We compute the instanton partition functions of SCFTs in class . We obtain this result via orbifolding Dp/D(p-4) brane systems and calculating the partition function of the supersymmetric gauge theory on the worldvolume of K D(p-4) branes. Starting with D5/D1 setups probing a orbifold singularity we obtain the K instanton partition functions of 6d theories on in the presence of orbifold defects on T2 via computing the 2d superconformal index of the worldvolume theory on K D1 branes wrapping the T2. We then reduce our results to the 5d and to the 4d instanton partition functions. For k = 1 we check that we reproduce the known elliptic, trigonometric and rational Nekrasov partition functions. Finally, we show that the instanton partition functions of quivers in class can be obtained from the class mother theory partition functions with gauge factors via imposing the ‘orbifold condition’ with and , on the Coulomb moduli and the mass parameters.