Optimal Segmentation Research Articles

Color Dominance-Based Polynomial Optimization Segmentation for Identifying Tomato Leaves and Fruits

Optimization processes or methods play an essential role in the continuous improvement of various human activities, particularly in agriculture, given its vital role in food production. In precision agriculture, which utilizes technology to optimize food production, a primary goal is to minimize the consumption of resources like water, fertilizers, and the detection of pests and diseases. In the fertilization process, it is essential to identify any deficiencies or excesses of chemical elements. Nutrient deficiencies, which are essential for plant development, are typically detected in the leaves of crops. This paper proposes a methodology for optimizing the color threshold dominance factors employed in the segmentation process for tomato crop leaves and fruits. The optimization is performed using an interpolation method to find the values that maximize the segmentation of leaves and fruits used by the color dominance segmentation method. A comparison of the interpolation method results with those obtained using a greedy algorithm, which iteratively finds the optimal segmentation values, shows nearly identical outcomes. Similarly, a UNetmodel is used for semantic segmentation, the results of which are inferior to those obtained by the proposed interpolation optimization method. The most significant contribution of the interpolation method is that it requires only a single iteration to generate the initial data, in contrast to the iterative search required by the greedy algorithm and the lengthy training process and video card dependency of the UNet model. This results in an 80% reduction in computation time.

Fractional order calculus enhanced dung beetle optimizer for function global optimization and multilevel threshold medical image segmentation

Fractional order calculus enhanced dung beetle optimizer for function global optimization and multilevel threshold medical image segmentation

Cap2Seg: leveraging caption generation for enhanced segmentation of COVID-19 medical images

Incorporating medical text annotations compensates for the quality deficiencies of image data, effectively overcoming the limitations of medical image segmentation. Many existing approaches achieve high-quality segmentation results by integrating text into the image modality. However, these approaches require matched image-text pairs during inference to maintain their performance, and the absence of corresponding text annotations results in degraded model performance. Additionally, these methods often assume that the input text annotations are ideal, overlooking the impact of poor-quality text on model performance in practical scenarios. To address these issues, we propose a novel generative medical image segmentation model, Cap2Seg (Leveraging Caption Generation for Enhanced Segmentation of COVID-19 Medical Images). Cap2Seg not only segments lesion areas but also generates related medical text descriptions, guiding the segmentation process. This design enables the model to perform optimal segmentation without requiring text input during inference. To mitigate the impact of inaccurate text on model performance, we consider the consistency between generated textual features and visual features and introduce the Scale-aware Textual Attention Module (SATaM), which reduces the model’s dependency on irrelevant or misleading text information. Subsequently, we design a word-pixel fusion decoding mechanism that effectively integrates textual features into visual features, ensuring that the text information effectively supplements and enhances the image segmentation task. Extensive experiments on two public datasets, MosMedData+ and QaTa-COV19, demonstrate that our method outperforms the current state-of-the-art models under the same conditions. Additionally, ablation studies have been conducted to demonstrate the effectiveness of each proposed module. The code is available at https://github.com/AllenZzzzzzzz/Cap2Seg.

Research on Improved Image Segmentation Algorithm Based on GrabCut

The classic interactive image segmentation algorithm GrabCut achieves segmentation through iterative optimization. However, GrabCut requires multiple iterations, resulting in slower performance. Moreover, relying solely on a rectangular bounding box can sometimes lead to inaccuracies, especially when dealing with complex shapes or intricate object boundaries. To address these issues in GrabCut, an improvement is introduced by incorporating appearance overlap terms to optimize segmentation energy function, thereby achieving optimal segmentation results in a single iteration. This enhancement significantly reduces computational costs while improving the overall segmentation speed without compromising accuracy. Additionally, users can directly provide seed points on the image to more accurately indicate foreground and background regions, rather than relying solely on a bounding box. This interactive approach not only enhances the algorithm’s ability to accurately segment complex objects but also simplifies the user experience. We evaluate the experimental results through qualitative and quantitative analysis. In qualitative analysis, improvements in segmentation accuracy are visibly demonstrated through segmented images and residual segmentation results. In quantitative analysis, the improved algorithm outperforms GrabCut and min_cut algorithms in processing speed. When dealing with scenes where complex objects or foreground objects are very similar to the background, the improved algorithm will display more stable segmentation results.

Analysis of electrode performance on amplitude integrated electroencephalography in neonates: evaluation of a new electrode aCUP-E vs. liquid gel electrodes.

Neonatologists and clinical neurophysiologists face challenges with the current electrodes used for long-duration amplitude-integrated electroencephalography (aEEG) in neonatal intensive care units (NICU), limiting the capacity to diagnose brain damage. The objectives of this study were to develop methods for comparing the performance of different electrodes to be used in aEEG. The comparison was done between a newly designed neonate-specific electrode, aCUP-E, with commercial liquid gel electrodes used in amplitude-integrated electroencephalography (aEEG). The comparison included impedance stability, electrode survival, recording quality, usability, and satisfaction of NICU staff. aEEG recordings with bipolar montage was used, with one hemisphere fitted with commercial electrodes and the other with aCUP-E electrodes, alternated among subjects. Continuous impedance and raw EEG data were collected over a minimum of 24 h, and signal processing was performed using Python and MATLAB. aCUP-E electrodes demonstrated superior performance, including: Increased impedance stability and electrode survival, enhanced recording quality with fewer artifacts, high correlation in signal capture between electrodes during optimal brain activity segments, higher signal-to-noise ratio (SNR) across varying impedance levels, greater staff satisfaction and ease of use. Moreover, Kaplan-Meier curves indicated a higher survival rate for aCUP-E electrodes over 24 h compared to commercial electrodes. Impedance variability analysis showed statistically significant stability improvements for aCUP-E. aCUP-E electrodes outperform commercial liquid gel electrodes in impedance stability, electrode survival, and recording quality. These results suggest that aCUP-E electrodes could significantly enhance aEEG utilization in diagnosing and treating neonatal brain conditions in NICUs. Future improvements to the aCUP-E electrode may further reduce artifacts and increase electrode longevity, potentially leading to a significant improvement in neonatal brain monitoring by means of aEEG.

An intelligent character segmentation system coupled with deep learning based recognition for the digitization of ancient Tamil palm leaf manuscripts

Palm-leaf manuscripts, rich with ancient knowledge in areas such as history, art, and medicine, are vital cultural treasures, making their digitization essential for preserving this heritage. Digitization of these organic and fragile manuscripts is required to safeguard the essential ancient data. This requires optimal character segmentation and recognition algorithms. A limited number of studies have been carried out in Tamil character recognition in literature. Handling row-overlapped characters, noise introduced due to lightning issues, and dirt, as well as the removal of punch holes, auto-cropping the content, filtering out noisy or improper segmentation, etc. are the essential concerns carried out in our proposed work. This work is executed as a four-step process (1) Palm Leaf Manuscript Acquisition (2) Pre-Processing (3) Segmentation of Tamil Characters and (4) Tamil Character Recognition. During acquisition, the scanners are used for recording palm leaf manuscripts from the Tamil Nadu-oriented manuscript library. In the Pre-processing step, the Fast Non-Local Means (Fast-NLM) method, paired with median filtering is used for Denoising the scanner output image. Later, the pixels that make the characters and borders (i.e., the foreground) are identified using Sauvola thresholding. The proposed methodology introduces efficient techniques to remove Punch hole impressions from the pre-processed image, and to crop the written content from the edges. After pre-processing, the Segmentation of Tamil Characters is performed as a three-step process (a) Manuscript (b) Line, and (c) character segmentation, which addresses conjoined lines, partially/completely empty segmentations that are not previously addressed by existing techniques. This work introduces an Augmented HPP line-splitting algorithm that accurately segments written lines, handling wrong segmentation cases that were previously not considered by existing techniques. The system achieves an average segmentation accuracy of 98.25%, which far outperforms existing techniques. It also proposes a novel Punch hole removal algorithm that can locate and remove the punch-hole impressions in the manuscript image. This algorithm, along with the automated content cropping technique, increases recognition accuracy and eliminates any manual labor needed. These features make the proposed methodology highly suitable for real-time archaeological and historical researches that include manuscripts. All 247 letters and 12 numeric digits are analyzed and separated into 125 distinct writable characters. In our work, characters are segmented and used for recognition of all 247 letters and 12 digits in Tamil using a multi-class CNN with 125 classes, which drastically reduces the complexity of the neural network compared to having 257 output nodes. It offered a notable performance of 96.04% accuracy. As compared with existing Tamil and other character recognitions, this work is effective in essence of considering real-time images and the increased number of characters used.

NPSFF-Net: Enhanced Building Segmentation in Remote Sensing Images via Novel Pseudo-Siamese Feature Fusion

Building segmentation has extensive research value and application prospects in high-resolution remote sensing image (HRSI) processing. However, complex architectural contexts, varied building morphologies, and non-building occlusions make building segmentation challenging. Compared with traditional methods, deep learning-based methods present certain advantages in terms of accuracy and intelligence. At present, the most popular option is to first apply a single neural network to encode an HRSI, then perform a decoding process through up-sampling or using a transposed convolution operation, and then finally obtain the segmented building image with the help of a loss function. Although effective, this approach not only tends to lead to a loss of detail information, but also fails to fully utilize the contextual features. As an alternative, we propose a novel network called NPSFF-Net. First, using an improved pseudo-Siamese network composed of ResNet-34 and ResNet-50, two sets of deep semantic features of buildings are extracted with the support of transfer learning, and four encoded features at different scales are obtained after fusion. Then, information from the deepest encoded feature is enriched using a feature enhancement module, and the resolutions are recovered via the operations of skip connections and transposed convolutions. Finally, the discriminative features of buildings are obtained using the designed feature fusion algorithm, and the optimal segmentation model is obtained by fitting a cross-entropy loss function. Our method obtained intersection-over-union values of 89.45% for the Aerial Imagery Dataset, 71.88% for the Massachusetts Buildings Dataset, and 68.72% for the Satellite Dataset I.

Ultrack: pushing the limits of cell tracking across biological scales.

Tracking live cells across 2D, 3D, and multi-channel time-lapse recordings is crucial for understanding tissue-scale biological processes. Despite advancements in imaging technology, achieving accurate cell tracking remains challenging, particularly in complex and crowded tissues where cell segmentation is often ambiguous. We present Ultrack, a versatile and scalable cell-tracking method that tackles this challenge by considering candidate segmentations derived from multiple algorithms and parameter sets. Ultrack employs temporal consistency to select optimal segments, ensuring robust performance even under segmentation uncertainty. We validate our method on diverse datasets, including terabyte-scale developmental time-lapses of zebrafish, fruit fly, and nematode embryos, as well as multi-color and label-free cellular imaging. We show that Ultrack achieves state-of-the-art performance on the Cell Tracking Challenge and demonstrates superior accuracy in tracking densely packed embryonic cells over extended periods. Moreover, we propose an approach to tracking validation via dual-channel sparse labeling that enables high-fidelity ground truth generation, pushing the boundaries of long-term cell tracking assessment. Our method is freely available as a Python package with Fiji and napari plugins and can be deployed in a high-performance computing environment, facilitating widespread adoption by the research community.

Design of an Anti-interference long-range acoustic Communication System Based on optimal length segment coding

Abstract With the increased demand for unmanned vehicles in marine development, the development of underwater acoustic communication technology has received much attention. One of the key technologies in the research of long-range underwater acoustic communication technology is the use of underwater acoustic channels for efficient and stable data transmission. The harsh environment of the underwater acoustic channel has a significant impact on the rate and quality of underwater acoustic communication, making it a challenging research direction to achieve high-speed and reliable telecommunication systems underwater. In this paper, a high-speed remote command-based communication system is investigated, and a long-range acoustic communication system with good adaptability to sudden and continuous interference is designed based on a remote unmanned platform. A method for encoding the communication message in segments of optimal length is proposed in this paper. This coding method can enhance the anti-sudden interference capability of the communication system which has a certain degree of communication confidentiality, and the performance of this anti-interference communication system is verified by laboratory tests and field tests. The verification results show that the proposed telecommunication system based on optimal length segment coding has better performance in anti-sudden interference and continuous interference, which can make the communication system performance more stable and increase the success rate of command-based communication significantly.

Estimation method of the Homodyned K-distribution based on the Improved Shuffled Frog Leaping Algorithm for ultrasound tissue characterization

Abstract Aiming at promoting the accuracy of the integral value of the probability distribution function (PDF) of Homodyned K-distribution (HK), a new maximum likelihood estimation method for HK distribution parameters is proposed by using the improved shuffled frog leaping algorithm (ADM-SFLA) and Newton-Raphson iterative algorithm (NR). To improve the accuracy of the global search of the traditional SFLA, two variation factors of Gauss and Cauchy are first used to find the global optimal solution in a convergence state. Secondly, to obtain the integral node with optimal segmentation, the ADM-SFLA is used to perform the non-equidistant adaptive segmentation of the integral interval. Then, the PDF of the HK distribution is calculated between each numerical integration cell based on Simpson integral formula. Subsequently, the integral value of the PDF for HK distribution is obtained by summing the integration values from each numerical integration cell. Finally, the optimal estimation of HK distribution parameters is obtained based on NR algorithm. The performance of the proposed method is evaluated and compared through simulated data as well as the envelope signals obtained from the ultrasonic simulation model with different scattering components. The results show that the ADM-SFLA based method can improve the estimation accuracy of HK distribution parameters effectively.

Optimal segmentation of non-linear and non-stationary time series based on fractal dimension and Poincare section and its application in solving EEG-signal

Non-linearity and non-stationarity characteristics in physiological and biological time series limit the reliability of conventional analysis. The main challenge in pattern recognition problems is determining the Optimal-Window-Duration (OWD) for segmenting these time series. Our study presents an innovative algorithm, based on Individual-Optimal-Segmentation (IOS), which integrates chaos theory using fractal dimension, and Poincare section into the estimation of the OWD for segmenting time series with non-linear and non-stationary characteristics. In the logistic map case study, the IOS algorithm proved to be effective in detecting cycles in a range of numerical examples, from period-2 to chaotic behavior. So that its performance was superior to previous approaches, especially when it comes to detecting chaotic behaviors. Furthermore, the combination of the IOS algorithm with the Welch signal processing method shows promise in identifying abnormal Power-Spectral-Density (PSD) curves related to Beta and Gamma rhythms in depression diagnosis scenarios. The generated depression diagnosis system attained an accuracy (%) of 99.07±0.35 (with 2-channel) using the Monte Carlo simulation method. These findings suggest a potentially valuable tool for addressing segmentation challenges in time series analysis, particularly in contexts involving complex, dynamic data. While, it is suggested that future research investigate the computational efficiency and robustness of the IOS algorithm when handling large-scale or real-time data and increase its application in various fields in data science and signal processing. Furthermore, expanding the application range of the IOS algorithm for other pattern recognition problems with physiological or biological data can strengthen the generalizability and practical application of the algorithm.

A systematic evaluation of computational methods for cell segmentation.

Cell segmentation is a fundamental task in analyzing biomedical images. Many computational methods have been developed for cell segmentation and instance segmentation, but their performances are not well understood in various scenarios. We systematically evaluated the performance of 18 segmentation methods to perform cell nuclei and whole cell segmentation using light microscopy and fluorescence staining images. We found that general-purpose methods incorporating the attention mechanism exhibit the best overall performance. We identified various factors influencing segmentation performances, including image channels, choice of training data, and cell morphology, and evaluated the generalizability of methods across image modalities. We also provide guidelines for choosing the optimal segmentation methods in various real application scenarios. We developed Seggal, an online resource for downloading segmentation models already pre-trained with various tissue and cell types, substantially reducing the time and effort for training cell segmentation models.

Development of a Daily Cloud-Free Snow-Cover Dataset Using MODIS-Based Snow-Cover Probability for High Mountain Asia during 2000–2020

Investigating the changes in snow cover caused by climate change is extremely important and has attracted increasing attention in cryosphere and climate research. Optimal remote sensing-based snow datasets can provide long-term daily and global spatial-temporal snow-cover distribution at regional and global scales. However, the application of these snow-cover products is inevitably limited because of the space–time discontinuities caused by cloud obscuration, which poses a significant challenge in snowpack-related studies, especially in High Mountain Asia (HMA), an area that has high-elevation mountains, complex terrain, and harsh environments and has fewer observation stations. To address this issue, we developed an improved five-step hybrid cloud removal strategy by integrating the daily merged snow-cover probability (SCP) algorithm, eight-day merged SCP algorithm, decision tree algorithm, temporal downscaling algorithm, and optimal threshold segmentation algorithm to produce a 21-year, daily cloud-free snow-cover dataset using two daily MODIS snow-cover products over the HMA. The accuracy assessment demonstrated that the newly developed cloud-free snow-cover product achieved a mean overall accuracy of 93.80%, based on daily classified snow depth observations from 86 meteorological stations over 10 years. The time series of the daily percentage of binary snow-cover over HMA was analyzed during this period, indicating that the maximum snow cover tended to change more dramatically than the minimum snow cover. The annual snow-cover duration (SCD) experienced an insignificantly increasing trend over most of the northeastern and southwestern HMA (e.g., Qilian, eastern Kun Lun, the east of Inner Tibet, the western Himalayas, the central Himalayas, and the Hindu Kush) and an insignificant declining trend over most of the northwestern and southeastern HMA (e.g., the eastern Himalayas, Hengduan, the west of Inner Tibet, Pamir, Hissar Alay, and Tien). This new high-quality snow-cover dataset will promote studies on climate systems, hydrological modeling, and water resource management in this remote and cold region.

Identifying sources of bias when testing three available algorithms for quantifying white matter lesions: BIANCA, LPA and LGA.

Brain magnetic resonance imaging frequently reveals white matter lesions (WMLs) in older adults. They are often associated with cognitive impairment and risk of dementia. Given the continuous search for the optimal segmentation algorithm, we broke down this question by exploring whether the output of algorithms frequently used might be biased by the presence of different influencing factors. We studied the impact of age, sex, blood glucose levels, diabetes, systolic blood pressure and hypertension on automatic WML segmentation algorithms. We evaluated three widely used algorithms (BIANCA, LPA and LGA) using the population-based 1000BRAINS cohort (N = 1166, aged 18-87, 523 females, 643 males). We analysed two main aspects. Firstly, we examined whether training data (TD) characteristics influenced WML estimations, assessing the impact of relevant factors in the TD. Secondly, algorithm's output and performance within selected subgroups defined by these factors were assessed. Results revealed that BIANCA's WML estimations are influenced by the characteristics present in the TD. LPA and LGA consistently provided lower WML estimations compared to BIANCA's output when tested on participants under 67 years of age without risk cardiovascular factors. Notably, LPA and LGA showed reduced accuracy for these participants. However, LPA and LGA showed better performance for older participants presenting cardiovascular risk factors. Results suggest that incorporating comprehensive cohort factors like diverse age, sex and participants with and without hypertension in the TD could enhance WML-based analyses and mitigate potential sources of bias. LPA and LGA are a fast and valid option for older participants with cardiovascular risk factors.

Boosting Your Context by Dual Similarity Checkup for In-Context Learning Medical Image Segmentation.

The recent advent of in-context learning (ICL) capabilities in large pre-trained models has yielded significant advancements in the generalization of segmentation models. By supplying domain-specific image-mask pairs, the ICL model can be effectively guided to produce optimal segmentation outcomes, eliminating the necessity for model fine-tuning or interactive prompting. However, current existing ICL-based segmentation models exhibit significant limitations when applied to medical segmentation datasets with substantial diversity. To address this issue, we propose a dual similarity checkup approach to guarantee the effectiveness of selected in-context samples so that their guidance can be maximally leveraged during inference. We first employ large pre-trained vision models for extracting strong semantic representations from input images and constructing a feature embedding memory bank for semantic similarity checkup during inference. Assuring the similarity in the input semantic space, we then minimize the discrepancy in the mask appearance distribution between the support set and the estimated mask appearance prior through similarity-weighted sampling and augmentation. We validate our proposed dual similarity checkup approach on eight publicly available medical segmentation datasets, and extensive experimental results demonstrate that our proposed method significantly improves the performance metrics of existing ICL-based segmentation models, particularly when applied to medical image datasets characterized by substantial diversity.

Interpolation-split: a data-centric deep learning approach with big interpolated data to boost airway segmentation performance

The morphology and distribution of airway tree abnormalities enable diagnosis and disease characterisation across a variety of chronic respiratory conditions. In this regard, airway segmentation plays a critical role in the production of the outline of the entire airway tree to enable estimation of disease extent and severity. Furthermore, the segmentation of a complete airway tree is challenging as the intensity, scale/size and shape of airway segments and their walls change across generations. The existing classical techniques either provide an undersegmented or oversegmented airway tree, and manual intervention is required for optimal airway tree segmentation. The recent development of deep learning methods provides a fully automatic way of segmenting airway trees; however, these methods usually require high GPU memory usage and are difficult to implement in low computational resource environments. Therefore, in this study, we propose a data-centric deep learning technique with big interpolated data, Interpolation-Split, to boost the segmentation performance of the airway tree. The proposed technique utilises interpolation and image split to improve data usefulness and quality. Then, an ensemble learning strategy is implemented to aggregate the segmented airway segments at different scales. In terms of average segmentation performance (dice similarity coefficient, DSC), our method (A) achieves 90.55%, 89.52%, and 85.80%; (B) outperforms the baseline models by 2.89%, 3.86%, and 3.87% on average; and (C) produces maximum segmentation performance gain by 14.11%, 9.28%, and 12.70% for individual cases when (1) nnU-Net with instant normalisation and leaky ReLU; (2) nnU-Net with batch normalisation and ReLU; and (3) modified dilated U-Net are used respectively. Our proposed method outperformed the state-of-the-art airway segmentation approaches. Furthermore, our proposed technique has low RAM and GPU memory usage, and it is GPU memory-efficient and highly flexible, enabling it to be deployed on any 2D deep learning model.

Novel Deep CNNs Explore Regions, Boundaries, and Residual Learning for COVID-19 Infection Analysis in Lung CT.

COVID-19 poses a global health crisis, necessitating precise diagnostic methods for timely containment. However, accurately delineating COVID-19-affected regions in lung CT scans is challenging due to contrast variations and significant texture diversity. In this regard, this study introduces a novel two-stage classification and segmentation CNN approach for COVID-19 lung radiological pattern analysis. A novel Residual-BRNet is developed to integrate boundary and regional operations with residual learning, capturing key COVID-19 radiological homogeneous regions, texture variations, and structural contrast patterns in the classification stage. Subsequently, infectious CT images undergo lesion segmentation using the newly proposed RESeg segmentation CNN in the second stage. The RESeg leverages both average and max-pooling implementations to simultaneously learn region homogeneity and boundary-related patterns. Furthermore, novel pixel attention (PA) blocks are integrated into RESeg to effectively address mildly COVID-19-infected regions. The evaluation of the proposed Residual-BRNet CNN in the classification stage demonstrates promising performance metrics, achieving an accuracy of 97.97%, F1-score of 98.01%, sensitivity of 98.42%, and MCC of 96.81%. Meanwhile, PA-RESeg in the segmentation phase achieves an optimal segmentation performance with an IoU score of 98.43% and a dice similarity score of 95.96% of the lesion region. The framework's effectiveness in detecting and segmenting COVID-19 lesions highlights its potential for clinical applications.

Hypofractionated stereotactic radiotherapy for brain metastases in lung cancer patients: dose‒response effect and toxicity

BackgroundLung cancer is a common cause of brain metastases, approximately 40% of patients with lung cancer will develop brain metastases at some point during their disease. Hypofractionated stereotactic radiotherapy (HSRT) has been demonstrated to be effective in controlling limited brain metastases. However, there is still no conclusive on the optimal segmentation of HSRT. The aim of our study was to explore the correlation between the HSRT dosage and its treatment effect and toxicity.MethodsA retrospective analysis was conducted on patients with non-small cell lung cancer (NSCLC) brain metastasis at Hangzhou Cancer Hospital from 1 January 2019 to 1 January 2021. The number of brain metastases did not exceed 10 in all patients and the number of fractions of HSRT was 5. The prescription dose ranges from 25 to 40 Gy. The Kaplan–Meier method was used for estimation of the localised intracranial control rate (iLC). Adverse radiation effects (AREs) were evaluated according to CTCAE 5.0. This study was approved by the Institutional Ethics Review Board of the Hangzhou Cancer Hospital (#73/HZCH-2022).ResultsForty eligible patients with a total of 70 brain metastases were included in this study. The 1-year iLC was 76% and 89% in the prescribed dose ≤ 30 Gy and > 30 Gy group, respectively (P < 0.05). For patients treated with HSRT combined with targeted therapy, immunotherapy and chemotherapy, the 1-year iLC was 89%, 100%, and 45%, respectively. No significant associations were observed between the number, maximum diameter, location, and type of pathology of brain metastases. The rate of all-grade AREs was 33%. Two patients who received a total dose of 40 Gy developed grade 3 headache, the rest of the AREs were grade 1–2.ConclusionsIncreasing the prescription dose of HSRT improves treatment effect but may also exacerbate the side effects. Systemic therapy might impact the iLC rate, and individualized treatment regimens need to be developed.

A systematic evaluation of computational methods for cell segmentation.

Cell segmentation is a fundamental task in analyzing biomedical images. Many computational methods have been developed for cell segmentation and instance segmentation, but their performances are not well understood in various scenarios. We systematically evaluated the performance of 18 segmentation methods to perform cell nuclei and whole cell segmentation using light microscopy and fluorescence staining images. We found that general-purpose methods incorporating the attention mechanism exhibit the best overall performance. We identified various factors influencing segmentation performances, including image channels, choice of training data, and cell morphology, and evaluated the generalizability of methods across image modalities. We also provide guidelines for choosing the optimal segmentation methods in various real application scenarios. We developed Seggal, an online resource for downloading segmentation models already pre-trained with various tissue and cell types, substantially reducing the time and effort for training cell segmentation models.

CUSTOMER SEGMENTATION USING MACHINE LEARNING

Businesses need to identify and segment their consumer base in order to effectively customize their strategies and improve customer satisfaction in the highly competitive market landscape of today. The goal of this study is to employ machine learning techniques to create a strong consumer segmentation model that will classify customers according to their demographics, behaviors, and purchase histories. Through the use of multiple clustering methods, including K-means, DBSCAN, and Hierarchical Clustering, the model seeks to find unique customer segments with shared attributes. To accomplish optimal segmentation, the segmentation process entails three steps: feature selection to identify the most significant features, model training, and data preprocessing to manage missing values and outliers. In-depth segment analysis is also included in the report to offer practical insights for better client retention tactics, tailored recommendations, and focused marketing efforts. The results of the study illustrate how machine learning may be used to find hidden patterns in consumer data, giving organizations the ability to make data- driven decisions. Organizations may improve their marketing efforts, allocate resources more efficiently, and eventually increase customer engagement and profitability by putting this customer segmentation strategy into practice. Key Words: K-Means Clustering, Hierarchical Clustering, Density-Based Spatial Clustering of Applications with Noise (DBSCAN), Cluster Plotting, Heatmaps, customer relationship management (CRM) system.