This study investigates the Total Annual Cost (TAC) optimization of a reactive distillation (RD) process for methyl acetate (MA) production as a function of tray pressure drop, focusing on the trade-off between chemical reaction kinetics and separation efficiency. The analysis examines how variations in column diameter and weir height influence the TAC across different liquid hold-ups with and without incorporating a tray pressure drop in the simulations. Results indicate that for larger liquid hold-ups, the decrease in separation efficiency predominates over kinetic advantages, leading to higher energy costs when pressure drop is considered. Despite the loss in separation efficiency with a high weir height, a pressure drop-incorporated column design featuring a high weir height and small diameter is shown to achieve lower TAC due to the comparatively lower installed costs. A reduction of tray liquid hold-up of more than 50 % is found for the optimal column design in the considered case study when the tray pressure drop is considered. A sensitivity analysis towards a hypothetical infinite fast reaction is conducted to illustrate how the energy costs are affected by the kinetic rate of the chemical reaction.
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