Oral Tumor Patients Research Articles

Comparison of the Efficacy of Indwelling Gastric Tubes in Preoperative and Postoperative Patients With Oral and Maxillofacial Malignancies

PurposeTo explore the optimal plan for the timing of indwelling gastric tube placement in oral and maxillofacial malignant tumor patients. DesignA prospective randomized controlled trial. Methods80 patients with oral and maxillofacial tumor were selected, and 40 patients were Pre-operative group. The remaining 40 patients were the control group, called Postoperative group. The body weight and hospital stay of the two groups were observed before and after surgery. Blood samples were taken before surgery and 1, 3 and 7 days after surgery to detect hemoglobin and plasma albumin. FindingsThe number of postoperative hospitalization days in the pre-operative group was significantly lower than that in the post-operative group; postoperative hemoglobin and plasma albumins were lower in both groups compared with the preoperative level. ConclusionsPreoperative nasogastric tube ensured early postoperative administration of gastrointestinal nutrition, promoted postoperative plasma albumin recovery, and shortened the days of hospitalization.

Application of Midline Catheter Placed Under Ultrasound Guidance in Intravenous Therapy for Oral and Maxillofacial Tumor

To examine the application effect of ultrasound-guided placement of midline catheter and to select the appropriate placement method of intravenous catheter for patients with oral and maxillofacial tumors. We retrospectively analyzed the general data and venous catheter-related information of 143 oral and maxillofacial tumor patients who received treatment between June 2019 and December 2021. There were two patient groups, a control group of patients with inserted peripheral venous catheters (PVC) and an observation group of patients with midline catheters placed under ultrasound guidance. We made a comparative analysis of the incidence of catheter-related complications, including bleeding at the insertion site, phlebitis, catheter blockage, extravasation, etc., in the two groups. When the baseline data from the two groups were not balanced, we used propensity score matching (PSM) to match the general data before comparing the complication incidence between the two groups. There were 71 patients who underwent 215 times of PVC placement in the control group and 72 patients who underwent 72 times of midline catheter placement in the observation group. There was no significant difference between the patients in the two groups in terms of age, sex, diagnosis, or the use of anticoagulant medication ( P>0.05) . The observation group had longer average length-of-stay than the control group did ( P<0.01). The cost of catheter placement in the observation group was 1080 yuan per set, with the average daily cost being about (56.27±20.23) yuan. Patients in the control group had PVC placement for an average of (3.03±0.93) times. The cost for PVC placement was 96 yuan per time and the average daily cost was about (19.94±7.50) yuan. There was significant difference in the average daily cost between the observation group and the control group ( P<0.01). PSM was performed for the two groups. Before PSM, the incidence of catheter-related complications in the observation group (8.3%, 6/72) was lower than that of the control group (30.2%, 65/215) and the difference was statistically significant ( P<0.01). After PSM, 72 times of catheter placement from each group were included in comparative analysis. The incidence of catheter-related complications in the observation group (8.3%, 6/72) was lower than that of the control group (54.2%, 39/72) and the difference was statistically significant ( P<0.01). Patients have low incidence of catheter-related complications when they have midline catheter placed under ultrasound guidance, which helps reduce the pain of repeated venous insertion that patients incur and the workload of clinical nurses. The use of midline catheters is appropriate for and should be popularized among patients with oral and maxillofacial malignant tumors, especially patients who have poor peripheral venous conditions and those who are undergoing repair and reconstruction surgeries.

Anatomical classification of adductor magnus perforator flap and its application in head and neck reconstruction

Objective: To investigate the anatomical classification of adductor magnus perforator flap and its application in head and neck reconstruction. Methods: From January 2017 to January 2020, Hunan Cancer Hospital treated 27 cases of oral tumor patients (15 cases of tongue cancer, 9 cases of gingival cancer and 3 cases of buccal cancer), including 24 males and 3 females, aged 31-56 years old. The course of disease was 1-12 months. Secondary soft tissue defects with the sizes of 5.0 cm × 3.5 cm to 11.0 cm × 8.0 cm were left after radical resection of the tumors, and were repaired with free adductor magnus perforator flaps. The flaps based on the origing locations of perforator vessels were divided into three categories: ① intramuscular perforator: vessel originated between the gracilis muscle and the adductor magnus or passed through a few adductor magnus muscles; ② adductor magnus middle layer perforator: vessel run between the deep and superficial layers of adductor magnus; ③ adductor magnus deep layer perforator: vessel run between the deep layer of adductor magnus and the semimembranous muscle. Descriptive analysis was used in this research. Results: Perforator vessels of adductor magnus were found in all cases, with a total of 62 perforator branches of adductor magnus. The anatomical classification of the perforator vessels was as follows: 12 branches for class ①, 31 branches for class ② and 19 branches for class ③. The vascular pedicles of the free adductor major perforator flaps included type ① for 3 cases, type ② for 16 cases and type ③ for 8 cases. All 27 flaps survived and the donor sites were closed directly. In 18 cases, the perforator arteries and the venae comitan were respectively anastomosed with the superior thyroid arteries and veins. In 9 cases, the pedicle arteries and the venae comitan were respectively anastomosed with the facial arteries and veins. Follow up for 12-40 months showed that the appearances of the flaps and the swallowing and language functions of patients were satisfactory, apart from linear scars were left in the donor sites with no significant affect on the functions of thigh. Local recurrence occurred in 3 cases and radical surgeries were performed again followed by repairs with pedicled pectoralis major myocutaneous flaps. Cervical lymph node metastasis occurred in 2 cases and cervical lymph node dissection was performed again. Conclusions: The adductor magnus perforator flap has soft texture, constant perforator vessel anatomy, flexible donor location and harvesting forms, and less damage to the donor site. It is an ideal choice for postoperative reconstruction in head and neck tumors.

Factors influencing the accuracy of multimodal image fusion for oral and maxillofacial tumors: a retrospective study

BackgroundEnsuring high accuracy in multimodal image fusion for oral and maxillofacial tumors is crucial before further application. The aim of this study was to explore the factors influencing the accuracy of multimodal image fusion for oral and maxillofacial tumors.MethodsPairs of single-modality images were obtained from oral and maxillofacial tumor patients, and were fused using a proprietary navigation system by using three algorithms (automatic fusion, manual fusion, and registration point-based fusion). Fusion accuracy was evaluated including two aspects—overall fusion accuracy and tumor volume fusion accuracy—and were indicated by mean deviation and fusion index, respectively. Image modality, fusion algorithm, and other characteristics of multimodal images that may have potential influence on fusion accuracy were recorded. Univariate and multivariate analysis were used to identify relevant affecting factors.ResultsNinety-three multimodal images were generated by fusing 31 pairs of single-modality images. The interaction effect of image modality and fusion algorithm (P = 0.02, P = 0.003) and thinner slice thickness (P = 0.006) were shown to significantly influence the overall fusion accuracy. The tumor volume (P < 0.001), tumor location (P = 0.007), and image modality (P = 0.01) were significant influencing factors for tumor volume fusion accuracy.ConclusionsTo ensure high overall fusion accuracy, manual fusion was not preferred in CT/MRI image fusion, and neither was automatic fusion in image fusion containing PET modality. Using image sets with thinner slice thickness could increase overall fusion accuracy. CT/MRI fusion yielded higher tumor volume fusion accuracy than fusion containing PET modality. The tumor volume fusion accuracy should be taken into consideration during image fusion when the tumor volume is small and the tumor is located in the mandible.

Analysis of Intervention Effect and Satisfaction of Holistic Nursing after Oral Tumor Resection.

Objective To explore the intervention effect and satisfaction analysis of holistic nursing after oral tumor resection. Methods A total of 70 oral tumor patients who underwent surgical treatment in our hospital from April 2020 to September 2021 were randomly divided into two groups, with 35 patients in each group. The control group was given basic oral care, the observation group was given overall oral care, and the actual effects of the two groups of care were compared, including the emotional status, compliance and nursing satisfaction, hospital stay and nursing quality scores, pain level, quality of life, and complications occurred. Results After nursing, the patients in the observation group had good mood, higher compliance and nursing satisfaction, shorter hospital stay, higher nursing quality and quality of life scores, lower pain level, and lower incidence of complications, when compared with the control group. Conclusion Holistic nursing has obvious effects on patients after oral tumor surgery, which can relieve patients' negative emotions, improve patients' compliance with treatment, improve their quality of life, and effectively reduce the degree of pain and the occurrence of complications, which is worthy of clinical promotion.

The progress of post-treatment restricted mouth opening in oral and maxillofacial malignant tumor patients

: Oral and maxillofacial malignant tumor seriously threaten the physical and mental health of patients, especially advanced malignant tumor requiring a comprehensive sequence of surgery-based treatment, resulting in facial deformity, difficulties with chewing, dysphagia and asophia. Among them, trismus (restricted mouth opening) is one of the most common complications after treatment of oral and maxillofacial malignant tumor. In severe cases, they may even suffer from trismus and eating difficulties, finally leading to malnutrition and even cachexia. Therefore, it not only affects the quality of life of the patients and even endangers their lives, but also brings heavy social and economic burden. How to effectively prevent and treat posttreatment trismus is a clinical problem which is easy to be ignored by oral and maxillofacial surgeons and needs to be solved urgently. In recent years, restricted mouth opening (trismus) after post-treatment of oropharyngeal, nasopharyngeal and other head and neck malignant tumors have been widely studied, but restricted mouth opening after comprehensive treatment of oral cancer has been neglected. We therefore conducted a systematic review with 3 aims: (I) to clear the definition of restricted mouth opening and trismus; (II) to identify epidemiology and pathogenesis of restricted mouth opening or trismus; and (III) to summarize the methods of interventions or treatment of oral and maxillofacial malignant tumor patients with restricted mouth opening or trismus.

MicroRNA: A key player in oral tumors pathogenesis

Oral tumors are one of malignancies which could be related with serious health problems worldwide. It has been indicated that several cellular and molecular pathways including genetics and epigenetics mechanisms (e.g. chromosomal alterations, and microRNA) could be anticipated in oral cancerogenesis. The recognition of these pathways is found as key steps for better treatment of oral tumor patients. MicroRNAs (miRNAs) are one of important molecules which could be involved in various physiological processes in oral tumors. These molecules are known as short non coding RNAs which are associated with initiation and progression of various diseases such as oral tumors. Multiple lines of evidence showed that various miRNAs (i.e. miR-9, miR-7, miR-21, miR-31, miR-15a and miR-16-1) via targeting various cellular and molecular pathways such as epidermal growth factor receptor (EGFR), MAPK, Akt, ERK, Jak/STAT, and PTEN could be involved in oral tumors pathogenesis. Here, we summarized various miRNAs which have critical roles in oral tumors pathogenesis. Moreover, we highlighted the utilization of various miRNAs as diagnostic and therapeutic biomarkers for patients with oral tumors.

Multivariate analysis of risk factors for postoperative wound infection following oral and oropharyngeal cancer surgery

PurposeThe goal of this study was to identify risk factors for wound infections in patients with oral cancer who underwent surgical procedures. Materials and methodsThis study included 195 patients who underwent surgical treatment of oral and oropharyngeal cancer over a 7-year period. Wound infection was defined as the occurrence of purulent content from the wound or as an appearance of exudate with signs of local infection and positive cultures taken from the wound. For every patient who was suspected to have a wound infection, a swab from the wound was taken, and microbiological analysis was performed. The patients were divided into 2 groups: patients with postoperative wound infections, and patients with postoperative wound infection. ResultsWound infection was present in 155 patients (59%). Univariate analysis indicated that the following factors were significantly related to the occurrence of wound infection: gender, smoking, tumor localization, size and stage of the tumor, type of surgery, neck dissection, type of reconstruction, nasogastric sonde, gastrostomy and tracheotomy. On multivariate analysis, statistically significant predictors of wound infection were gender, tumor localization and type of reconstruction. ConclusionsThe occurrence of wound infection is high despite antibiotic prophylaxis. To minimize the risk of wound infection and for prompt recognition of risk factors, surgeons managing oral tumor patients should have a better understanding of the risk factors such as gender, tumor localization and type of reconstruction.

Oral tumors in children: Diagnosis and management.

Oral tumors are one of important tumors which could be associated with serious problems in infant and children. It has been showed that a variety of cellular and molecular pathways including genetics and epigenetics mechanisms (eg, chromosomal alterations, and microRNA) involved in pathogenesis events present in oral tumors. Identification of these pathways could contribute to better treatment of oral tumor patients. Early detection is one of key steps in management of oral tumors which could contribute to improve clinical outcomes and better treatment of infant with oral tumors. Despite of easy accession of the oral cavity, oral tumors (malign/benign) are diagnosed in advance stages. Therefore, these tumors indicate a poor survival rate. It has been showed that various approaches including imaging techniques, chemical, genetics, and epigenetic biomarkers could have critical roles in early detection of oral tumors. Treatment of oral tumors is associated with employing of various therapeutic approaches including surgery, chemotherapy, and radiation. Data on effective diagnostic platforms and therapeutic approaches for oral tumors in children and infant are rare. We offer that a variety of biomarkers such as microRNAs which could be used for oral tumors in adults may be good candidates for early detection of oral tumors in children. Here, we summarized various aspects of oral tumors in children such as molecular pathways, diagnosis, and management of them.

Diagnostic values of serum tumor markers Cyfra21-1, SCCAg, ferritin, CEA, CA19-9, and AFP in oral/oropharyngeal squamous cell carcinoma.

BackgroundAt present, the research on serum tumor markers in the early diagnosis of malignant tumors has aroused widespread concern. The aim of this study was to investigate the diagnostic values of serum tumor markers cytokeratin 19 fragment (Cyfra21-1), squamous cell carcinoma antigen (SCCAg), ferritin, carcinoembryonic antigen (CEA), carbohydrate antigen 19-9 (CA19-9), and α-fetoprotein (AFP) for patients with oral/oropharyngeal squamous carcinoma (OSCC/OPSCC).MethodsOne hundred and sixty-nine cases of patients with OSCC/OPSCC as the experimental group, 86 cases of oral benign tumor patients as the control group, and 30 cases of healthy people as the normal control group were studied. The levels of serum Cyfra21-1, SCCAg, ferritin, CEA, CA19-9, and AFP were measured using electrochemiluminescence immunoassay.ResultsThe levels of serum Cyfra21-1, SCCAg, ferritin, and CEA in patients with OSCC/OPSCC were significantly higher than those of benign tumor and healthy control group (P<0.05). The levels of CA19-9 and AFP showed no significant difference between patients with OSCC/OPSCC, benign tumor, and healthy group (P>0.05). The level of serum Cyfra21-1 in patients with early OSCC/OPSCC (stage I + II) was significantly higher than that of benign tumor and healthy control group (P<0.05). However, the levels of serum SCCAg, ferritin, CEA, CA19-9, and AFP showed no significant difference between patients with early OSCC/OPSCC, benign tumor, and healthy control group (P>0.05). The levels of serum Cyfra21-1, SCCAg, ferritin, and CEA in the middle-late stage of patients with OSCC/OPSCC (stage III + IV) were significantly higher than those of patients with the early OSCC/OPSCC, benign tumor, and healthy control group (P<0.05). The diagnostic cutoff levels of Cyfra21-1, SCCAg, ferritin, and CEA were 2.17, 0.72, 109.95, and 1.99 ng/mL, respectively. The sensitivities were 60.36%, 73.37%, 81.66%, and 66.27%, respectively. The specificities were 81.03%, 68.10%, 40.52%, and 61.21%, respectively.ConclusionCyfra21-1, SCCAg, ferritin, and CEA had diagnostic values for patients with OSCC/OPSCC. Meanwhile, Cyfra21-1 had better early diagnostic value for patients with OSCC/OPSCC.

Impact of Postoperative Radiotherapy and Chemotherapy on Survival for Patients with Node Positive Oral Cancer

Purpose: The aim of the present study is to compare between the use of post-operative concurrent chemotherapy and radiotherapy alone on survival for patients with high risk oral cavity tumors at the National cancer Institute of Egypt, undergoing surgery and receiving adjuvant treatment. Patients and Methods: This is a retrospective study, which was carried out at the National Cancer Institute (Cairo University) on patients with node positive oral cavity cancer diagnosed between the year 2000 and 2008. The study included 60 patients (45 males and 15 females) with median age 57 years old. The patients underwent surgery, followed by postoperative radiotherapy 60 Gy/6 weeks versus postoperative radiotherapy 60 Gy/6 weeks with concurrent cisplatin 100 mg/m2 at day 1, day 22 and day 43. Results: Regarding use of concurrent chemotherapy, there was a significant difference in overall survival rate and locoregional control favoring patients who received concurrent chemotherapy and radiotherapy, 3 years and 5 years overall survival rates respectively were 53.8% and 40.4% compared to 37.5% and 26.3% for patients who didn’t receive any chemotherapy with (p 0.038) for 5 years. Regarding age, there was a significant difference in overall survival rate favoring patients ≤57 years in both arm groups, 3 years and 5 years overall survival rates respectively were 51.6% and 38.9% compared to 28.3% and 18.9% for patients >57 years with (p 0.028) for 5 years. Conclusion: We recommend for oral cavity tumor patients at the NCI of Egypt who have positive neck nodes to be treated with concurrent chemo-radiotherapy rather than radiotherapy alone especially by using the new techniques as intensity modulated radiotherapy (IMRT) and image guided radiotherapy (IGRT).

Metabonomics study of oral cancer using gas chromatography-mass spectrometry and liquid chromatography-mass spectrometry

Oral cancer is the sixth common cancer in the world, and precisely distinguishing health control, benign and malignant oral tumors is important for the proper and timely selection of therapeutic treatment. In the current study, the metabolic profiles of the plasma, urine and saliva of three groups, consisting of malignant oral tumor patients, benign oral tumor patients and healthy controls, were analyzed using liquid chromatography-mass spectrometry and gas chromatography-mass spectrometry. Utilizing a partial least squares-discriminant analysis with orthogonal signal correction data filter, the three groups were discriminated based on their plasma, urine and saliva metabolic profiles. Nineteen differential metabolites were identified including 3 acylcarnitines and 4 lyso-phosphatidylcholines in plasma, 3 amino acids and 2 organic acids in urine, 4 organic acids and 3 other metabolites in saliva. The identified metabolites were studied in the context of the pathways in which they were involved and their biological activities. The results indicated that benign and malignant oral tumor patients have altered energy metabolism, disordered lipolysis compared with healthy controls. Furthermore malignant oral tumor patients even present a distorted Krebs cycle and inositol metabolism.

Simultaneous measurements of serum insulin-like growth factor-i and leptin reflect the postoperative nutrition status of oral tumor patients

Objective Recent evidence has shown that circulating levels of insulin-like growth factor-I (IGF-I) and leptin are regulated by nutrition support. Our objective was to investigate the reliability of IGF-I and leptin in monitoring the efficacy of nutrition support and nutrition status in oral tumor patients. Methods Fifty-one male patients scheduled to receive resection operation for oral tumor were recruited. Fasted blood samples were collected before surgery (d0), on the first postoperative day before feeding (d1), and on the seventh postoperative day (d7) with nasogastric tube feeding (35 kcal · kg −1 · d −1). Fifty male healthy volunteers were recruited as controls. Results After adjustment for age, patients had significantly greater serum concentrations of transferrin and significantly lower serum concentrations of prealbumin and tumor-necrosis factor-α than did healthy volunteers on d0. In oral tumor patients, resection with prolonged fasting significantly increased levels of growth hormone and interleukin-6 and significantly decreased levels prealbumin, retinol-binding protein, IGF-I, and leptin, and these alterations were reversed by nutrition support for 6 d in oral tumor patients. Serum IGF-I was further increased on d7 compared with d0. In addition, leptin was the only nutrition-related serum protein showing significantly positive correlation with body mass index in healthy volunteers and patients. Conclusions Our results suggested that simultaneous measurements of serum IGF-I and leptin may provide information with regard to the efficacy of nutrition support and nutrition status in oral tumor patients undergoing surgery.

Clinical analysis of implant losses in oral tumor and defect patients.

In the period between 1990 and 1996, 279 endosteal dental Bone-Lock implants were placed in 79 patients. Of them 63 have been treated with ablative tumor and reconstructive surgery in the oral cavity, the rest presented with maxillo-mandibular defects of different origin. The circumstances of implant loss were noted down for descriptive analysis concerning age, sex, topography, implant dimensions, loading, time in place and type of superstructure. Failure analysis was done concerning the implants and the patients. Five causes for implant loss could be detected: lacking primary osseointegration, acute inflammation, bone loss, biomechanical overloading and tumor recurrence. No predictive factors for implant loss and no age influence on implant loss could be detected, no specific local implant site and no specific superstructure had an identifiable higher risk. Survival rate of all placed implants in oral tumor and defect patients was 83.5% after 6 years observation. Male tumor patients were found to have a higher risk to lose implants than females. Free iliac bone grafts impaired osseointegration of implants. The mandible offered a better prognosis for the implants than the maxilla. Shorter and thinner implants had a higher risk of being lost. A quarter of all patients (26.3%) had to face implant loss. Clustering of implant loss in several patients was caused by free iliac bone grafting and by prosthetic faults. Chemotherapy had no negative influence on implant survival. Most implants were lost early (76%) before fabrication of the prosthesis. After restoration there was a nearly 100% probability of function. It is concluded that implant treatment can be equally effective for tumor and defect patients as it is known for healthy subjects.

Home and Inpatient Hospice Care of Terminal Head and Neck Cancer Patients

The objective is to evaluate and compare data on a cohort of terminal head and neck cancer (HNC) patients from both home and hospital-based hospice programs and to define the particular problems and needs of those patients. The setting was a tertiary academic referral centre in Tel Hashomer, Israel. We carried out a retrospective survey of patient charts based on hospice databases and death certificates of the hospital tumor registry. Charts of 102 HNC patients admitted to the hospice between 1988 and 1994 and 24 charts of HNC patients cared for by the home hospice program between 1990 and 1994 were studied. Pain, airway problems, and dysphagia were the common problems reported. A comparison of the two programs showed home hospice patients to be younger and with lower pain levels, less weight loss, and less oral candidiasis. There were fewer oral cavity tumor patients in the home hospice group. The incidence of distant metastases was in 50% range in both groups. Judging by chart entries relating to pain, airway care, and food intake, treatment protocols were effective in both programs in the alleviation of pain and other symptoms. Both programs appeared to provide adequate care for terminal HNC patients. The main difference in care between the two groups stemmed from the decisions of referring physicians and not from a predetermined level of care. The incidence of distant metastases was higher than that reported in earlier clinical series.

Feeding interactions of preterm small for gestational age infants and their mothers

The goal of this study was to identify risk factors for wound infections in patients with oral cancer who underwent surgical procedures.This study included 195 patients who underwent surgical treatment of oral and oropharyngeal cancer over a 7-year period. Wound infection was defined as the occurrence of purulent content from the wound or as an appearance of exudate with signs of local infection and positive cultures taken from the wound. For every patient who was suspected to have a wound infection, a swab from the wound was taken, and microbiological analysis was performed. The patients were divided into 2 groups: patients with postoperative wound infections, and patients with postoperative wound infection.Wound infection was present in 155 patients (59%). Univariate analysis indicated that the following factors were significantly related to the occurrence of wound infection: gender, smoking, tumor localization, size and stage of the tumor, type of surgery, neck dissection, type of reconstruction, nasogastric sonde, gastrostomy and tracheotomy. On multivariate analysis, statistically significant predictors of wound infection were gender, tumor localization and type of reconstruction.The occurrence of wound infection is high despite antibiotic prophylaxis. To minimize the risk of wound infection and for prompt recognition of risk factors, surgeons managing oral tumor patients should have a better understanding of the risk factors such as gender, tumor localization and type of reconstruction.

口腔領域の悪性腫よう手術後の下顎骨二次再建の９例について

口腔領域の悪性腫よう手術後の下顎骨二次再建の９例について

口腔領域悪性腫ようの頚部リンパ節転移に関する臨床統計的検討

Clinicostatistical investigation was made about 105 patients performed neck dissection (including radical and partial neck dissection and lymph node extirpation) out of 197 oral malignant tumor patients at the Department of Oral and Maxillofacial Surgery 1st, Hiroshima University, School of Dentistry between October 1974 and September 1984.Metastasis to the cervical lymph nodes were histologically confirmed in 45 patients. They were most frequently found at submandibular lymph nodes, but in some patients found only at lower cervical lymph nodes. Thus radical neck dissection should be proposed for the first choice of the treatment.The comulative five year survival rates of patients performed prophylactic and therapeutic neck dissection were 60% and 62%. Although there is no significant difference between them, prophylactic neck dissection may have reduced late metastasis.34 patients confirmed metastasis histologically were performed conservative radical neck dissection, and only 3 patients (9%) had recurrence at the cervical region. This indicates that conservative radical neck dissection is valuable provided there is no metastasis to the internal juglar vein.

顔面および口腔に腫りゅうを形成した多発性骨髄腫の１例

The chief complaints of multiple myeloma are commonly described as weakness, skeletal pain, and arthralgia. Oral manifestations of multiple myeloma are rare in Japan. In our Department of Oral Surgery, Sapporo Medical College, from 1976 to 1986, multipul myeloma was seen in only one of 325 oral malignant tumor patients. This study reports on this particular case. A 51-year-old man having a mass formation in his posterior mandible of the right side is described.He had biphasic IgD-λ type M-proteins in serum and Bence-Jones protein of λ type in urine, and he also had OKT 4 epitope deficiency.