To present the demographic and clinical profile and management strategies of patients with periocular and orbital amyloidosis. This study retrospectively reviewed the clinical records of twelve patients with periocular and orbital amyloidosis between January 2011 and February 2019 in Bangladesh. Clinical evaluation and Imaging studies were helpful to diagnosis the patients, but surgical biopsy followed by histopathological study was done to confirm the diagnosis. All cases were investigated to rule out systemic amyloidosis with limited facility and no systemic involvement was found. Informed written consent for surgical procedure and Clinical photographs were taken for all patients for documentation and clinical research. The study included thirteen patients including nine male (69.2%) and four female (30.8%) patients. Among the patients, seven (53.8%) were unilateral and six (46.2%) were bilateral. Clinical signs and symptoms were visible or palpable periocular mass or tissue infiltration in all 13 (100%) cases, mechanical ptosis was observed in 6 (46.2%) cases, and proptosis or globe displacement was found in 4 (30.8%). Age ranges from 25 years to 65 years. The Mean age ± SD was 48.23 ± 10.64 years. Treatment modalities were mainly open surgical biopsy either excision (53.8%) or debulking (46.2%). Periocular and orbital amyloidosis may present with a wide spectrum of clinical findings depending on the location of the disease. The goal of treatment is to preserve function and to prevent sight-threatening complications.