineralization of fly ash, thermogravimetric analysis experiments, and flame-retardant property experiments. Additionally, the changes in the physical structure and morphology of fly ash before and after mineralization were analyzed by X-ray diffraction (XRD) and scanning electron microscope (SEM). The carbon sequestration capacity and fluidity of fly ash slurry, as well as the ability of mineralized fly ash slurry to inhibit spontaneous coal combustion are comprehensively investigated. The research results indicate that CO2 is sequestered as calcite on the fly ash surface after mineralization. The optimal CO2 sequestration capacity of fly ash is 65.12 kg/t when 0.5 mol/L NaHCO3 is used as an additive. The fluidity of mineralized fly ash slurry is greater than that of fly ash slurry, and the lower the water-cement ratio is, the worse the fluidity. Mineralized fly ash slurry with a water-cement ratio of 3:1 has a strong carbon sequestration capacity and high fluidity, making it suitable for preventing coal spontaneous ignition in mine goafs. Mineralized fly ash slurry exhibits a regular trend where the better the mineralization effect, the lower the CO release during the low-temperature oxidation stage of coal, and the higher the cross-point temperature. Mineralized fly ash slurry has a stronger ability to inhibit spontaneous coal combustion than does ordinary fly ash slurry.